Gene Page: APRT
Summary ?
| GeneID | 353 |
| Symbol | APRT |
| Synonyms | AMP|APRTD |
| Description | adenine phosphoribosyltransferase |
| Reference | MIM:102600|HGNC:HGNC:626|Ensembl:ENSG00000198931|HPRD:00029|Vega:OTTHUMG00000175454 |
| Gene type | protein-coding |
| Map location | 16q24 |
| Pascal p-value | 0.02 |
| Sherlock p-value | 0.139 |
| eGene | Putamen basal ganglia Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs698613 | chr18 | 46527492 | APRT | 353 | 0.2 | trans | ||
| rs77797289 | 16 | 88867074 | APRT | ENSG00000198931.6 | 3.359E-8 | 0 | 11278 | gtex_brain_putamen_basal |
| rs111495915 | 16 | 88867478 | APRT | ENSG00000198931.6 | 4.974E-7 | 0 | 10874 | gtex_brain_putamen_basal |
| rs111831652 | 16 | 88868127 | APRT | ENSG00000198931.6 | 4.685E-7 | 0 | 10225 | gtex_brain_putamen_basal |
| rs4782345 | 16 | 88868700 | APRT | ENSG00000198931.6 | 4.439E-7 | 0 | 9652 | gtex_brain_putamen_basal |
| rs11276723 | 16 | 88868918 | APRT | ENSG00000198931.6 | 4.336E-7 | 0 | 9434 | gtex_brain_putamen_basal |
| rs113312896 | 16 | 88869239 | APRT | ENSG00000198931.6 | 4.197E-7 | 0 | 9113 | gtex_brain_putamen_basal |
| rs139880672 | 16 | 88869942 | APRT | ENSG00000198931.6 | 3.774E-7 | 0 | 8410 | gtex_brain_putamen_basal |
| rs1834065 | 16 | 88871908 | APRT | ENSG00000198931.6 | 1.515E-7 | 0 | 6444 | gtex_brain_putamen_basal |
| rs3218722 | 16 | 88872542 | APRT | ENSG00000198931.6 | 2.813E-8 | 0 | 5810 | gtex_brain_putamen_basal |
| rs113599906 | 16 | 88875386 | APRT | ENSG00000198931.6 | 5.219E-7 | 0 | 2966 | gtex_brain_putamen_basal |
| rs4695 | 16 | 88875928 | APRT | ENSG00000198931.6 | 5.834E-9 | 0 | 2424 | gtex_brain_putamen_basal |
| rs200229196 | 16 | 88876671 | APRT | ENSG00000198931.6 | 9.324E-7 | 0 | 1681 | gtex_brain_putamen_basal |
| rs8191488 | 16 | 88876678 | APRT | ENSG00000198931.6 | 1.007E-6 | 0 | 1674 | gtex_brain_putamen_basal |
| rs8191469 | 16 | 88878357 | APRT | ENSG00000198931.6 | 4.715E-7 | 0 | -5 | gtex_brain_putamen_basal |
| rs3759946 | 16 | 88880323 | APRT | ENSG00000198931.6 | 3.972E-7 | 0 | -1971 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG PURINE METABOLISM | 159 | 96 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF NUCLEOTIDES | 72 | 45 | All SZGR 2.0 genes in this pathway |
| REACTOME PURINE SALVAGE | 13 | 11 | All SZGR 2.0 genes in this pathway |
| REACTOME PURINE METABOLISM | 33 | 24 | All SZGR 2.0 genes in this pathway |
| LIU PROSTATE CANCER UP | 96 | 57 | All SZGR 2.0 genes in this pathway |
| PUIFFE INVASION INHIBITED BY ASCITES DN | 145 | 91 | All SZGR 2.0 genes in this pathway |
| CHARAFE BREAST CANCER BASAL VS MESENCHYMAL UP | 121 | 45 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN NPM1 MUTATED SIGNATURE 1 DN | 126 | 86 | All SZGR 2.0 genes in this pathway |
| ENK UV RESPONSE KERATINOCYTE UP | 530 | 342 | All SZGR 2.0 genes in this pathway |
| CONCANNON APOPTOSIS BY EPOXOMICIN DN | 172 | 112 | All SZGR 2.0 genes in this pathway |
| LI AMPLIFIED IN LUNG CANCER | 178 | 108 | All SZGR 2.0 genes in this pathway |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP | 479 | 299 | All SZGR 2.0 genes in this pathway |
| LOPEZ MBD TARGETS | 957 | 597 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 16Q24 AMPLICON | 53 | 38 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER MYC UP | 54 | 30 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS | 882 | 572 | All SZGR 2.0 genes in this pathway |
| LEI MYB TARGETS | 318 | 215 | All SZGR 2.0 genes in this pathway |
| JAIN NFKB SIGNALING | 75 | 44 | All SZGR 2.0 genes in this pathway |
| ZAMORA NOS2 TARGETS UP | 69 | 41 | All SZGR 2.0 genes in this pathway |
| CHIBA RESPONSE TO TSA UP | 52 | 33 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 48HR DN | 504 | 323 | All SZGR 2.0 genes in this pathway |
| DAZARD RESPONSE TO UV NHEK UP | 244 | 151 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 18HR DN | 178 | 121 | All SZGR 2.0 genes in this pathway |
| DAZARD UV RESPONSE CLUSTER G4 | 21 | 15 | All SZGR 2.0 genes in this pathway |
| RODWELL AGING KIDNEY UP | 487 | 303 | All SZGR 2.0 genes in this pathway |
| CUI TCF21 TARGETS 2 UP | 428 | 266 | All SZGR 2.0 genes in this pathway |
| XU GH1 AUTOCRINE TARGETS UP | 268 | 157 | All SZGR 2.0 genes in this pathway |
| HONMA DOCETAXEL RESISTANCE | 34 | 23 | All SZGR 2.0 genes in this pathway |
| GRATIAS RETINOBLASTOMA 16Q24 | 17 | 15 | All SZGR 2.0 genes in this pathway |
| SWEET LUNG CANCER KRAS UP | 491 | 316 | All SZGR 2.0 genes in this pathway |
| CAIRO HEPATOBLASTOMA CLASSES UP | 605 | 377 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE DN | 841 | 431 | All SZGR 2.0 genes in this pathway |
| LI DCP2 BOUND MRNA | 89 | 57 | All SZGR 2.0 genes in this pathway |
| BAKKER FOXO3 TARGETS DN | 187 | 109 | All SZGR 2.0 genes in this pathway |
| VANDESLUIS COMMD1 TARGETS GROUP 3 UP | 89 | 50 | All SZGR 2.0 genes in this pathway |