Gene Page: IL3RA
Summary ?
| GeneID | 3563 |
| Symbol | IL3RA |
| Synonyms | CD123|IL3R|IL3RAY|IL3RX|IL3RY|hIL-3Ra |
| Description | interleukin 3 receptor subunit alpha |
| Reference | MIM:308385|MIM:430000|HGNC:HGNC:6012|Ensembl:ENSG00000185291|HPRD:02392|HPRD:08951|Vega:OTTHUMG00000021059 |
| Gene type | protein-coding |
| Map location | Xp22.3 or Yp11.3 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Association | A combined odds ratio method (Sun et al. 2008), association studies | 1 | Link to SZGene |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| RPN2 | 0.81 | 0.79 |
| CC2D2A | 0.81 | 0.82 |
| RCBTB2 | 0.81 | 0.80 |
| CBY1 | 0.80 | 0.78 |
| PPP4R1 | 0.80 | 0.81 |
| EIF4A3 | 0.80 | 0.77 |
| B4GALT4 | 0.80 | 0.78 |
| STT3A | 0.80 | 0.76 |
| COG4 | 0.79 | 0.78 |
| APH1A | 0.79 | 0.78 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.27 | -0.65 | -0.73 |
| MT-CO2 | -0.63 | -0.71 |
| AF347015.31 | -0.61 | -0.71 |
| AF347015.33 | -0.61 | -0.70 |
| AF347015.8 | -0.61 | -0.71 |
| MT-CYB | -0.60 | -0.70 |
| AF347015.15 | -0.58 | -0.70 |
| C5orf53 | -0.57 | -0.64 |
| FBXO2 | -0.57 | -0.61 |
| AF347015.2 | -0.56 | -0.70 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004872 | receptor activity | IEA | - | |
| GO:0004896 | cytokine receptor activity | IEA | - | |
| GO:0004912 | interleukin-3 receptor activity | TAS | 1833064 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0016020 | membrane | IEA | - | |
| GO:0016021 | integral to membrane | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION | 267 | 161 | All SZGR 2.0 genes in this pathway |
| KEGG APOPTOSIS | 88 | 62 | All SZGR 2.0 genes in this pathway |
| KEGG JAK STAT SIGNALING PATHWAY | 155 | 105 | All SZGR 2.0 genes in this pathway |
| KEGG HEMATOPOIETIC CELL LINEAGE | 88 | 60 | All SZGR 2.0 genes in this pathway |
| BIOCARTA IL3 PATHWAY | 15 | 11 | All SZGR 2.0 genes in this pathway |
| BIOCARTA BAD PATHWAY | 26 | 23 | All SZGR 2.0 genes in this pathway |
| PID IL3 PATHWAY | 27 | 19 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY ILS | 107 | 86 | All SZGR 2.0 genes in this pathway |
| REACTOME IL 3 5 AND GM CSF SIGNALING | 43 | 34 | All SZGR 2.0 genes in this pathway |
| REACTOME IL RECEPTOR SHC SIGNALING | 27 | 21 | All SZGR 2.0 genes in this pathway |
| REACTOME IL 2 SIGNALING | 41 | 34 | All SZGR 2.0 genes in this pathway |
| REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
| REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM | 270 | 204 | All SZGR 2.0 genes in this pathway |
| TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D DN | 205 | 127 | All SZGR 2.0 genes in this pathway |
| KLEIN TARGETS OF BCR ABL1 FUSION | 45 | 34 | All SZGR 2.0 genes in this pathway |
| LOPEZ MBD TARGETS IMPRINTED AND X LINKED | 17 | 8 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL QTL CIS | 128 | 77 | All SZGR 2.0 genes in this pathway |
| BYSTROEM CORRELATED WITH IL5 UP | 51 | 30 | All SZGR 2.0 genes in this pathway |
| TENEDINI MEGAKARYOCYTE MARKERS | 66 | 48 | All SZGR 2.0 genes in this pathway |
| HELLER SILENCED BY METHYLATION UP | 282 | 183 | All SZGR 2.0 genes in this pathway |
| LEE METASTASIS AND ALTERNATIVE SPLICING UP | 74 | 51 | All SZGR 2.0 genes in this pathway |
| BASSO HAIRY CELL LEUKEMIA DN | 80 | 66 | All SZGR 2.0 genes in this pathway |
| BOQUEST STEM CELL DN | 216 | 143 | All SZGR 2.0 genes in this pathway |
| WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN | 374 | 217 | All SZGR 2.0 genes in this pathway |
| WIERENGA STAT5A TARGETS UP | 217 | 131 | All SZGR 2.0 genes in this pathway |
| WIERENGA STAT5A TARGETS GROUP1 | 136 | 76 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP B | 549 | 316 | All SZGR 2.0 genes in this pathway |
| BILANGES SERUM SENSITIVE GENES | 90 | 54 | All SZGR 2.0 genes in this pathway |
| DELACROIX RAR BOUND ES | 462 | 273 | All SZGR 2.0 genes in this pathway |
| PEDRIOLI MIR31 TARGETS DN | 418 | 245 | All SZGR 2.0 genes in this pathway |