Gene Page: ACADS

Summary ?
GeneID35
SymbolACADS
SynonymsACAD3|SCAD
Descriptionacyl-CoA dehydrogenase, C-2 to C-3 short chain
ReferenceMIM:606885|HGNC:HGNC:90|Ensembl:ENSG00000122971|HPRD:06053|Vega:OTTHUMG00000169203
Gene typeprotein-coding
Map location12q24.31
Pascal p-value0.002
eGeneAnterior cingulate cortex BA24
Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Frontal Cortex BA9
Hippocampus
Hypothalamus
Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17070904chr1860917055ACADS350.18trans
rs10853963chr192909032ACADS350.13trans
rs200545512121128699ACADSENSG00000122971.46.777E-70.01-34839gtex_brain_ba24
rs1043138512121128882ACADSENSG00000122971.46.777E-70.01-34656gtex_brain_ba24
rs99872712121149064ACADSENSG00000122971.42.725E-70.01-14474gtex_brain_ba24
rs5762370512121151062ACADSENSG00000122971.48.223E-70.01-12476gtex_brain_ba24
rs3473484712121154221ACADSENSG00000122971.49.859E-70.01-9317gtex_brain_ba24
rs5627304912121156041ACADSENSG00000122971.49.864E-70.01-7497gtex_brain_ba24
rs3536096412121156290ACADSENSG00000122971.49.864E-70.01-7248gtex_brain_ba24
rs5617945812121157535ACADSENSG00000122971.49.848E-70.01-6003gtex_brain_ba24
rs5573000512121157536ACADSENSG00000122971.41.035E-60.01-6002gtex_brain_ba24
rs375253112121157851ACADSENSG00000122971.49.848E-70.01-5687gtex_brain_ba24
rs294814912121162854ACADSENSG00000122971.41.084E-70.01-684gtex_brain_ba24
rs302133812121162989ACADSENSG00000122971.49.021E-70.01-549gtex_brain_ba24
rs223976012121163518ACADSENSG00000122971.41.123E-70.01-20gtex_brain_ba24
rs1230218912121199329ACADSENSG00000122971.49.985E-70.0135791gtex_brain_ba24
rs1043783712121211693ACADSENSG00000122971.49.985E-70.0148155gtex_brain_ba24
rs14176707512121219266ACADSENSG00000122971.49.985E-70.0155728gtex_brain_ba24
rs1084978912121231461ACADSENSG00000122971.49.985E-70.0167923gtex_brain_ba24
rs7322913512121250315ACADSENSG00000122971.49.985E-70.0186777gtex_brain_ba24
rs1084979512121251889ACADSENSG00000122971.49.985E-70.0188351gtex_brain_ba24
rs14541482412121252464ACADSENSG00000122971.49.992E-70.0188926gtex_brain_ba24
rs1106527612121254654ACADSENSG00000122971.49.985E-70.0191116gtex_brain_ba24
rs1084979612121265642ACADSENSG00000122971.49.985E-70.01102104gtex_brain_ba24
rs7322915612121270733ACADSENSG00000122971.41.49E-60.01107195gtex_brain_ba24
rs1084979812121273374ACADSENSG00000122971.49.984E-70.01109836gtex_brain_ba24
rs1084979912121274189ACADSENSG00000122971.49.981E-70.01110651gtex_brain_ba24
rs1084980812121315630ACADSENSG00000122971.49.985E-70.01152092gtex_brain_ba24
rs1084980912121316726ACADSENSG00000122971.49.985E-70.01153188gtex_brain_ba24
rs1043137312121319619ACADSENSG00000122971.49.985E-70.01156081gtex_brain_ba24
rs7441660412121341495ACADSENSG00000122971.41.013E-60.01177957gtex_brain_ba24
rs1084981712121349427ACADSENSG00000122971.49.985E-70.01185889gtex_brain_ba24
rs1106533112121359856ACADSENSG00000122971.45.166E-70.01196318gtex_brain_ba24
rs1106534112121369960ACADSENSG00000122971.47.657E-70.01206422gtex_brain_ba24
rs1106534412121372509ACADSENSG00000122971.41E-60.01208971gtex_brain_ba24
rs1084982112121377329ACADSENSG00000122971.41.165E-60.01213791gtex_brain_ba24
rs1106535512121378477ACADSENSG00000122971.41.152E-60.01214939gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
STMN10.910.89
STMN20.900.88
CDC420.900.90
PWP10.890.89
NT5C30.890.90
RARS0.890.90
ASNSD10.880.90
PPP3CC0.880.87
CCDC90B0.880.88
ACAT20.880.90
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.27-0.71-0.78
AF347015.33-0.70-0.77
MT-CO2-0.69-0.76
HLA-F-0.69-0.73
MT-CYB-0.69-0.77
AF347015.8-0.68-0.77
AF347015.15-0.68-0.78
AF347015.31-0.68-0.76
AF347015.2-0.67-0.80
AF347015.9-0.64-0.75

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG FATTY ACID METABOLISM 4229All SZGR 2.0 genes in this pathway
KEGG VALINE LEUCINE AND ISOLEUCINE DEGRADATION 4426All SZGR 2.0 genes in this pathway
KEGG BUTANOATE METABOLISM 3420All SZGR 2.0 genes in this pathway
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION 1410All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478302All SZGR 2.0 genes in this pathway
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM 168115All SZGR 2.0 genes in this pathway
BIDUS METASTASIS DN 16193All SZGR 2.0 genes in this pathway
WANG BARRETTS ESOPHAGUS UP 5127All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER METASTASIS UP 5631All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405264All SZGR 2.0 genes in this pathway
RUAN RESPONSE TO TNF DN 8450All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE DN 261183All SZGR 2.0 genes in this pathway
MARIADASON RESPONSE TO CURCUMIN SULINDAC 5 2317All SZGR 2.0 genes in this pathway
JI RESPONSE TO FSH UP 7456All SZGR 2.0 genes in this pathway
GERHOLD ADIPOGENESIS UP 4940All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 6 189112All SZGR 2.0 genes in this pathway
LEE LIVER CANCER 4929All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540340All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN 274165All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002 429260All SZGR 2.0 genes in this pathway
MOOTHA PGC 420269All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL UP 185112All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA 447277All SZGR 2.0 genes in this pathway
KESHELAVA MULTIPLE DRUG RESISTANCE 8856All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S3 266180All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA DN 267160All SZGR 2.0 genes in this pathway
MOOTHA FFA OXYDATION 2213All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 36HR 15288All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882506All SZGR 2.0 genes in this pathway