Gene Page: ING1

Summary ?
GeneID3621
SymbolING1
Synonymsp24ING1c|p33|p33ING1|p33ING1b|p47|p47ING1a
Descriptioninhibitor of growth family member 1
ReferenceMIM:601566|HGNC:HGNC:6062|Ensembl:ENSG00000153487|HPRD:03337|Vega:OTTHUMG00000017346
Gene typeprotein-coding
Map location13q34
Pascal p-value0.05
Sherlock p-value0.109
Fetal beta1.13
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
CV:PheWASPhenome-wide association studies (PheWAS)157 SNPs associated with schizophrenia 0
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@CV:PheWAS

SNP IDChromosomePositionAllelePFunctionGeneUp/Down Distance

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg0255060213111366822ING17.62E-80.0051.8E-5DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AC068888.10.940.88
POLR1D0.940.92
DPH50.930.93
TINP10.920.88
IGBP10.920.91
NPM10.920.88
CCT20.910.91
EIF2A0.910.90
RSL1D10.910.89
TEX100.910.91
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SLC9A3R2-0.61-0.69
HLA-F-0.59-0.79
AIFM3-0.58-0.78
AL132868.3-0.57-0.75
ZBTB47-0.57-0.62
APOL1-0.56-0.79
FBXO2-0.56-0.70
ATP10A-0.56-0.74
LHPP-0.55-0.61
APOL3-0.55-0.78

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTL6AACTL6 | Arp4 | BAF53A | INO80K | MGC5382actin-like 6AAffinity Capture-MSBioGRID11784859 
ARID1AB120 | BAF250 | BAF250a | BM029 | C1orf4 | P270 | SMARCF1AT rich interactive domain 1A (SWI-like)Affinity Capture-MSBioGRID11784859 
C20orf20Eaf7 | FLJ10914 | MRG15BP | MRGBP | URCC4chromosome 20 open reading frame 20-HPRD12963728 
CREBBPCBP | KAT3A | RSTSCREB binding proteinAffinity Capture-WesternBioGRID12015309 
DMAP1DKFZp686L09142 | DNMAP1 | DNMTAP1 | EAF2 | FLJ11543 | KIAA1425 | SWC4DNA methyltransferase 1 associated protein 1-HPRD,BioGRID14665632 
EP300KAT3B | p300E1A binding protein p300-HPRD,BioGRID12015309 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1Affinity Capture-MS
Affinity Capture-Western		BioGRID11784859 |12015309 
HDAC2RPD3 | YAF1histone deacetylase 2Affinity Capture-MSBioGRID11784859 
HIST2H3AH3/n | H3/ohistone cluster 2, H3aBiochemical ActivityBioGRID12015309 
HIST4H4H4/p | MGC24116histone cluster 4, H4Biochemical ActivityBioGRID12015309 
KAT2BCAF | P | P/CAF | PCAFK(lysine) acetyltransferase 2B-HPRD,BioGRID12015309 
PCNAMGC8367proliferating cell nuclear antigen-HPRD,BioGRID11682605 |12015309 
RBBP4NURF55 | RBAP48retinoblastoma binding protein 4Affinity Capture-MSBioGRID11784859 
RBBP7MGC138867 | MGC138868 | RbAp46retinoblastoma binding protein 7Affinity Capture-MSBioGRID11784859 
SAP30-Sin3A-associated protein, 30kDa-HPRD,BioGRID11784859 
SIN3ADKFZp434K2235 | FLJ90319 | KIAA0700SIN3 homolog A, transcription regulator (yeast)Affinity Capture-WesternBioGRID11784859 
SMARCA4BAF190 | BRG1 | FLJ39786 | SNF2 | SNF2-BETA | SNF2L4 | SNF2LB | SWI2 | hSNF2bSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4Affinity Capture-MS
Affinity Capture-Western		BioGRID11784859 
SMARCB1BAF47 | INI1 | RDT | SNF5 | SNF5L1 | Sfh1p | Snr1 | hSNFSSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1Affinity Capture-MSBioGRID11784859 
SMARCC1BAF155 | CRACC1 | Rsc8 | SRG3 | SWI3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1Affinity Capture-MS
Affinity Capture-Western		BioGRID11784859 
SMARCC2BAF170 | CRACC2 | Rsc8SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2Affinity Capture-MSBioGRID11784859 
SMARCD1BAF60A | CRACD1 | Rsc6pSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1Affinity Capture-MSBioGRID11784859 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53-HPRD,BioGRID9440695 |12208736 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53p53 interacts with ING1b. This interaction was modelled on a demonstrated interaction between p53 from an unspecified species and human ING1b.BIND12208736 
TRRAPFLJ10671 | PAF350/400 | PAF400 | STAF40 | TR-AP | Tra1transformation/transcription domain-associated proteinAffinity Capture-WesternBioGRID12015309 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP 329196All SZGR 2.0 genes in this pathway
ROVERSI GLIOMA COPY NUMBER DN 5437All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
SCHWAB TARGETS OF BMYB POLYMORPHIC VARIANTS UP 139All SZGR 2.0 genes in this pathway
FRIDMAN SENESCENCE UP 7760All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775494All SZGR 2.0 genes in this pathway
DING LUNG CANCER EXPRESSION BY COPY NUMBER 10062All SZGR 2.0 genes in this pathway
WILLERT WNT SIGNALING 2413All SZGR 2.0 genes in this pathway
PEART HDAC PROLIFERATION CLUSTER UP 5735All SZGR 2.0 genes in this pathway
SASAKI ADULT T CELL LEUKEMIA 176122All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH REARRANGEMENTS UP 4834All SZGR 2.0 genes in this pathway
HADDAD B LYMPHOCYTE PROGENITOR 293193All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH3 21 DN 4929All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR UP 156101All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 10HR UP 10169All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434302All SZGR 2.0 genes in this pathway
SATO SILENCED BY DEACETYLATION IN PANCREATIC CANCER 5030All SZGR 2.0 genes in this pathway
STEARMAN LUNG CANCER EARLY VS LATE UP 12589All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317208All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461298All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648398All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425298All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES 462273All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770480All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 COMPLETE 227151All SZGR 2.0 genes in this pathway