Gene Page: IFNB1

Summary ?
GeneID3456
SymbolIFNB1
SynonymsIFB|IFF|IFN-beta|IFNB
Descriptioninterferon, beta 1, fibroblast
ReferenceMIM:147640|HGNC:HGNC:5434|Ensembl:ENSG00000171855|HPRD:00972|Vega:OTTHUMG00000019652
Gene typeprotein-coding
Map location9p21
Pascal p-value0.175

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
EIF3H0.970.95
RPL40.970.94
KARS0.960.95
CCT30.960.95
BTF30.960.96
TUT10.950.87
POLR1D0.950.93
MRPL450.950.94
TEX100.940.93
NACA0.940.92
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
HLA-F-0.68-0.79
AF347015.33-0.68-0.85
AF347015.27-0.67-0.83
MT-CO2-0.67-0.83
AIFM3-0.67-0.78
MT-CYB-0.66-0.84
AF347015.31-0.66-0.82
AF347015.8-0.65-0.84
TINAGL1-0.65-0.78
AF347015.15-0.64-0.83

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267161All SZGR 2.0 genes in this pathway
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY 10288All SZGR 2.0 genes in this pathway
KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY 7151All SZGR 2.0 genes in this pathway
KEGG CYTOSOLIC DNA SENSING PATHWAY 5644All SZGR 2.0 genes in this pathway
KEGG JAK STAT SIGNALING PATHWAY 155105All SZGR 2.0 genes in this pathway
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY 13792All SZGR 2.0 genes in this pathway
BIOCARTA RANKL PATHWAY 1413All SZGR 2.0 genes in this pathway
BIOCARTA CYTOKINE PATHWAY 2216All SZGR 2.0 genes in this pathway
BIOCARTA INFLAM PATHWAY 2924All SZGR 2.0 genes in this pathway
BIOCARTA DC PATHWAY 2220All SZGR 2.0 genes in this pathway
BIOCARTA IL1R PATHWAY 3329All SZGR 2.0 genes in this pathway
ST TYPE I INTERFERON PATHWAY 98All SZGR 2.0 genes in this pathway
PID SMAD2 3NUCLEAR PATHWAY 8263All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED IRF7 ACTIVATION 3026All SZGR 2.0 genes in this pathway
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 132101All SZGR 2.0 genes in this pathway
REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 1410All SZGR 2.0 genes in this pathway
REACTOME INTERFERON ALPHA BETA SIGNALING 6450All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF IFNA SIGNALING 2422All SZGR 2.0 genes in this pathway
REACTOME INTERFERON SIGNALING 159116All SZGR 2.0 genes in this pathway
REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS 7357All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM 279178All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270204All SZGR 2.0 genes in this pathway
NOJIMA SFRP2 TARGETS DN 2518All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 6HR UP 8554All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431237All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 6 119All SZGR 2.0 genes in this pathway
KUROKAWA LIVER CANCER CHEMOTHERAPY DN 4128All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405264All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314201All SZGR 2.0 genes in this pathway
ZHU CMV ALL UP 12089All SZGR 2.0 genes in this pathway
ZHANG ANTIVIRAL RESPONSE TO RIBAVIRIN DN 5132All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 6HR UP 7148All SZGR 2.0 genes in this pathway
ZHU CMV 8 HR UP 4739All SZGR 2.0 genes in this pathway
ISHIKAWA STING SIGNALING 86All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP 165118All SZGR 2.0 genes in this pathway
ZHANG INTERFERON RESPONSE 2314All SZGR 2.0 genes in this pathway
WORSCHECH TUMOR EVASION AND TOLEROGENICITY UP 3019All SZGR 2.0 genes in this pathway
BOSCO TH1 CYTOTOXIC MODULE 11462All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS 344197All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway