Gene Page: MCC
Summary ?
| GeneID | 4163 |
| Symbol | MCC |
| Synonyms | MCC1 |
| Description | mutated in colorectal cancers |
| Reference | MIM:159350|HGNC:HGNC:6935|Ensembl:ENSG00000171444|HPRD:01157|Vega:OTTHUMG00000128804 |
| Gene type | protein-coding |
| Map location | 5q21 |
| Pascal p-value | 0.18 |
| Fetal beta | -0.981 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWAScat | Genome-wide Association Studies | This data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb. | |
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias | Click to show details |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 12.7012 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| CMTM3 | 0.77 | 0.73 |
| SMO | 0.75 | 0.60 |
| ERBB2 | 0.73 | 0.56 |
| CENPM | 0.72 | 0.62 |
| NME4 | 0.72 | 0.68 |
| MFAP2 | 0.72 | 0.70 |
| CPXM1 | 0.72 | 0.70 |
| EPHB4 | 0.72 | 0.64 |
| TGIF2 | 0.72 | 0.56 |
| CHST14 | 0.71 | 0.56 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| HTATIP2 | -0.45 | -0.57 |
| CHN1 | -0.45 | -0.58 |
| TESK2 | -0.44 | -0.56 |
| HABP4 | -0.44 | -0.61 |
| MAP7 | -0.44 | -0.61 |
| SEPT8 | -0.44 | -0.56 |
| OSBPL1A | -0.43 | -0.59 |
| CBX7 | -0.43 | -0.59 |
| CPEB1 | -0.43 | -0.58 |
| SNAP25 | -0.43 | -0.62 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004872 | receptor activity | TAS | 1848370 | |
| GO:0005509 | calcium ion binding | IEA | - | |
| GO:0005515 | protein binding | IPI | 14743216 |17353931 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0007165 | signal transduction | TAS | 1848370 | |
| GO:0045786 | negative regulation of cell cycle | IEA | - |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| CBR1 | CBR | hCBR1 | carbonyl reductase 1 | Affinity Capture-MS | BioGRID | 17353931 |
| CCNA1 | - | cyclin A1 | Affinity Capture-MS | BioGRID | 17353931 |
| CLTC | CHC | CHC17 | CLH-17 | CLTCL2 | Hc | KIAA0034 | clathrin, heavy chain (Hc) | Affinity Capture-MS | BioGRID | 17353931 |
| CSNK1D | HCKID | casein kinase 1, delta | Affinity Capture-MS | BioGRID | 17353931 |
| CSNK1E | HCKIE | MGC10398 | casein kinase 1, epsilon | Affinity Capture-MS | BioGRID | 17353931 |
| DFFA | DFF-45 | DFF1 | ICAD | DNA fragmentation factor, 45kDa, alpha polypeptide | Affinity Capture-MS | BioGRID | 17353931 |
| EIF3A | EIF3 | EIF3S10 | KIAA0139 | P167 | TIF32 | eIF3-p170 | eIF3-theta | p180 | p185 | eukaryotic translation initiation factor 3, subunit A | Affinity Capture-MS | BioGRID | 17353931 |
| EPRS | DKFZp313B047 | EARS | GLUPRORS | PARS | PIG32 | QARS | QPRS | glutamyl-prolyl-tRNA synthetase | Affinity Capture-MS | BioGRID | 17353931 |
| EZR | CVIL | CVL | DKFZp762H157 | FLJ26216 | MGC1584 | VIL2 | ezrin | Affinity Capture-MS | BioGRID | 17353931 |
| FAM40A | FLJ14743 | KIAA1761 | MGC148091 | RP4-773N10.1 | family with sequence similarity 40, member A | Affinity Capture-MS | BioGRID | 17353931 |
| HPRT1 | HGPRT | HPRT | hypoxanthine phosphoribosyltransferase 1 | Affinity Capture-MS | BioGRID | 17353931 |
| IARS | FLJ20736 | IARS1 | ILRS | PRO0785 | isoleucyl-tRNA synthetase | Affinity Capture-MS | BioGRID | 17353931 |
| KRT18 | CYK18 | K18 | keratin 18 | Affinity Capture-MS | BioGRID | 17353931 |
| LTA4H | - | leukotriene A4 hydrolase | Affinity Capture-MS | BioGRID | 17353931 |
| MARS | FLJ35667 | METRS | MTRNS | methionyl-tRNA synthetase | Affinity Capture-MS | BioGRID | 17353931 |
| MTHFD1 | MTHFC | MTHFD | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | Affinity Capture-MS | BioGRID | 17353931 |
| MYH10 | MGC134913 | MGC134914 | NMMHCB | myosin, heavy chain 10, non-muscle | Affinity Capture-MS | BioGRID | 17353931 |
| NFKBIB | IKBB | TRIP9 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | MCC1 interacts with NFKBIB (I-kappa-B-beta). | BIND | 14743216 |
| PAICS | ADE2 | ADE2H1 | AIRC | DKFZp781N1372 | MGC1343 | MGC5024 | PAIS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | Affinity Capture-MS | BioGRID | 17353931 |
| PDCD10 | CCM3 | MGC1212 | MGC24477 | TFAR15 | programmed cell death 10 | Affinity Capture-MS | BioGRID | 17353931 |
| PFAS | FGAMS | FGARAT | KIAA0361 | PURL | phosphoribosylformylglycinamidine synthase | Affinity Capture-MS | BioGRID | 17353931 |
| PFKP | FLJ40226 | PFK-C | PFKF | phosphofructokinase, platelet | Affinity Capture-MS | BioGRID | 17353931 |
| PPP2R1A | MGC786 | PR65A | protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform | Affinity Capture-MS | BioGRID | 17353931 |
| PSMD2 | MGC14274 | P97 | Rpn1 | S2 | TRAP2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | Affinity Capture-MS | BioGRID | 17353931 |
| PSME3 | Ki | PA28-gamma | PA28G | REG-GAMMA | proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) | Affinity Capture-MS | BioGRID | 17353931 |
| SNRNP200 | ASCC3L1 | BRR2 | HELIC2 | U5-200KD | small nuclear ribonucleoprotein 200kDa (U5) | Affinity Capture-MS | BioGRID | 17353931 |
| STK24 | MST-3 | MST3 | MST3B | STE20 | STK3 | serine/threonine kinase 24 (STE20 homolog, yeast) | Affinity Capture-MS | BioGRID | 17353931 |
| STRN | MGC125642 | SG2NA | striatin, calmodulin binding protein | Affinity Capture-MS | BioGRID | 17353931 |
| STRN3 | SG2NA | striatin, calmodulin binding protein 3 | Affinity Capture-MS | BioGRID | 17353931 |
| STRN4 | FLJ35594 | ZIN | zinedin | striatin, calmodulin binding protein 4 | Affinity Capture-MS | BioGRID | 17353931 |
| TARS | MGC9344 | ThrRS | threonyl-tRNA synthetase | Affinity Capture-MS | BioGRID | 17353931 |
| TPM3 | FLJ41118 | MGC14582 | MGC3261 | MGC72094 | NEM1 | OK/SW-cl.5 | TM-5 | TM3 | TM30 | TM30nm | TPMsk3 | TRK | hscp30 | tropomyosin 3 | Affinity Capture-MS | BioGRID | 17353931 |
| VCP | IBMPFD | MGC131997 | MGC148092 | MGC8560 | TERA | p97 | valosin-containing protein | Affinity Capture-MS | BioGRID | 17353931 |
| VDAC1 | MGC111064 | PORIN | PORIN-31-HL | voltage-dependent anion channel 1 | Affinity Capture-MS | BioGRID | 17353931 |
| VHL | HRCA1 | RCA1 | VHL1 | von Hippel-Lindau tumor suppressor | Affinity Capture-MS | BioGRID | 17353931 |
| VPS35 | DKFZp434E1211 | DKFZp434P1672 | FLJ10752 | FLJ13588 | FLJ20388 | MEM3 | vacuolar protein sorting 35 homolog (S. cerevisiae) | Affinity Capture-MS | BioGRID | 17353931 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PEREZ TP53 TARGETS | 1174 | 695 | All SZGR 2.0 genes in this pathway |
| XU HGF TARGETS REPRESSED BY AKT1 DN | 95 | 58 | All SZGR 2.0 genes in this pathway |
| KIM MYC AMPLIFICATION TARGETS UP | 201 | 127 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| BENPORATH NANOG TARGETS | 988 | 594 | All SZGR 2.0 genes in this pathway |
| BENPORATH OCT4 TARGETS | 290 | 172 | All SZGR 2.0 genes in this pathway |
| CUI TCF21 TARGETS 2 DN | 830 | 547 | All SZGR 2.0 genes in this pathway |
| WANG SMARCE1 TARGETS UP | 280 | 183 | All SZGR 2.0 genes in this pathway |
| MONNIER POSTRADIATION TUMOR ESCAPE UP | 393 | 244 | All SZGR 2.0 genes in this pathway |
| MCCOLLUM GELDANAMYCIN RESISTANCE UP | 10 | 9 | All SZGR 2.0 genes in this pathway |
| LEIN CEREBELLUM MARKERS | 85 | 47 | All SZGR 2.0 genes in this pathway |
| ACEVEDO METHYLATED IN LIVER CANCER DN | 940 | 425 | All SZGR 2.0 genes in this pathway |
| CADWELL ATG16L1 TARGETS DN | 70 | 43 | All SZGR 2.0 genes in this pathway |
| CROONQUIST NRAS VS STROMAL STIMULATION UP | 41 | 26 | All SZGR 2.0 genes in this pathway |
| CHIANG LIVER CANCER SUBCLASS CTNNB1 DN | 170 | 105 | All SZGR 2.0 genes in this pathway |
| ZHAN MULTIPLE MYELOMA CD2 DN | 46 | 29 | All SZGR 2.0 genes in this pathway |
| DANG REGULATED BY MYC DN | 253 | 192 | All SZGR 2.0 genes in this pathway |
| CHANDRAN METASTASIS DN | 306 | 191 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 4HR DN | 254 | 158 | All SZGR 2.0 genes in this pathway |
| STAMBOLSKY RESPONSE TO VITAMIN D3 UP | 84 | 48 | All SZGR 2.0 genes in this pathway |
| VERHAAK GLIOBLASTOMA CLASSICAL | 162 | 122 | All SZGR 2.0 genes in this pathway |
| RATTENBACHER BOUND BY CELF1 | 467 | 251 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |