Gene Page: LYL1

Summary ?
GeneID4066
SymbolLYL1
SynonymsbHLHa18
Descriptionlymphoblastic leukemia associated hematopoiesis regulator 1
ReferenceMIM:151440|HGNC:HGNC:6734|Ensembl:ENSG00000104903|HPRD:01046|Vega:OTTHUMG00000180736
Gene typeprotein-coding
Map location19p13.2
Pascal p-value1.327E-4
Sherlock p-value0.014
Fetal beta-0.341
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs4844714chr1208874118LYL140660.02trans
rs17354739chr59921373LYL140660.12trans
rs10038062chr535220518LYL140660.09trans
rs7731153chr535220864LYL140660.09trans
rs9327725chr5134887432LYL140660.13trans
rs17775722chr926199256LYL140660.16trans
rs3860999chr936848141LYL140660.2trans
rs17076272chr1322726361LYL140660.02trans
rs17076274chr1322726381LYL140660.02trans
rs7053743chrX19247669LYL140660.13trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ID10.840.76
ENG0.800.83
SOX170.780.77
GIMAP10.740.71
A4GALT0.730.73
SEMA3G0.730.77
SHE0.720.75
GATA20.720.74
PTRF0.720.78
TMEM2040.710.72
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
COQ3-0.55-0.58
FRG1-0.54-0.64
GNL3-0.53-0.54
EIF2B3-0.53-0.54
SETD4-0.53-0.52
SUPV3L1-0.53-0.55
FAM92A1-0.53-0.58
FARSB-0.53-0.54
HYLS1-0.52-0.54
NDUFAF2-0.52-0.64

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS TURQUOISE DN 5325All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF UP 215137All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 324 DN 14993All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP 390236All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS B LYMPHOCYTE DN 3825All SZGR 2.0 genes in this pathway
BYSTROEM CORRELATED WITH IL5 UP 5130All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366238All SZGR 2.0 genes in this pathway
NEMETH INFLAMMATORY RESPONSE LPS DN 3225All SZGR 2.0 genes in this pathway
TAVOR CEBPA TARGETS DN 3021All SZGR 2.0 genes in this pathway
PETROVA ENDOTHELIUM LYMPHATIC VS BLOOD DN 162102All SZGR 2.0 genes in this pathway
PETROVA PROX1 TARGETS DN 6438All SZGR 2.0 genes in this pathway
IGLESIAS E2F TARGETS UP 151103All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P3 160103All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476285All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323240All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE 346192All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435289All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
MEISSNER ES ICP WITH H3K4ME3 AND H3K27ME3 148All SZGR 2.0 genes in this pathway
MEISSNER NPC ICP WITH H3 UNMETHYLATED 2415All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE UP 181106All SZGR 2.0 genes in this pathway
MIKKELSEN IPS ICP WITH H3K4ME3 AND H327ME3 12683All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 AND H3K27ME3 13785All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION 456287All SZGR 2.0 genes in this pathway
ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS DN 11674All SZGR 2.0 genes in this pathway
PLASARI TGFB1 SIGNALING VIA NFIC 10HR DN 3025All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway