Summary ?
GeneID4179
SymbolCD46
SynonymsAHUS2|MCP|MIC10|TLX|TRA2.10
DescriptionCD46 molecule
ReferenceMIM:120920|HGNC:HGNC:6953|Ensembl:ENSG00000117335|HPRD:00406|Vega:OTTHUMG00000036397
Gene typeprotein-coding
Map location1q32
Sherlock p-value0.373
Fetal beta0.622
eGeneCaudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Hippocampus
Putamen basal ganglia
Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs2107425chr112021074CD4641790.17trans
rs570612411208164366CD46ENSG00000117335.141.28156E-60.02238964gtex_brain_putamen_basal
rs5859421208170545CD46ENSG00000117335.142.93467E-60.02245143gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
BRD40.890.89
SF3A10.880.89
SMARCC20.880.89
CRKRS0.880.91
ARIH10.880.91
POLR1A0.870.91
SLC12A60.870.89
ZC3H180.870.88
C16orf720.870.88
WDR260.860.89
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.73-0.82
MT-CO2-0.71-0.82
HIGD1B-0.70-0.81
FXYD1-0.70-0.79
MT-CYB-0.68-0.78
AF347015.33-0.68-0.76
IFI27-0.67-0.77
AF347015.27-0.66-0.78
TLCD1-0.66-0.76
AF347015.8-0.66-0.79

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
C3ARMD9 | ASP | CPAMD1complement component 3-HPRD,BioGRID1717583 
C4BC4A | C4A13 | C4A91 | C4B1 | C4B12 | C4B2 | C4B3 | C4B5 | C4F | CH | CO4 | CPAMD3 | FLJ60561 | MGC164979complement component 4B (Childo blood group)-HPRD,BioGRID1717583 
CD151GP27 | MER2 | PETA-3 | RAPH | SFA1 | TSPAN24CD151 molecule (Raph blood group)Affinity Capture-WesternBioGRID10741407 
CD46MCP | MGC26544 | MIC10 | TLX | TRA2.10CD46 molecule, complement regulatory protein-HPRD10357804 
CD81S5.7 | TAPA1 | TSPAN28CD81 moleculeAffinity Capture-WesternBioGRID10741407 
CD824F9 | C33 | GR15 | IA4 | KAI1 | R2 | SAR2 | ST6 | TSPAN27CD82 moleculeAffinity Capture-WesternBioGRID10741407 
CD95H9 | BA2 | BTCC-1 | DRAP-27 | GIG2 | MIC3 | MRP-1 | P24 | TSPAN29CD9 moleculeAffinity Capture-WesternBioGRID10741407 
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)-HPRD,BioGRID11714708 
ITGA2BR | CD49B | GPIa | VLA-2 | VLAA2integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)Affinity Capture-WesternBioGRID10741407 
ITGB1CD29 | FNRB | GPIIA | MDF2 | MSK12 | VLA-BETA | VLABintegrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)-HPRD,BioGRID10741407 
LLGL1DLG4 | HUGL | HUGL-1 | HUGL1 | LLGLlethal giant larvae homolog 1 (Drosophila)-HPRD,BioGRID11714708 
MSN-moesin-HPRD7884872|12082081 
MSN-moesin-HPRD,BioGRID7884872 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD,BioGRID10657632 
TSPAN4NAG-2 | NAG2 | TETRASPAN | TM4SF7 | TSPAN-4tetraspanin 4-HPRD10741407 
YES1HsT441 | P61-YES | Yes | c-yesv-yes-1 Yamaguchi sarcoma viral oncogene homolog 1-HPRD,BioGRID11901164 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG COMPLEMENT AND COAGULATION CASCADES 6949All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF COMPLEMENT CASCADE 1412All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM 279178All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME COMPLEMENT CASCADE 3222All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP 423283All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE DN 5438All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS DN 260143All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP 501327All SZGR 2.0 genes in this pathway
LEE NEURAL CREST STEM CELL DN 11879All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485334All SZGR 2.0 genes in this pathway
SEIDEN ONCOGENESIS BY MET 8853All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747453All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584395All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024594All SZGR 2.0 genes in this pathway
GUENTHER GROWTH SPHERICAL VS ADHERENT DN 2619All SZGR 2.0 genes in this pathway
SUNG METASTASIS STROMA UP 11070All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT REJECTED VS OK DN 5135All SZGR 2.0 genes in this pathway
MAGRANGEAS MULTIPLE MYELOMA IGLL VS IGLK DN 2418All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555346All SZGR 2.0 genes in this pathway
CROMER METASTASIS UP 7946All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225163All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC DN 228146All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP 198132All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720440All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP 578341All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973570All SZGR 2.0 genes in this pathway
SMID BREAST CANCER ERBB2 UP 14783All SZGR 2.0 genes in this pathway
CHANG CORE SERUM RESPONSE DN 209137All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S2 11574All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA UP 207143All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 DN 4530All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505328All SZGR 2.0 genes in this pathway