Gene Page: ITGB5

Summary
GeneID  3693
Symbol  ITGB5
Synonyms  FLJ26658
Description  integrin, beta 5
See related  HGNC:6160|MIM:147561|Ensembl:ENSG00000082781|HPRD:00949|
Locus tag  -
Gene type  protein-coding
Map location  3q21.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0708 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PIGZ0.810.84
ABCG40.800.82
TAPBP0.800.78
DNASE1L10.790.81
MYADM0.790.78
SLC6A70.790.76
PPAPDC30.780.79
PRRT30.780.81
AC135048.10.780.79
SYNGR10.770.78
Top 10 negatively co-expressed genes
SNRPG-0.41-0.51
GTF3C6-0.41-0.41
ANP32C-0.41-0.43
FAM36A-0.40-0.37
RBMX2-0.39-0.39
C9orf46-0.39-0.39
RPL38-0.39-0.49
RPS20-0.39-0.46
RPS25P8-0.38-0.43
RPL35A-0.38-0.42
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0005178integrin bindingIEA-
GO:0005515protein bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007160cell-matrix adhesionIEA-
GO:0007155cell adhesionIEA-
GO:0007229integrin-mediated signaling pathwayIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0008305integrin complexIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ANXA5ANX5 | ENX2 | PP4annexin A5-HPRD,BioGRID12769841 
CYR61CCN1 | GIG1 | IGFBP10cysteine-rich, angiogenic inducer, 61-HPRD,BioGRID11287419 
GNB2L1Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1-HPRD9442085 
ITGA5CD49e | FNRA | VLA5Aintegrin, alpha 5 (fibronectin receptor, alpha polypeptide)-HPRD7592829|11462216 
ITGAVCD51 | DKFZp686A08142 | MSK8 | VNRAintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)Integrin-alphaV interacts with integrin-beta5.BIND1694173 
ITGAV (alphaV) interacts with ITGB5 (beta5).BIND12459484 
-HPRD,BioGRID7689573 
ITGB1CD29 | FNRB | GPIIA | MDF2 | MSK12 | VLA-BETA | VLABintegrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)-HPRD11462216 
ITGB3BPCENP-R | CENPR | HSU37139 | NRIF3 | TAP20integrin beta 3 binding protein (beta3-endonexin)in vivoBioGRID10579726 
LTBP1MGC163161latent transforming growth factor beta binding protein 1-HPRD,BioGRID12358597 
LTBP3DKFZp586M2123 | FLJ33431 | FLJ39893 | FLJ42533 | FLJ44138 | LTBP-3 | LTBP2 | pp6425latent transforming growth factor beta binding protein 3-HPRD,BioGRID12358597 
MYO10FLJ10639 | FLJ21066 | FLJ22268 | FLJ43256 | KIAA0799 | MGC131988myosin XIntegrin-beta-5 interacts with Myo10. This interaction was modeled on a demonstrated interaction between human integrin-beta-5 and mouse Myo10.BIND15156152 
P2RY2HP2U | MGC20088 | MGC40010 | P2RU1 | P2U | P2U1 | P2UR | P2Y2 | P2Y2Rpurinergic receptor P2Y, G-protein coupled, 2-HPRD,BioGRID11331301 
PAK4-p21 protein (Cdc42/Rac)-activated kinase 4-HPRD,BioGRID12356872 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2Affinity Capture-Western
Reconstituted Complex		BioGRID11927607 
TENC1C1-TEN | C1TEN | DKFZp686D13244 | FLJ16320 | KIAA1075 | TNS2tensin like C1 domain containing phosphatase (tensin 2)-HPRD12606711 
ZBTB17MIZ-1 | ZNF151 | ZNF60 | pHZ-67zinc finger and BTB domain containing 17-HPRD,BioGRID12356872 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
KEGG_ECM_RECEPTOR_INTERACTION 8453All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 8565All SZGR genes in this pathway
KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 7659All SZGR genes in this pathway
KEGG_DILATED_CARDIOMYOPATHY 9268All SZGR genes in this pathway
PID_SMAD2_3NUCLEAR_PATHWAY 8263All SZGR genes in this pathway
PID_INTEGRIN_CS_PATHWAY 2616All SZGR genes in this pathway
PID_UPA_UPAR_PATHWAY 4230All SZGR genes in this pathway
PID_INTEGRIN5_PATHWAY 179All SZGR genes in this pathway
PID_FAK_PATHWAY 5945All SZGR genes in this pathway
REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION 7648All SZGR genes in this pathway
REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS 7948All SZGR genes in this pathway
REACTOME_MUSCLE_CONTRACTION 4824All SZGR genes in this pathway
REACTOME_SMOOTH_MUSCLE_CONTRACTION 2514All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 251156All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_UP 285181All SZGR genes in this pathway
BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_DN 169118All SZGR genes in this pathway
RODRIGUES_NTN1_TARGETS_DN 158102All SZGR genes in this pathway
WANG_LMO4_TARGETS_UP 372227All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_UP 204140All SZGR genes in this pathway
ODONNELL_TFRC_TARGETS_DN 13976All SZGR genes in this pathway
KIM_WT1_TARGETS_12HR_UP 162116All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_DN 14295All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_DN 9061All SZGR genes in this pathway
FARMER_BREAST_CANCER_BASAL_VS_LULMINAL 330215All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
WOTTON_RUNX_TARGETS_UP 2114All SZGR genes in this pathway
RICKMAN_METASTASIS_UP 344180All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN 514330All SZGR genes in this pathway
PASQUALUCCI_LYMPHOMA_BY_GC_STAGE_UP 283177All SZGR genes in this pathway
AMIT_EGF_RESPONSE_480_HELA 164118All SZGR genes in this pathway
WANG_PROSTATE_CANCER_ANDROGEN_INDEPENDENT 6637All SZGR genes in this pathway
MORI_EMU_MYC_LYMPHOMA_BY_ONSET_TIME_DN 179All SZGR genes in this pathway
JI_METASTASIS_REPRESSED_BY_STK11 2717All SZGR genes in this pathway
KENNY_CTNNB1_TARGETS_DN 5234All SZGR genes in this pathway
JECHLINGER_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 6647All SZGR genes in this pathway
ADDYA_ERYTHROID_DIFFERENTIATION_BY_HEMIN 7347All SZGR genes in this pathway
ALCALAY_AML_BY_NPM1_LOCALIZATION_UP 14083All SZGR genes in this pathway
HASLINGER_B_CLL_WITH_13Q14_DELETION 2418All SZGR genes in this pathway
LENAOUR_DENDRITIC_CELL_MATURATION_UP 11484All SZGR genes in this pathway
TAVOR_CEBPA_TARGETS_DN 3021All SZGR genes in this pathway
PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN 162102All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_TBH_AND_H2O2 3624All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN 408274All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP 390242All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C6 3927All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
MAHAJAN_RESPONSE_TO_IL1A_DN 7657All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
LINDVALL_IMMORTALIZED_BY_TERT_DN 8056All SZGR genes in this pathway
VERRECCHIA_EARLY_RESPONSE_TO_TGFB1 5843All SZGR genes in this pathway
LEE_AGING_CEREBELLUM_UP 8458All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN 287208All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_UP 280183All SZGR genes in this pathway
VERRECCHIA_RESPONSE_TO_TGFB1_C3 1410All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_DN 373196All SZGR genes in this pathway
LEIN_ASTROCYTE_MARKERS 4235All SZGR genes in this pathway
LEIN_CHOROID_PLEXUS_MARKERS 10361All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P3 160103All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_4NQO 3824All SZGR genes in this pathway
KYNG_DNA_DAMAGE_DN 195135All SZGR genes in this pathway
HELLER_HDAC_TARGETS_DN 292189All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_DN 281179All SZGR genes in this pathway
LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP 7451All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_DN 12081All SZGR genes in this pathway
GRADE_COLON_AND_RECTAL_CANCER_UP 285167All SZGR genes in this pathway
QI_PLASMACYTOMA_DN 10063All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_D_DN 252155All SZGR genes in this pathway
CHAUHAN_RESPONSE_TO_METHOXYESTRADIOL_UP 5132All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_UP 293203All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
JISON_SICKLE_CELL_DISEASE_UP 181106All SZGR genes in this pathway
YAMASHITA_LIVER_CANCER_STEM_CELL_UP 4738All SZGR genes in this pathway
FOURNIER_ACINAR_DEVELOPMENT_LATE_2 277172All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
SASSON_RESPONSE_TO_GONADOTROPHINS_DN 8766All SZGR genes in this pathway
SASSON_RESPONSE_TO_FORSKOLIN_DN 8868All SZGR genes in this pathway
RAGHAVACHARI_PLATELET_SPECIFIC_GENES 7046All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_DN 374217All SZGR genes in this pathway
WIERENGA_STAT5A_TARGETS_DN 213127All SZGR genes in this pathway
WANG_NFKB_TARGETS 2515All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_7 403240All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
ALFANO_MYC_TARGETS 239156All SZGR genes in this pathway


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