Gene Page: KIT

Summary
GeneID  3815
Symbol  KIT
Synonyms  C-Kit|CD117|PBT|SCFR
Description  v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
See related  HGNC:6342|MIM:164920|Ensembl:ENSG00000157404|HPRD:01287|
Locus tag  -
Gene type  protein-coding
Map location  4q11-q12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0486 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
IPO70.960.96
UBE3A0.950.95
CSNK1G30.950.95
CAND10.950.96
ATF20.950.96
ARMC10.950.95
CUL4B0.950.95
ABCE10.940.94
FYTTD10.940.94
NUDT210.940.95
Top 10 negatively co-expressed genes
MT-CO2-0.76-0.81
AF347015.31-0.75-0.80
FXYD1-0.74-0.81
AF347015.8-0.73-0.80
MT-CYB-0.73-0.78
HIGD1B-0.73-0.79
AF347015.33-0.73-0.78
AF347015.21-0.72-0.80
AF347015.27-0.72-0.78
IFI27-0.71-0.78
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005021vascular endothelial growth factor receptor activityIEA-
GO:0004872receptor activityIEA-
GO:0004716receptor signaling protein tyrosine kinase activityTAS9438854 
GO:0005020stem cell factor receptor activityIEA-
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI17662946 
GO:0005524ATP bindingIEA-
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayIEA-
GO:0007243protein kinase cascadeIEA-
GO:0007165signal transductionTAS9990072 
GO:0008284positive regulation of cell proliferationIEA-
GO:0048066pigmentation during developmentIEA-
GO:0009314response to radiationIEA-
GO:0018108peptidyl-tyrosine phosphorylationIEA-
GO:0019221cytokine-mediated signaling pathwayIEA-
GO:0043406positive regulation of MAP kinase activityIEA-
GO:0030097hemopoiesisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA18029348 
GO:0005737cytoplasmIDA18029348 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0009897external side of plasma membraneIEA-
GO:0005886plasma membraneIDA18029348 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BCRALL | BCR-ABL1 | BCR1 | CML | D22S11 | D22S662 | FLJ16453 | PHLbreakpoint cluster regionAffinity Capture-WesternBioGRID8757502 
CBLBDKFZp686J10223 | DKFZp779A0729 | DKFZp779F1443 | FLJ36865 | FLJ41152 | Nbla00127 | RNF56Cas-Br-M (murine) ecotropic retroviral transforming sequence bAffinity Capture-WesternBioGRID12177062 
CD63LAMP-3 | ME491 | MLA1 | OMA81H | TSPAN30CD63 molecule-HPRD,BioGRID12036870 
CD81S5.7 | TAPA1 | TSPAN28CD81 molecule-HPRD,BioGRID12036870 
CD95H9 | BA2 | BTCC-1 | DRAP-27 | GIG2 | MIC3 | MRP-1 | P24 | TSPAN29CD9 molecule-HPRD,BioGRID12036870 
CLTCCHC | CHC17 | CLH-17 | CLTCL2 | Hc | KIAA0034clathrin, heavy chain (Hc)-HPRD,BioGRID10477727 
CRKL-v-crk sarcoma virus CT10 oncogene homolog (avian)-like-HPRD,BioGRID9092574 
DOK1MGC117395 | MGC138860 | P62DOKdocking protein 1, 62kDa (downstream of tyrosine kinase 1)-HPRD,BioGRID11825908 
EPORMGC138358erythropoietin receptor-HPRD11124255 
GRAPMGC64880GRB2-related adaptor protein-HPRD,BioGRID8647802 
GRAP2GADS | GRAP-2 | GRB2L | GRBLG | GRID | GRPL | GrbX | Grf40 | Mona | P38GRB2-related adaptor protein 2-HPRD9872323 
GRB10GRB-IR | Grb-10 | IRBP | KIAA0207 | MEG1 | RSSgrowth factor receptor-bound protein 10-HPRD,BioGRID11809791 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2Kit interacts with Grb2. This interaction was modeled on a demonstrated interaction between mouse proteins.BIND10022833 
Grb2 interacts with c-Kit upon stimulation with SLF. This interaction was modeled on a demonstrated interaction between mouse Grb2 and human c-Kit.BIND7523381 
-HPRD,BioGRID10377264 
GRB7-growth factor receptor-bound protein 7-HPRD,BioGRID10377264 
INPP5DMGC104855 | MGC142140 | MGC142142 | SHIP | SHIP1 | SIP-145 | hp51CNinositol polyphosphate-5-phosphatase, 145kDaReconstituted ComplexBioGRID11071635 
JAK2JTK10Janus kinase 2 (a protein tyrosine kinase)-HPRD,BioGRID7527392 |8611693 
|9355737 
KITLGDKFZp686F2250 | KL-1 | Kitl | MGF | SCF | SF | SHEP7KIT ligand-HPRD1375232|7680037 
Affinity Capture-Western
Reconstituted Complex		BioGRID1375232 |7680037 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinase-HPRD,BioGRID9788619 
LYNFLJ26625 | JTK8v-yes-1 Yamaguchi sarcoma viral related oncogene homologc-Kit interacts with p53Lyn.BIND9341198 
-HPRD,BioGRID9341198 
c-Kit interacts with p56Lyn.BIND9341198 
MATKCHK | CTK | DKFZp434N1212 | HHYLTK | HYL | HYLTK | Lsk | MGC1708 | MGC2101megakaryocyte-associated tyrosine kinase-HPRD,BioGRID7536744 |9038210 
MPDZDKFZp781P216 | FLJ25909 | FLJ34626 | FLJ90240 | MUPP1multiple PDZ domain proteinReconstituted Complex
Two-hybrid		BioGRID11018522 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)Kit interacts with p85-alpha. This interaction was modeled on a demonstrated interaction between mouse proteinsBIND10022833 
-HPRD,BioGRID7509796 
PIK3R2P85B | p85 | p85-BETAphosphoinositide-3-kinase, regulatory subunit 2 (beta)Kit interacts with p85-beta. This interaction was modeled on a demonstrated interaction between mouse proteins.BIND10022833 
Two-hybridBioGRID10022833 
-HPRD7537096 
PLCG1PLC-II | PLC1 | PLC148 | PLCgamma1phospholipase C, gamma 1Kit interacts with PLC-gamma. This interaction was modeled on a demonstrated interaction between mouse proteins.BIND10022833 
-HPRD,BioGRID7536744 
PTPN11BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2protein tyrosine phosphatase, non-receptor type 11-HPRD,BioGRID7523381 |9528781 
Syp interacts with c-Kit via its SH2 domain.BIND7523381 
PTPN6HCP | HCPH | HPTP1C | PTP-1C | SH-PTP1 | SHP-1 | SHP-1L | SHP1protein tyrosine phosphatase, non-receptor type 6-HPRD,BioGRID7684496 |9528781 
PTPROGLEPP1 | PTP-U2 | PTPU2protein tyrosine phosphatase, receptor type, O-HPRD,BioGRID10397721 
RFC1A1 | MGC51786 | MHCBFB | PO-GA | RECC1 | RFC | RFC140replication factor C (activator 1) 1, 145kDaAffinity Capture-WesternBioGRID10353443 
SH2B2APSSH2B adaptor protein 2-HPRD10872802 
SH3KBP1CIN85 | GIG10 | MIG18SH3-domain kinase binding protein 1Affinity Capture-WesternBioGRID12177062 
SOCS1CIS1 | CISH1 | JAB | SOCS-1 | SSI-1 | SSI1 | TIP3suppressor of cytokine signaling 1-HPRD,BioGRID10022833 
Socs1 interacts with Kit. This interaction was modeled on a demonstrated interaction between mouse proteinsBIND10022833 
SPRED1FLJ33903 | NFLSsprouty-related, EVH1 domain containing 1-HPRD12646235 
SPRED2FLJ21897 | FLJ31917 | MGC163164 | Spred-2sprouty-related, EVH1 domain containing 2-HPRD12646235 |14981116 
STAP1BRDG1 | STAP-1signal transducing adaptor family member 1-HPRD10679268 
STAT1DKFZp686B04100 | ISGF-3 | STAT91signal transducer and activator of transcription 1, 91kDaSTAT1-alpha interacts with c-kitBIND9355737 
-HPRD,BioGRID9355737 
TECMGC126760 | MGC126762 | PSCTK4tec protein tyrosine kinase-HPRD,BioGRID7526158 
YES1HsT441 | P61-YES | Yes | c-yesv-yes-1 Yamaguchi sarcoma viral oncogene homolog 1Reconstituted ComplexBioGRID11071635 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_ENDOCYTOSIS 183132All SZGR genes in this pathway
KEGG_HEMATOPOIETIC_CELL_LINEAGE 8860All SZGR genes in this pathway
KEGG_MELANOGENESIS 10280All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_ACUTE_MYELOID_LEUKEMIA 6047All SZGR genes in this pathway
BIOCARTA_BAD_PATHWAY 2623All SZGR genes in this pathway
PID_CMYB_PATHWAY 8461All SZGR genes in this pathway
PID_KIT_PATHWAY 5240All SZGR genes in this pathway
REACTOME_SIGNALING_BY_SCF_KIT 7859All SZGR genes in this pathway
REACTOME_REGULATION_OF_KIT_SIGNALING 1710All SZGR genes in this pathway
LIU_PROSTATE_CANCER_DN 481290All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_UP 408247All SZGR genes in this pathway
TURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_DUCTAL_NORMAL_DN 198110All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_DN 367220All SZGR genes in this pathway
SMIRNOV_CIRCULATING_ENDOTHELIOCYTES_IN_CANCER_UP 158103All SZGR genes in this pathway
JAEGER_METASTASIS_DN 258141All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP 194122All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_16D_UP 175108All SZGR genes in this pathway
JAATINEN_HEMATOPOIETIC_STEM_CELL_UP 316190All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
DELYS_THYROID_CANCER_DN 232154All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_3_4WK_UP 214144All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
ZIRN_TRETINOIN_RESPONSE_WT1_UP 2314All SZGR genes in this pathway
MAHADEVAN_IMATINIB_RESISTANCE_DN 2011All SZGR genes in this pathway
BEGUM_TARGETS_OF_PAX3_FOXO1_FUSION_DN 4534All SZGR genes in this pathway
PEREZ_TP63_TARGETS 355243All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL 326213All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_BASAL 330217All SZGR genes in this pathway
SHI_SPARC_TARGETS_DN 138All SZGR genes in this pathway
HATADA_METHYLATED_IN_LUNG_CANCER_UP 390236All SZGR genes in this pathway
WEI_MIR34A_TARGETS 14897All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_UP 487286All SZGR genes in this pathway
TENEDINI_MEGAKARYOCYTE_MARKERS 6648All SZGR genes in this pathway
RADAEVA_RESPONSE_TO_IFNA1_DN 105All SZGR genes in this pathway
HEDVAT_ELF4_TARGETS_UP 128All SZGR genes in this pathway
PARK_HSC_MARKERS 4431All SZGR genes in this pathway
NAKAJIMA_MAST_CELL 4634All SZGR genes in this pathway
VERHAAK_AML_WITH_NPM1_MUTATED_DN 246180All SZGR genes in this pathway
ZHOU_TNF_SIGNALING_4HR 5436All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_24HR_DN 148102All SZGR genes in this pathway
YAMAZAKI_TCEB3_TARGETS_UP 175116All SZGR genes in this pathway
YIH_RESPONSE_TO_ARSENITE_C2 1815All SZGR genes in this pathway
NIELSEN_GIST_AND_SYNOVIAL_SARCOMA_UP 2015All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
LEIN_CEREBELLUM_MARKERS 8547All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
MATZUK_EMBRYONIC_GERM_CELL 1916All SZGR genes in this pathway
MATZUK_SPERMATOGONIA 2417All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
ALONSO_METASTASIS_NEURAL_UP 1813All SZGR genes in this pathway
MUELLER_PLURINET 299189All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_D_DN 252155All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
CHANG_CORE_SERUM_RESPONSE_DN 209137All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION 368247All SZGR genes in this pathway
KORKOLA_EMBRYONIC_CARCINOMA_VS_SEMINOMA_DN 2514All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
KYNG_RESPONSE_TO_H2O2_VIA_ERCC6_UP 4030All SZGR genes in this pathway
NIELSEN_GIST 9866All SZGR genes in this pathway
LI_INDUCED_T_TO_NATURAL_KILLER_UP 307182All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_UP 259159All SZGR genes in this pathway
BAKKER_FOXO3_TARGETS_UP 6141All SZGR genes in this pathway
WANG_THOC1_TARGETS_DN 2014All SZGR genes in this pathway
HUANG_GATA2_TARGETS_UP 14996All SZGR genes in this pathway
DELACROIX_RAR_BOUND_ES 462273All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway
LIM_MAMMARY_LUMINAL_PROGENITOR_UP 5830All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-130/30116491655m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-137196319691Ahsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-142-5p20302036m8hsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-151124112471Ahsa-miR-151brainACUAGACUGAAGCUCCUUGAGG
miR-1816721678m8hsa-miR-18aUAAGGUGCAUCUAGUGCAGAUA
hsa-miR-18bUAAGGUGCAUCUAGUGCAGUUA
miR-1916481654m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-193108810951A,m8hsa-miR-193aAACUGGCCUACAAAGUCCCAG
hsa-miR-193bAACUGGCCCUCAAAGUCCCGCUUU
miR-2057978031Ahsa-miR-205UCCUUCAUUCCACCGGAGUCUG
miR-218844850m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-221/222195919661A,m8hsa-miR-221brainAGCUACAUUGUCUGCUGGGUUUC
hsa-miR-222brainAGCUACAUCUGGCUACUGGGUCUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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