Gene Page: KCNE1
Summary ?
| GeneID | 3753 |
| Symbol | KCNE1 |
| Synonyms | ISK|JLNS|JLNS2|LQT2/5|LQT5|MinK |
| Description | potassium voltage-gated channel subfamily E regulatory subunit 1 |
| Reference | MIM:176261|HGNC:HGNC:6240|Ensembl:ENSG00000180509|HPRD:01442|Vega:OTTHUMG00000086236 |
| Gene type | protein-coding |
| Map location | 21q22.12 |
| Pascal p-value | 0.205 |
| Fetal beta | 0.435 |
| eGene | Myers' cis & trans |
| Support | EXCITABILITY |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs1578978 | chr8 | 118196802 | KCNE1 | 3753 | 0.15 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| KCNB1 | 0.95 | 0.90 |
| SCN8A | 0.95 | 0.84 |
| CNNM1 | 0.93 | 0.88 |
| C2orf21 | 0.93 | 0.90 |
| ARHGAP26 | 0.93 | 0.88 |
| AADACL1 | 0.93 | 0.92 |
| CMTM4 | 0.92 | 0.91 |
| NALCN | 0.92 | 0.86 |
| GABRB2 | 0.92 | 0.86 |
| GRIN2A | 0.92 | 0.84 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| BCL7C | -0.51 | -0.61 |
| C9orf46 | -0.48 | -0.52 |
| RPL23A | -0.48 | -0.55 |
| EXOSC8 | -0.46 | -0.45 |
| C21orf57 | -0.46 | -0.53 |
| GTF3C6 | -0.46 | -0.48 |
| RPL35 | -0.46 | -0.54 |
| RPLP1 | -0.45 | -0.52 |
| RPS6 | -0.45 | -0.52 |
| RPS19P3 | -0.45 | -0.58 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| LIU SOX4 TARGETS DN | 309 | 191 | All SZGR 2.0 genes in this pathway |
| SENGUPTA NASOPHARYNGEAL CARCINOMA DN | 349 | 157 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 2 | 473 | 224 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP A | 898 | 516 | All SZGR 2.0 genes in this pathway |
| ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF | 516 | 308 | All SZGR 2.0 genes in this pathway |