Gene Page: IPP
Summary ?
| GeneID | 3652 |
| Symbol | IPP |
| Synonyms | KLHL27 |
| Description | intracisternal A particle-promoted polypeptide |
| Reference | MIM:147485|HGNC:HGNC:6108|Ensembl:ENSG00000197429|HPRD:00940|Vega:OTTHUMG00000008004 |
| Gene type | protein-coding |
| Map location | 1p34-p32 |
| Pascal p-value | 0.552 |
| Sherlock p-value | 0.859 |
| Fetal beta | 0.629 |
| eGene | Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs12749130 | chr1 | 45447798 | IPP | 3652 | 0.17 | cis | ||
| rs487174 | chr1 | 46009535 | IPP | 3652 | 0.06 | cis | ||
| rs3014216 | chr1 | 46035759 | IPP | 3652 | 7.95E-4 | cis | ||
| rs1084086 | chr1 | 46041099 | IPP | 3652 | 4.853E-13 | cis | ||
| rs17410308 | chr1 | 46078190 | IPP | 3652 | 2.772E-5 | cis | ||
| rs2050376 | chr1 | 46078629 | IPP | 3652 | 1.555E-11 | cis | ||
| rs1972410 | chr1 | 46080946 | IPP | 3652 | 1.451E-11 | cis | ||
| rs2991986 | chr1 | 46081281 | IPP | 3652 | 1.974E-11 | cis | ||
| rs1547924 | chr1 | 46085111 | IPP | 3652 | 2.661E-12 | cis | ||
| rs1547925 | chr1 | 46085355 | IPP | 3652 | 2.636E-11 | cis | ||
| rs2275086 | chr1 | 46085878 | IPP | 3652 | 1.322E-11 | cis | ||
| rs3014245 | chr1 | 46086912 | IPP | 3652 | 1.451E-11 | cis | ||
| rs11211145 | chr1 | 46108490 | IPP | 3652 | 1.283E-11 | cis | ||
| rs4660313 | chr1 | 46110840 | IPP | 3652 | 1.174E-12 | cis | ||
| rs4660880 | chr1 | 46111039 | IPP | 3652 | 6.678E-12 | cis | ||
| rs11211176 | chr1 | 46223085 | IPP | 3652 | 4.034E-6 | cis | ||
| rs11211177 | chr1 | 46226348 | IPP | 3652 | 3.93E-9 | cis | ||
| rs6661163 | chr1 | 46255003 | IPP | 3652 | 0.01 | cis | ||
| rs7539800 | chr1 | 46262128 | IPP | 3652 | 2.372E-8 | cis | ||
| rs10890361 | chr1 | 46346233 | IPP | 3652 | 0.01 | cis | ||
| rs10890365 | chr1 | 46359347 | IPP | 3652 | 1.452E-7 | cis | ||
| rs7556436 | chr1 | 46363879 | IPP | 3652 | 0 | cis | ||
| rs10890370 | chr1 | 46389216 | IPP | 3652 | 2.372E-8 | cis | ||
| rs10890373 | chr1 | 46393754 | IPP | 3652 | 2.218E-9 | cis | ||
| rs10789486 | chr1 | 46408666 | IPP | 3652 | 1.537E-8 | cis | ||
| rs10890378 | chr1 | 46410656 | IPP | 3652 | 1.262E-7 | cis | ||
| rs11211232 | chr1 | 46411145 | IPP | 3652 | 3.897E-9 | cis | ||
| rs4660334 | chr1 | 46462125 | IPP | 3652 | 1.101E-8 | cis | ||
| rs4073847 | chr1 | 46463011 | IPP | 3652 | 1.101E-8 | cis | ||
| rs11579634 | chr1 | 46466390 | IPP | 3652 | 0 | cis | ||
| rs946527 | chr1 | 46485969 | IPP | 3652 | 1.281E-8 | cis | ||
| rs785480 | chr1 | 46492163 | IPP | 3652 | 1.101E-8 | cis | ||
| rs1768809 | chr1 | 46502835 | IPP | 3652 | 2.212E-10 | cis | ||
| rs7538978 | chr1 | 46505053 | IPP | 3652 | 3.045E-8 | cis | ||
| rs1707322 | chr1 | 46505146 | IPP | 3652 | 1.752E-9 | cis | ||
| rs1707321 | chr1 | 46505308 | IPP | 3652 | 0 | cis | ||
| rs785465 | chr1 | 46522576 | IPP | 3652 | 1.101E-8 | cis | ||
| rs785495 | chr1 | 46587886 | IPP | 3652 | 0.01 | cis | ||
| rs2486445 | chr1 | 46605368 | IPP | 3652 | 0 | cis | ||
| rs4141964 | chr1 | 46865039 | IPP | 3652 | 0 | cis | ||
| rs3014216 | chr1 | 46035759 | IPP | 3652 | 0.06 | trans | ||
| rs1084086 | chr1 | 46041099 | IPP | 3652 | 1.184E-10 | trans | ||
| rs7548549 | 0 | IPP | 3652 | 6.565E-10 | trans | |||
| rs17410308 | chr1 | 46078190 | IPP | 3652 | 0 | trans | ||
| rs2050376 | chr1 | 46078629 | IPP | 3652 | 4.063E-9 | trans | ||
| rs1972410 | chr1 | 46080946 | IPP | 3652 | 3.767E-9 | trans | ||
| rs2991986 | chr1 | 46081281 | IPP | 3652 | 5.133E-9 | trans | ||
| rs1547924 | chr1 | 46085111 | IPP | 3652 | 6.565E-10 | trans | ||
| rs1547925 | chr1 | 46085355 | IPP | 3652 | 6.927E-9 | trans | ||
| rs2275086 | chr1 | 46085878 | IPP | 3652 | 3.376E-9 | trans | ||
| rs3014245 | chr1 | 46086912 | IPP | 3652 | 3.767E-9 | trans | ||
| rs11211145 | chr1 | 46108490 | IPP | 3652 | 3.228E-9 | trans | ||
| rs4660313 | chr1 | 46110840 | IPP | 3652 | 2.961E-10 | trans | ||
| rs4660880 | chr1 | 46111039 | IPP | 3652 | 1.72E-9 | trans | ||
| rs11211176 | chr1 | 46223085 | IPP | 3652 | 6.968E-4 | trans | ||
| rs11211177 | chr1 | 46226348 | IPP | 3652 | 9.599E-7 | trans | ||
| rs7539800 | chr1 | 46262128 | IPP | 3652 | 5.592E-6 | trans | ||
| rs10890365 | chr1 | 46359347 | IPP | 3652 | 3.159E-5 | trans | ||
| rs7556436 | chr1 | 46363879 | IPP | 3652 | 0.13 | trans | ||
| rs10890370 | chr1 | 46389216 | IPP | 3652 | 5.592E-6 | trans | ||
| rs10890373 | chr1 | 46393754 | IPP | 3652 | 5.309E-7 | trans | ||
| rs10789486 | chr1 | 46408666 | IPP | 3652 | 3.657E-6 | trans | ||
| rs10890378 | chr1 | 46410656 | IPP | 3652 | 2.772E-5 | trans | ||
| rs11211232 | chr1 | 46411145 | IPP | 3652 | 9.482E-7 | trans | ||
| rs4660334 | chr1 | 46462125 | IPP | 3652 | 2.621E-6 | trans | ||
| rs4073847 | chr1 | 46463011 | IPP | 3652 | 2.621E-6 | trans | ||
| rs11579634 | chr1 | 46466390 | IPP | 3652 | 0.16 | trans | ||
| rs946527 | chr1 | 46485969 | IPP | 3652 | 3.031E-6 | trans | ||
| rs785480 | chr1 | 46492163 | IPP | 3652 | 2.621E-6 | trans | ||
| rs1768809 | chr1 | 46502835 | IPP | 3652 | 5.451E-8 | trans | ||
| rs1707322 | chr1 | 46505146 | IPP | 3652 | 4.279E-7 | trans | ||
| rs1707321 | chr1 | 46505308 | IPP | 3652 | 0.15 | trans | ||
| rs785465 | chr1 | 46522576 | IPP | 3652 | 2.621E-6 | trans | ||
| rs2486445 | chr1 | 46605368 | IPP | 3652 | 0.11 | trans | ||
| rs4141964 | chr1 | 46865039 | IPP | 3652 | 0.09 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| SCIBETTA KDM5B TARGETS DN | 81 | 55 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN | 770 | 415 | All SZGR 2.0 genes in this pathway |
| LASTOWSKA NEUROBLASTOMA COPY NUMBER DN | 800 | 473 | All SZGR 2.0 genes in this pathway |
| PEREZ TP53 TARGETS | 1174 | 695 | All SZGR 2.0 genes in this pathway |
| BUYTAERT PHOTODYNAMIC THERAPY STRESS DN | 637 | 377 | All SZGR 2.0 genes in this pathway |
| GOLDRATH HOMEOSTATIC PROLIFERATION | 171 | 102 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE INCIPIENT UP | 390 | 242 | All SZGR 2.0 genes in this pathway |
| HU GENOTOXIN ACTION DIRECT VS INDIRECT 24HR | 55 | 38 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
| MONNIER POSTRADIATION TUMOR ESCAPE DN | 373 | 196 | All SZGR 2.0 genes in this pathway |
| STAMBOLSKY RESPONSE TO VITAMIN D3 DN | 26 | 14 | All SZGR 2.0 genes in this pathway |
| GABRIELY MIR21 TARGETS | 289 | 187 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 3 DN | 918 | 550 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |