Summary ?
GeneID3352
SymbolHTR1D
Synonyms5-HT1D|HT1DA|HTR1DA|HTRL|RDC4
Description5-hydroxytryptamine receptor 1D
ReferenceMIM:182133|HGNC:HGNC:5289|Ensembl:ENSG00000179546|HPRD:01636|Vega:OTTHUMG00000003235
Gene typeprotein-coding
Map location1p36.3-p34.3
Pascal p-value0.537
eGeneCaudate basal ganglia
Cortex
Nucleus accumbens basal ganglia
Putamen basal ganglia
Myers' cis & trans
Meta
SupportGPCR SIGNALLING
SEROTONIN

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
ADT:Sun_2012Systematic Investigation of Antipsychotic Drugs and Their TargetsA total of 382 drug-target associations involving 43 antipsychotic drugs and 49 target genes.
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs2806570chr123527004HTR1D33520.16cis
rs4654830123283362HTR1DENSG00000179546.33.348E-60.03237860gtex_brain_putamen_basal
rs309509123283380HTR1DENSG00000179546.32.525E-60.03237842gtex_brain_putamen_basal
rs2294518123372771HTR1DENSG00000179546.32.959E-60.03148451gtex_brain_putamen_basal
rs12409321123398065HTR1DENSG00000179546.32.957E-60.03123157gtex_brain_putamen_basal
rs12751560123407081HTR1DENSG00000179546.32.084E-60.03114141gtex_brain_putamen_basal
rs2235546123409538HTR1DENSG00000179546.32.959E-60.03111684gtex_brain_putamen_basal
rs71020475123410469HTR1DENSG00000179546.33.272E-60.03110753gtex_brain_putamen_basal
rs2806563123506625HTR1DENSG00000179546.33.458E-60.0314597gtex_brain_putamen_basal
rs654585123514714HTR1DENSG00000179546.32.279E-60.036508gtex_brain_putamen_basal
rs61777102123543352HTR1DENSG00000179546.32.765E-60.03-22130gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004993serotonin receptor activityTASserotonin, Neurotransmitter (GO term level: 8)1565658 
GO:0004872receptor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)1565658 
GO:0007187G-protein signaling, coupled to cyclic nucleotide second messengerTAS1565658 
GO:0007165signal transductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS1652050 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305177All SZGR 2.0 genes in this pathway
REACTOME AMINE LIGAND BINDING RECEPTORS 3833All SZGR 2.0 genes in this pathway
REACTOME SEROTONIN RECEPTORS 1211All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME G ALPHA I SIGNALLING EVENTS 195114All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408246All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 6 8454All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435318All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-379657663m8hsa-miR-379brainUGGUAGACUAUGGAACGUA