Gene Page: SP110
Summary ?
| GeneID | 3431 |
| Symbol | SP110 |
| Synonyms | IFI41|IFI75|IPR1|VODI |
| Description | SP110 nuclear body protein |
| Reference | MIM:604457|HGNC:HGNC:5401|Ensembl:ENSG00000135899|HPRD:06832|Vega:OTTHUMG00000133204 |
| Gene type | protein-coding |
| Map location | 2q37.1 |
| Pascal p-value | 0.021 |
| Sherlock p-value | 0.873 |
| Fetal beta | -1.256 |
| DMG | 1 (# studies) |
| eGene | Cerebellum Cortex Putamen basal ganglia Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
| Expression | Meta-analysis of gene expression | P value: 3.131 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg02056135 | 2 | 231084523 | SP110 | 5.48E-5 | -0.697 | 0.022 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs4973285 | chr2 | 231045942 | SP110 | 3431 | 0.01 | cis | ||
| rs10804364 | chr2 | 231047302 | SP110 | 3431 | 0.02 | cis | ||
| rs10755048 | chr2 | 231047644 | SP110 | 3431 | 0.01 | cis | ||
| rs3948464 | chr2 | 231050714 | SP110 | 3431 | 0.2 | cis | ||
| rs6752361 | chr2 | 231053317 | SP110 | 3431 | 0.03 | cis | ||
| rs4973298 | chr2 | 231060002 | SP110 | 3431 | 0.01 | cis | ||
| rs12474683 | chr2 | 231060445 | SP110 | 3431 | 0.05 | cis | ||
| rs7601299 | chr2 | 231077993 | SP110 | 3431 | 0.03 | cis | ||
| rs13023481 | chr2 | 213839772 | SP110 | 3431 | 0.18 | trans | ||
| rs9784019 | 2 | 231035575 | SP110 | ENSG00000135899.12 | 1.035E-6 | 0 | 54869 | gtex_brain_putamen_basal |
| rs9783992 | 2 | 231035589 | SP110 | ENSG00000135899.12 | 1.035E-6 | 0 | 54855 | gtex_brain_putamen_basal |
| rs13010998 | 2 | 231035729 | SP110 | ENSG00000135899.12 | 1.035E-6 | 0 | 54715 | gtex_brain_putamen_basal |
| rs13010639 | 2 | 231035745 | SP110 | ENSG00000135899.12 | 1.035E-6 | 0 | 54699 | gtex_brain_putamen_basal |
| rs9783994 | 2 | 231035957 | SP110 | ENSG00000135899.12 | 1.035E-6 | 0 | 54487 | gtex_brain_putamen_basal |
| rs12988385 | 2 | 231036311 | SP110 | ENSG00000135899.12 | 1.035E-6 | 0 | 54133 | gtex_brain_putamen_basal |
| rs34897866 | 2 | 231036754 | SP110 | ENSG00000135899.12 | 1.035E-6 | 0 | 53690 | gtex_brain_putamen_basal |
| rs34034766 | 2 | 231036768 | SP110 | ENSG00000135899.12 | 1.035E-6 | 0 | 53676 | gtex_brain_putamen_basal |
| rs13018234 | 2 | 231036866 | SP110 | ENSG00000135899.12 | 1.035E-6 | 0 | 53578 | gtex_brain_putamen_basal |
| rs12995739 | 2 | 231037481 | SP110 | ENSG00000135899.12 | 1.035E-6 | 0 | 52963 | gtex_brain_putamen_basal |
| rs13025520 | 2 | 231038029 | SP110 | ENSG00000135899.12 | 1.035E-6 | 0 | 52415 | gtex_brain_putamen_basal |
| rs13025209 | 2 | 231038169 | SP110 | ENSG00000135899.12 | 1.035E-6 | 0 | 52275 | gtex_brain_putamen_basal |
| rs13026323 | 2 | 231038403 | SP110 | ENSG00000135899.12 | 1.035E-6 | 0 | 52041 | gtex_brain_putamen_basal |
| rs2162478 | 2 | 231038640 | SP110 | ENSG00000135899.12 | 1.035E-6 | 0 | 51804 | gtex_brain_putamen_basal |
| rs139482435 | 2 | 231038830 | SP110 | ENSG00000135899.12 | 1.035E-6 | 0 | 51614 | gtex_brain_putamen_basal |
| rs5839362 | 2 | 231038831 | SP110 | ENSG00000135899.12 | 1.035E-6 | 0 | 51613 | gtex_brain_putamen_basal |
| rs1004868 | 2 | 231038910 | SP110 | ENSG00000135899.12 | 1.035E-6 | 0 | 51534 | gtex_brain_putamen_basal |
| rs2114585 | 2 | 231039341 | SP110 | ENSG00000135899.12 | 1.035E-6 | 0 | 51103 | gtex_brain_putamen_basal |
| rs34122378 | 2 | 231040163 | SP110 | ENSG00000135899.12 | 1.035E-6 | 0 | 50281 | gtex_brain_putamen_basal |
| rs41543719 | 2 | 231041940 | SP110 | ENSG00000135899.12 | 1.035E-6 | 0 | 48504 | gtex_brain_putamen_basal |
| rs35574529 | 2 | 231043479 | SP110 | ENSG00000135899.12 | 1.712E-7 | 0 | 46965 | gtex_brain_putamen_basal |
| rs35849510 | 2 | 231043495 | SP110 | ENSG00000135899.12 | 1.712E-7 | 0 | 46949 | gtex_brain_putamen_basal |
| rs3948464 | 2 | 231050715 | SP110 | ENSG00000135899.12 | 6.942E-7 | 0 | 39729 | gtex_brain_putamen_basal |
| rs6756480 | 2 | 231054329 | SP110 | ENSG00000135899.12 | 6.301E-7 | 0 | 36115 | gtex_brain_putamen_basal |
| rs2894695 | 2 | 231057189 | SP110 | ENSG00000135899.12 | 6.647E-7 | 0 | 33255 | gtex_brain_putamen_basal |
| rs1007661 | 2 | 231062616 | SP110 | ENSG00000135899.12 | 6.061E-7 | 0 | 27828 | gtex_brain_putamen_basal |
| rs4973299 | 2 | 231076617 | SP110 | ENSG00000135899.12 | 1.77E-8 | 0 | 13827 | gtex_brain_putamen_basal |
| rs6749386 | 2 | 231077360 | SP110 | ENSG00000135899.12 | 1.764E-8 | 0 | 13084 | gtex_brain_putamen_basal |
| rs1129411 | 2 | 231077725 | SP110 | ENSG00000135899.12 | 1.761E-8 | 0 | 12719 | gtex_brain_putamen_basal |
| rs1427294 | 2 | 231078448 | SP110 | ENSG00000135899.12 | 1.761E-8 | 0 | 11996 | gtex_brain_putamen_basal |
| rs1427293 | 2 | 231078645 | SP110 | ENSG00000135899.12 | 2.34E-8 | 0 | 11799 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003677 | DNA binding | TAS | 7693701 | |
| GO:0005062 | hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity | TAS | 7693701 | |
| GO:0005515 | protein binding | IEA | - | |
| GO:0008270 | zinc ion binding | IEA | - | |
| GO:0046872 | metal ion binding | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | - | |
| GO:0006350 | transcription | IEA | - | |
| GO:0044419 | interspecies interaction between organisms | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005634 | nucleus | IEA | - | |
| GO:0005634 | nucleus | TAS | 7693701 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PARENT MTOR SIGNALING UP | 567 | 375 | All SZGR 2.0 genes in this pathway |
| ONKEN UVEAL MELANOMA UP | 783 | 507 | All SZGR 2.0 genes in this pathway |
| FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN | 463 | 290 | All SZGR 2.0 genes in this pathway |
| DOANE RESPONSE TO ANDROGEN DN | 241 | 146 | All SZGR 2.0 genes in this pathway |
| OSMAN BLADDER CANCER DN | 406 | 230 | All SZGR 2.0 genes in this pathway |
| TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP | 182 | 110 | All SZGR 2.0 genes in this pathway |
| TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP | 194 | 122 | All SZGR 2.0 genes in this pathway |
| DITTMER PTHLH TARGETS DN | 73 | 51 | All SZGR 2.0 genes in this pathway |
| GOZGIT ESR1 TARGETS DN | 781 | 465 | All SZGR 2.0 genes in this pathway |
| ENK UV RESPONSE EPIDERMIS UP | 293 | 179 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP | 552 | 347 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP | 211 | 136 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN UP | 1142 | 669 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP | 612 | 367 | All SZGR 2.0 genes in this pathway |
| BARIS THYROID CANCER DN | 59 | 45 | All SZGR 2.0 genes in this pathway |
| MISSIAGLIA REGULATED BY METHYLATION UP | 126 | 78 | All SZGR 2.0 genes in this pathway |
| EINAV INTERFERON SIGNATURE IN CANCER | 27 | 16 | All SZGR 2.0 genes in this pathway |
| DAUER STAT3 TARGETS DN | 50 | 34 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| SCHAEFFER PROSTATE DEVELOPMENT 6HR UP | 176 | 115 | All SZGR 2.0 genes in this pathway |
| DER IFN ALPHA RESPONSE UP | 74 | 48 | All SZGR 2.0 genes in this pathway |
| WIELAND UP BY HBV INFECTION | 101 | 66 | All SZGR 2.0 genes in this pathway |
| DER IFN BETA RESPONSE UP | 102 | 67 | All SZGR 2.0 genes in this pathway |
| SMITH TERT TARGETS DN | 87 | 69 | All SZGR 2.0 genes in this pathway |
| DER IFN GAMMA RESPONSE UP | 71 | 45 | All SZGR 2.0 genes in this pathway |
| DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP | 314 | 201 | All SZGR 2.0 genes in this pathway |
| BROWNE INTERFERON RESPONSIVE GENES | 68 | 44 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RB1 TARGETS DN | 543 | 317 | All SZGR 2.0 genes in this pathway |
| MARTINEZ TP53 TARGETS DN | 593 | 372 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RB1 AND TP53 TARGETS DN | 591 | 366 | All SZGR 2.0 genes in this pathway |
| RIZKI TUMOR INVASIVENESS 3D DN | 270 | 181 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER NORMAL LIKE UP | 476 | 285 | All SZGR 2.0 genes in this pathway |
| TOOKER GEMCITABINE RESISTANCE UP | 79 | 40 | All SZGR 2.0 genes in this pathway |
| ZHANG INTERFERON RESPONSE | 23 | 14 | All SZGR 2.0 genes in this pathway |
| WUNDER INFLAMMATORY RESPONSE AND CHOLESTEROL UP | 58 | 38 | All SZGR 2.0 genes in this pathway |
| RUTELLA RESPONSE TO CSF2RB AND IL4 DN | 315 | 201 | All SZGR 2.0 genes in this pathway |
| RUTELLA RESPONSE TO HGF DN | 235 | 144 | All SZGR 2.0 genes in this pathway |
| RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP | 408 | 276 | All SZGR 2.0 genes in this pathway |
| LEE DIFFERENTIATING T LYMPHOCYTE | 200 | 115 | All SZGR 2.0 genes in this pathway |
| ZHANG TLX TARGETS 36HR UP | 221 | 150 | All SZGR 2.0 genes in this pathway |
| ZHANG TLX TARGETS 60HR UP | 293 | 203 | All SZGR 2.0 genes in this pathway |
| ZHANG TLX TARGETS UP | 108 | 78 | All SZGR 2.0 genes in this pathway |
| STAMBOLSKY TARGETS OF MUTATED TP53 DN | 50 | 24 | All SZGR 2.0 genes in this pathway |
| GREGORY SYNTHETIC LETHAL WITH IMATINIB | 145 | 83 | All SZGR 2.0 genes in this pathway |
| PURBEY TARGETS OF CTBP1 NOT SATB1 UP | 344 | 215 | All SZGR 2.0 genes in this pathway |
| PURBEY TARGETS OF CTBP1 NOT SATB1 DN | 448 | 282 | All SZGR 2.0 genes in this pathway |
| YANG BCL3 TARGETS UP | 364 | 236 | All SZGR 2.0 genes in this pathway |