Gene Page: ACADS
Summary ?
GeneID | 35 |
Symbol | ACADS |
Synonyms | ACAD3|SCAD |
Description | acyl-CoA dehydrogenase, C-2 to C-3 short chain |
Reference | MIM:606885|HGNC:HGNC:90|Ensembl:ENSG00000122971|HPRD:06053|Vega:OTTHUMG00000169203 |
Gene type | protein-coding |
Map location | 12q24.31 |
Pascal p-value | 0.002 |
eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Myers' cis & trans Meta |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
---|---|---|---|---|---|---|---|---|
rs17070904 | chr18 | 60917055 | ACADS | 35 | 0.18 | trans | ||
rs10853963 | chr19 | 2909032 | ACADS | 35 | 0.13 | trans | ||
rs2005455 | 12 | 121128699 | ACADS | ENSG00000122971.4 | 6.777E-7 | 0.01 | -34839 | gtex_brain_ba24 |
rs10431385 | 12 | 121128882 | ACADS | ENSG00000122971.4 | 6.777E-7 | 0.01 | -34656 | gtex_brain_ba24 |
rs998727 | 12 | 121149064 | ACADS | ENSG00000122971.4 | 2.725E-7 | 0.01 | -14474 | gtex_brain_ba24 |
rs57623705 | 12 | 121151062 | ACADS | ENSG00000122971.4 | 8.223E-7 | 0.01 | -12476 | gtex_brain_ba24 |
rs34734847 | 12 | 121154221 | ACADS | ENSG00000122971.4 | 9.859E-7 | 0.01 | -9317 | gtex_brain_ba24 |
rs56273049 | 12 | 121156041 | ACADS | ENSG00000122971.4 | 9.864E-7 | 0.01 | -7497 | gtex_brain_ba24 |
rs35360964 | 12 | 121156290 | ACADS | ENSG00000122971.4 | 9.864E-7 | 0.01 | -7248 | gtex_brain_ba24 |
rs56179458 | 12 | 121157535 | ACADS | ENSG00000122971.4 | 9.848E-7 | 0.01 | -6003 | gtex_brain_ba24 |
rs55730005 | 12 | 121157536 | ACADS | ENSG00000122971.4 | 1.035E-6 | 0.01 | -6002 | gtex_brain_ba24 |
rs3752531 | 12 | 121157851 | ACADS | ENSG00000122971.4 | 9.848E-7 | 0.01 | -5687 | gtex_brain_ba24 |
rs2948149 | 12 | 121162854 | ACADS | ENSG00000122971.4 | 1.084E-7 | 0.01 | -684 | gtex_brain_ba24 |
rs3021338 | 12 | 121162989 | ACADS | ENSG00000122971.4 | 9.021E-7 | 0.01 | -549 | gtex_brain_ba24 |
rs2239760 | 12 | 121163518 | ACADS | ENSG00000122971.4 | 1.123E-7 | 0.01 | -20 | gtex_brain_ba24 |
rs12302189 | 12 | 121199329 | ACADS | ENSG00000122971.4 | 9.985E-7 | 0.01 | 35791 | gtex_brain_ba24 |
rs10437837 | 12 | 121211693 | ACADS | ENSG00000122971.4 | 9.985E-7 | 0.01 | 48155 | gtex_brain_ba24 |
rs141767075 | 12 | 121219266 | ACADS | ENSG00000122971.4 | 9.985E-7 | 0.01 | 55728 | gtex_brain_ba24 |
rs10849789 | 12 | 121231461 | ACADS | ENSG00000122971.4 | 9.985E-7 | 0.01 | 67923 | gtex_brain_ba24 |
rs73229135 | 12 | 121250315 | ACADS | ENSG00000122971.4 | 9.985E-7 | 0.01 | 86777 | gtex_brain_ba24 |
rs10849795 | 12 | 121251889 | ACADS | ENSG00000122971.4 | 9.985E-7 | 0.01 | 88351 | gtex_brain_ba24 |
rs145414824 | 12 | 121252464 | ACADS | ENSG00000122971.4 | 9.992E-7 | 0.01 | 88926 | gtex_brain_ba24 |
rs11065276 | 12 | 121254654 | ACADS | ENSG00000122971.4 | 9.985E-7 | 0.01 | 91116 | gtex_brain_ba24 |
rs10849796 | 12 | 121265642 | ACADS | ENSG00000122971.4 | 9.985E-7 | 0.01 | 102104 | gtex_brain_ba24 |
rs73229156 | 12 | 121270733 | ACADS | ENSG00000122971.4 | 1.49E-6 | 0.01 | 107195 | gtex_brain_ba24 |
rs10849798 | 12 | 121273374 | ACADS | ENSG00000122971.4 | 9.984E-7 | 0.01 | 109836 | gtex_brain_ba24 |
rs10849799 | 12 | 121274189 | ACADS | ENSG00000122971.4 | 9.981E-7 | 0.01 | 110651 | gtex_brain_ba24 |
rs10849808 | 12 | 121315630 | ACADS | ENSG00000122971.4 | 9.985E-7 | 0.01 | 152092 | gtex_brain_ba24 |
rs10849809 | 12 | 121316726 | ACADS | ENSG00000122971.4 | 9.985E-7 | 0.01 | 153188 | gtex_brain_ba24 |
rs10431373 | 12 | 121319619 | ACADS | ENSG00000122971.4 | 9.985E-7 | 0.01 | 156081 | gtex_brain_ba24 |
rs74416604 | 12 | 121341495 | ACADS | ENSG00000122971.4 | 1.013E-6 | 0.01 | 177957 | gtex_brain_ba24 |
rs10849817 | 12 | 121349427 | ACADS | ENSG00000122971.4 | 9.985E-7 | 0.01 | 185889 | gtex_brain_ba24 |
rs11065331 | 12 | 121359856 | ACADS | ENSG00000122971.4 | 5.166E-7 | 0.01 | 196318 | gtex_brain_ba24 |
rs11065341 | 12 | 121369960 | ACADS | ENSG00000122971.4 | 7.657E-7 | 0.01 | 206422 | gtex_brain_ba24 |
rs11065344 | 12 | 121372509 | ACADS | ENSG00000122971.4 | 1E-6 | 0.01 | 208971 | gtex_brain_ba24 |
rs10849821 | 12 | 121377329 | ACADS | ENSG00000122971.4 | 1.165E-6 | 0.01 | 213791 | gtex_brain_ba24 |
rs11065355 | 12 | 121378477 | ACADS | ENSG00000122971.4 | 1.152E-6 | 0.01 | 214939 | gtex_brain_ba24 |
Section II. Transcriptome annotation
General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
STMN1 | 0.91 | 0.89 |
STMN2 | 0.90 | 0.88 |
CDC42 | 0.90 | 0.90 |
PWP1 | 0.89 | 0.89 |
NT5C3 | 0.89 | 0.90 |
RARS | 0.89 | 0.90 |
ASNSD1 | 0.88 | 0.90 |
PPP3CC | 0.88 | 0.87 |
CCDC90B | 0.88 | 0.88 |
ACAT2 | 0.88 | 0.90 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
AF347015.27 | -0.71 | -0.78 |
AF347015.33 | -0.70 | -0.77 |
MT-CO2 | -0.69 | -0.76 |
HLA-F | -0.69 | -0.73 |
MT-CYB | -0.69 | -0.77 |
AF347015.8 | -0.68 | -0.77 |
AF347015.15 | -0.68 | -0.78 |
AF347015.31 | -0.68 | -0.76 |
AF347015.2 | -0.67 | -0.80 |
AF347015.9 | -0.64 | -0.75 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
KEGG FATTY ACID METABOLISM | 42 | 29 | All SZGR 2.0 genes in this pathway |
KEGG VALINE LEUCINE AND ISOLEUCINE DEGRADATION | 44 | 26 | All SZGR 2.0 genes in this pathway |
KEGG BUTANOATE METABOLISM | 34 | 20 | All SZGR 2.0 genes in this pathway |
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | 14 | 10 | All SZGR 2.0 genes in this pathway |
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS | 478 | 302 | All SZGR 2.0 genes in this pathway |
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM | 168 | 115 | All SZGR 2.0 genes in this pathway |
BIDUS METASTASIS DN | 161 | 93 | All SZGR 2.0 genes in this pathway |
WANG BARRETTS ESOPHAGUS UP | 51 | 27 | All SZGR 2.0 genes in this pathway |
VANTVEER BREAST CANCER METASTASIS UP | 56 | 31 | All SZGR 2.0 genes in this pathway |
KUMAR TARGETS OF MLL AF9 FUSION | 405 | 264 | All SZGR 2.0 genes in this pathway |
RUAN RESPONSE TO TNF DN | 84 | 50 | All SZGR 2.0 genes in this pathway |
BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
KAAB HEART ATRIUM VS VENTRICLE DN | 261 | 183 | All SZGR 2.0 genes in this pathway |
MARIADASON RESPONSE TO CURCUMIN SULINDAC 5 | 23 | 17 | All SZGR 2.0 genes in this pathway |
JI RESPONSE TO FSH UP | 74 | 56 | All SZGR 2.0 genes in this pathway |
GERHOLD ADIPOGENESIS UP | 49 | 40 | All SZGR 2.0 genes in this pathway |
BURTON ADIPOGENESIS 6 | 189 | 112 | All SZGR 2.0 genes in this pathway |
LEE LIVER CANCER | 49 | 29 | All SZGR 2.0 genes in this pathway |
ACEVEDO LIVER CANCER DN | 540 | 340 | All SZGR 2.0 genes in this pathway |
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN | 274 | 165 | All SZGR 2.0 genes in this pathway |
MOOTHA HUMAN MITODB 6 2002 | 429 | 260 | All SZGR 2.0 genes in this pathway |
MOOTHA PGC | 420 | 269 | All SZGR 2.0 genes in this pathway |
LEE LIVER CANCER SURVIVAL UP | 185 | 112 | All SZGR 2.0 genes in this pathway |
MOOTHA MITOCHONDRIA | 447 | 277 | All SZGR 2.0 genes in this pathway |
KESHELAVA MULTIPLE DRUG RESISTANCE | 88 | 56 | All SZGR 2.0 genes in this pathway |
HOSHIDA LIVER CANCER SUBCLASS S3 | 266 | 180 | All SZGR 2.0 genes in this pathway |
CAIRO HEPATOBLASTOMA DN | 267 | 160 | All SZGR 2.0 genes in this pathway |
MOOTHA FFA OXYDATION | 22 | 13 | All SZGR 2.0 genes in this pathway |
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 36HR | 152 | 88 | All SZGR 2.0 genes in this pathway |
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D | 882 | 506 | All SZGR 2.0 genes in this pathway |