Gene Page: KCNA4
Summary ?
| GeneID | 3739 |
| Symbol | KCNA4 |
| Synonyms | HBK4|HK1|HPCN2|HUKII|KCNA4L|KCNA8|KV1.4|PCN2 |
| Description | potassium voltage-gated channel subfamily A member 4 |
| Reference | MIM:176266|HGNC:HGNC:6222|Ensembl:ENSG00000182255|HPRD:01444|Vega:OTTHUMG00000166144 |
| Gene type | protein-coding |
| Map location | 11p14 |
| Pascal p-value | 0.025 |
| Sherlock p-value | 0.978 |
| Support | EXCITABILITY |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PRDX3 | 0.57 | 0.57 |
| PHYH | 0.57 | 0.58 |
| SELT | 0.56 | 0.60 |
| NGB | 0.54 | 0.53 |
| PCCB | 0.54 | 0.54 |
| GLO1 | 0.53 | 0.53 |
| KCNMB2 | 0.53 | 0.53 |
| DHRS7B | 0.52 | 0.54 |
| SMYD2 | 0.52 | 0.53 |
| COMMD10 | 0.51 | 0.53 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| OBSCN | -0.46 | -0.33 |
| ZNF814 | -0.43 | -0.46 |
| AC005921.3 | -0.42 | -0.48 |
| UPF3A | -0.42 | -0.43 |
| ZRSR1 | -0.41 | -0.42 |
| C1orf145 | -0.41 | -0.27 |
| AC010522.1 | -0.40 | -0.36 |
| ZNF587 | -0.39 | -0.36 |
| AC004148.1 | -0.38 | -0.41 |
| ZNF552 | -0.37 | -0.36 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| DLG1 | DKFZp761P0818 | DKFZp781B0426 | DLGH1 | SAP97 | dJ1061C18.1.1 | hdlg | discs, large homolog 1 (Drosophila) | - | HPRD,BioGRID | 12860415 |
| DLG2 | DKFZp781D1854 | DKFZp781E0954 | FLJ37266 | MGC131811 | PSD-93 | discs, large homolog 2, chapsyn-110 (Drosophila) | - | HPRD,BioGRID | 11997254 |
| DLG4 | FLJ97752 | FLJ98574 | PSD95 | SAP90 | discs, large homolog 4 (Drosophila) | - | HPRD | 8938729 |9581762 |12435606 |
| DLG4 | FLJ97752 | FLJ98574 | PSD95 | SAP90 | discs, large homolog 4 (Drosophila) | Affinity Capture-Western Reconstituted Complex Two-hybrid | BioGRID | 8938729 |9581762 |11997254 |12435606 |
| DLGAP1 | DAP-1 | DAP-1-ALPHA | DAP-1-BETA | GKAP | MGC88156 | SAPAP1 | hGKAP | discs, large (Drosophila) homolog-associated protein 1 | - | HPRD | 9024696 |
| ERBB2IP | ERBIN | LAP2 | erbb2 interacting protein | Reconstituted Complex | BioGRID | 11278603 |
| KCNA1 | AEMK | EA1 | HBK1 | HUK1 | KV1.1 | MBK1 | MGC126782 | MGC138385 | MK1 | RBK1 | potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) | Affinity Capture-Western | BioGRID | 10428084 |
| KCNA2 | HBK5 | HK4 | HUKIV | KV1.2 | MGC50217 | MK2 | NGK1 | RBK2 | potassium voltage-gated channel, shaker-related subfamily, member 2 | Affinity Capture-Western | BioGRID | 10428084 |
| KCNA3 | HGK5 | HLK3 | HPCN3 | HUKIII | KV1.3 | MK3 | PCN3 | potassium voltage-gated channel, shaker-related subfamily, member 3 | Affinity Capture-Western | BioGRID | 10428084 |
| NDUFA4L2 | FLJ26118 | NUOMS | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 | Two-hybrid | BioGRID | 16169070 |
| SAT1 | DC21 | KFSD | SAT | SSAT | SSAT-1 | spermidine/spermine N1-acetyltransferase 1 | Two-hybrid | BioGRID | 16169070 |
| SNTG1 | G1SYN | SYN4 | syntrophin, gamma 1 | - | HPRD | 11352924 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME NEURONAL SYSTEM | 279 | 221 | All SZGR 2.0 genes in this pathway |
| REACTOME VOLTAGE GATED POTASSIUM CHANNELS | 43 | 32 | All SZGR 2.0 genes in this pathway |
| REACTOME POTASSIUM CHANNELS | 98 | 68 | All SZGR 2.0 genes in this pathway |
| HATADA METHYLATED IN LUNG CANCER UP | 390 | 236 | All SZGR 2.0 genes in this pathway |
| SCHAEFFER PROSTATE DEVELOPMENT 48HR DN | 428 | 306 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS | 882 | 572 | All SZGR 2.0 genes in this pathway |
| NOUZOVA METHYLATED IN APL | 68 | 39 | All SZGR 2.0 genes in this pathway |
| MCCLUNG CREB1 TARGETS DN | 57 | 39 | All SZGR 2.0 genes in this pathway |
| HARRIS BRAIN CANCER PROGENITORS | 44 | 23 | All SZGR 2.0 genes in this pathway |
| RIZKI TUMOR INVASIVENESS 3D DN | 270 | 181 | All SZGR 2.0 genes in this pathway |
| WEST ADRENOCORTICAL TUMOR DN | 546 | 362 | All SZGR 2.0 genes in this pathway |
| LIN NPAS4 TARGETS DN | 68 | 48 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| ROME INSULIN TARGETS IN MUSCLE DN | 204 | 114 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MCV6 ICP WITH H3K4ME3 AND H3K27ME3 | 34 | 21 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF ICP WITH H3K4ME3 AND H3K27ME3 | 38 | 34 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES ICP WITH H3K4ME3 | 718 | 401 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN NPC ICP WITH H3K4ME3 | 445 | 257 | All SZGR 2.0 genes in this pathway |
| WANG MLL TARGETS | 289 | 188 | All SZGR 2.0 genes in this pathway |
| DURAND STROMA S UP | 297 | 194 | All SZGR 2.0 genes in this pathway |