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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Gene Page: JAK1

Summary

GeneID

3716

Symbol

JAK1

Synonyms

JAK1A|JAK1B|JTK3

Description

Janus kinase 1 (a protein tyrosine kinase)

Locus tag

Gene type

protein-coding

Map location

1p32.3-p31.3

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_IIA

genome scan meta-analysis (All samples)

Psr: 0.02692

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0058

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

TSPAN9

0.88

0.50

FOXO1

0.84

0.54

IL28RA

0.82

0.45

AP000911.1

0.82

0.37

C10orf41

0.82

0.42

SIX3

0.82

0.44

SERTAD4

0.82

0.43

RXRG

0.81

0.48

ZNF521

0.81

0.54

PBX3

0.81

0.50

Top 10 negatively co-expressed genes

SLC26A4

-0.29

-0.28

EMX1

-0.26

-0.23

ID2

-0.24

-0.29

CIDEA

-0.24

-0.20

AF347015.31

-0.24

-0.15

GPR22

-0.23

-0.18

AF347015.21

-0.23

-0.15

AF347015.2

-0.22

-0.14

MT-CO2

-0.22

-0.15

AF347015.8

-0.22

-0.14

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000166

nucleotide binding

IEA

GO:0005515

protein binding

IEA

GO:0005524

ATP binding

IEA

GO:0004718

Janus kinase activity

IEA

GO:0004715

non-membrane spanning protein tyrosine kinase activity

IEA

GO:0016740

transferase activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007243

protein kinase cascade

IEA

GO:0007167

enzyme linked receptor protein signaling pathway

IEA

GO:0018108

peptidyl-tyrosine phosphorylation

IEA

GO:0019221

cytokine-mediated signaling pathway

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0012505

endomembrane system

IEA

GO:0005856

cytoskeleton

IEA

GO:0016020

membrane

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABL1	ABL \| JTK7 \| bcr/abl \| c-ABL \| p150 \| v-abl	c-abl oncogene 1, receptor tyrosine kinase	Reconstituted Complex	BioGRID	9774693
ABL1	ABL \| JTK7 \| bcr/abl \| c-ABL \| p150 \| v-abl	c-abl oncogene 1, receptor tyrosine kinase	-	HPRD	12130510
ABL2	ABLL \| ARG \| FLJ22224 \| FLJ31718 \| FLJ41441	v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)	Affinity Capture-Western	BioGRID	9774693
ARRB1	ARB1 \| ARR1	arrestin, beta 1	Affinity Capture-MS	BioGRID	17353931
ATIC	AICAR \| AICARFT \| FLJ93545 \| IMPCHASE \| PURH	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Affinity Capture-MS	BioGRID	17353931
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	-	HPRD,BioGRID	11163768
BTK	AGMX1 \| AT \| ATK \| BPK \| IMD1 \| MGC126261 \| MGC126262 \| PSCTK1 \| XLA	Bruton agammaglobulinemia tyrosine kinase	-	HPRD,BioGRID	9178903
CSF3R	CD114 \| GCSFR	colony stimulating factor 3 receptor (granulocyte)	-	HPRD,BioGRID	7512720
ELF3	EPR-1 \| ERT \| ESE-1 \| ESX	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	Affinity Capture-MS	BioGRID	17353931
ELP2	FLJ10879 \| SHINC-2 \| STATIP1 \| StIP	elongation protein 2 homolog (S. cerevisiae)	-	HPRD,BioGRID	10954736
GHR	GHBP	growth hormone receptor	-	HPRD,BioGRID	10502458
GNB2L1	Gnb2-rs1 \| H12.3 \| HLC-7 \| PIG21 \| RACK1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	RACK-1 interacts with Jak1.	BIND	12960323
GNB2L1	Gnb2-rs1 \| H12.3 \| HLC-7 \| PIG21 \| RACK1		-	HPRD,BioGRID	12960323
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD,BioGRID	8536716 \|11527382
IFNAR2	IFN-R \| IFN-alpha-REC \| IFNABR \| IFNARB	interferon (alpha, beta and omega) receptor 2	Reconstituted Complex	BioGRID	12133952
IFNAR2	IFN-R \| IFN-alpha-REC \| IFNABR \| IFNARB	interferon (alpha, beta and omega) receptor 2	IFNR-beta-L interacts with Jak1.	BIND	12960323
IFNGR1	CD119 \| FLJ45734 \| IFNGR	interferon gamma receptor 1	Reconstituted Complex	BioGRID	12133952
IGF1R	CD221 \| IGFIR \| JTK13 \| MGC142170 \| MGC142172 \| MGC18216	insulin-like growth factor 1 receptor	Phosphorylated IGF-1R-beta interacts with JAK-1.	BIND	9492017
IGF1R	CD221 \| IGFIR \| JTK13 \| MGC142170 \| MGC142172 \| MGC18216	insulin-like growth factor 1 receptor	-	HPRD,BioGRID	9492017
IL10RA	CDW210A \| HIL-10R \| IL-10R1 \| IL10R	interleukin 10 receptor, alpha	-	HPRD,BioGRID	12133952 \|12374810
IL10RA	CDW210A \| HIL-10R \| IL-10R1 \| IL10R	interleukin 10 receptor, alpha	IL-10R-alpha interacts with Jak1.	BIND	12133952
IL21R	MGC10967 \| NILR	interleukin 21 receptor	Affinity Capture-Western	BioGRID	11016959
IL27RA	CRL1 \| IL27R \| TCCR \| WSX1 \| zcytor1	interleukin 27 receptor, alpha	Affinity Capture-Western	BioGRID	12734330
IL2RB	CD122 \| P70-75	interleukin 2 receptor, beta	-	HPRD,BioGRID	7973659 \|12133952
IL2RB	CD122 \| P70-75	interleukin 2 receptor, beta	IL-2R-beta interacts with Jak1.	BIND	12133952
IL4R	CD124 \| IL4RA	interleukin 4 receptor	-	HPRD,BioGRID	12133952
IL4R	CD124 \| IL4RA	interleukin 4 receptor	JAK1 interacts with IL4R-alpha.	BIND	12133952
IL5RA	CD125 \| CDw125 \| HSIL5R3 \| IL5R \| MGC26560	interleukin 5 receptor, alpha	-	HPRD,BioGRID	9516124
IL6ST	CD130 \| CDw130 \| GP130 \| GP130-RAPS \| IL6R-beta	interleukin 6 signal transducer (gp130, oncostatin M receptor)	-	HPRD,BioGRID	11468294 \|11742534
IL9R	CD129	interleukin 9 receptor	-	HPRD,BioGRID	8756628
INSR	CD220 \| HHF5	insulin receptor	Phosphorylated IR-beta interacts with JAK-1.	BIND	9492017
IRS1	HIRS-1	insulin receptor substrate 1	Affinity Capture-Western Biochemical Activity	BioGRID	7499365 \|9492017
IRS2	-	insulin receptor substrate 2	-	HPRD,BioGRID	7499365
JAK3	JAK-3 \| JAK3_HUMAN \| JAKL \| L-JAK \| LJAK	Janus kinase 3 (a protein tyrosine kinase, leukocyte)	-	HPRD,BioGRID	9553136
JAKMIP1	FLJ31564 \| Gababrbp \| JAMIP1 \| MARLIN1	janus kinase and microtubule interacting protein 1	Jamip1 interacts with Jak1.	BIND	15277531
MDK	FLJ27379 \| MK \| NEGF2	midkine (neurite growth-promoting factor 2)	-	HPRD	9452495
OSMR	MGC150626 \| MGC150627 \| MGC75127 \| OSMRB	oncostatin M receptor	-	HPRD	10586060
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	-	HPRD,BioGRID	9774657
PLAUR	CD87 \| UPAR \| URKR	plasminogen activator, urokinase receptor	-	HPRD,BioGRID	9417082
PRMT5	HRMT1L5 \| IBP72 \| JBP1 \| SKB1 \| SKB1Hs	protein arginine methyltransferase 5	-	HPRD,BioGRID	10531356
PTK2B	CADTK \| CAKB \| FADK2 \| FAK2 \| FRNK \| PKB \| PTK \| PYK2 \| RAFTK	PTK2B protein tyrosine kinase 2 beta	-	HPRD,BioGRID	10702271
PTPN11	BPTP3 \| CFC \| MGC14433 \| NS1 \| PTP-1D \| PTP2C \| SH-PTP2 \| SH-PTP3 \| SHP2	protein tyrosine phosphatase, non-receptor type 11	-	HPRD,BioGRID	8995399 \|11036942 \|12403768
PTPN6	HCP \| HCPH \| HPTP1C \| PTP-1C \| SH-PTP1 \| SHP-1 \| SHP-1L \| SHP1	protein tyrosine phosphatase, non-receptor type 6	Biochemical Activity	BioGRID	7629131
PTPRC	B220 \| CD45 \| CD45R \| GP180 \| LCA \| LY5 \| T200	protein tyrosine phosphatase, receptor type, C	-	HPRD	11201744
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	-	HPRD,BioGRID	9446616
SHB	RP11-3J10.8 \| bA3J10.2	Src homology 2 domain containing adaptor protein B	-	HPRD,BioGRID	12200137
SOCS1	CIS1 \| CISH1 \| JAB \| SOCS-1 \| SSI-1 \| SSI1 \| TIP3	suppressor of cytokine signaling 1	-	HPRD	11133764
STAM2	DKFZp564C047 \| Hbp \| STAM2A \| STAM2B	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	-	HPRD,BioGRID	10899310 \|10993906
STAT1	DKFZp686B04100 \| ISGF-3 \| STAT91	signal transducer and activator of transcription 1, 91kDa	-	HPRD	11722592
STAT3	APRF \| FLJ20882 \| HIES \| MGC16063	signal transducer and activator of transcription 3 (acute-phase response factor)	-	HPRD,BioGRID	11722592
STAT5A	MGF \| STAT5	signal transducer and activator of transcription 5A	-	HPRD	11722592
STAT5A	MGF \| STAT5	signal transducer and activator of transcription 5A	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	9047382
STAT5B	STAT5	signal transducer and activator of transcription 5B	Affinity Capture-Western Two-hybrid	BioGRID	9047382
SYK	DKFZp313N1010 \| FLJ25043 \| FLJ37489	spleen tyrosine kinase	-	HPRD	10825200
TEC	MGC126760 \| MGC126762 \| PSCTK4	tec protein tyrosine kinase	-	HPRD,BioGRID	9178903
TNFRSF1A	CD120a \| FPF \| MGC19588 \| TBP1 \| TNF-R \| TNF-R-I \| TNF-R55 \| TNFAR \| TNFR1 \| TNFR55 \| TNFR60 \| p55 \| p55-R \| p60	tumor necrosis factor receptor superfamily, member 1A	-	HPRD,BioGRID	11801527
TSHR	CHNG1 \| LGR3 \| MGC75129 \| hTSHR-I	thyroid stimulating hormone receptor	-	HPRD,BioGRID	10809230
TYK2	JTK1	tyrosine kinase 2	-	HPRD,BioGRID	7589562

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_JAK_STAT_SIGNALING_PATHWAY	155	105	All SZGR genes in this pathway
KEGG_LEISHMANIA_INFECTION	72	56	All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER	328	259	All SZGR genes in this pathway
KEGG_PANCREATIC_CANCER	70	56	All SZGR genes in this pathway
BIOCARTA_EGF_PATHWAY	31	25	All SZGR genes in this pathway
BIOCARTA_IL2_PATHWAY	22	16	All SZGR genes in this pathway
BIOCARTA_IL4_PATHWAY	11	8	All SZGR genes in this pathway
BIOCARTA_IL6_PATHWAY	22	16	All SZGR genes in this pathway
BIOCARTA_IL10_PATHWAY	17	14	All SZGR genes in this pathway
BIOCARTA_IL2RB_PATHWAY	38	26	All SZGR genes in this pathway
BIOCARTA_IL22BP_PATHWAY	16	12	All SZGR genes in this pathway
BIOCARTA_IL7_PATHWAY	17	14	All SZGR genes in this pathway
BIOCARTA_PDGF_PATHWAY	32	25	All SZGR genes in this pathway
ST_INTERFERON_GAMMA_PATHWAY	10	7	All SZGR genes in this pathway
SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	27	23	All SZGR genes in this pathway
ST_JAK_STAT_PATHWAY	9	8	All SZGR genes in this pathway
ST_STAT3_PATHWAY	11	10	All SZGR genes in this pathway
ST_TYPE_I_INTERFERON_PATHWAY	9	8	All SZGR genes in this pathway
ST_INTERLEUKIN_4_PATHWAY	26	18	All SZGR genes in this pathway
PID_P73PATHWAY	79	59	All SZGR genes in this pathway
PID_IL4_2PATHWAY	65	43	All SZGR genes in this pathway
PID_IL27_PATHWAY	26	20	All SZGR genes in this pathway
PID_TCPTP_PATHWAY	43	33	All SZGR genes in this pathway
PID_SHP2_PATHWAY	58	46	All SZGR genes in this pathway
PID_IL2_1PATHWAY	55	43	All SZGR genes in this pathway
PID_IL2_PI3K_PATHWAY	34	27	All SZGR genes in this pathway
PID_IFNG_PATHWAY	40	34	All SZGR genes in this pathway
PID_IL6_7_PATHWAY	47	40	All SZGR genes in this pathway
PID_PDGFRA_PATHWAY	22	18	All SZGR genes in this pathway
PID_IL2_STAT5_PATHWAY	30	23	All SZGR genes in this pathway
REACTOME_IL_7_SIGNALING	11	9	All SZGR genes in this pathway
REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES	66	45	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ILS	107	86	All SZGR genes in this pathway
REACTOME_IL_3_5_AND_GM_CSF_SIGNALING	43	34	All SZGR genes in this pathway
REACTOME_IL_RECEPTOR_SHC_SIGNALING	27	21	All SZGR genes in this pathway
REACTOME_REGULATION_OF_IFNG_SIGNALING	14	10	All SZGR genes in this pathway
REACTOME_INTERFERON_GAMMA_SIGNALING	63	48	All SZGR genes in this pathway
REACTOME_INTERFERON_ALPHA_BETA_SIGNALING	64	50	All SZGR genes in this pathway
REACTOME_REGULATION_OF_IFNA_SIGNALING	24	22	All SZGR genes in this pathway
REACTOME_INTERFERON_SIGNALING	159	116	All SZGR genes in this pathway
REACTOME_IL_2_SIGNALING	41	34	All SZGR genes in this pathway
REACTOME_IL_6_SIGNALING	11	9	All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM	933	616	All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM	270	204	All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP	255	177	All SZGR genes in this pathway
GRABARCZYK_BCL11B_TARGETS_UP	81	40	All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_DN	242	165	All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_DN	281	186	All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP	501	327	All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN	800	473	All SZGR genes in this pathway
SIMBULAN_UV_RESPONSE_IMMORTALIZED_DN	31	26	All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN	584	395	All SZGR genes in this pathway
PUJANA_BREAST_CANCER_LIT_INT_NETWORK	101	73	All SZGR genes in this pathway
SWEET_KRAS_TARGETS_UP	84	51	All SZGR genes in this pathway
PENG_RAPAMYCIN_RESPONSE_UP	203	130	All SZGR genes in this pathway
ZHANG_TARGETS_OF_EWSR1_FLI1_FUSION	88	68	All SZGR genes in this pathway
STAEGE_EWING_FAMILY_TUMOR	33	22	All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN	225	163	All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN	408	274	All SZGR genes in this pathway
ZHENG_RESPONSE_TO_ARSENITE_DN	18	15	All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN	830	547	All SZGR genes in this pathway
KAYO_AGING_MUSCLE_UP	244	165	All SZGR genes in this pathway
JI_RESPONSE_TO_FSH_DN	58	43	All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_UP	198	132	All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_DN	142	94	All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP	953	554	All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP	783	442	All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1	528	324	All SZGR genes in this pathway
HOWLIN_CITED1_TARGETS_1_UP	35	25	All SZGR genes in this pathway
HOWLIN_CITED1_TARGETS_1_DN	37	22	All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_T7	98	63	All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P3	160	103	All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3	491	310	All SZGR genes in this pathway
ZHENG_FOXP3_TARGETS_IN_T_LYMPHOCYTE_DN	37	29	All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP	673	430	All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP	602	364	All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP	601	369	All SZGR genes in this pathway
OUYANG_PROSTATE_CANCER_PROGRESSION_UP	20	14	All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP	430	288	All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_UP	439	257	All SZGR genes in this pathway
LINDSTEDT_DENDRITIC_CELL_MATURATION_C	69	49	All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP	338	225	All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_UP	418	282	All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_DN	245	150	All SZGR genes in this pathway
JISON_SICKLE_CELL_DISEASE_DN	181	97	All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION	368	247	All SZGR genes in this pathway
SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_UP	83	63	All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE	721	492	All SZGR genes in this pathway
BAE_BRCA1_TARGETS_DN	32	27	All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_UP	430	288	All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_UP	259	159	All SZGR genes in this pathway
IVANOVSKA_MIR106B_TARGETS	90	56	All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN	882	538	All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP	570	339	All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A	770	480	All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38	337	236	All SZGR genes in this pathway
PECE_MAMMARY_STEM_CELL_DN	146	88	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-142-5p	1303	1309	1A	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-17-5p/20/93.mr/106/519.d	1289	1295	m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-448	1285	1291	m8	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.