Summary ?
GeneID3689
SymbolITGB2
SynonymsCD18|LAD|LCAMB|LFA-1|MAC-1|MF17|MFI7
Descriptionintegrin subunit beta 2
ReferenceMIM:600065|HGNC:HGNC:6155|Ensembl:ENSG00000160255|HPRD:02506|Vega:OTTHUMG00000090257
Gene typeprotein-coding
Map location21q22.3
Pascal p-value0.656
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:vanEijk_2014Genome-wide DNA methylation analysisThis dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 1
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 5.707 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg047901292146340810ITGB29.067E-4-4.48DMG:vanEijk_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs2892394chr101740277ITGB236890.18trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SPIRE20.900.90
C7orf510.890.90
MAST10.890.90
KIFC30.890.90
ZNF512B0.880.92
ABCC100.880.88
CIC0.880.90
AC010536.20.870.89
ANO80.870.87
SNAPC40.870.90
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.67-0.73
S100B-0.65-0.72
COPZ2-0.65-0.71
AC021016.1-0.64-0.76
AF347015.27-0.64-0.71
B2M-0.64-0.70
MT-CO2-0.64-0.72
PSMB9-0.64-0.69
AF347015.33-0.63-0.68
C5orf53-0.63-0.64

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0005488bindingIEA-
GO:0005515protein bindingIPI12885943 
GO:0019901protein kinase bindingIPI12885943 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007160cell-matrix adhesionIEA-
GO:0007155cell adhesionIEA-
GO:0007155cell adhesionTAS1694220 
GO:0007267cell-cell signalingNAS12885943 
GO:0007229integrin-mediated signaling pathwayIEA-
GO:0007229integrin-mediated signaling pathwayNAS12885943 
GO:0008360regulation of cell shapeNAS12885943 
GO:0006954inflammatory responseNAS12885943 
GO:0006915apoptosisNAS12885943 
GO:0007159leukocyte adhesionIDA12885943 
GO:0030593neutrophil chemotaxisIDA12885943 
GO:0050730regulation of peptidyl-tyrosine phosphorylationIDA12885943 
GO:0045123cellular extravasationIEA-
GO:0050798activated T cell proliferationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005624membrane fractionIEA-
GO:0005737cytoplasmIDA18029348 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneEXP11857637 
GO:0005886plasma membraneIDA18029348 
GO:0008305integrin complexIEA-
GO:0008305integrin complexNAS12885943 
GO:0045121membrane raftIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CD14-CD14 molecule-HPRD11745332 
CD226DNAM-1 | DNAM1 | PTA1 | TLiSA1CD226 molecule-HPRD,BioGRID10591186 
CD824F9 | C33 | GR15 | IA4 | KAI1 | R2 | SAR2 | ST6 | TSPAN27CD82 molecule-HPRD10602019 
CYTH1B2-1 | CYTOHESIN-1 | D17S811E | FLJ34050 | FLJ41900 | PSCD1 | SEC7cytohesin 1-HPRD,BioGRID10835351 
CYTH1B2-1 | CYTOHESIN-1 | D17S811E | FLJ34050 | FLJ41900 | PSCD1 | SEC7cytohesin 1Integrin beta-2 interacts with cytohesin-1.BIND9765275 
ESM1endocanendothelial cell-specific molecule 1-HPRD11544294 
FHL2AAG11 | DRAL | SLIM3four and a half LIM domains 2-HPRD,BioGRID10906324 
FUT4CD15 | ELFT | FCT3A | FUC-TIVfucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)-HPRD3305706 
GNB2L1Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1-HPRD,BioGRID9442085 
HPBP | HP2-ALPHA-2 | HPA1S | MGC111141haptoglobin-HPRD11967116 
ICAM1BB2 | CD54 | P3.58intercellular adhesion molecule 1-HPRD7642561 |11279101 
ICAM1BB2 | CD54 | P3.58intercellular adhesion molecule 1in vitro
in vivo
Reconstituted Complex
BioGRID7642561 |10352278 
|11279101 
ICAM2CD102intercellular adhesion molecule 2-HPRD9786897 
ICAM3CD50 | CDW50 | ICAM-Rintercellular adhesion molecule 3-HPRD,BioGRID7822326 |11353828 
ICAM4CD242 | LWintercellular adhesion molecule 4 (Landsteiner-Wiener blood group)-HPRD10846180 
ICAM5TLCN | TLNintercellular adhesion molecule 5, telencephalin-HPRD,BioGRID8995416 
ILKDKFZp686F1765 | P59integrin-linked kinase-HPRD9736715 
ITGADADB2 | CD11D | FLJ39841integrin, alpha D-HPRD,BioGRID8777714 
ITGALCD11A | LFA-1 | LFA1Aintegrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)Affinity Capture-WesternBioGRID9442085 
ITGAMCD11B | CR3A | MAC-1 | MAC1A | MGC117044 | MO1A | SLEB6integrin, alpha M (complement component 3 receptor 3 subunit)-HPRD,BioGRID2454931 
ITGAXCD11C | SLEB6integrin, alpha X (complement component 3 receptor 4 subunit)-HPRD,BioGRID11937543 
KNG1BDK | KNGkininogen 1-HPRD,BioGRID10845911 
PLAURCD87 | UPAR | URKRplasminogen activator, urokinase receptorAffinity Capture-WesternBioGRID10388537 
PRTN3ACPA | AGP7 | C-ANCA | MBT | P29 | PR-3proteinase 3-HPRD12960243 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2-HPRD8649427 
PTK2BCADTK | CAKB | FADK2 | FAK2 | FRNK | PKB | PTK | PYK2 | RAFTKPTK2B protein tyrosine kinase 2 beta-HPRD,BioGRID10961871 
RANBP9RANBPMRAN binding protein 9RanBPM interacts with beta-2 integrin LFA-1.BIND14722085 
SYKDKFZp313N1010 | FLJ25043 | FLJ37489spleen tyrosine kinaseAffinity Capture-WesternBioGRID10961871 
TLN1ILWEQ | KIAA1027 | TLNtalin 1-HPRD2150484 
VNN2FOAP-4 | GPI-80vanin 2-HPRD,BioGRID12056825 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CELL ADHESION MOLECULES CAMS 13493All SZGR 2.0 genes in this pathway
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY 13792All SZGR 2.0 genes in this pathway
KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION 11878All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON 216144All SZGR 2.0 genes in this pathway
KEGG LEISHMANIA INFECTION 7256All SZGR 2.0 genes in this pathway
KEGG VIRAL MYOCARDITIS 7358All SZGR 2.0 genes in this pathway
BIOCARTA GRANULOCYTES PATHWAY 149All SZGR 2.0 genes in this pathway
BIOCARTA LYM PATHWAY 116All SZGR 2.0 genes in this pathway
BIOCARTA BLYMPHOCYTE PATHWAY 118All SZGR 2.0 genes in this pathway
BIOCARTA LAIR PATHWAY 1712All SZGR 2.0 genes in this pathway
BIOCARTA CTL PATHWAY 1511All SZGR 2.0 genes in this pathway
BIOCARTA MONOCYTE PATHWAY 115All SZGR 2.0 genes in this pathway
BIOCARTA TCYTOTOXIC PATHWAY 1411All SZGR 2.0 genes in this pathway
BIOCARTA THELPER PATHWAY 1411All SZGR 2.0 genes in this pathway
PID INTEGRIN CS PATHWAY 2616All SZGR 2.0 genes in this pathway
PID AMB2 NEUTROPHILS PATHWAY 4132All SZGR 2.0 genes in this pathway
PID INTEGRIN2 PATHWAY 2918All SZGR 2.0 genes in this pathway
PID UPA UPAR PATHWAY 4230All SZGR 2.0 genes in this pathway
PID CXCR3 PATHWAY 4334All SZGR 2.0 genes in this pathway
PID HIF1 TFPATHWAY 6652All SZGR 2.0 genes in this pathway
REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 7037All SZGR 2.0 genes in this pathway
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 9165All SZGR 2.0 genes in this pathway
REACTOME INTEGRIN CELL SURFACE INTERACTIONS 7948All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP 423283All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404246All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP 380236All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418263All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN 226132All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF UP 215137All SZGR 2.0 genes in this pathway
HERNANDEZ MITOTIC ARREST BY DOCETAXEL 2 DN 1913All SZGR 2.0 genes in this pathway
SHI SPARC TARGETS DN 138All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358245All SZGR 2.0 genes in this pathway
WANG RESPONSE TO BEXAROTENE DN 2919All SZGR 2.0 genes in this pathway
FERRANDO TAL1 NEIGHBORS 2115All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK UP 8758All SZGR 2.0 genes in this pathway
BROWN MYELOID CELL DEVELOPMENT UP 165100All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366238All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225163All SZGR 2.0 genes in this pathway
LIAN NEUTROPHIL GRANULE CONSTITUENTS 2513All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA DN 4127All SZGR 2.0 genes in this pathway
ZHOU TNF SIGNALING 4HR 5436All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS DN 7455All SZGR 2.0 genes in this pathway
NIELSEN GIST AND SYNOVIAL SARCOMA DN 2015All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504323All SZGR 2.0 genes in this pathway
VERRECCHIA RESPONSE TO TGFB1 C2 2518All SZGR 2.0 genes in this pathway
VERRECCHIA EARLY RESPONSE TO TGFB1 5843All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES DN 245144All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP 487303All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES UP 253147All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP 299167All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430288All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP 259185All SZGR 2.0 genes in this pathway
WU SILENCED BY METHYLATION IN BLADDER CANCER 5542All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE 35D UP 13179All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION D 6844All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER ESR1 DN 240153All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491316All SZGR 2.0 genes in this pathway
SWEET KRAS ONCOGENIC SIGNATURE 8956All SZGR 2.0 genes in this pathway
LEE DIFFERENTIATING T LYMPHOCYTE 200115All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
LIU VAV3 PROSTATE CARCINOGENESIS UP 8961All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER UP 288168All SZGR 2.0 genes in this pathway
YAMANAKA GLIOBLASTOMA SURVIVAL DN 97All SZGR 2.0 genes in this pathway
OKAMOTO LIVER CANCER MULTICENTRIC OCCURRENCE UP 2515All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1 237159All SZGR 2.0 genes in this pathway
NIELSEN SYNOVIAL SARCOMA DN 2013All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 30MIN DN 15099All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION 456287All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL 216130All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 2 DN 98All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 5 DN 5031All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP 259159All SZGR 2.0 genes in this pathway
SERVITJA ISLET HNF1A TARGETS UP 163111All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 6 2920All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770480All SZGR 2.0 genes in this pathway