Gene Page: MAX

Summary ?
GeneID4149
SymbolMAX
SynonymsbHLHd4
DescriptionMYC associated factor X
ReferenceMIM:154950|HGNC:HGNC:6913|Ensembl:ENSG00000125952|HPRD:01113|Vega:OTTHUMG00000142809
Gene typeprotein-coding
Map location14q23
Pascal p-value0.011
Sherlock p-value0.169
Fetal beta-1.249

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias,schizotypalClick to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MCM20.970.86
TIMELESS0.960.86
CDC45L0.950.73
PCNA0.950.75
CDCA40.950.81
TP530.950.86
POLD10.950.86
GINS20.950.76
FAM83D0.950.68
ORC1L0.940.77
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C5orf53-0.51-0.73
PTH1R-0.48-0.63
HLA-F-0.48-0.62
FBXO2-0.48-0.59
AF347015.27-0.48-0.75
AF347015.31-0.47-0.76
AIFM3-0.47-0.62
MT-CO2-0.47-0.77
CA4-0.46-0.67
AF347015.33-0.46-0.73

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BLOC1S1BLOS1 | FLJ39337 | FLJ97089 | GCN5L1 | MGC87455 | MICoA | RT14biogenesis of lysosomal organelles complex-1, subunit 1-HPRD10611234 
EP400CAGH32 | DKFZP434I225 | FLJ42018 | FLJ45115 | P400 | TNRC12E1A binding protein p400Affinity Capture-WesternBioGRID11509179 
KAT2AGCN5 | GCN5L2 | MGC102791 | PCAF-b | hGCN5K(lysine) acetyltransferase 2AAffinity Capture-WesternBioGRID10611234 
MAXMGC10775 | MGC11225 | MGC18164 | MGC34679 | MGC36767 | bHLHd4 | orf1MYC associated factor Xin vitroBioGRID9115440 |12553908 
MAXMGC10775 | MGC11225 | MGC18164 | MGC34679 | MGC36767 | bHLHd4 | orf1MYC associated factor X-HPRD2006410|9115440|12553908 
MNTMAD6 | MXD6 | ROX | bHLHd3MAX binding protein-HPRD,BioGRID9184233 
MSH2COCA1 | FCC1 | HNPCC | HNPCC1 | LCFS2mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)-HPRD,BioGRID12584560 
MSH2COCA1 | FCC1 | HNPCC | HNPCC1 | LCFS2mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)Max interacts with MSH2. This is a modeled interaction between Max from an unspecified source and human MSH2.BIND12584560 
MXD1MAD | MAD1 | MGC104659MAX dimerization protein 1in vitro
in vivo
Reconstituted Complex
Two-hybrid		BioGRID8425218 |9528857 
|10229200 |11602341 
|12391307 
MXD1MAD | MAD1 | MGC104659MAX dimerization protein 1Max interacts with Mad1.BIND9528857 
MXD1MAD | MAD1 | MGC104659MAX dimerization protein 1-HPRD8425218 |10229200 
|11602341|10229200 |11602341 
MXD3MAD3 | MGC2383 | bHLHc13MAX dimerization protein 3Two-hybridBioGRID9528857 |10593926 
MXD3MAD3 | MGC2383 | bHLHc13MAX dimerization protein 3-HPRD8521822 
MXD4MAD4 | MST149 | MSTP149 | bHLHc12MAX dimerization protein 4Two-hybridBioGRID9528857 |10593926 
MXD4MAD4 | MST149 | MSTP149 | bHLHc12MAX dimerization protein 4-HPRD8521822 
MXI1MAD2 | MGC43220 | MXD2 | MXI | bHLHc11MAX interactor 1Two-hybridBioGRID9528857 |10593926 
|16189514 
MXI1MAD2 | MGC43220 | MXD2 | MXI | bHLHc11MAX interactor 1Max interacts with Mxi1.BIND9528857 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)Myc interacts with Max. This interaction was modeled on a demonstrated interaction between human Myc and Max from an unspecified source.BIND12584560 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)Affinity Capture-MS
Affinity Capture-Western
in vitro
in vivo
Reconstituted Complex
Two-hybrid		BioGRID2006410 |9528857 
|9708738 |10229200 
|10319872 |10593926 
|10611234 |12391307 
|12584560 |17353931 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)-HPRD2006410 |10229200 
MYCL1LMYC | MYCL | bHLHe38v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)-HPRD,BioGRID10229200 
MYCL2-v-myc myelocytomatosis viral oncogene homolog 2 (avian)in vitroBioGRID10229200 
MYCNMODED | N-myc | NMYC | ODED | bHLHe37v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)-HPRD,BioGRID10229200 
PLEKHF2FLJ13187 | PHAFIN2 | ZFYVE18pleckstrin homology domain containing, family F (with FYVE domain) member 2Two-hybridBioGRID16189514 
SMAD3DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396SMAD family member 3-HPRD,BioGRID12551947 
SMAD4DPC4 | JIP | MADH4SMAD family member 4-HPRD,BioGRID12551947 
SPAG9FLJ13450 | FLJ14006 | FLJ26141 | FLJ34602 | HLC4 | JLP | KIAA0516 | MGC117291 | MGC14967 | MGC74461 | PHET | PIG6sperm associated antigen 9-HPRD,BioGRID12391307 
TEAD1AA | REF1 | TCF13 | TEF-1TEA domain family member 1 (SV40 transcriptional enhancer factor)-HPRD,BioGRID9199327 
TRRAPFLJ10671 | PAF350/400 | PAF400 | STAF40 | TR-AP | Tra1transformation/transcription domain-associated protein-HPRD,BioGRID10611234 
ZBTB17MIZ-1 | ZNF151 | ZNF60 | pHZ-67zinc finger and BTB domain containing 17Reconstituted ComplexBioGRID11283613 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG MAPK SIGNALING PATHWAY 267205All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328259All SZGR 2.0 genes in this pathway
KEGG SMALL CELL LUNG CANCER 8467All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY 8768All SZGR 2.0 genes in this pathway
BIOCARTA P38MAPK PATHWAY 4031All SZGR 2.0 genes in this pathway
PID SMAD2 3NUCLEAR PATHWAY 8263All SZGR 2.0 genes in this pathway
PID MYC ACTIV PATHWAY 7962All SZGR 2.0 genes in this pathway
PID HDAC CLASSI PATHWAY 6650All SZGR 2.0 genes in this pathway
PID TELOMERASE PATHWAY 6848All SZGR 2.0 genes in this pathway
PID MYC PATHWAY 2522All SZGR 2.0 genes in this pathway
PID MYC REPRESS PATHWAY 6352All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421253All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC 325185All SZGR 2.0 genes in this pathway
REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 6540All SZGR 2.0 genes in this pathway
REACTOME G1 S TRANSITION 11263All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES 13779All SZGR 2.0 genes in this pathway
REACTOME S PHASE 10966All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493298All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463290All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN 431263All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP 423283All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS UP 372227All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY UP 7841All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS UP 457269All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552347All SZGR 2.0 genes in this pathway
VANHARANTA UTERINE FIBROID WITH 7Q DELETION UP 6737All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION 7751All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION 149101All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 7 2722All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 DN 169102All SZGR 2.0 genes in this pathway
YAGI AML FAB MARKERS 191131All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 8HR UP 10573All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR UP 156101All SZGR 2.0 genes in this pathway
AMUNDSON POOR SURVIVAL AFTER GAMMA RADIATION 8G 9562All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN 543317All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593372All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591366All SZGR 2.0 genes in this pathway
CHUNG BLISTER CYTOTOXICITY DN 4429All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366257All SZGR 2.0 genes in this pathway
RAGHAVACHARI PLATELET SPECIFIC GENES 7046All SZGR 2.0 genes in this pathway
PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 DN 157106All SZGR 2.0 genes in this pathway
DELPUECH FOXO3 TARGETS UP 6849All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 227149All SZGR 2.0 genes in this pathway