Gene Page: SMAD6

Summary ?
GeneID4091
SymbolSMAD6
SynonymsAOVD2|HsT17432|MADH6|MADH7
DescriptionSMAD family member 6
ReferenceMIM:602931|HGNC:HGNC:6772|HPRD:04240|
Gene typeprotein-coding
Map location15q22.31
Pascal p-value0.274
Fetal beta0.09
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 3

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg061036241566998926SMAD62.38E-50.5330.017DMG:Wockner_2014
cg040933491566998947SMAD63.978E-40.4550.044DMG:Wockner_2014
cg121751721567073649SMAD64.704E-40.3240.046DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs8016302chr1495828478SMAD640910.1trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SHFM10.810.77
CKS1B0.800.64
NUDT50.790.72
SRP140.780.79
PIN40.780.78
AC106037.20.780.78
THOC40.770.70
SNRPF0.770.76
LSM60.770.72
SYF20.770.70
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CYB-0.53-0.58
AF347015.31-0.52-0.56
AF347015.2-0.52-0.58
MT-CO2-0.51-0.54
AF347015.33-0.51-0.56
AF347015.15-0.51-0.58
AF347015.9-0.50-0.59
AF347015.27-0.50-0.57
AF347015.26-0.49-0.58
AF347015.8-0.49-0.54

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CTBP1BARS | MGC104684C-terminal binding protein 1Affinity Capture-WesternBioGRID14645520 
HOXC8HOX3 | HOX3Ahomeobox C8-HPRD,BioGRID10722652 
MAP3K7TAK1 | TGF1amitogen-activated protein kinase kinase kinase 7-HPRD,BioGRID10748100 
MAP3K7IP13'-Tab1 | MGC57664 | TAB1mitogen-activated protein kinase kinase kinase 7 interacting protein 1-HPRD,BioGRID11737269 
PIAS4FLJ12419 | MGC35296 | PIASY | Piasg | ZMIZ6protein inhibitor of activated STAT, 4Affinity Capture-Western
Two-hybrid		BioGRID12815042 
RNF111ARK | DKFZp313E0731 | DKFZp686H1966 | DKFZp761D081 | FLJ38008ring finger protein 111-HPRD,BioGRID14657019 
SMAD1BSP1 | JV4-1 | JV41 | MADH1 | MADR1SMAD family member 1-HPRD11483516 
SMAD7CRCS3 | FLJ16482 | MADH7 | MADH8SMAD family member 7-HPRD,BioGRID9256479 
SMURF1KIAA1625SMAD specific E3 ubiquitin protein ligase 1-HPRD,BioGRID11278251 
STAMBPAMSH | MGC126516 | MGC126518STAM binding protein-HPRD,BioGRID11483516 
STRAPMAWD | PT-WD | UNRIPserine/threonine kinase receptor associated protein-HPRD,BioGRID10757800 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG TGF BETA SIGNALING PATHWAY 8664All SZGR 2.0 genes in this pathway
BIOCARTA ALK PATHWAY 3729All SZGR 2.0 genes in this pathway
PID BMP PATHWAY 4231All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY BMP 2315All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579346All SZGR 2.0 genes in this pathway
DOANE RESPONSE TO ANDROGEN DN 241146All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL UP 13378All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS DN 232139All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN 329219All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS DN 14295All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 DN 229142All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN 228137All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN DN 172112All SZGR 2.0 genes in this pathway
ODONNELL METASTASIS DN 2413All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN 394258All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION 7751All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION CCNE1 4026All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174695All SZGR 2.0 genes in this pathway
PEREZ TP63 TARGETS 355243All SZGR 2.0 genes in this pathway
PEREZ TP53 AND TP63 TARGETS 205145All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855609All SZGR 2.0 genes in this pathway
ROPERO HDAC2 TARGETS 11471All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN 411249All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF DN 10364All SZGR 2.0 genes in this pathway
GOTTWEIN TARGETS OF KSHV MIR K12 11 6345All SZGR 2.0 genes in this pathway
MANALO HYPOXIA UP 207145All SZGR 2.0 genes in this pathway
HALMOS CEBPA TARGETS DN 4626All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 16HR DN 8662All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN 298200All SZGR 2.0 genes in this pathway
MEDINA SMARCA4 TARGETS 4429All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 8 8657All SZGR 2.0 genes in this pathway
TSENG IRS1 TARGETS DN 13588All SZGR 2.0 genes in this pathway
YIH RESPONSE TO ARSENITE C3 3624All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS DN 14192All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 12HR DN 10164All SZGR 2.0 genes in this pathway
BILD E2F3 ONCOGENIC SIGNATURE 246153All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566371All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE UP 15692All SZGR 2.0 genes in this pathway
GAUTSCHI SRC SIGNALING 86All SZGR 2.0 genes in this pathway
HUANG FOXA2 TARGETS DN 3621All SZGR 2.0 genes in this pathway
TOOKER GEMCITABINE RESISTANCE DN 12284All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435289All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP 395249All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME3 AND H3K27ME3 142103All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422277All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K4ME3 AND H3K27ME3 210148All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 30MIN DN 15099All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 4HR DN 254158All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS DN 213127All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898516All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE EARLY LATE 317190All SZGR 2.0 genes in this pathway
ISSAEVA MLL2 TARGETS 6235All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824528All SZGR 2.0 genes in this pathway
DELACROIX RARG BOUND MEF 367231All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN 308187All SZGR 2.0 genes in this pathway
GHANDHI BYSTANDER IRRADIATION DN 1210All SZGR 2.0 genes in this pathway