Gene Page: ZNF880
Summary ?
| GeneID | 400713 |
| Symbol | ZNF880 |
| Synonyms | - |
| Description | zinc finger protein 880 |
| Reference | HGNC:HGNC:37249|Ensembl:ENSG00000221923|Vega:OTTHUMG00000167972 |
| Gene type | protein-coding |
| Map location | 19q13.41 |
| Pascal p-value | 0.023 |
| DMG | 1 (# studies) |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg27558396 | 19 | 52873277 | ZNF880 | 3.44E-10 | -0.022 | 7.22E-7 | DMG:Jaffe_2016 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs1054612 | 19 | 52870052 | ZNF880 | ENSG00000221923.4 | 1.181E-14 | 0 | -3118 | gtex_brain_ba24 |
| rs17780009 | 19 | 52873618 | ZNF880 | ENSG00000221923.4 | 7.476E-7 | 0 | 448 | gtex_brain_ba24 |
| rs4802926 | 19 | 52880265 | ZNF880 | ENSG00000221923.4 | 1.353E-16 | 0 | 7095 | gtex_brain_ba24 |
| rs34425941 | 19 | 52880612 | ZNF880 | ENSG00000221923.4 | 3.374E-17 | 0 | 7442 | gtex_brain_ba24 |
| rs34221182 | 19 | 52881360 | ZNF880 | ENSG00000221923.4 | 1.353E-16 | 0 | 8190 | gtex_brain_ba24 |
| rs2062971 | 19 | 52881854 | ZNF880 | ENSG00000221923.4 | 2.764E-15 | 0 | 8684 | gtex_brain_ba24 |
| rs2059817 | 19 | 52882285 | ZNF880 | ENSG00000221923.4 | 1.353E-16 | 0 | 9115 | gtex_brain_ba24 |
| rs3070398 | 19 | 52882362 | ZNF880 | ENSG00000221923.4 | 1.313E-16 | 0 | 9192 | gtex_brain_ba24 |
| rs576761981 | 19 | 52882475 | ZNF880 | ENSG00000221923.4 | 1.365E-16 | 0 | 9305 | gtex_brain_ba24 |
| rs2059818 | 19 | 52882520 | ZNF880 | ENSG00000221923.4 | 2.666E-15 | 0 | 9350 | gtex_brain_ba24 |
| rs10445583 | 19 | 52882733 | ZNF880 | ENSG00000221923.4 | 1.353E-16 | 0 | 9563 | gtex_brain_ba24 |
| rs10445584 | 19 | 52882805 | ZNF880 | ENSG00000221923.4 | 1.353E-16 | 0 | 9635 | gtex_brain_ba24 |
| rs10445585 | 19 | 52882824 | ZNF880 | ENSG00000221923.4 | 1.353E-16 | 0 | 9654 | gtex_brain_ba24 |
| rs10445586 | 19 | 52883123 | ZNF880 | ENSG00000221923.4 | 1.353E-16 | 0 | 9953 | gtex_brain_ba24 |
| rs62108317 | 19 | 52883483 | ZNF880 | ENSG00000221923.4 | 1.353E-16 | 0 | 10313 | gtex_brain_ba24 |
| rs62108318 | 19 | 52883575 | ZNF880 | ENSG00000221923.4 | 3.374E-17 | 0 | 10405 | gtex_brain_ba24 |
| rs146377915 | 19 | 52883770 | ZNF880 | ENSG00000221923.4 | 1.297E-16 | 0 | 10600 | gtex_brain_ba24 |
| rs71335644 | 19 | 52883771 | ZNF880 | ENSG00000221923.4 | 1.343E-16 | 0 | 10601 | gtex_brain_ba24 |
| rs62108319 | 19 | 52883830 | ZNF880 | ENSG00000221923.4 | 1.353E-16 | 0 | 10660 | gtex_brain_ba24 |
| rs62108320 | 19 | 52884023 | ZNF880 | ENSG00000221923.4 | 5.502E-17 | 0 | 10853 | gtex_brain_ba24 |
| rs62108321 | 19 | 52884078 | ZNF880 | ENSG00000221923.4 | 1.159E-16 | 0 | 10908 | gtex_brain_ba24 |
| rs1993531 | 19 | 52884886 | ZNF880 | ENSG00000221923.4 | 1.353E-16 | 0 | 11716 | gtex_brain_ba24 |
| rs1993530 | 19 | 52885009 | ZNF880 | ENSG00000221923.4 | 1.353E-16 | 0 | 11839 | gtex_brain_ba24 |
| rs3070403 | 19 | 52885085 | ZNF880 | ENSG00000221923.4 | 1.353E-16 | 0 | 11915 | gtex_brain_ba24 |
| rs11084150 | 19 | 52885104 | ZNF880 | ENSG00000221923.4 | 1.353E-16 | 0 | 11934 | gtex_brain_ba24 |
| rs11084151 | 19 | 52885324 | ZNF880 | ENSG00000221923.4 | 2.153E-16 | 0 | 12154 | gtex_brain_ba24 |
| rs11084152 | 19 | 52885348 | ZNF880 | ENSG00000221923.4 | 1.342E-16 | 0 | 12178 | gtex_brain_ba24 |
| rs11084153 | 19 | 52885395 | ZNF880 | ENSG00000221923.4 | 1.353E-16 | 0 | 12225 | gtex_brain_ba24 |
| rs11084154 | 19 | 52885421 | ZNF880 | ENSG00000221923.4 | 1.353E-16 | 0 | 12251 | gtex_brain_ba24 |
| rs60935857 | 19 | 52885859 | ZNF880 | ENSG00000221923.4 | 1.353E-16 | 0 | 12689 | gtex_brain_ba24 |
| rs324126 | 19 | 52886137 | ZNF880 | ENSG00000221923.4 | 2.941E-14 | 0 | 12967 | gtex_brain_ba24 |
| rs56944154 | 19 | 52886677 | ZNF880 | ENSG00000221923.4 | 5.383E-17 | 0 | 13507 | gtex_brain_ba24 |
| rs11084155 | 19 | 52886866 | ZNF880 | ENSG00000221923.4 | 1.353E-16 | 0 | 13696 | gtex_brain_ba24 |
| rs11084156 | 19 | 52886887 | ZNF880 | ENSG00000221923.4 | 1.353E-16 | 0 | 13717 | gtex_brain_ba24 |
| rs11084157 | 19 | 52886905 | ZNF880 | ENSG00000221923.4 | 1.353E-16 | 0 | 13735 | gtex_brain_ba24 |
| rs398101268 | 19 | 52887145 | ZNF880 | ENSG00000221923.4 | 1.353E-16 | 0 | 13975 | gtex_brain_ba24 |
| rs398071206 | 19 | 52887246 | ZNF880 | ENSG00000221923.4 | 1.353E-16 | 0 | 14076 | gtex_brain_ba24 |
| rs8104808 | 19 | 52887427 | ZNF880 | ENSG00000221923.4 | 1.353E-16 | 0 | 14257 | gtex_brain_ba24 |
| rs8104812 | 19 | 52887437 | ZNF880 | ENSG00000221923.4 | 1.353E-16 | 0 | 14267 | gtex_brain_ba24 |
| rs2042913 | 19 | 52887904 | ZNF880 | ENSG00000221923.4 | 1.363E-16 | 0 | 14734 | gtex_brain_ba24 |
| rs56151179 | 19 | 52888210 | ZNF880 | ENSG00000221923.4 | 3.374E-17 | 0 | 15040 | gtex_brain_ba24 |
| rs55748277 | 19 | 52888245 | ZNF880 | ENSG00000221923.4 | 3.251E-17 | 0 | 15075 | gtex_brain_ba24 |
| rs3170100 | 19 | 52888620 | ZNF880 | ENSG00000221923.4 | 3.374E-17 | 0 | 15450 | gtex_brain_ba24 |
| rs4802929 | 19 | 52889256 | ZNF880 | ENSG00000221923.4 | 1.634E-9 | 0 | 16086 | gtex_brain_ba24 |
| rs7260085 | 19 | 52889687 | ZNF880 | ENSG00000221923.4 | 1.592E-9 | 0 | 16517 | gtex_brain_ba24 |
| rs7259863 | 19 | 52889719 | ZNF880 | ENSG00000221923.4 | 2.938E-9 | 0 | 16549 | gtex_brain_ba24 |
| rs11883308 | 19 | 52889803 | ZNF880 | ENSG00000221923.4 | 1.575E-9 | 0 | 16633 | gtex_brain_ba24 |
| rs12977007 | 19 | 52890010 | ZNF880 | ENSG00000221923.4 | 1.784E-9 | 0 | 16840 | gtex_brain_ba24 |
| rs12978111 | 19 | 52890454 | ZNF880 | ENSG00000221923.4 | 1.586E-9 | 0 | 17284 | gtex_brain_ba24 |
| rs17780037 | 19 | 52891464 | ZNF880 | ENSG00000221923.4 | 1.289E-11 | 0 | 18294 | gtex_brain_ba24 |
| rs7253837 | 19 | 52893473 | ZNF880 | ENSG00000221923.4 | 2.468E-10 | 0 | 20303 | gtex_brain_ba24 |
| rs4390703 | 19 | 52893992 | ZNF880 | ENSG00000221923.4 | 1.388E-9 | 0 | 20822 | gtex_brain_ba24 |
| rs34177595 | 19 | 52896029 | ZNF880 | ENSG00000221923.4 | 1.792E-9 | 0 | 22859 | gtex_brain_ba24 |
| rs1054612 | 19 | 52870052 | ZNF880 | ENSG00000221923.4 | 2.063E-11 | 0 | -3118 | gtex_brain_putamen_basal |
| rs707311 | 19 | 52878279 | ZNF880 | ENSG00000221923.4 | 8.998E-7 | 0 | 5109 | gtex_brain_putamen_basal |
| rs182751 | 19 | 52878665 | ZNF880 | ENSG00000221923.4 | 8.192E-7 | 0 | 5495 | gtex_brain_putamen_basal |
| rs4802926 | 19 | 52880265 | ZNF880 | ENSG00000221923.4 | 1.347E-17 | 0 | 7095 | gtex_brain_putamen_basal |
| rs34425941 | 19 | 52880612 | ZNF880 | ENSG00000221923.4 | 2.121E-17 | 0 | 7442 | gtex_brain_putamen_basal |
| rs34221182 | 19 | 52881360 | ZNF880 | ENSG00000221923.4 | 5.967E-18 | 0 | 8190 | gtex_brain_putamen_basal |
| rs2062971 | 19 | 52881854 | ZNF880 | ENSG00000221923.4 | 2.075E-12 | 0 | 8684 | gtex_brain_putamen_basal |
| rs2059817 | 19 | 52882285 | ZNF880 | ENSG00000221923.4 | 1.437E-12 | 0 | 9115 | gtex_brain_putamen_basal |
| rs3070398 | 19 | 52882362 | ZNF880 | ENSG00000221923.4 | 6.923E-18 | 0 | 9192 | gtex_brain_putamen_basal |
| rs576761981 | 19 | 52882475 | ZNF880 | ENSG00000221923.4 | 7.36E-18 | 0 | 9305 | gtex_brain_putamen_basal |
| rs2059818 | 19 | 52882520 | ZNF880 | ENSG00000221923.4 | 8.57E-12 | 0 | 9350 | gtex_brain_putamen_basal |
| rs10445583 | 19 | 52882733 | ZNF880 | ENSG00000221923.4 | 7.39E-18 | 0 | 9563 | gtex_brain_putamen_basal |
| rs10445584 | 19 | 52882805 | ZNF880 | ENSG00000221923.4 | 7.39E-18 | 0 | 9635 | gtex_brain_putamen_basal |
| rs10445585 | 19 | 52882824 | ZNF880 | ENSG00000221923.4 | 7.39E-18 | 0 | 9654 | gtex_brain_putamen_basal |
| rs10445586 | 19 | 52883123 | ZNF880 | ENSG00000221923.4 | 7.39E-18 | 0 | 9953 | gtex_brain_putamen_basal |
| rs62108317 | 19 | 52883483 | ZNF880 | ENSG00000221923.4 | 7.39E-18 | 0 | 10313 | gtex_brain_putamen_basal |
| rs62108318 | 19 | 52883575 | ZNF880 | ENSG00000221923.4 | 1.84E-17 | 0 | 10405 | gtex_brain_putamen_basal |
| rs146377915 | 19 | 52883770 | ZNF880 | ENSG00000221923.4 | 6.73E-18 | 0 | 10600 | gtex_brain_putamen_basal |
| rs71335644 | 19 | 52883771 | ZNF880 | ENSG00000221923.4 | 7.945E-18 | 0 | 10601 | gtex_brain_putamen_basal |
| rs62108319 | 19 | 52883830 | ZNF880 | ENSG00000221923.4 | 7.39E-18 | 0 | 10660 | gtex_brain_putamen_basal |
| rs62108320 | 19 | 52884023 | ZNF880 | ENSG00000221923.4 | 7.39E-18 | 0 | 10853 | gtex_brain_putamen_basal |
| rs62108321 | 19 | 52884078 | ZNF880 | ENSG00000221923.4 | 5.709E-16 | 0 | 10908 | gtex_brain_putamen_basal |
| rs162127 | 19 | 52884500 | ZNF880 | ENSG00000221923.4 | 6.082E-7 | 0 | 11330 | gtex_brain_putamen_basal |
| rs1993531 | 19 | 52884886 | ZNF880 | ENSG00000221923.4 | 7.39E-18 | 0 | 11716 | gtex_brain_putamen_basal |
| rs1993530 | 19 | 52885009 | ZNF880 | ENSG00000221923.4 | 7.39E-18 | 0 | 11839 | gtex_brain_putamen_basal |
| rs3070403 | 19 | 52885085 | ZNF880 | ENSG00000221923.4 | 7.39E-18 | 0 | 11915 | gtex_brain_putamen_basal |
| rs11084150 | 19 | 52885104 | ZNF880 | ENSG00000221923.4 | 7.39E-18 | 0 | 11934 | gtex_brain_putamen_basal |
| rs11084151 | 19 | 52885324 | ZNF880 | ENSG00000221923.4 | 7.49E-18 | 0 | 12154 | gtex_brain_putamen_basal |
| rs11084152 | 19 | 52885348 | ZNF880 | ENSG00000221923.4 | 4.027E-17 | 0 | 12178 | gtex_brain_putamen_basal |
| rs11084153 | 19 | 52885395 | ZNF880 | ENSG00000221923.4 | 7.39E-18 | 0 | 12225 | gtex_brain_putamen_basal |
| rs11084154 | 19 | 52885421 | ZNF880 | ENSG00000221923.4 | 7.39E-18 | 0 | 12251 | gtex_brain_putamen_basal |
| rs60935857 | 19 | 52885859 | ZNF880 | ENSG00000221923.4 | 1.089E-12 | 0 | 12689 | gtex_brain_putamen_basal |
| rs324126 | 19 | 52886137 | ZNF880 | ENSG00000221923.4 | 2.811E-11 | 0 | 12967 | gtex_brain_putamen_basal |
| rs56944154 | 19 | 52886677 | ZNF880 | ENSG00000221923.4 | 1.553E-17 | 0 | 13507 | gtex_brain_putamen_basal |
| rs11084155 | 19 | 52886866 | ZNF880 | ENSG00000221923.4 | 7.39E-18 | 0 | 13696 | gtex_brain_putamen_basal |
| rs11084156 | 19 | 52886887 | ZNF880 | ENSG00000221923.4 | 7.39E-18 | 0 | 13717 | gtex_brain_putamen_basal |
| rs11084157 | 19 | 52886905 | ZNF880 | ENSG00000221923.4 | 7.39E-18 | 0 | 13735 | gtex_brain_putamen_basal |
| rs398101268 | 19 | 52887145 | ZNF880 | ENSG00000221923.4 | 7.39E-18 | 0 | 13975 | gtex_brain_putamen_basal |
| rs398071206 | 19 | 52887246 | ZNF880 | ENSG00000221923.4 | 7.39E-18 | 0 | 14076 | gtex_brain_putamen_basal |
| rs324125 | 19 | 52887282 | ZNF880 | ENSG00000221923.4 | 6.386E-7 | 0 | 14112 | gtex_brain_putamen_basal |
| rs8104808 | 19 | 52887427 | ZNF880 | ENSG00000221923.4 | 7.39E-18 | 0 | 14257 | gtex_brain_putamen_basal |
| rs8104812 | 19 | 52887437 | ZNF880 | ENSG00000221923.4 | 7.39E-18 | 0 | 14267 | gtex_brain_putamen_basal |
| rs2042913 | 19 | 52887904 | ZNF880 | ENSG00000221923.4 | 1.579E-17 | 0 | 14734 | gtex_brain_putamen_basal |
| rs324124 | 19 | 52888048 | ZNF880 | ENSG00000221923.4 | 6.666E-7 | 0 | 14878 | gtex_brain_putamen_basal |
| rs56151179 | 19 | 52888210 | ZNF880 | ENSG00000221923.4 | 1.84E-17 | 0 | 15040 | gtex_brain_putamen_basal |
| rs55748277 | 19 | 52888245 | ZNF880 | ENSG00000221923.4 | 1.84E-17 | 0 | 15075 | gtex_brain_putamen_basal |
| rs3170100 | 19 | 52888620 | ZNF880 | ENSG00000221923.4 | 1.84E-17 | 0 | 15450 | gtex_brain_putamen_basal |
| rs4802929 | 19 | 52889256 | ZNF880 | ENSG00000221923.4 | 3.63E-12 | 0 | 16086 | gtex_brain_putamen_basal |
| rs7260085 | 19 | 52889687 | ZNF880 | ENSG00000221923.4 | 1.021E-12 | 0 | 16517 | gtex_brain_putamen_basal |
| rs7259863 | 19 | 52889719 | ZNF880 | ENSG00000221923.4 | 3.514E-12 | 0 | 16549 | gtex_brain_putamen_basal |
| rs11883308 | 19 | 52889803 | ZNF880 | ENSG00000221923.4 | 1.01E-12 | 0 | 16633 | gtex_brain_putamen_basal |
| rs12977007 | 19 | 52890010 | ZNF880 | ENSG00000221923.4 | 5.389E-12 | 0 | 16840 | gtex_brain_putamen_basal |
| rs12978111 | 19 | 52890454 | ZNF880 | ENSG00000221923.4 | 1.047E-12 | 0 | 17284 | gtex_brain_putamen_basal |
| rs12151000 | 19 | 52891119 | ZNF880 | ENSG00000221923.4 | 2.416E-7 | 0 | 17949 | gtex_brain_putamen_basal |
| rs17780037 | 19 | 52891464 | ZNF880 | ENSG00000221923.4 | 7.31E-13 | 0 | 18294 | gtex_brain_putamen_basal |
| rs7253837 | 19 | 52893473 | ZNF880 | ENSG00000221923.4 | 1.31E-9 | 0 | 20303 | gtex_brain_putamen_basal |
| rs2657916 | 19 | 52893539 | ZNF880 | ENSG00000221923.4 | 1.099E-6 | 0 | 20369 | gtex_brain_putamen_basal |
| rs4390703 | 19 | 52893992 | ZNF880 | ENSG00000221923.4 | 4.438E-9 | 0 | 20822 | gtex_brain_putamen_basal |
| rs324121 | 19 | 52894445 | ZNF880 | ENSG00000221923.4 | 1.08E-6 | 0 | 21275 | gtex_brain_putamen_basal |
| rs965222 | 19 | 52895538 | ZNF880 | ENSG00000221923.4 | 8.011E-7 | 0 | 22368 | gtex_brain_putamen_basal |
| rs34177595 | 19 | 52896029 | ZNF880 | ENSG00000221923.4 | 4.341E-8 | 0 | 22859 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| KIM MYC AMPLIFICATION TARGETS DN | 97 | 51 | All SZGR 2.0 genes in this pathway |