Gene Page: CXCL8

Summary ?
GeneID3576
SymbolCXCL8
SynonymsGCP-1|GCP1|IL8|LECT|LUCT|LYNAP|MDNCF|MONAP|NAF|NAP-1|NAP1
DescriptionC-X-C motif chemokine ligand 8
ReferenceMIM:146930|HGNC:HGNC:6025|Ensembl:ENSG00000169429|HPRD:00909|Vega:OTTHUMG00000151316
Gene typeprotein-coding
Map location4q13-q21

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs10915489chr14321466IL835760.01trans
rs1342707chr1147264296IL835760.02trans
rs10494951chr1212429258IL835760.1trans
rs2907143chr1243147434IL835760trans
rs1437972chr2100987386IL835760.08trans
rs1597005chr2116736707IL835760.01trans
rs2218030chr2184261431IL835760.08trans
snp_a-19748900IL835760.02trans
rs16846456chr3172757337IL835760.01trans
rs17052594chr4167698562IL835760.03trans
rs1678893chr531763244IL835760.08trans
rs31304chr552942082IL835765.276E-5trans
rs888819chr580257108IL835760.01trans
rs10515260chr597076547IL835760.01trans
rs9313842chr5159690030IL835760trans
rs7716085chr5172099132IL835760.12trans
rs11749499chr5172288696IL835760.07trans
rs11743007chr5172288906IL835760.07trans
rs7822021chr88145522IL835760.01trans
rs9325708chr812402940IL835760.09trans
rs1355060chr8118717710IL835760.18trans
rs2280828chr8118762435IL835760.17trans
rs2082711chr983109430IL835760.08trans
rs11029936chr1127338854IL835760.1trans
rs2512874chr11131461291IL835761.959E-5trans
rs7329574chr1392663432IL835760.05trans
rs6491786chr13104328014IL835760.09trans
rs9519136chr13104332406IL835760.09trans
rs9324006chr1499505533IL835760.07trans
rs6575709chr1499506341IL835760.01trans
rs8028951chr1527187231IL835760.04trans
rs2711647chr1554235527IL835760.12trans
rs6497089chr1594163348IL835760.09trans
rs16955255chr1681420130IL835760.17trans
rs4303487chr1690033254IL835760trans
rs16976379chr1840198836IL835760trans
rs10425739chr1929582202IL835760.04trans
rs11882031chr1956193661IL835760.03trans
rs6076060chr2023345068IL835760.01trans
rs805944chr2038261717IL835760.07trans
rs1701853chr2038266160IL835760.07trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
HLA-F0.670.70
TINAGL10.650.73
HLA-E0.640.69
FGR0.640.69
HLA-B0.630.70
C1QTNF10.630.73
APOL30.630.68
HLA-C0.610.66
ST6GALNAC10.610.67
GBP20.610.68
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ZNF821-0.57-0.60
ZNF671-0.57-0.61
NT5C3-0.56-0.62
MPP3-0.56-0.61
STMN1-0.56-0.63
ZNF354A-0.56-0.61
ZBED5-0.56-0.63
DUSP12-0.56-0.61
GSTA4-0.56-0.60
DEM1-0.56-0.58

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CCL4ACT2 | AT744.1 | G-26 | LAG1 | MGC104418 | MGC126025 | MGC126026 | MIP-1-beta | MIP1B | MIP1B1 | SCYA2 | SCYA4chemokine (C-C motif) ligand 4-HPRD8077676 
CCL5D17S136E | MGC17164 | RANTES | SCYA5 | SISd | TCP228chemokine (C-C motif) ligand 5Reconstituted ComplexBioGRID11509627 
CHUKIKBKA | IKK-alpha | IKK1 | IKKA | NFKBIKA | TCF16conserved helix-loop-helix ubiquitous kinaseThe IL-8 promoter interacts with IKK-alpha.BIND15494311 
DARCCCBP1 | CD234 | Dfy | FY | GPD | GpFy | WBCQ1Duffy blood group, chemokine receptor-HPRD9921412 
EP300KAT3B | p300E1A binding protein p300The IL-8 promoter interacts with p300.BIND15494311 
GNAI2GIP | GNAI2B | H_LUCA15.1 | H_LUCA16.1guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2-HPRD,BioGRID8662698 
HDAC3HD3 | RPD3 | RPD3-2histone deacetylase 3The IL-8 promoter interacts with HDAC3.BIND15494311 
HIST3H3H3.4 | H3/g | H3FT | H3t | MGC126886 | MGC126888histone cluster 3, H3The IL-8 promoter interacts with phosphorylated and/or acetylated H3.BIND15494311 
IKBKBFLJ40509 | IKK-beta | IKK2 | IKKB | MGC131801 | NFKBIKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase betaThe IL-8 promoter interacts with IKK-beta.BIND15494311 
IL8CXCL8 | GCP-1 | GCP1 | LECT | LUCT | LYNAP | MDNCF | MONAP | NAF | NAP-1 | NAP1interleukin 8-HPRD,BioGRID2184886 
IL8RAC-C | C-C-CKR-1 | CD128 | CD181 | CDw128a | CKR-1 | CMKAR1 | CXCR1 | IL8R1 | IL8RBAinterleukin 8 receptor, alpha-HPRD1840701 
IL8RAC-C | C-C-CKR-1 | CD128 | CD181 | CDw128a | CKR-1 | CMKAR1 | CXCR1 | IL8R1 | IL8RBAinterleukin 8 receptor, alphaThe amino terminus of CXCR1 interacts with IL-8. This interaction was modeled on a demonstrated interaction between rabbit CXCR1 and human IL-8.BIND15133028 
IL8RBCD182 | CDw128b | CMKAR2 | CXCR2 | IL8R2 | IL8RAinterleukin 8 receptor, beta-HPRD,BioGRID8702798 |9464567 
NCOR2CTG26 | SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1nuclear receptor co-repressor 2The IL-8 promoter interacts with SMRT.BIND15494311 
NFKB1DKFZp686C01211 | EBP-1 | KBF1 | MGC54151 | NF-kappa-B | NFKB-p105 | NFKB-p50 | p105nuclear factor of kappa light polypeptide gene enhancer in B-cells 1The IL-8 promoter interacts with p50.BIND15494311 
POLR2AMGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1polymerase (RNA) II (DNA directed) polypeptide A, 220kDaThe IL-8 promoter interacts with Pol II.BIND15494311 
RELAMGC131774 | NFKB3 | p65v-rel reticuloendotheliosis viral oncogene homolog A (avian)The IL-8 promoter interacts with p65.BIND15494311 
SDC1CD138 | SDC | SYND1 | syndecansyndecan 1-HPRD,BioGRID12902511 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
NABA SECRETED FACTORS 344197All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway