Gene Page: GSTK1

Summary ?
GeneID373156
SymbolGSTK1
SynonymsGST|GST 13-13|GST13|GST13-13|GSTK1-1|hGSTK1
Descriptionglutathione S-transferase kappa 1
ReferenceMIM:602321|HGNC:HGNC:16906|Ensembl:ENSG00000197448|Vega:OTTHUMG00000152637
Gene typeprotein-coding
Map location7q34
Pascal p-value6.83E-4
Fetal beta-1.072
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.2287 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg045037437142960869GSTK15.835E-4-0.2220.049DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004602glutathione peroxidase activityIEA-
GO:0004364glutathione transferase activityIEA-
GO:0016740transferase activityIEA-
GO:0015035protein disulfide oxidoreductase activityIEA-
GO:0042802identical protein bindingIPI17353931 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006749glutathione metabolic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIDA11256614 
GO:0005739mitochondrionIEA-
GO:0005743mitochondrial inner membraneIEA-
GO:0005777peroxisomeIEA-
GO:0030288outer membrane-bounded periplasmic spaceIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATXN10E46L | FLJ37990 | SCA10ataxin 10Affinity Capture-MSBioGRID17353931 
CYCSCYC | HCScytochrome c, somaticAffinity Capture-MSBioGRID17353931 
DCTN1DAP-150 | DP-150 | HMN7B | P135dynactin 1 (p150, glued homolog, Drosophila)Affinity Capture-MSBioGRID17353931 
DDOSTAGE-R1 | KIAA0115 | MGC2191 | OK/SW-cl.45 | OST | OST48 | WBP1dolichyl-diphosphooligosaccharide-protein glycosyltransferaseAffinity Capture-MSBioGRID17353931 
EFTUD2DKFZp686E24196 | FLJ44695 | KIAA0031 | Snrp116 | Snu114 | U5-116KDelongation factor Tu GTP binding domain containing 2Affinity Capture-MSBioGRID17353931 
EPPK1EPIPL | EPIPL1epiplakin 1Affinity Capture-MSBioGRID17353931 
FANCIFLJ10719 | KIAA1794Fanconi anemia, complementation group IAffinity Capture-MSBioGRID17353931 
HEATR2FLJ20397 | FLJ25564 | FLJ31671 | FLJ39381HEAT repeat containing 2Affinity Capture-MSBioGRID17353931 
HNRNPMDKFZp547H118 | HNRNPM4 | HNRPM | HNRPM4 | HTGR1 | NAGR1heterogeneous nuclear ribonucleoprotein MAffinity Capture-MSBioGRID17353931 
HRNRS100A16 | S100a18hornerinAffinity Capture-MSBioGRID17353931 
HTR1B5-HT1B | 5-HT1DB | HTR1D2 | HTR1DB | S125-hydroxytryptamine (serotonin) receptor 1BAffinity Capture-MSBioGRID17353931 
IARSFLJ20736 | IARS1 | ILRS | PRO0785isoleucyl-tRNA synthetaseAffinity Capture-MSBioGRID17353931 
IPO4FLJ23338 | Imp4 | MGC131665importin 4Affinity Capture-MSBioGRID17353931 
KIAA1279DKFZp586B0923 | KBP | TTC20KIAA1279Affinity Capture-MSBioGRID17353931 
KIAA1967DBC-1 | DBC1KIAA1967Affinity Capture-MSBioGRID17353931 
LRPPRCCLONE-23970 | GP130 | LRP130 | LSFCleucine-rich PPR-motif containingAffinity Capture-MSBioGRID17353931 
MATR3DKFZp686K0542 | DKFZp686K23100 | KIAA0723 | MGC9105matrin 3Affinity Capture-MSBioGRID17353931 
MCM7CDABP0042 | CDC47 | MCM2 | P1.1-MCM3 | P1CDC47 | P85MCM | PNAS-146minichromosome maintenance complex component 7Affinity Capture-MSBioGRID17353931 
PDCD6IPAIP1 | Alix | DRIP4 | HP95 | MGC17003programmed cell death 6 interacting proteinAffinity Capture-MSBioGRID17353931 
RPN1DKFZp686B16177 | OST1 | RBPH1ribophorin IAffinity Capture-MSBioGRID17353931 
RPN2RIBIIR | RPN-II | RPNII | SWP1ribophorin IIAffinity Capture-MSBioGRID17353931 
SEC63ERdj2 | PRO2507 | SEC63LSEC63 homolog (S. cerevisiae)Affinity Capture-MSBioGRID17353931 
SLC3A24F2 | 4F2HC | 4T2HC | CD98 | CD98HC | MDU1 | NACAEsolute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2Affinity Capture-MSBioGRID17353931 
TSC22D1DKFZp686O19206 | MGC17597 | RP11-269C23.2 | TGFB1I4 | TSC22TSC22 domain family, member 1Affinity Capture-MSBioGRID17353931 
XPO5FLJ14239 | FLJ32057 | FLJ45606 | KIAA1291exportin 5Affinity Capture-MSBioGRID17353931 
ZW10HZW10 | KNTC1AP | MGC149821ZW10, kinetochore associated, homolog (Drosophila)Affinity Capture-MSBioGRID17353931 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG GLUTATHIONE METABOLISM 5034All SZGR 2.0 genes in this pathway
KEGG METABOLISM OF XENOBIOTICS BY CYTOCHROME P450 7044All SZGR 2.0 genes in this pathway
KEGG DRUG METABOLISM CYTOCHROME P450 7247All SZGR 2.0 genes in this pathway
KEGG PEROXISOME 7847All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459276All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP UP 265158All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR DN 6439All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR DN 7550All SZGR 2.0 genes in this pathway
SAENZ DETOX PATHWAY AND CARCINOGENESIS DN 1311All SZGR 2.0 genes in this pathway
HEIDENBLAD AMPLICON 8Q24 DN 4628All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM4 261153All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487286All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366238All SZGR 2.0 genes in this pathway
GUO HEX TARGETS DN 6536All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681420All SZGR 2.0 genes in this pathway
YANG MUC2 TARGETS DUODENUM 3MO DN 2314All SZGR 2.0 genes in this pathway
YANG MUC2 TARGETS DUODENUM 6MO DN 2112All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528324All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS UP 388234All SZGR 2.0 genes in this pathway
MELLMAN TUT1 TARGETS DN 4729All SZGR 2.0 genes in this pathway
KESHELAVA MULTIPLE DRUG RESISTANCE 8856All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535325All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721492All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 12 7954All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA CLASSICAL 162122All SZGR 2.0 genes in this pathway
PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 DN 157106All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP 430288All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682433All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL DN 428246All SZGR 2.0 genes in this pathway