Gene Page: JAK3
Summary ?
| GeneID | 3718 |
| Symbol | JAK3 |
| Synonyms | JAK-3|JAK3_HUMAN|JAKL|L-JAK|LJAK |
| Description | Janus kinase 3 |
| Reference | MIM:600173|HGNC:HGNC:6193|Ensembl:ENSG00000105639|HPRD:02547|Vega:OTTHUMG00000165648 |
| Gene type | protein-coding |
| Map location | 19p13.1 |
| Pascal p-value | 0.015 |
| eGene | Cerebellar Hemisphere Cerebellum |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ALK | CD246 | Ki-1 | TFG/ALK | anaplastic lymphoma receptor tyrosine kinase | - | HPRD,BioGRID | 11850821 |
| CD247 | CD3-ZETA | CD3H | CD3Q | CD3Z | T3Z | TCRZ | CD247 molecule | - | HPRD,BioGRID | 11349123 |
| CD3E | FLJ18683 | T3E | TCRE | CD3e molecule, epsilon (CD3-TCR complex) | Affinity Capture-Western | BioGRID | 11349123 |
| CXCR4 | CD184 | D2S201E | FB22 | HM89 | HSY3RR | LAP3 | LCR1 | LESTR | NPY3R | NPYR | NPYRL | NPYY3R | WHIM | chemokine (C-X-C motif) receptor 4 | - | HPRD,BioGRID | 10506573 |
| IL2RB | CD122 | P70-75 | interleukin 2 receptor, beta | - | HPRD,BioGRID | 7973659 |9553136 |10825200 |
| IL2RG | CD132 | IMD4 | SCIDX | SCIDX1 | interleukin 2 receptor, gamma (severe combined immunodeficiency) | - | HPRD,BioGRID | 7973658 |
| IL4R | CD124 | IL4RA | interleukin 4 receptor | - | HPRD,BioGRID | 7538655 |
| IRS1 | HIRS-1 | insulin receptor substrate 1 | - | HPRD,BioGRID | 7499365 |
| IRS2 | - | insulin receptor substrate 2 | - | HPRD | 7499365 |
| JAK1 | JAK1A | JAK1B | JTK3 | Janus kinase 1 (a protein tyrosine kinase) | - | HPRD,BioGRID | 9553136 |
| JAK3 | JAK-3 | JAK3_HUMAN | JAKL | L-JAK | LJAK | Janus kinase 3 (a protein tyrosine kinase, leukocyte) | JAK3S autophosphorylates JAK3S. | BIND | 7559633 |
| JAK3 | JAK-3 | JAK3_HUMAN | JAKL | L-JAK | LJAK | Janus kinase 3 (a protein tyrosine kinase, leukocyte) | JAK3B interacts with JAK3S. | BIND | 7559633 |
| LCK | YT16 | p56lck | pp58lck | lymphocyte-specific protein tyrosine kinase | - | HPRD | 11278738 |
| LEPR | CD295 | OBR | leptin receptor | Affinity Capture-Western | BioGRID | 11585385 |
| PRMT5 | HRMT1L5 | IBP72 | JBP1 | SKB1 | SKB1Hs | protein arginine methyltransferase 5 | - | HPRD,BioGRID | 10531356 |
| PTK2B | CADTK | CAKB | FADK2 | FAK2 | FRNK | PKB | PTK | PYK2 | RAFTK | PTK2B protein tyrosine kinase 2 beta | - | HPRD,BioGRID | 9512511 |
| PTPRC | B220 | CD45 | CD45R | GP180 | LCA | LY5 | T200 | protein tyrosine phosphatase, receptor type, C | - | HPRD | 11994288 |
| SH2B2 | APS | SH2B adaptor protein 2 | - | HPRD | 10872802 |
| SHB | RP11-3J10.8 | bA3J10.2 | Src homology 2 domain containing adaptor protein B | - | HPRD,BioGRID | 12200137 |
| SOCS1 | CIS1 | CISH1 | JAB | SOCS-1 | SSI-1 | SSI1 | TIP3 | suppressor of cytokine signaling 1 | - | HPRD | 11133764 |
| STAM | DKFZp686J2352 | STAM1 | signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 | - | HPRD,BioGRID | 10899310 |
| STAM2 | DKFZp564C047 | Hbp | STAM2A | STAM2B | signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 | - | HPRD,BioGRID | 10899310 |
| STAT3 | APRF | FLJ20882 | HIES | MGC16063 | signal transducer and activator of transcription 3 (acute-phase response factor) | - | HPRD,BioGRID | 10037026 |
| STAT5A | MGF | STAT5 | signal transducer and activator of transcription 5A | - | HPRD,BioGRID | 9047382 |10037026 |
| STAT5B | STAT5 | signal transducer and activator of transcription 5B | Two-hybrid | BioGRID | 9047382 |
| TIAF1 | MAJN | MYO18A | MYSPDZ | SPR210 | TGFB1-induced anti-apoptotic factor 1 | - | HPRD,BioGRID | 10733938 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG CHEMOKINE SIGNALING PATHWAY | 190 | 128 | All SZGR 2.0 genes in this pathway |
| KEGG JAK STAT SIGNALING PATHWAY | 155 | 105 | All SZGR 2.0 genes in this pathway |
| KEGG PRIMARY IMMUNODEFICIENCY | 35 | 28 | All SZGR 2.0 genes in this pathway |
| BIOCARTA IL2 PATHWAY | 22 | 16 | All SZGR 2.0 genes in this pathway |
| BIOCARTA IL4 PATHWAY | 11 | 8 | All SZGR 2.0 genes in this pathway |
| BIOCARTA IL6 PATHWAY | 22 | 16 | All SZGR 2.0 genes in this pathway |
| BIOCARTA IL2RB PATHWAY | 38 | 26 | All SZGR 2.0 genes in this pathway |
| BIOCARTA IL22BP PATHWAY | 16 | 12 | All SZGR 2.0 genes in this pathway |
| BIOCARTA IL7 PATHWAY | 17 | 14 | All SZGR 2.0 genes in this pathway |
| SIG IL4RECEPTOR IN B LYPHOCYTES | 27 | 23 | All SZGR 2.0 genes in this pathway |
| ST JAK STAT PATHWAY | 9 | 8 | All SZGR 2.0 genes in this pathway |
| ST STAT3 PATHWAY | 11 | 10 | All SZGR 2.0 genes in this pathway |
| ST INTERLEUKIN 4 PATHWAY | 26 | 18 | All SZGR 2.0 genes in this pathway |
| PID IL4 2PATHWAY | 65 | 43 | All SZGR 2.0 genes in this pathway |
| PID CD40 PATHWAY | 31 | 26 | All SZGR 2.0 genes in this pathway |
| PID TCPTP PATHWAY | 43 | 33 | All SZGR 2.0 genes in this pathway |
| PID SHP2 PATHWAY | 58 | 46 | All SZGR 2.0 genes in this pathway |
| PID IL2 1PATHWAY | 55 | 43 | All SZGR 2.0 genes in this pathway |
| PID IL2 PI3K PATHWAY | 34 | 27 | All SZGR 2.0 genes in this pathway |
| PID IL2 STAT5 PATHWAY | 30 | 23 | All SZGR 2.0 genes in this pathway |
| REACTOME IL 7 SIGNALING | 11 | 9 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY ILS | 107 | 86 | All SZGR 2.0 genes in this pathway |
| REACTOME IL 3 5 AND GM CSF SIGNALING | 43 | 34 | All SZGR 2.0 genes in this pathway |
| REACTOME IL RECEPTOR SHC SIGNALING | 27 | 21 | All SZGR 2.0 genes in this pathway |
| REACTOME IL 2 SIGNALING | 41 | 34 | All SZGR 2.0 genes in this pathway |
| REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
| REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM | 270 | 204 | All SZGR 2.0 genes in this pathway |
| BASAKI YBX1 TARGETS DN | 384 | 230 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP | 552 | 347 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN UP | 1142 | 669 | All SZGR 2.0 genes in this pathway |
| LINDGREN BLADDER CANCER CLUSTER 2B | 392 | 251 | All SZGR 2.0 genes in this pathway |
| SCHLOSSER SERUM RESPONSE AUGMENTED BY MYC | 108 | 74 | All SZGR 2.0 genes in this pathway |
| HATADA METHYLATED IN LUNG CANCER DN | 38 | 13 | All SZGR 2.0 genes in this pathway |
| SAKAI CHRONIC HEPATITIS VS LIVER CANCER DN | 36 | 24 | All SZGR 2.0 genes in this pathway |
| SASAKI ADULT T CELL LEUKEMIA | 176 | 122 | All SZGR 2.0 genes in this pathway |
| AFFAR YY1 TARGETS UP | 214 | 133 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE INCIPIENT UP | 390 | 242 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
| SAFFORD T LYMPHOCYTE ANERGY | 87 | 54 | All SZGR 2.0 genes in this pathway |
| LEE CALORIE RESTRICTION MUSCLE DN | 51 | 28 | All SZGR 2.0 genes in this pathway |
| FINETTI BREAST CANCER KINOME GREEN | 16 | 14 | All SZGR 2.0 genes in this pathway |
| RIGGI EWING SARCOMA PROGENITOR UP | 430 | 288 | All SZGR 2.0 genes in this pathway |
| HAN SATB1 TARGETS DN | 442 | 275 | All SZGR 2.0 genes in this pathway |
| YAGI AML WITH T 8 21 TRANSLOCATION | 368 | 247 | All SZGR 2.0 genes in this pathway |
| YAGI AML WITH 11Q23 REARRANGED | 351 | 238 | All SZGR 2.0 genes in this pathway |
| ZHAN MULTIPLE MYELOMA CD2 DN | 46 | 29 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF HCP WITH H3 UNMETHYLATED | 228 | 119 | All SZGR 2.0 genes in this pathway |
| STAMBOLSKY TARGETS OF MUTATED TP53 UP | 49 | 35 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP A | 898 | 516 | All SZGR 2.0 genes in this pathway |
| PURBEY TARGETS OF CTBP1 NOT SATB1 DN | 448 | 282 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D | 658 | 397 | All SZGR 2.0 genes in this pathway |
| FORTSCHEGGER PHF8 TARGETS DN | 784 | 464 | All SZGR 2.0 genes in this pathway |
| DURAND STROMA S UP | 297 | 194 | All SZGR 2.0 genes in this pathway |