Gene Page: L1CAM

Summary
GeneID  3897
Symbol  L1CAM
Synonyms  CAML1|CD171|HSAS|HSAS1|MASA|MIC5|N-CAML1|S10|SPG1
Description  L1 cell adhesion molecule
See related  HGNC:6470|MIM:308840|Ensembl:ENSG00000198910|HPRD:02394|
Locus tag  -
Gene type  protein-coding
Map location  Xq28
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenics, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.019 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentTASneurite (GO term level: 5)1769655 
GO:0007155cell adhesionNAS7920659 
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ANK1ANK | SPH1 | SPH2ankyrin 1, erythrocytic-HPRD,BioGRID11222639 
ANK2DKFZp686M09125 | DKFZp686P0948 | FLJ38277 | LQT4ankyrin 2, neuronalL1CAM interacts with Ankyrin. This interaction was modelled on a demonstrated interaction between human L1CAM and drosophila ankyrin.BIND15647482 
-HPRD9832558 
AP2A1ADTAA | AP2-ALPHA | CLAPA1adaptor-related protein complex 2, alpha 1 subunitAffinity Capture-WesternBioGRID12942088 
AP2M1AP50 | CLAPM1 | mu2adaptor-related protein complex 2, mu 1 subunitL1CAM interacts with AP-2 mu2 chain. This interaction was modelled on a demonstrated interaction between human L1CAM and AP-2 mu2 chain from an unspecified species.BIND15647482 
CNTN1F3 | GP135contactin 1-HPRD,BioGRID7595520 
CNTN2AXT | DKFZp781D102 | FLJ42746 | MGC157722 | TAG-1 | TAX | TAX1contactin 2 (axonal)L1-CAM interacts with TAG-1.BIND9837910 
-HPRD,BioGRID12139915 
EZRCVIL | CVL | DKFZp762H157 | FLJ26216 | MGC1584 | VIL2ezrin-HPRD,BioGRID12070130 
ITGA5CD49e | FNRA | VLA5Aintegrin, alpha 5 (fibronectin receptor, alpha polypeptide)-HPRD,BioGRID10871287 
ITGAVCD51 | DKFZp686A08142 | MSK8 | VNRAintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)-HPRD,BioGRID10871287 
MSN-moesin-HPRD12070130 
NCAM1CD56 | MSK39 | NCAMneural cell adhesion molecule 1-HPRD8509458 |10611478 
NCANCSPG3 | FLJ44681neurocan-HPRD,BioGRID7513709 |10934197 
NUMBS171numb homolog (Drosophila)-HPRD,BioGRID12942088 
PEA15HMAT1 | HUMMAT1H | MAT1 | MAT1H | PEA-15 | PEDphosphoprotein enriched in astrocytes 15Two-hybridBioGRID16169070 
PRNPASCR | CD230 | CJD | GSS | MGC26679 | PRIP | PrP | PrP27-30 | PrP33-35C | PrPc | prionprion protein-HPRD15146195 
RANBP9RANBPMRAN binding protein 9L1CAM interacts with RanBPM.BIND16000162 
RDXDFNB24radixin-HPRD12070130 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_AXON_GUIDANCE 129103All SZGR genes in this pathway
KEGG_CELL_ADHESION_MOLECULES_CAMS 13493All SZGR genes in this pathway
BIOCARTA_EPHA4_PATHWAY 108All SZGR genes in this pathway
PID_INTEGRIN3_PATHWAY 4325All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL 9165All SZGR genes in this pathway
REACTOME_BASIGIN_INTERACTIONS 3023All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_L1CAM_INTERACTIONS 8662All SZGR genes in this pathway
REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS 2319All SZGR genes in this pathway
REACTOME_SIGNAL_TRANSDUCTION_BY_L1 3425All SZGR genes in this pathway
REACTOME_RECYCLING_PATHWAY_OF_L1 2715All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
WILCOX_RESPONSE_TO_PROGESTERONE_DN 6644All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_UP 290177All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_UP 204140All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_DN 260143All SZGR genes in this pathway
LEE_NEURAL_CREST_STEM_CELL_UP 14699All SZGR genes in this pathway
SABATES_COLORECTAL_ADENOMA_DN 291176All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_E_UP 9760All SZGR genes in this pathway
SEITZ_NEOPLASTIC_TRANSFORMATION_BY_8P_DELETION_DN 3025All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
MURATA_VIRULENCE_OF_H_PILORI 2416All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_UP 10869All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
LIN_APC_TARGETS 7755All SZGR genes in this pathway
SMITH_TERT_TARGETS_DN 8769All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
HARRIS_HYPOXIA 8164All SZGR genes in this pathway
MODY_HIPPOCAMPUS_NEONATAL 3525All SZGR genes in this pathway
NIELSEN_SCHWANNOMA_UP 1816All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
HELLER_SILENCED_BY_METHYLATION_UP 282183All SZGR genes in this pathway
HELLER_HDAC_TARGETS_UP 317208All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP 461298All SZGR genes in this pathway
LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP 7451All SZGR genes in this pathway
MCCABE_BOUND_BY_HOXC6 469239All SZGR genes in this pathway
MASRI_RESISTANCE_TO_TAMOXIFEN_AND_AROMATASE_INHIBITORS_DN 2011All SZGR genes in this pathway
MCCABE_HOXC6_TARGETS_CANCER_UP 3123All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_DN 315197All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
SASAI_TARGETS_OF_CXCR6_AND_PTCH1_UP 139All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A12 317177All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
MIKKELSEN_MCV6_HCP_WITH_H3K27ME3 435318All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
YIH_RESPONSE_TO_ARSENITE_C5 107All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_UP 430288All SZGR genes in this pathway
ISSAEVA_MLL2_TARGETS 6235All SZGR genes in this pathway
PEDRIOLI_MIR31_TARGETS_UP 221120All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1821441511A,m8hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-4885285341Ahsa-miR-488CCCAGAUAAUGGCACUCUCAA
miR-961451511Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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