Gene Page: RHOG

Summary ?
GeneID391
SymbolRHOG
SynonymsARHG
Descriptionras homolog family member G
ReferenceMIM:179505|HGNC:HGNC:672|Ensembl:ENSG00000177105|HPRD:01537|Vega:OTTHUMG00000012287
Gene typeprotein-coding
Map location11p15.5-p15.4
Pascal p-value0.332
Sherlock p-value0.041
Fetal beta-1.086
DMG1 (# studies)
eGeneMyers' cis & trans
SupportG2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
CompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg12991791113863056RHOG1.37E-9-0.021.37E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs7830259chr814087643RHOG3910.04trans
rs6632306chrX35590460RHOG3910.06trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ACAP20.870.88
LIFR0.860.87
PTAR10.860.85
DNAJC30.850.86
PIK3C2A0.850.87
STK38L0.850.84
ITGAV0.840.83
DPY19L40.840.85
KIAA10330.840.82
MKLN10.840.81
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AL022328.1-0.46-0.47
IL32-0.45-0.43
HES4-0.43-0.46
MRPL52-0.42-0.38
NUDT8-0.41-0.45
AC016757.1-0.41-0.39
AF347015.21-0.41-0.30
DPM3-0.40-0.43
APOC1-0.40-0.33
ST20-0.40-0.37

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARHGDIGRHOGDI-3Rho GDP dissociation inhibitor (GDI) gamma-HPRD,BioGRID8939998 
DOCK1DOCK180 | ced5dedicator of cytokinesis 1-HPRD,BioGRID12879077 
ECT2FLJ10461 | MGC138291epithelial cell transforming sequence 2 oncogene-HPRD12376551 
ELMO1CED-12 | CED12 | ELMO-1 | KIAA0281 | MGC126406engulfment and cell motility 1ELMO1 interacts with RhoG.BIND15620647 
ELMO2CED-12 | CED12 | ELMO-2 | FLJ11656 | KIAA1834engulfment and cell motility 2-HPRD12879077 
ELMOD29830169G11Rik | MGC10084ELMO/CED-12 domain containing 2Affinity Capture-Western
Reconstituted Complex		BioGRID12879077 
IQGAP2-IQ motif containing GTPase activating protein 2Reconstituted ComplexBioGRID12376551 
KTN1CG1 | KIAA0004 | KNT | MGC133337 | MU-RMS-40.19kinectin 1 (kinesin receptor)-HPRD,BioGRID11689693 
MAP3K11MGC17114 | MLK-3 | MLK3 | PTK1 | SPRKmitogen-activated protein kinase kinase kinase 11-HPRD,BioGRID12376551 
MCF2LARHGEF14 | DBS | FLJ12122 | KIAA0362 | OSTMCF.2 cell line derived transforming sequence-like-HPRD12376551 
PLD1-phospholipase D1, phosphatidylcholine-specific-HPRD12376551 
VAV2-vav 2 guanine nucleotide exchange factor-HPRD11909943 
VAV3FLJ40431vav 3 guanine nucleotide exchange factor-HPRD,BioGRID10523675 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID ILK PATHWAY 4532All SZGR 2.0 genes in this pathway
PID TRKR PATHWAY 6248All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY RHO GTPASES 11381All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396292All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME GPVI MEDIATED ACTIVATION CASCADE 3125All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE 251188All SZGR 2.0 genes in this pathway
REACTOME G ALPHA1213 SIGNALLING EVENTS 7456All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME SEMA4D IN SEMAPHORIN SIGNALING 3222All SZGR 2.0 genes in this pathway
REACTOME SEMAPHORIN INTERACTIONS 6853All SZGR 2.0 genes in this pathway
REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 2721All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208138All SZGR 2.0 genes in this pathway
DAVICIONI MOLECULAR ARMS VS ERMS DN 182111All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 12HR DN 209122All SZGR 2.0 genes in this pathway
HUMMERICH BENIGN SKIN TUMOR UP 188All SZGR 2.0 genes in this pathway
HUMMERICH MALIGNANT SKIN TUMOR UP 168All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE UP 13493All SZGR 2.0 genes in this pathway
DIRMEIER LMP1 RESPONSE LATE UP 5741All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358245All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS DN 261155All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX 230156All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS B LYMPHOCYTE DN 3825All SZGR 2.0 genes in this pathway
MAGRANGEAS MULTIPLE MYELOMA IGLL VS IGLK DN 2418All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN 337230All SZGR 2.0 genes in this pathway
CHIBA RESPONSE TO TSA UP 5233All SZGR 2.0 genes in this pathway
VERRECCHIA RESPONSE TO TGFB1 C2 2518All SZGR 2.0 genes in this pathway
VERRECCHIA EARLY RESPONSE TO TGFB1 5843All SZGR 2.0 genes in this pathway
LEE AGING NEOCORTEX UP 8959All SZGR 2.0 genes in this pathway
LEE AGING CEREBELLUM UP 8458All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673430All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593372All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591366All SZGR 2.0 genes in this pathway
ITO PTTG1 TARGETS DN 97All SZGR 2.0 genes in this pathway
ZHAN EARLY DIFFERENTIATION GENES DN 4229All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL 216130All SZGR 2.0 genes in this pathway
ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS DN 11674All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080713All SZGR 2.0 genes in this pathway
HUANG GATA2 TARGETS UP 14996All SZGR 2.0 genes in this pathway