Summary ?
GeneID4146
SymbolMATN1
SynonymsCMP|CRTM
Descriptionmatrilin 1, cartilage matrix protein
ReferenceMIM:115437|HGNC:HGNC:6907|Ensembl:ENSG00000162510|HPRD:00276|Vega:OTTHUMG00000003705
Gene typeprotein-coding
Map location1p35
Pascal p-value0.01
Fetal beta-0.356
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg13203239131192158MATN11.8E-10-0.0285.29E-7DMG:Jaffe_2016
cg01809819131192165MATN12.12E-8-0.0137.22E-6DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MCM50.970.86
TIMELESS0.970.90
FAM83D0.970.75
DTL0.970.87
ORC1L0.970.81
FAM64A0.960.78
UHRF10.960.82
KIF2C0.960.83
CDK20.960.63
CDC45L0.960.76
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C5orf53-0.46-0.77
HLA-F-0.45-0.77
PTH1R-0.44-0.71
FBXO2-0.44-0.61
AIFM3-0.44-0.74
AF347015.27-0.43-0.88
AF347015.31-0.43-0.88
AF347015.33-0.43-0.88
S100B-0.43-0.81
MT-CO2-0.43-0.90

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
SHIPP DLBCL CURED VS FATAL DN 4530All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 2 5034All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE DN 12376All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 419273All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL OPTIMAL DEBULKING 246152All SZGR 2.0 genes in this pathway
FONTAINE PAPILLARY THYROID CARCINOMA DN 8053All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K27ME3 128All SZGR 2.0 genes in this pathway
HOLLEMAN PREDNISOLONE RESISTANCE B ALL DN 128All SZGR 2.0 genes in this pathway
HOLLEMAN PREDNISOLONE RESISTANCE ALL DN 118All SZGR 2.0 genes in this pathway
NABA ECM GLYCOPROTEINS 19699All SZGR 2.0 genes in this pathway
NABA CORE MATRISOME 275148All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway