Gene Page: RBPMS2
Summary ?
| GeneID | 348093 |
| Symbol | RBPMS2 |
| Synonyms | - |
| Description | RNA binding protein with multiple splicing 2 |
| Reference | HGNC:HGNC:19098|Ensembl:ENSG00000166831|HPRD:18601|Vega:OTTHUMG00000172423 |
| Gene type | protein-coding |
| Map location | 15q22.31 |
| Pascal p-value | 0.003 |
| Sherlock p-value | 0.008 |
| Fetal beta | -1.378 |
| DMG | 1 (# studies) |
| eGene | Cerebellar Hemisphere Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg11479165 | 15 | 65068594 | RBPMS2 | 5.37E-8 | -0.024 | 1.39E-5 | DMG:Jaffe_2016 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs7403350 | chr15 | 65045290 | RBPMS2 | 348093 | 0.18 | cis | ||
| rs4953361 | chr2 | 46598567 | RBPMS2 | 348093 | 0.08 | trans | ||
| rs17772345 | chr2 | 195903575 | RBPMS2 | 348093 | 0.18 | trans | ||
| rs1491690 | chr3 | 70131340 | RBPMS2 | 348093 | 0.04 | trans | ||
| rs2701130 | chr12 | 52429439 | RBPMS2 | 348093 | 0 | trans | ||
| rs6486443 | chr12 | 129765549 | RBPMS2 | 348093 | 0.08 | trans | ||
| rs7958970 | chr12 | 129768897 | RBPMS2 | 348093 | 0.01 | trans | ||
| rs3899870 | chr13 | 97205717 | RBPMS2 | 348093 | 0.04 | trans | ||
| rs973639 | chr14 | 24578015 | RBPMS2 | 348093 | 0.09 | trans | ||
| rs3742499 | chr14 | 24586832 | RBPMS2 | 348093 | 0.1 | trans | ||
| snp_a-4245556 | 0 | RBPMS2 | 348093 | 0.15 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| VECCHI GASTRIC CANCER EARLY DN | 367 | 220 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC1 AND HDAC2 TARGETS UP | 238 | 144 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC2 TARGETS UP | 114 | 66 | All SZGR 2.0 genes in this pathway |
| LINDGREN BLADDER CANCER CLUSTER 2B | 392 | 251 | All SZGR 2.0 genes in this pathway |
| DAIRKEE TERT TARGETS DN | 124 | 79 | All SZGR 2.0 genes in this pathway |
| ROZANOV MMP14 TARGETS UP | 266 | 171 | All SZGR 2.0 genes in this pathway |
| DOUGLAS BMI1 TARGETS UP | 566 | 371 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 | 720 | 440 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER UP | 973 | 570 | All SZGR 2.0 genes in this pathway |
| MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 | 1069 | 729 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 4 UP | 112 | 64 | All SZGR 2.0 genes in this pathway |
| WIERENGA STAT5A TARGETS DN | 213 | 127 | All SZGR 2.0 genes in this pathway |
| ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN | 308 | 187 | All SZGR 2.0 genes in this pathway |
| DURAND STROMA S UP | 297 | 194 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | All SZGR 2.0 genes in this pathway |