Summary ?
GeneID335
SymbolAPOA1
Synonymsapo(a)
Descriptionapolipoprotein A-I
ReferenceMIM:107680|HGNC:HGNC:600|Ensembl:ENSG00000118137|HPRD:02517|Vega:OTTHUMG00000046112
Gene typeprotein-coding
Map location11q23-q24
Pascal p-value0.635
Fetal beta-1.698

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IGenome scan meta-analysisPsr: 0.006 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.3212 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PRPS20.710.76
OXCT10.700.78
LRRC4C0.690.78
PAK60.680.79
DLG20.680.71
FAM102B0.680.73
CDH100.670.75
TMEM1960.670.65
PLCH10.660.77
LANCL20.660.73
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
IMPA2-0.38-0.46
IRF7-0.35-0.41
RAB13-0.34-0.44
NUDT8-0.34-0.32
AP002478.3-0.33-0.36
TEAD4-0.33-0.38
SLC25A20-0.32-0.28
ACSF2-0.32-0.31
DCI-0.32-0.35
RHBDL3-0.31-0.32

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0001540beta-amyloid bindingIDA11297421 
GO:0005543phospholipid bindingIDA12810715 
GO:0005319lipid transporter activityIEA-
GO:0008289lipid bindingIEA-
GO:0017127cholesterol transporter activityIDA9651324 
GO:0017127cholesterol transporter activityIMP15464323 
GO:0015485cholesterol bindingIDA15464323 
GO:0042802identical protein bindingIPI8049247 
GO:0019899enzyme bindingIPI1587806 
GO:0034191apolipoprotein A-I receptor bindingIPI16443932 
GO:0060228phosphatidylcholine-sterol O-acyltransferase activator activityIDA4335615 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0002740negative regulation of cytokine secretion during immune responseIDA12458630 
GO:0007186G-protein coupled receptor protein signaling pathwayIDA16443932 
GO:0008202steroid metabolic processIEA-
GO:0008203cholesterol metabolic processIEA-
GO:0006656phosphatidylcholine biosynthetic processIDA4335615 
GO:0006629lipid metabolic processIEA-
GO:0006869lipid transportIEA-
GO:0033344cholesterol effluxIDA11162594 |14703508 |16443932 
GO:0042157lipoprotein metabolic processIEA-
GO:0050821protein stabilizationIDA17655203 
GO:0034435cholesterol esterificationIDA4335615 
GO:0032488Cdc42 protein signal transductionIDA16443932 
GO:0033700phospholipid effluxIDA11162594 |14703508 
GO:0042632cholesterol homeostasisIMP15464323 
GO:0050713negative regulation of interleukin-1 beta secretionIDA12458630 
GO:0043691reverse cholesterol transportIMP15464323 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005788endoplasmic reticulum lumenEXP12692552 
GO:0005576extracellular regionEXP4345202 |12692552 
GO:0005576extracellular regionIEA-
GO:0030139endocytic vesicleIDA14747463 
GO:0031410cytoplasmic vesicleIDA14703508 
GO:0034364high-density lipoprotein particleIDA210174 |3104518 |15464323 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABCA1ABC-1 | ABC1 | CERP | FLJ14958 | HDLDT1 | MGC164864 | MGC165011 | TGDATP-binding cassette, sub-family A (ABC1), member 1Reconstituted ComplexBioGRID12084722 
APOA1MGC117399apolipoprotein A-I-HPRD,BioGRID9003180 |9200714 
|9356442 
APOA1BPAIBP | MGC119143 | MGC119144 | MGC119145 | YJEFN1apolipoprotein A-I binding protein-HPRD11991719 
APOFApo-F | DKFZp781G18150 | LTIP | MGC22520apolipoprotein FCo-purificationBioGRID6816269 
APOL1APO-L | APOL | APOL-Iapolipoprotein L, 1-HPRD,BioGRID9325276 
GPLD1GPIPLD | GPIPLDM | MGC22590 | PIGPLD | PIGPLD1glycosylphosphatidylinositol specific phospholipase D1-HPRD,BioGRID11254757 
HPRA-259H10.2 | HPhaptoglobin-related proteinin vitroBioGRID10085035 
LBPMGC22233lipopolysaccharide binding proteinAffinity Capture-WesternBioGRID8663389 
LCAT-lecithin-cholesterol acyltransferaseReconstituted ComplexBioGRID1644835 
MAP7D1FLJ10350 | FLJ39022 | MGC117315 | PARCC1 | RPRC1MAP7 domain containing 1Two-hybridBioGRID16169070 
PDE1AHCAM1 | HSPDE1A | MGC26303phosphodiesterase 1A, calmodulin-dependentTwo-hybridBioGRID11991719 
PLTPHDLCQ9phospholipid transfer proteinCo-purification
Reconstituted Complex
BioGRID9469594 
PLTPHDLCQ9phospholipid transfer protein-HPRD11854286 
SCARB1CD36L1 | CLA-1 | CLA1 | MGC138242 | SR-BI | SRB1scavenger receptor class B, member 1in vivoBioGRID1076467 
TNFRSF10CCD263 | DCR1 | LIT | MGC149501 | MGC149502 | TRAILR3 | TRIDtumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domainTwo-hybridBioGRID16169070 
TOMM20KIAA0016 | MAS20 | MGC117367 | MOM19 | TOM20translocase of outer mitochondrial membrane 20 homolog (yeast)Two-hybridBioGRID16169070 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG PPAR SIGNALING PATHWAY 6947All SZGR 2.0 genes in this pathway
BIOCARTA PPARA PATHWAY 5843All SZGR 2.0 genes in this pathway
PID HNF3B PATHWAY 4537All SZGR 2.0 genes in this pathway
REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 1811All SZGR 2.0 genes in this pathway
REACTOME PPARA ACTIVATES GENE EXPRESSION 10472All SZGR 2.0 genes in this pathway
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 8956All SZGR 2.0 genes in this pathway
REACTOME HDL MEDIATED LIPID TRANSPORT 1512All SZGR 2.0 genes in this pathway
REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT 3421All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413270All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478302All SZGR 2.0 genes in this pathway
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM 168115All SZGR 2.0 genes in this pathway
REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT 4637All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
REACTOME LIPOPROTEIN METABOLISM 2824All SZGR 2.0 genes in this pathway
REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT 1615All SZGR 2.0 genes in this pathway
REACTOME AMYLOIDS 8363All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208138All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY DN 367220All SZGR 2.0 genes in this pathway
KORKOLA YOLK SAC TUMOR 6233All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN 514319All SZGR 2.0 genes in this pathway
CERVERA SDHB TARGETS 2 11476All SZGR 2.0 genes in this pathway
HSIAO LIVER SPECIFIC GENES 244154All SZGR 2.0 genes in this pathway
NIELSEN LIPOSARCOMA UP 1813All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE DN 261183All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540340All SZGR 2.0 genes in this pathway
CADWELL ATG16L1 TARGETS UP 9356All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S3 266180All SZGR 2.0 genes in this pathway
PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 UP 13485All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504321All SZGR 2.0 genes in this pathway
VANDESLUIS COMMD1 TARGETS GROUP 4 UP 1912All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682433All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION UP 271165All SZGR 2.0 genes in this pathway