SZGR2

Summary ?

GeneID	3761
Symbol	KCNJ4
Synonyms	HIR\|HIRK2\|HRK1\|IRK-3\|IRK3\|Kir2.3
Description	potassium voltage-gated channel subfamily J member 4
Reference	MIM:600504\|HGNC:HGNC:6265\|Ensembl:ENSG00000168135\|HPRD:02738\|Vega:OTTHUMG00000151131
Gene type	protein-coding
Map location	22q13.1
Pascal p-value	0.015
Sherlock p-value	0.956
Fetal beta	-2.062
Support	EXCITABILITY G2Cdb.human_TAP-PSD-95-CORE G2Cdb.humanPSD G2Cdb.humanPSP

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MYO5A	0.89	0.91
CDKL5	0.89	0.92
HECW2	0.87	0.88
PRICKLE2	0.87	0.88
PCLO	0.86	0.89
INPP4A	0.86	0.88
FAM20B	0.86	0.88
DLG3	0.86	0.87
MEF2A	0.86	0.87
ASTN1	0.85	0.86

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
RAB34	-0.54	-0.63
AL139819.3	-0.54	-0.60
AP002478.3	-0.53	-0.61
FXYD1	-0.53	-0.55
AF347015.21	-0.52	-0.56
ACSF2	-0.52	-0.57
HIGD1B	-0.52	-0.57
AC021016.1	-0.52	-0.56
TLCD1	-0.51	-0.54
DBI	-0.51	-0.61

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CASK	CAGH39 \| CMG \| FLJ22219 \| FLJ31914 \| LIN2 \| MICPCH \| TNRC8	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	-	HPRD	11742811
CASK	CAGH39 \| CMG \| FLJ22219 \| FLJ31914 \| LIN2 \| MICPCH \| TNRC8	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	Affinity Capture-Western	BioGRID	14960569 \|15024025
DLG1	DKFZp761P0818 \| DKFZp781B0426 \| DLGH1 \| SAP97 \| dJ1061C18.1.1 \| hdlg	discs, large homolog 1 (Drosophila)	Affinity Capture-Western Reconstituted Complex	BioGRID	11181181 \|14960569 \|15024025
DLG2	DKFZp781D1854 \| DKFZp781E0954 \| FLJ37266 \| MGC131811 \| PSD-93	discs, large homolog 2, chapsyn-110 (Drosophila)	Affinity Capture-Western	BioGRID	11997254
DLG4	FLJ97752 \| FLJ98574 \| PSD95 \| SAP90	discs, large homolog 4 (Drosophila)	Affinity Capture-Western Two-hybrid	BioGRID	10627592 \|11997254 \|14960569
DMD	BMD \| CMD3B \| DXS142 \| DXS164 \| DXS206 \| DXS230 \| DXS239 \| DXS268 \| DXS269 \| DXS270 \| DXS272	dystrophin	Affinity Capture-Western	BioGRID	15024025
GNGT2	G-GAMMA-8 \| G-GAMMA-C \| GNG8 \| GNG9 \| GNGT8	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2	-	HPRD,BioGRID	8943291
IL16	FLJ16806 \| FLJ42735 \| FLJ44234 \| HsT19289 \| IL-16 \| LCF \| prIL-16	interleukin 16 (lymphocyte chemoattractant factor)	-	HPRD,BioGRID	10479680
LIN7A	LIN-7A \| LIN7 \| MALS-1 \| MGC148143 \| TIP-33 \| VELI1	lin-7 homolog A (C. elegans)	Affinity Capture-Western	BioGRID	14960569
LIN7B	LIN-7B \| MALS-2 \| MALS2 \| VELI2	lin-7 homolog B (C. elegans)	Affinity Capture-Western Two-hybrid	BioGRID	11742811
LIN7C	FLJ11215 \| LIN-7-C \| LIN-7C \| MALS-3 \| MALS3 \| VELI3	lin-7 homolog C (C. elegans)	Affinity Capture-Western	BioGRID	14960569 \|15024025
SNTA1	SNT1 \| TACIP1 \| dJ1187J4.5	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	Affinity Capture-Western	BioGRID	15024025

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	186	155	All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM	279	221	All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL	137	110	All SZGR 2.0 genes in this pathway
REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	25	17	All SZGR 2.0 genes in this pathway
REACTOME GABA B RECEPTOR ACTIVATION	38	26	All SZGR 2.0 genes in this pathway
REACTOME GABA RECEPTOR ACTIVATION	52	40	All SZGR 2.0 genes in this pathway
REACTOME POTASSIUM CHANNELS	98	68	All SZGR 2.0 genes in this pathway
REACTOME INWARDLY RECTIFYING K CHANNELS	31	20	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 UP	309	199	All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER DN	203	134	All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM5	94	59	All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3	1118	744	All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN	357	212	All SZGR 2.0 genes in this pathway
IIZUKA LIVER CANCER PROGRESSION G1 G2 UP	12	9	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON UP	77	47	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A12	317	177	All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME3 AND H3K27ME3	142	103	All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3	1069	729	All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3	435	318	All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K4ME3 AND H3K27ME3	210	148	All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP	857	456	All SZGR 2.0 genes in this pathway

Gene Page: KCNJ4