SZGR2

Summary ?

GeneID	4085
Symbol	MAD2L1
Synonyms	HSMAD2\|MAD2
Description	MAD2 mitotic arrest deficient-like 1 (yeast)
Reference	MIM:601467\|HGNC:HGNC:6763\|HPRD:03274\|
Gene type	protein-coding
Map location	4q27
Pascal p-value	0.155
Fetal beta	0.735
DMG	1 (# studies)

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	1

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg23781003	4	120988207	MAD2L1	6.64E-9	-0.024	3.41E-6	DMG:Jaffe_2016

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ADAM10	AD10 \| CD156c \| HsT18717 \| MADM \| kuz	ADAM metallopeptidase domain 10	Affinity Capture-Western	BioGRID	11741929
ADAM15	MDC15	ADAM metallopeptidase domain 15	Affinity Capture-Western	BioGRID	11741929
ADAM17	CD156b \| MGC71942 \| TACE \| cSVP	ADAM metallopeptidase domain 17	MAD2 interacts with TACE.	BIND	10527948
ADAM17	CD156b \| MGC71942 \| TACE \| cSVP	ADAM metallopeptidase domain 17	-	HPRD,BioGRID	10527948
APC	BTPS2 \| DP2 \| DP2.5 \| DP3 \| GS	adenomatous polyposis coli	-	HPRD,BioGRID	9637688
BUB1B	BUB1beta \| BUBR1 \| Bub1A \| MAD3L \| SSK1 \| hBUBR1	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	Affinity Capture-Western Co-purification	BioGRID	11535616
CDC16	APC6	cell division cycle 16 homolog (S. cerevisiae)	-	HPRD	9628895
CDC20	CDC20A \| MGC102824 \| bA276H19.3 \| p55CDC	cell division cycle 20 homolog (S. cerevisiae)	-	HPRD	9628895 \|9637688 \|9736712 \|10700282 \|11804586
CDC20	CDC20A \| MGC102824 \| bA276H19.3 \| p55CDC	cell division cycle 20 homolog (S. cerevisiae)	MAD2 interacts with p55CDC.	BIND	12456649
CDC20	CDC20A \| MGC102824 \| bA276H19.3 \| p55CDC	cell division cycle 20 homolog (S. cerevisiae)	MAD2L1 (Mad2) interacts with Cdc20.	BIND	15694304
CDC20	CDC20A \| MGC102824 \| bA276H19.3 \| p55CDC	cell division cycle 20 homolog (S. cerevisiae)	Mad2 interacts with Cdc20.	BIND	15525512
CDC20	CDC20A \| MGC102824 \| bA276H19.3 \| p55CDC	cell division cycle 20 homolog (S. cerevisiae)	Affinity Capture-Western Co-crystal Structure Reconstituted Complex Two-hybrid	BioGRID	9628895 \|9637688 \|9736712 \|10700282 \|11438673 \|11707408 \|12196507 \|14561775 \|14607335
CDC27	APC3 \| CDC27Hs \| D0S1430E \| D17S978E \| HNUC	cell division cycle 27 homolog (S. cerevisiae)	-	HPRD,BioGRID	9736712
CSF2RB	CD131 \| CDw131 \| IL3RB \| IL5RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	-	HPRD,BioGRID	11551900
CSF2RB	CD131 \| CDw131 \| IL3RB \| IL5RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	MAD2 interacts with CSF2RB. This interaction was modelled on a demonstrated interaction between mouse MAD2 and human CSFR2B.	BIND	11551900
E2F1	E2F-1 \| RBAP1 \| RBBP3 \| RBP3	E2F transcription factor 1	E2F1 interacts with the MAD2 promoter.	BIND	11799067
E2F1	E2F-1 \| RBAP1 \| RBBP3 \| RBP3	E2F transcription factor 1	E2F interacts with the MAD2 promoter and 5-prime UTR.	BIND	15306814
E2F4	E2F-4	E2F transcription factor 4, p107/p130-binding	E2F4 interacts with the MAD2 promoter region.	BIND	11799067
ESR2	ER-BETA \| ESR-BETA \| ESRB \| ESTRB \| Erb \| NR3A2	estrogen receptor 2 (ER beta)	MAD2 interacts with ER beta. This interaction was modeled on a demonstrated interaction between MAD2 from human and sheep and ER beta from rat and mouse.	BIND	10706629
ESR2	ER-BETA \| ESR-BETA \| ESRB \| ESTRB \| Erb \| NR3A2	estrogen receptor 2 (ER beta)	-	HPRD,BioGRID	10706629
MAD1L1	HsMAD1 \| MAD1 \| PIG9 \| TP53I9 \| TXBP181	MAD1 mitotic arrest deficient-like 1 (yeast)	-	HPRD	11804586
MAD1L1	HsMAD1 \| MAD1 \| PIG9 \| TP53I9 \| TXBP181	MAD1 mitotic arrest deficient-like 1 (yeast)	MAD1L1 (Mad1) interacts with MAD2L1 (Mad2).	BIND	15694304
MAD1L1	HsMAD1 \| MAD1 \| PIG9 \| TP53I9 \| TXBP181	MAD1 mitotic arrest deficient-like 1 (yeast)	Reconstituted Complex Two-hybrid	BioGRID	10660610 \|11707408 \|16189514
MAD1L1	HsMAD1 \| MAD1 \| PIG9 \| TP53I9 \| TXBP181	MAD1 mitotic arrest deficient-like 1 (yeast)	TXBP181 interacts with HsMAD2.	BIND	9546394
MAD2L1BP	CMT2 \| KIAA0110 \| MGC11282 \| RP1-261G23.6	MAD2L1 binding protein	MAD2 interacts with CMT2.	BIND	12456649
MAD2L1BP	CMT2 \| KIAA0110 \| MGC11282 \| RP1-261G23.6	MAD2L1 binding protein	-	HPRD,BioGRID	12456649
MAD2L2	MAD2B \| REV7	MAD2 mitotic arrest deficient-like 2 (yeast)	Reconstituted Complex	BioGRID	10660610
MBL2	COLEC1 \| HSMBPC \| MBL \| MBP \| MBP1 \| MGC116832 \| MGC116833	mannose-binding lectin (protein C) 2, soluble (opsonic defect)	-	HPRD	11804586
NDC80	HEC \| HEC1 \| KNTC2 \| TID3 \| hsNDC80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	-	HPRD	12351790
REV3L	POLZ \| REV3	REV3-like, catalytic subunit of DNA polymerase zeta (yeast)	-	HPRD,BioGRID	10660610
REV3L	POLZ \| REV3	REV3-like, catalytic subunit of DNA polymerase zeta (yeast)	hREV3 interacts with hMAD2.	BIND	10660610
RIPK5	DustyPK \| HDCMD38P \| KIAA0472 \| RIP5	receptor interacting protein kinase 5	Affinity Capture-MS	BioGRID	17353931
TSC22D4	THG-1 \| THG1	TSC22 domain family, member 4	Two-hybrid	BioGRID	16189514
UBD	FAT10 \| GABBR1 \| UBD-3	ubiquitin D	MAD2 interacts with FAT10.	BIND	10200259
UBD	FAT10 \| GABBR1 \| UBD-3	ubiquitin D	-	HPRD,BioGRID	10200259

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CELL CYCLE	128	84	All SZGR 2.0 genes in this pathway
KEGG OOCYTE MEIOSIS	114	79	All SZGR 2.0 genes in this pathway
KEGG PROGESTERONE MEDIATED OOCYTE MATURATION	86	59	All SZGR 2.0 genes in this pathway
REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	24	12	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE	421	253	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC	325	185	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE CHECKPOINTS	124	70	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MITOTIC CELL CYCLE	85	46	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC M M G1 PHASES	172	98	All SZGR 2.0 genes in this pathway
REACTOME DNA REPLICATION	192	110	All SZGR 2.0 genes in this pathway
REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS	73	40	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC PROMETAPHASE	87	51	All SZGR 2.0 genes in this pathway
REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A	28	12	All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA UP	294	178	All SZGR 2.0 genes in this pathway
SOTIRIOU BREAST CANCER GRADE 1 VS 3 UP	151	84	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP	305	185	All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS DN	310	188	All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS UP	290	177	All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP	430	232	All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN	362	238	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP	557	331	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN	459	276	All SZGR 2.0 genes in this pathway
GRAHAM CML DIVIDING VS NORMAL QUIESCENT UP	181	101	All SZGR 2.0 genes in this pathway
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING DN	87	49	All SZGR 2.0 genes in this pathway
BIDUS METASTASIS UP	214	134	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP	633	376	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP	722	443	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN	485	334	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP	329	196	All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN	228	137	All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN DN	172	112	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP	536	340	All SZGR 2.0 genes in this pathway
OLSSON E2F3 TARGETS DN	49	33	All SZGR 2.0 genes in this pathway
SCHLOSSER MYC TARGETS REPRESSED BY SERUM	159	93	All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER CLUSTER 2	33	17	All SZGR 2.0 genes in this pathway
ROSTY CERVICAL CANCER PROLIFERATION CLUSTER	140	73	All SZGR 2.0 genes in this pathway
XU HGF SIGNALING NOT VIA AKT1 48HR DN	20	12	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
MANN RESPONSE TO AMIFOSTINE DN	10	5	All SZGR 2.0 genes in this pathway
PUJANA XPRSS INT NETWORK	168	103	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK	423	265	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
PUJANA BRCA CENTERED NETWORK	117	72	All SZGR 2.0 genes in this pathway
KAUFFMANN MELANOMA RELAPSE UP	61	25	All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX	795	478	All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS	775	494	All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES	648	385	All SZGR 2.0 genes in this pathway
BENPORATH PROLIFERATION	147	80	All SZGR 2.0 genes in this pathway
GEORGES CELL CYCLE MIR192 TARGETS	62	46	All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215	893	528	All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPAIR GENES	230	137	All SZGR 2.0 genes in this pathway
BASSO B LYMPHOCYTE NETWORK	143	96	All SZGR 2.0 genes in this pathway
KUROKAWA LIVER CANCER CHEMOTHERAPY DN	41	28	All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN	289	166	All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER METASTASIS DN	121	65	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN	309	206	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC E2F1 UP	56	34	All SZGR 2.0 genes in this pathway
LE EGR2 TARGETS UP	108	75	All SZGR 2.0 genes in this pathway
PENG GLUCOSE DEPRIVATION DN	169	112	All SZGR 2.0 genes in this pathway
REN BOUND BY E2F	61	40	All SZGR 2.0 genes in this pathway
SASAKI ADULT T CELL LEUKEMIA	176	122	All SZGR 2.0 genes in this pathway
HOFMANN CELL LYMPHOMA DN	39	29	All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 DN	163	115	All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS DN	234	137	All SZGR 2.0 genes in this pathway
ALCALAY AML BY NPM1 LOCALIZATION DN	184	132	All SZGR 2.0 genes in this pathway
KAMMINGA EZH2 TARGETS	41	26	All SZGR 2.0 genes in this pathway
GREENBAUM E2A TARGETS UP	33	18	All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN	371	218	All SZGR 2.0 genes in this pathway
KANG DOXORUBICIN RESISTANCE UP	54	33	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR UP	180	125	All SZGR 2.0 genes in this pathway
RHODES UNDIFFERENTIATED CANCER	69	44	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 3	101	64	All SZGR 2.0 genes in this pathway
SONG TARGETS OF IE86 CMV PROTEIN	60	42	All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRCA1 VS BRCA2	163	113	All SZGR 2.0 genes in this pathway
RAMASWAMY METASTASIS UP	66	43	All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC UP	202	115	All SZGR 2.0 genes in this pathway
CHEN ETV5 TARGETS TESTIS	23	14	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN	911	527	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN	1011	592	All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED	728	415	All SZGR 2.0 genes in this pathway
AMUNDSON GAMMA RADIATION RESPONSE	40	25	All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION UP	180	114	All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN	270	181	All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 2D DN	64	35	All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS DN	202	132	All SZGR 2.0 genes in this pathway
ZHENG GLIOBLASTOMA PLASTICITY UP	250	168	All SZGR 2.0 genes in this pathway
WHITEFORD PEDIATRIC CANCER MARKERS	116	63	All SZGR 2.0 genes in this pathway
BHATI G2M ARREST BY 2METHOXYESTRADIOL UP	125	68	All SZGR 2.0 genes in this pathway
MALONEY RESPONSE TO 17AAG DN	79	45	All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN	342	220	All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE	346	192	All SZGR 2.0 genes in this pathway
RUIZ TNC TARGETS DN	142	79	All SZGR 2.0 genes in this pathway
CHANG CYCLING GENES	148	83	All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6	456	285	All SZGR 2.0 genes in this pathway
CROONQUIST IL6 DEPRIVATION DN	98	69	All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER UP	288	168	All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G3 UP	188	121	All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS PROLIFERATION UP	178	108	All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN	193	112	All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR DN	251	151	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP	605	377	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE	335	193	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2	182	102	All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN	841	431	All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN	374	217	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN	918	550	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP	570	339	All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS UP	135	96	All SZGR 2.0 genes in this pathway
ZHOU CELL CYCLE GENES IN IR RESPONSE 6HR	85	49	All SZGR 2.0 genes in this pathway
ZHOU CELL CYCLE GENES IN IR RESPONSE 24HR	128	73	All SZGR 2.0 genes in this pathway

Gene Page: MAD2L1