Summary ?
GeneID4155
SymbolMBP
Synonyms-
Descriptionmyelin basic protein
ReferenceMIM:159430|HGNC:HGNC:6925|Ensembl:ENSG00000197971|HPRD:01158|Vega:OTTHUMG00000132874
Gene typeprotein-coding
Map location18q23
Pascal p-value0.076
DMG2 (# studies)
eGeneCerebellum
Myers' cis & trans
SupportCELL ADHESION AND TRANSSYNAPTIC SIGNALING
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.human_clathrin
G2Cdb.human_PocklingtonH1
G2Cdb.human_Synaptosome
G2Cdb.humanNRC
CompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 4
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 4
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 4 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0328 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg234709141874800080MBP9.53E-60.6610.013DMG:Wockner_2014
cg208010561874844767MBP3.004E-4-0.3680.04DMG:Wockner_2014
cg154073731874800029MBP3.788E-40.3630.043DMG:Wockner_2014
cg183629361874844011MBP6.87E-8-0.011.68E-5DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs1733504chr371372796MBP41550.03trans
rs1290499chr371393339MBP41550.08trans
rs6448932chr412595798MBP41550.17trans
rs17057381chr827416800MBP41550.15trans
rs758167chr121915558MBP41550.05trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0019911structural constituent of myelin sheathIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007417central nervous system developmentTASBrain (GO term level: 6)2434243 
GO:0008366axon ensheathmentTASneuron, axon (GO term level: 12)2434243 
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)2434243 
GO:0006955immune responseTAS7504278 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043209myelin sheathIEAneuron, axon, oligodendrocyte, Glial (GO term level: 7)-
GO:0005886plasma membraneIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BMP2KBIKE | DKFZp434K0614 | DKFZp434P0116 | HRIHFB2017BMP2 inducible kinase-HPRD11500515 
CLK1CLK | CLK/STY | STYCDC-like kinase 1-HPRD8798720 
CRKRSCRK7 | CRKR | KIAA0904Cdc2-related kinase, arginine/serine-rich-HPRD11683387 
CTDSP1NLIIF | SCP1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1-HPRD14743429 
DYRK1BMIRKdual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B-HPRD10910078 
EFHA11110008L20Rik | FLJ25016 | FLJ34588EF-hand domain family, member A1-HPRD11124993 
HLA-DRAHLA-DRA1major histocompatibility complex, class II, DR alpha-HPRD,BioGRID9782128 
MAGGMA | S-MAG | SIGLEC-4A | SIGLEC4Amyelin associated glycoprotein-HPRD12237860 
MAPK1ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapkmitogen-activated protein kinase 1MBP interacts with MAPK1. This interaction was modeled on a demonstrated interaction between MBP from an unspecified species, and monkey and mouse MAPK1.BIND9792705 
MAPK13MGC99536 | PRKM13 | SAPK4 | p38deltamitogen-activated protein kinase 13-HPRD9207191 
MAPK15ERK7 | ERK8mitogen-activated protein kinase 15-HPRD11875070 
MAPKAPK5PRAKmitogen-activated protein kinase-activated protein kinase 5-HPRD9628874 
MKNK1MNK1MAP kinase interacting serine/threonine kinase 1-HPRD9155018 
MMP7MMP-7 | MPSL1 | PUMP-1matrix metallopeptidase 7 (matrilysin, uterine)-HPRD8786845 
NEK9DKFZp434D0935 | MGC138306 | MGC16714 | NERCC | NERCC1 | Nek8NIMA (never in mitosis gene a)- related kinase 9-HPRD11864968 
PLP1MMPL | PLP | PLP/DM20 | PMD | SPG2proteolipid protein 1-HPRD,BioGRID2467009 |6083474 
PRKCAAAG6 | MGC129900 | MGC129901 | PKC-alpha | PKCA | PRKACAprotein kinase C, alphaPKC-alpha phosphorylates and interacts with MBP. This interaction was modeled on a demonstrated interaction between PKC-alpha and MBP, both from unspecified species.BIND10383403 
PRKCDMAY1 | MGC49908 | PKCD | nPKC-deltaprotein kinase C, deltaPKC-delta phosphorylates and interacts with MBP. This interaction was modeled on a demonstrated interaction between PKC-delta and MBP, both from unspecified species.BIND10383403 
PRKCIDXS1179E | MGC26534 | PKCI | nPKC-iotaprotein kinase C, iotaPKC-lambda phosphorylates and interacts with MBP. This interaction was modeled on a demonstrated interaction between PKC-lambda and MBP, both from unspecified species.BIND10383403 
PRKCZPKC-ZETA | PKC2protein kinase C, zetaPKC-zeta phosphorylates and interacts with MBP. This interaction was modeled on a demonstrated interaction between PKC-zeta and MBP, both from unspecified species.BIND10383403 
PRMT5HRMT1L5 | IBP72 | JBP1 | SKB1 | SKB1Hsprotein arginine methyltransferase 5-HPRD,BioGRID11152681 
ROCK1MGC131603 | MGC43611 | P160ROCK | PRO0435Rho-associated, coiled-coil containing protein kinase 1ROCK1 (ROCK) interacts with and phosphorylates MBP.BIND15797222 
ROCK2KIAA0619Rho-associated, coiled-coil containing protein kinase 2ROCK2 (ROCK) interacts with and phosphorylates MBP.BIND15797222 
RP6-213H19.1MASK | MST4serine/threonine protein kinase MST4-HPRD11641781 
SRPK1SFRSK1SFRS protein kinase 1-HPRD10390541 
STK16FLJ39635 | KRCT | MPSK | PKL12 | TSF1serine/threonine kinase 16-HPRD10947953 
STK39DCHT | DKFZp686K05124 | PASK | SPAKserine threonine kinase 39 (STE20/SPS1 homolog, yeast)-HPRD,BioGRID10980603 
STK4DKFZp686A2068 | KRS2 | MST1 | YSK3serine/threonine kinase 4-HPRD7665586 
TLK1KIAA0137 | PKU-betatousled-like kinase 1-HPRD10523312 
TLK2MGC44450 | PKU-ALPHAtousled-like kinase 2-HPRD10523312 
TRPM7CHAK | CHAK1 | FLJ20117 | FLJ25718 | LTRPC7 | TRP-PLIKtransient receptor potential cation channel, subfamily M, member 7-HPRD,BioGRID14594813 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
HOLLMANN APOPTOSIS VIA CD40 DN 267178All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS UP 13794All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463290All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473314All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE DN 384220All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN 320184All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN 455304All SZGR 2.0 genes in this pathway
RODRIGUES DCC TARGETS DN 12184All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC DN 187115All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA DN 284156All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS UP 214155All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805505All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 3 4WK DN 3927All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 6 7WK DN 7954All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795478All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487286All SZGR 2.0 genes in this pathway
SCHAEFFER SOX9 TARGETS IN PROSTATE DEVELOPMENT UP 2119All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 480 HELA 164118All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464276All SZGR 2.0 genes in this pathway
LE EGR2 TARGETS DN 10884All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO UP 205126All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
GUO HEX TARGETS DN 6536All SZGR 2.0 genes in this pathway
NEMETH INFLAMMATORY RESPONSE LPS DN 3225All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412249All SZGR 2.0 genes in this pathway
MOREAUX B LYMPHOCYTE MATURATION BY TACI UP 9258All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390242All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
HOWLIN CITED1 TARGETS 1 UP 3525All SZGR 2.0 genes in this pathway
LEIN OLIGODENDROCYTE MARKERS 7453All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P3 160103All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
MARSON FOXP3 TARGETS STIMULATED UP 2919All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN 292189All SZGR 2.0 genes in this pathway
LIN MELANOMA COPY NUMBER DN 4134All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN 543317All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593372All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591366All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476285All SZGR 2.0 genes in this pathway
ZHENG GLIOBLASTOMA PLASTICITY UP 250168All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL UP 260174All SZGR 2.0 genes in this pathway
RAY TUMORIGENESIS BY ERBB2 CDC25A DN 159105All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE UP 14985All SZGR 2.0 genes in this pathway
CHANG CORE SERUM RESPONSE DN 209137All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER DN 238145All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN 442275All SZGR 2.0 genes in this pathway
LIU VAV3 PROSTATE CARCINOGENESIS UP 8961All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491319All SZGR 2.0 genes in this pathway
MARSON FOXP3 TARGETS DN 5438All SZGR 2.0 genes in this pathway
ZEMBUTSU SENSITIVITY TO CYCLOPHOSPHAMIDE 1812All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION 456287All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA NEURAL 12985All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP D 280158All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 UP 344215All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080713All SZGR 2.0 genes in this pathway
GOBERT CORE OLIGODENDROCYTE DIFFERENTIATION 4028All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES 462273All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 COMPLETE 227151All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467251All SZGR 2.0 genes in this pathway
ZWANG CLASS 3 TRANSIENTLY INDUCED BY EGF 222159All SZGR 2.0 genes in this pathway
ZWANG EGF INTERVAL DN 214124All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-15/16/195/424/4974064131A,m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-5034074131Ahsa-miR-503UAGCAGCGGGAACAGUUCUGCAG