SZGR2

Summary ?

GeneID	3839
Symbol	KPNA3
Synonyms	IPOA4\|SRP1\|SRP1gamma\|SRP4\|hSRP1
Description	karyopherin subunit alpha 3
Reference	MIM:601892\|HGNC:HGNC:6396\|Ensembl:ENSG00000102753\|HPRD:03536\|Vega:OTTHUMG00000016922
Gene type	protein-coding
Map location	13q14.3
Pascal p-value	0.164
Sherlock p-value	0.207
Fetal beta	0.53

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association	A combined odds ratio method (Sun et al. 2008), association studies	1	Link to SZGene
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005488	binding	IEA		-
GO:0005515	protein binding	IPI		15057270 \|17353931 \|17981117
GO:0008565	protein transporter activity	IEA		-
GO:0008139	nuclear localization sequence binding	TAS		9435235
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006461	protein complex assembly	TAS		9435235
GO:0006607	NLS-bearing substrate import into nucleus	TAS		9435235
GO:0006886	intracellular protein transport	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005634	nucleus	IEA		-
GO:0005643	nuclear pore	TAS		9154134
GO:0005737	cytoplasm	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	66	45	All SZGR 2.0 genes in this pathway
REACTOME INTERFERON SIGNALING	159	116	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	270	204	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP	404	246	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN	770	415	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN	483	336	All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN	514	319	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS	734	436	All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS	775	494	All SZGR 2.0 genes in this pathway
TCGA GLIOBLASTOMA COPY NUMBER DN	31	21	All SZGR 2.0 genes in this pathway
BYSTROEM CORRELATED WITH IL5 DN	64	47	All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE DN	245	154	All SZGR 2.0 genes in this pathway
NEMETH INFLAMMATORY RESPONSE LPS UP	88	64	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED	1022	619	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN	409	268	All SZGR 2.0 genes in this pathway
LIN MELANOMA COPY NUMBER DN	41	34	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP	973	570	All SZGR 2.0 genes in this pathway
BONCI TARGETS OF MIR15A AND MIR16 1	91	75	All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP	871	505	All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP	285	167	All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR UP	294	199	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR DN	185	116	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP	518	299	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS DN	414	237	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN	918	550	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE EARLY LATE	317	190	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	1045	1051	1A	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-103/107	2303	2309	1A	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
miR-103/107	2303	2309	1A	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-124/506	1844	1850	m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	1844	1850	m8	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-128	1512	1518	1A	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	1512	1518	1A	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-134	141	147	m8	hsa-miR-134^brain	UGUGACUGGUUGACCAGAGGG
miR-135	130	136	m8	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	130	136	m8	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-138	1114	1120	1A	hsa-miR-138^brain	AGCUGGUGUUGUGAAUC
miR-141/200a	2327	2333	m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	2327	2333	m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-144	1045	1051	1A	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-15/16/195/424/497	2459	2465	1A	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-17-5p/20/93.mr/106/519.d	2307	2313	m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
				hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-182	155	162	1A,m8	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-186	1854	1860	1A	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-188	1462	1469	1A,m8	hsa-miR-188	CAUCCCUUGCAUGGUGGAGGGU
miR-19	2100	2107	1A,m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	2100	2107	1A,m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-208	1057	1063	1A	hsa-miR-208	AUAAGACGAGCAAAAAGCUUGU
miR-214	757	763	m8	hsa-miR-214^brain	ACAGCAGGCACAGACAGGCAG
miR-223	524	531	1A,m8	hsa-miR-223	UGUCAGUUUGUCAAAUACCCC
miR-23	1457	1463	1A	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	1457	1463	1A	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-24	428	434	m8	hsa-miR-24^SZ	UGGCUCAGUUCAGCAGGAACAG
miR-26	821	827	1A	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	821	827	1A	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-27	1512	1518	m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	1512	1518	m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-30-5p	1041	1047	m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-323	1096	1102	m8	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-324-3p	1270	1276	1A	hsa-miR-324-3p	CCACUGCCCCAGGUGCUGCUGG
miR-33	1447	1453	m8	hsa-miR-33	GUGCAUUGUAGUUGCAUUG
miR-33	1447	1453	m8	hsa-miR-33b	GUGCAUUGCUGUUGCAUUGCA
miR-381	1657	1663	m8	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-381	1657	1663	m8	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-409-5p	1079	1085	1A	hsa-miR-409-5p	AGGUUACCCGAGCAACUUUGCA
miR-409-5p	1079	1085	1A	hsa-miR-409-5p	AGGUUACCCGAGCAACUUUGCA
miR-431	370	376	1A	hsa-miR-431	UGUCUUGCAGGCCGUCAUGCA
miR-448	190	196	m8	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-455	1817	1823	1A	hsa-miR-455	UAUGUGCCUUUGGACUACAUCG
miR-499	1056	1063	1A,m8	hsa-miR-499	UUAAGACUUGCAGUGAUGUUUAA
miR-500	414	420	m8	hsa-miR-500	AUGCACCUGGGCAAGGAUUCUG
miR-503	2459	2465	1A	hsa-miR-503	UAGCAGCGGGAACAGUUCUGCAG
miR-539	1779	1785	m8	hsa-miR-539	GGAGAAAUUAUCCUUGGUGUGU
miR-542-3p	1399	1406	1A,m8	hsa-miR-542-3p	UGUGACAGAUUGAUAACUGAAA
miR-96	156	162	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: KPNA3