Gene Page: JAK1
Summary ?
GeneID | 3716 |
Symbol | JAK1 |
Synonyms | JAK1A|JAK1B|JTK3 |
Description | Janus kinase 1 |
Reference | MIM:147795|HGNC:HGNC:6190|Ensembl:ENSG00000162434|HPRD:00992|Vega:OTTHUMG00000009310 |
Gene type | protein-coding |
Map location | 1p32.3-p31.3 |
Pascal p-value | 0.003 |
Fetal beta | -0.986 |
DMG | 1 (# studies) |
eGene | Cerebellar Hemisphere Cerebellum Cortex |
Support | CompositeSet Darnell FMRP targets Ascano FMRP targets |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
GSMA_IIA | Genome scan meta-analysis (All samples) | Psr: 0.02692 | |
Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0058 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
---|---|---|---|---|---|---|---|
cg16618003 | 1 | 65432492 | JAK1 | 1.57E-11 | -0.012 | 2.86E-7 | DMG:Jaffe_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
TSPAN9 | 0.88 | 0.50 |
FOXO1 | 0.84 | 0.54 |
IL28RA | 0.82 | 0.45 |
AP000911.1 | 0.82 | 0.37 |
C10orf41 | 0.82 | 0.42 |
SIX3 | 0.82 | 0.44 |
SERTAD4 | 0.82 | 0.43 |
RXRG | 0.81 | 0.48 |
ZNF521 | 0.81 | 0.54 |
PBX3 | 0.81 | 0.50 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
SLC26A4 | -0.29 | -0.28 |
EMX1 | -0.26 | -0.23 |
ID2 | -0.24 | -0.29 |
CIDEA | -0.24 | -0.20 |
AF347015.31 | -0.24 | -0.15 |
GPR22 | -0.23 | -0.18 |
AF347015.21 | -0.23 | -0.15 |
AF347015.2 | -0.22 | -0.14 |
MT-CO2 | -0.22 | -0.15 |
AF347015.8 | -0.22 | -0.14 |
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0000166 | nucleotide binding | IEA | - | |
GO:0005515 | protein binding | IEA | - | |
GO:0005524 | ATP binding | IEA | - | |
GO:0004718 | Janus kinase activity | IEA | - | |
GO:0004715 | non-membrane spanning protein tyrosine kinase activity | IEA | - | |
GO:0016740 | transferase activity | IEA | - | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0007243 | protein kinase cascade | IEA | - | |
GO:0007167 | enzyme linked receptor protein signaling pathway | IEA | - | |
GO:0018108 | peptidyl-tyrosine phosphorylation | IEA | - | |
GO:0019221 | cytokine-mediated signaling pathway | IEA | - | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0012505 | endomembrane system | IEA | - | |
GO:0005856 | cytoskeleton | IEA | - | |
GO:0016020 | membrane | IEA | - |
Section IV. Protein-protein interaction annotation
Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
---|---|---|---|---|---|
ABL1 | ABL | JTK7 | bcr/abl | c-ABL | p150 | v-abl | c-abl oncogene 1, receptor tyrosine kinase | Reconstituted Complex | BioGRID | 9774693 |
ABL1 | ABL | JTK7 | bcr/abl | c-ABL | p150 | v-abl | c-abl oncogene 1, receptor tyrosine kinase | - | HPRD | 12130510 |
ABL2 | ABLL | ARG | FLJ22224 | FLJ31718 | FLJ41441 | v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) | Affinity Capture-Western | BioGRID | 9774693 |
ARRB1 | ARB1 | ARR1 | arrestin, beta 1 | Affinity Capture-MS | BioGRID | 17353931 |
ATIC | AICAR | AICARFT | FLJ93545 | IMPCHASE | PURH | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase | Affinity Capture-MS | BioGRID | 17353931 |
BRCA1 | BRCAI | BRCC1 | IRIS | PSCP | RNF53 | breast cancer 1, early onset | - | HPRD,BioGRID | 11163768 |
BTK | AGMX1 | AT | ATK | BPK | IMD1 | MGC126261 | MGC126262 | PSCTK1 | XLA | Bruton agammaglobulinemia tyrosine kinase | - | HPRD,BioGRID | 9178903 |
CSF3R | CD114 | GCSFR | colony stimulating factor 3 receptor (granulocyte) | - | HPRD,BioGRID | 7512720 |
ELF3 | EPR-1 | ERT | ESE-1 | ESX | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | Affinity Capture-MS | BioGRID | 17353931 |
ELP2 | FLJ10879 | SHINC-2 | STATIP1 | StIP | elongation protein 2 homolog (S. cerevisiae) | - | HPRD,BioGRID | 10954736 |
GHR | GHBP | growth hormone receptor | - | HPRD,BioGRID | 10502458 |
GNB2L1 | Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1 | guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | RACK-1 interacts with Jak1. | BIND | 12960323 |
GNB2L1 | Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1 | guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | - | HPRD,BioGRID | 12960323 |
GRB2 | ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084 | growth factor receptor-bound protein 2 | - | HPRD,BioGRID | 8536716 |11527382 |
IFNAR2 | IFN-R | IFN-alpha-REC | IFNABR | IFNARB | interferon (alpha, beta and omega) receptor 2 | Reconstituted Complex | BioGRID | 12133952 |
IFNAR2 | IFN-R | IFN-alpha-REC | IFNABR | IFNARB | interferon (alpha, beta and omega) receptor 2 | IFNR-beta-L interacts with Jak1. | BIND | 12960323 |
IFNGR1 | CD119 | FLJ45734 | IFNGR | interferon gamma receptor 1 | Reconstituted Complex | BioGRID | 12133952 |
IGF1R | CD221 | IGFIR | JTK13 | MGC142170 | MGC142172 | MGC18216 | insulin-like growth factor 1 receptor | Phosphorylated IGF-1R-beta interacts with JAK-1. | BIND | 9492017 |
IGF1R | CD221 | IGFIR | JTK13 | MGC142170 | MGC142172 | MGC18216 | insulin-like growth factor 1 receptor | - | HPRD,BioGRID | 9492017 |
IL10RA | CDW210A | HIL-10R | IL-10R1 | IL10R | interleukin 10 receptor, alpha | - | HPRD,BioGRID | 12133952 |12374810 |
IL10RA | CDW210A | HIL-10R | IL-10R1 | IL10R | interleukin 10 receptor, alpha | IL-10R-alpha interacts with Jak1. | BIND | 12133952 |
IL21R | MGC10967 | NILR | interleukin 21 receptor | Affinity Capture-Western | BioGRID | 11016959 |
IL27RA | CRL1 | IL27R | TCCR | WSX1 | zcytor1 | interleukin 27 receptor, alpha | Affinity Capture-Western | BioGRID | 12734330 |
IL2RB | CD122 | P70-75 | interleukin 2 receptor, beta | - | HPRD,BioGRID | 7973659 |12133952 |
IL2RB | CD122 | P70-75 | interleukin 2 receptor, beta | IL-2R-beta interacts with Jak1. | BIND | 12133952 |
IL4R | CD124 | IL4RA | interleukin 4 receptor | - | HPRD,BioGRID | 12133952 |
IL4R | CD124 | IL4RA | interleukin 4 receptor | JAK1 interacts with IL4R-alpha. | BIND | 12133952 |
IL5RA | CD125 | CDw125 | HSIL5R3 | IL5R | MGC26560 | interleukin 5 receptor, alpha | - | HPRD,BioGRID | 9516124 |
IL6ST | CD130 | CDw130 | GP130 | GP130-RAPS | IL6R-beta | interleukin 6 signal transducer (gp130, oncostatin M receptor) | - | HPRD,BioGRID | 11468294 |11742534 |
IL9R | CD129 | interleukin 9 receptor | - | HPRD,BioGRID | 8756628 |
INSR | CD220 | HHF5 | insulin receptor | Phosphorylated IR-beta interacts with JAK-1. | BIND | 9492017 |
IRS1 | HIRS-1 | insulin receptor substrate 1 | Affinity Capture-Western Biochemical Activity | BioGRID | 7499365 |9492017 |
IRS2 | - | insulin receptor substrate 2 | - | HPRD,BioGRID | 7499365 |
JAK3 | JAK-3 | JAK3_HUMAN | JAKL | L-JAK | LJAK | Janus kinase 3 (a protein tyrosine kinase, leukocyte) | - | HPRD,BioGRID | 9553136 |
JAKMIP1 | FLJ31564 | Gababrbp | JAMIP1 | MARLIN1 | janus kinase and microtubule interacting protein 1 | Jamip1 interacts with Jak1. | BIND | 15277531 |
MDK | FLJ27379 | MK | NEGF2 | midkine (neurite growth-promoting factor 2) | - | HPRD | 9452495 |
OSMR | MGC150626 | MGC150627 | MGC75127 | OSMRB | oncostatin M receptor | - | HPRD | 10586060 |
PIK3R1 | GRB1 | p85 | p85-ALPHA | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | - | HPRD,BioGRID | 9774657 |
PLAUR | CD87 | UPAR | URKR | plasminogen activator, urokinase receptor | - | HPRD,BioGRID | 9417082 |
PRMT5 | HRMT1L5 | IBP72 | JBP1 | SKB1 | SKB1Hs | protein arginine methyltransferase 5 | - | HPRD,BioGRID | 10531356 |
PTK2B | CADTK | CAKB | FADK2 | FAK2 | FRNK | PKB | PTK | PYK2 | RAFTK | PTK2B protein tyrosine kinase 2 beta | - | HPRD,BioGRID | 10702271 |
PTPN11 | BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2 | protein tyrosine phosphatase, non-receptor type 11 | - | HPRD,BioGRID | 8995399 |11036942 |12403768 |
PTPN6 | HCP | HCPH | HPTP1C | PTP-1C | SH-PTP1 | SHP-1 | SHP-1L | SHP1 | protein tyrosine phosphatase, non-receptor type 6 | Biochemical Activity | BioGRID | 7629131 |
PTPRC | B220 | CD45 | CD45R | GP180 | LCA | LY5 | T200 | protein tyrosine phosphatase, receptor type, C | - | HPRD | 11201744 |
RAF1 | CRAF | NS5 | Raf-1 | c-Raf | v-raf-1 murine leukemia viral oncogene homolog 1 | - | HPRD,BioGRID | 9446616 |
SHB | RP11-3J10.8 | bA3J10.2 | Src homology 2 domain containing adaptor protein B | - | HPRD,BioGRID | 12200137 |
SOCS1 | CIS1 | CISH1 | JAB | SOCS-1 | SSI-1 | SSI1 | TIP3 | suppressor of cytokine signaling 1 | - | HPRD | 11133764 |
STAM2 | DKFZp564C047 | Hbp | STAM2A | STAM2B | signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 | - | HPRD,BioGRID | 10899310 |10993906 |
STAT1 | DKFZp686B04100 | ISGF-3 | STAT91 | signal transducer and activator of transcription 1, 91kDa | - | HPRD | 11722592 |
STAT3 | APRF | FLJ20882 | HIES | MGC16063 | signal transducer and activator of transcription 3 (acute-phase response factor) | - | HPRD,BioGRID | 11722592 |
STAT5A | MGF | STAT5 | signal transducer and activator of transcription 5A | - | HPRD | 11722592 |
STAT5A | MGF | STAT5 | signal transducer and activator of transcription 5A | Affinity Capture-Western Reconstituted Complex Two-hybrid | BioGRID | 9047382 |
STAT5B | STAT5 | signal transducer and activator of transcription 5B | Affinity Capture-Western Two-hybrid | BioGRID | 9047382 |
SYK | DKFZp313N1010 | FLJ25043 | FLJ37489 | spleen tyrosine kinase | - | HPRD | 10825200 |
TEC | MGC126760 | MGC126762 | PSCTK4 | tec protein tyrosine kinase | - | HPRD,BioGRID | 9178903 |
TNFRSF1A | CD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60 | tumor necrosis factor receptor superfamily, member 1A | - | HPRD,BioGRID | 11801527 |
TSHR | CHNG1 | LGR3 | MGC75129 | hTSHR-I | thyroid stimulating hormone receptor | - | HPRD,BioGRID | 10809230 |
TYK2 | JTK1 | tyrosine kinase 2 | - | HPRD,BioGRID | 7589562 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
KEGG JAK STAT SIGNALING PATHWAY | 155 | 105 | All SZGR 2.0 genes in this pathway |
KEGG LEISHMANIA INFECTION | 72 | 56 | All SZGR 2.0 genes in this pathway |
KEGG PATHWAYS IN CANCER | 328 | 259 | All SZGR 2.0 genes in this pathway |
KEGG PANCREATIC CANCER | 70 | 56 | All SZGR 2.0 genes in this pathway |
BIOCARTA EGF PATHWAY | 31 | 25 | All SZGR 2.0 genes in this pathway |
BIOCARTA IL2 PATHWAY | 22 | 16 | All SZGR 2.0 genes in this pathway |
BIOCARTA IL4 PATHWAY | 11 | 8 | All SZGR 2.0 genes in this pathway |
BIOCARTA IL6 PATHWAY | 22 | 16 | All SZGR 2.0 genes in this pathway |
BIOCARTA IL10 PATHWAY | 17 | 14 | All SZGR 2.0 genes in this pathway |
BIOCARTA IL2RB PATHWAY | 38 | 26 | All SZGR 2.0 genes in this pathway |
BIOCARTA IL22BP PATHWAY | 16 | 12 | All SZGR 2.0 genes in this pathway |
BIOCARTA IL7 PATHWAY | 17 | 14 | All SZGR 2.0 genes in this pathway |
BIOCARTA PDGF PATHWAY | 32 | 25 | All SZGR 2.0 genes in this pathway |
ST INTERFERON GAMMA PATHWAY | 10 | 7 | All SZGR 2.0 genes in this pathway |
SIG IL4RECEPTOR IN B LYPHOCYTES | 27 | 23 | All SZGR 2.0 genes in this pathway |
ST JAK STAT PATHWAY | 9 | 8 | All SZGR 2.0 genes in this pathway |
ST STAT3 PATHWAY | 11 | 10 | All SZGR 2.0 genes in this pathway |
ST TYPE I INTERFERON PATHWAY | 9 | 8 | All SZGR 2.0 genes in this pathway |
ST INTERLEUKIN 4 PATHWAY | 26 | 18 | All SZGR 2.0 genes in this pathway |
PID P73PATHWAY | 79 | 59 | All SZGR 2.0 genes in this pathway |
PID IL4 2PATHWAY | 65 | 43 | All SZGR 2.0 genes in this pathway |
PID IL27 PATHWAY | 26 | 20 | All SZGR 2.0 genes in this pathway |
PID TCPTP PATHWAY | 43 | 33 | All SZGR 2.0 genes in this pathway |
PID SHP2 PATHWAY | 58 | 46 | All SZGR 2.0 genes in this pathway |
PID IL2 1PATHWAY | 55 | 43 | All SZGR 2.0 genes in this pathway |
PID IL2 PI3K PATHWAY | 34 | 27 | All SZGR 2.0 genes in this pathway |
PID IFNG PATHWAY | 40 | 34 | All SZGR 2.0 genes in this pathway |
PID IL6 7 PATHWAY | 47 | 40 | All SZGR 2.0 genes in this pathway |
PID PDGFRA PATHWAY | 22 | 18 | All SZGR 2.0 genes in this pathway |
PID IL2 STAT5 PATHWAY | 30 | 23 | All SZGR 2.0 genes in this pathway |
REACTOME IL 7 SIGNALING | 11 | 9 | All SZGR 2.0 genes in this pathway |
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | 66 | 45 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALING BY ILS | 107 | 86 | All SZGR 2.0 genes in this pathway |
REACTOME IL 3 5 AND GM CSF SIGNALING | 43 | 34 | All SZGR 2.0 genes in this pathway |
REACTOME IL RECEPTOR SHC SIGNALING | 27 | 21 | All SZGR 2.0 genes in this pathway |
REACTOME REGULATION OF IFNG SIGNALING | 14 | 10 | All SZGR 2.0 genes in this pathway |
REACTOME INTERFERON GAMMA SIGNALING | 63 | 48 | All SZGR 2.0 genes in this pathway |
REACTOME INTERFERON ALPHA BETA SIGNALING | 64 | 50 | All SZGR 2.0 genes in this pathway |
REACTOME REGULATION OF IFNA SIGNALING | 24 | 22 | All SZGR 2.0 genes in this pathway |
REACTOME INTERFERON SIGNALING | 159 | 116 | All SZGR 2.0 genes in this pathway |
REACTOME IL 2 SIGNALING | 41 | 34 | All SZGR 2.0 genes in this pathway |
REACTOME IL 6 SIGNALING | 11 | 9 | All SZGR 2.0 genes in this pathway |
REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM | 270 | 204 | All SZGR 2.0 genes in this pathway |
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP | 255 | 177 | All SZGR 2.0 genes in this pathway |
GRABARCZYK BCL11B TARGETS UP | 81 | 40 | All SZGR 2.0 genes in this pathway |
MULLIGHAN MLL SIGNATURE 1 DN | 242 | 165 | All SZGR 2.0 genes in this pathway |
MULLIGHAN MLL SIGNATURE 2 DN | 281 | 186 | All SZGR 2.0 genes in this pathway |
SENESE HDAC3 TARGETS UP | 501 | 327 | All SZGR 2.0 genes in this pathway |
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN | 800 | 473 | All SZGR 2.0 genes in this pathway |
SIMBULAN UV RESPONSE IMMORTALIZED DN | 31 | 26 | All SZGR 2.0 genes in this pathway |
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN | 584 | 395 | All SZGR 2.0 genes in this pathway |
PUJANA BREAST CANCER LIT INT NETWORK | 101 | 73 | All SZGR 2.0 genes in this pathway |
SWEET KRAS TARGETS UP | 84 | 51 | All SZGR 2.0 genes in this pathway |
PENG RAPAMYCIN RESPONSE UP | 203 | 130 | All SZGR 2.0 genes in this pathway |
ZHANG TARGETS OF EWSR1 FLI1 FUSION | 88 | 68 | All SZGR 2.0 genes in this pathway |
STAEGE EWING FAMILY TUMOR | 33 | 22 | All SZGR 2.0 genes in this pathway |
THEILGAARD NEUTROPHIL AT SKIN WOUND DN | 225 | 163 | All SZGR 2.0 genes in this pathway |
REN ALVEOLAR RHABDOMYOSARCOMA DN | 408 | 274 | All SZGR 2.0 genes in this pathway |
ZHENG RESPONSE TO ARSENITE DN | 18 | 15 | All SZGR 2.0 genes in this pathway |
CUI TCF21 TARGETS 2 DN | 830 | 547 | All SZGR 2.0 genes in this pathway |
KAYO AGING MUSCLE UP | 244 | 165 | All SZGR 2.0 genes in this pathway |
JI RESPONSE TO FSH DN | 58 | 43 | All SZGR 2.0 genes in this pathway |
WELCSH BRCA1 TARGETS UP | 198 | 132 | All SZGR 2.0 genes in this pathway |
XU GH1 AUTOCRINE TARGETS DN | 142 | 94 | All SZGR 2.0 genes in this pathway |
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP | 953 | 554 | All SZGR 2.0 genes in this pathway |
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP | 783 | 442 | All SZGR 2.0 genes in this pathway |
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 | 528 | 324 | All SZGR 2.0 genes in this pathway |
HOWLIN CITED1 TARGETS 1 UP | 35 | 25 | All SZGR 2.0 genes in this pathway |
HOWLIN CITED1 TARGETS 1 DN | 37 | 22 | All SZGR 2.0 genes in this pathway |
GAVIN FOXP3 TARGETS CLUSTER T7 | 98 | 63 | All SZGR 2.0 genes in this pathway |
GAVIN FOXP3 TARGETS CLUSTER P3 | 160 | 103 | All SZGR 2.0 genes in this pathway |
ZHENG BOUND BY FOXP3 | 491 | 310 | All SZGR 2.0 genes in this pathway |
ZHENG FOXP3 TARGETS IN T LYMPHOCYTE DN | 37 | 29 | All SZGR 2.0 genes in this pathway |
MARTINEZ RB1 TARGETS UP | 673 | 430 | All SZGR 2.0 genes in this pathway |
MARTINEZ TP53 TARGETS UP | 602 | 364 | All SZGR 2.0 genes in this pathway |
MARTINEZ RB1 AND TP53 TARGETS UP | 601 | 369 | All SZGR 2.0 genes in this pathway |
OUYANG PROSTATE CANCER PROGRESSION UP | 20 | 14 | All SZGR 2.0 genes in this pathway |
RIGGI EWING SARCOMA PROGENITOR UP | 430 | 288 | All SZGR 2.0 genes in this pathway |
MITSIADES RESPONSE TO APLIDIN UP | 439 | 257 | All SZGR 2.0 genes in this pathway |
LINDSTEDT DENDRITIC CELL MATURATION C | 69 | 49 | All SZGR 2.0 genes in this pathway |
RUTELLA RESPONSE TO CSF2RB AND IL4 UP | 338 | 225 | All SZGR 2.0 genes in this pathway |
RUTELLA RESPONSE TO HGF UP | 418 | 282 | All SZGR 2.0 genes in this pathway |
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN | 245 | 150 | All SZGR 2.0 genes in this pathway |
JISON SICKLE CELL DISEASE DN | 181 | 97 | All SZGR 2.0 genes in this pathway |
YAGI AML WITH T 8 21 TRANSLOCATION | 368 | 247 | All SZGR 2.0 genes in this pathway |
SAKAI CHRONIC HEPATITIS VS LIVER CANCER UP | 83 | 63 | All SZGR 2.0 genes in this pathway |
WONG ADULT TISSUE STEM MODULE | 721 | 492 | All SZGR 2.0 genes in this pathway |
BAE BRCA1 TARGETS DN | 32 | 27 | All SZGR 2.0 genes in this pathway |
JOHNSTONE PARVB TARGETS 3 UP | 430 | 288 | All SZGR 2.0 genes in this pathway |
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP | 259 | 159 | All SZGR 2.0 genes in this pathway |
IVANOVSKA MIR106B TARGETS | 90 | 56 | All SZGR 2.0 genes in this pathway |
LEE BMP2 TARGETS DN | 882 | 538 | All SZGR 2.0 genes in this pathway |
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP | 570 | 339 | All SZGR 2.0 genes in this pathway |
KRIEG HYPOXIA NOT VIA KDM3A | 770 | 480 | All SZGR 2.0 genes in this pathway |
PHONG TNF RESPONSE NOT VIA P38 | 337 | 236 | All SZGR 2.0 genes in this pathway |
PECE MAMMARY STEM CELL DN | 146 | 88 | All SZGR 2.0 genes in this pathway |
Section VI. microRNA annotation
miRNA family | Target position | miRNA ID | miRNA seq | ||
---|---|---|---|---|---|
UTR start | UTR end | Match method | |||
miR-142-5p | 1303 | 1309 | 1A | hsa-miR-142-5p | CAUAAAGUAGAAAGCACUAC |
miR-17-5p/20/93.mr/106/519.d | 1289 | 1295 | m8 | hsa-miR-17-5p | CAAAGUGCUUACAGUGCAGGUAGU |
hsa-miR-20abrain | UAAAGUGCUUAUAGUGCAGGUAG | ||||
hsa-miR-106a | AAAAGUGCUUACAGUGCAGGUAGC | ||||
hsa-miR-106bSZ | UAAAGUGCUGACAGUGCAGAU | ||||
hsa-miR-20bSZ | CAAAGUGCUCAUAGUGCAGGUAG | ||||
hsa-miR-519d | CAAAGUGCCUCCCUUUAGAGUGU | ||||
miR-448 | 1285 | 1291 | m8 | hsa-miR-448 | UUGCAUAUGUAGGAUGUCCCAU |
- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.