SZGR2

Summary ?

GeneID	4193
Symbol	MDM2
Synonyms	ACTFS\|HDMX\|hdm2
Description	MDM2 proto-oncogene
Reference	MIM:164785\|HGNC:HGNC:6973\|Ensembl:ENSG00000135679\|HPRD:01272\|
Gene type	protein-coding
Map location	12q14.3-q15
Pascal p-value	0.311
Fetal beta	1.575
eGene	Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0316

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs10994209	chr10	61877705	MDM2	4193		0.07		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
TRA2B	0.94	0.93
DKC1	0.93	0.92
TSR1	0.93	0.92
TARDBP	0.93	0.92
UBE2I	0.93	0.90
SSRP1	0.92	0.93
DHX9	0.92	0.92
NUP205	0.92	0.94
HNRNPK	0.92	0.92
DDX23	0.92	0.93

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MT-CO2	-0.75	-0.85
AF347015.31	-0.75	-0.85
FXYD1	-0.74	-0.85
C5orf53	-0.74	-0.77
IFI27	-0.74	-0.85
AF347015.33	-0.72	-0.83
AF347015.27	-0.71	-0.83
HIGD1B	-0.71	-0.84
MT-CYB	-0.70	-0.81
HLA-F	-0.70	-0.75

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0002039	p53 binding	IEA		-
GO:0005515	protein binding	IEA		-
GO:0004842	ubiquitin-protein ligase activity	IDA		9450543
GO:0004842	ubiquitin-protein ligase activity	IEA		-
GO:0016874	ligase activity	IEA		-
GO:0008270	zinc ion binding	IDA		10722742
GO:0008270	zinc ion binding	IEA		-
GO:0042802	identical protein binding	IPI		17936559
GO:0019899	enzyme binding	IPI		15577914
GO:0017163	negative regulator of basal transcription activity	IDA		9271120
GO:0017163	negative regulator of basal transcription activity	ISS		-
GO:0046872	metal ion binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA		9271120
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	ISS		-
GO:0006461	protein complex assembly	IDA		10608892 \|12915590
GO:0006511	ubiquitin-dependent protein catabolic process	IEA		-
GO:0007089	traversing start control point of mitotic cell cycle	IEA		-
GO:0008285	negative regulation of cell proliferation	TAS		7791904
GO:0016567	protein ubiquitination	IDA		9450543
GO:0016567	protein ubiquitination	IEA		-
GO:0042176	regulation of protein catabolic process	IDA		9153395
GO:0030163	protein catabolic process	IEA		-
GO:0044419	interspecies interaction between organisms	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	EXP		11715018
GO:0005622	intracellular	IEA		-
GO:0005626	insoluble fraction	IDA		12915590
GO:0005634	nucleus	IEA		-
GO:0005654	nucleoplasm	EXP		11331603
GO:0005654	nucleoplasm	IDA		10707090 \|12915590
GO:0005730	nucleolus	IDA		10707090
GO:0005730	nucleolus	IEA		-
GO:0005737	cytoplasm	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABL1	ABL \| JTK7 \| bcr/abl \| c-ABL \| p150 \| v-abl	c-abl oncogene 1, receptor tyrosine kinase	-	HPRD,BioGRID	12110584
AKT1	AKT \| MGC99656 \| PKB \| PKB-ALPHA \| PRKBA \| RAC \| RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1	HDM2 interacts with and is phosphorylated by Akt.	BIND	11960368
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	androgen receptor	-	HPRD	12145204
ARRB1	ARB1 \| ARR1	arrestin, beta 1	Affinity Capture-Western	BioGRID	12538596
ARRB2	ARB2 \| ARR2 \| BARR2 \| DKFZp686L0365	arrestin, beta 2	-	HPRD,BioGRID	12488444 \|12538596
ARRB2	ARB2 \| ARR2 \| BARR2 \| DKFZp686L0365	arrestin, beta 2	-	HPRD	11588219 \|12488444 \|12538596\|12488444 \|12538596
CCNG1	CCNG	cyclin G1	-	HPRD,BioGRID	12556559
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	Mdm2 interacts with the p21 promoter.	BIND	15546622
CDKN2A	ARF \| CDK4I \| CDKN2 \| CMM2 \| INK4 \| INK4a \| MLM \| MTS1 \| TP16 \| p14 \| p14ARF \| p16 \| p16INK4 \| p16INK4a \| p19	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	-	HPRD	9529248 \|12085228\|9529249
CDKN2A	ARF \| CDK4I \| CDKN2 \| CMM2 \| INK4 \| INK4a \| MLM \| MTS1 \| TP16 \| p14 \| p14ARF \| p16 \| p16INK4 \| p16INK4a \| p19	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	p14ARF interacts with an unspecified isoform of Mdm2.	BIND	12582152
CDKN2A	ARF \| CDK4I \| CDKN2 \| CMM2 \| INK4 \| INK4a \| MLM \| MTS1 \| TP16 \| p14 \| p14ARF \| p16 \| p16INK4 \| p16INK4a \| p19	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	Affinity Capture-MS Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	9529248 \|9529249 \|12085228 \|14612427
CDKN2A	ARF \| CDK4I \| CDKN2 \| CMM2 \| INK4 \| INK4a \| MLM \| MTS1 \| TP16 \| p14 \| p14ARF \| p16 \| p16INK4 \| p16INK4a \| p19	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	Mdm2 interacts with p14ARF.	BIND	10822382
CDKN2A	ARF \| CDK4I \| CDKN2 \| CMM2 \| INK4 \| INK4a \| MLM \| MTS1 \| TP16 \| p14 \| p14ARF \| p16 \| p16INK4 \| p16INK4a \| p19	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	p14 interacts with MDM2.	BIND	15355988
CDKN2A	ARF \| CDK4I \| CDKN2 \| CMM2 \| INK4 \| INK4a \| MLM \| MTS1 \| TP16 \| p14 \| p14ARF \| p16 \| p16INK4 \| p16INK4a \| p19	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	MDM2 interacts with p14ARF	BIND	9653180
CTBP1	BARS \| MGC104684	C-terminal binding protein 1	Affinity Capture-Western Far Western	BioGRID	12867035
CTBP2	-	C-terminal binding protein 2	Affinity Capture-Western Reconstituted Complex	BioGRID	12867035
DHCR24	KIAA0018 \| Nbla03646 \| SELADIN1 \| seladin-1	24-dehydrocholesterol reductase	Seladin-1 interacts with an unspecified isoform of Mdm2.	BIND	15577914
EID1	C15orf3 \| CRI1 \| EID-1 \| IRO45620 \| MGC138883 \| MGC138884 \| PNAS-22 \| PTD014 \| RBP21	EP300 interacting inhibitor of differentiation 1	-	HPRD,BioGRID	11073989
EP300	KAT3B \| p300	E1A binding protein p300	-	HPRD,BioGRID	9809062
ESR1	DKFZp686N23123 \| ER \| ESR \| ESRA \| Era \| NR3A1	estrogen receptor 1	Reconstituted Complex	BioGRID	10766163
GTF2E1	FE \| TF2E1 \| TFIIE-A	general transcription factor IIE, polypeptide 1, alpha 56kDa	Reconstituted Complex	BioGRID	9271120
GTF2E2	FE \| TF2E2 \| TFIIE-B	general transcription factor IIE, polypeptide 2, beta 34kDa	-	HPRD	9271120
HDAC1	DKFZp686H12203 \| GON-10 \| HD1 \| RPD3 \| RPD3L1	histone deacetylase 1	-	HPRD,BioGRID	12426395
HIF1A	HIF-1alpha \| HIF1 \| HIF1-ALPHA \| MOP1 \| PASD8	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	Affinity Capture-Western Biochemical Activity Reconstituted Complex	BioGRID	10640274 \|12606552
HIF1A	HIF-1alpha \| HIF1 \| HIF1-ALPHA \| MOP1 \| PASD8	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	-	HPRD	10640274\|12606552
HIST3H3	H3.4 \| H3/g \| H3FT \| H3t \| MGC126886 \| MGC126888	histone cluster 3, H3	Mdm2 interacts with H3.	BIND	15546622
HIST4H4	H4/p \| MGC24116	histone cluster 4, H4	Mdm2 interacts with H4.	BIND	15546622
KAT2B	CAF \| P \| P/CAF \| PCAF	K(lysine) acetyltransferase 2B	-	HPRD,BioGRID	12068014
KAT5	ESA1 \| HTATIP \| HTATIP1 \| PLIP \| TIP \| TIP60 \| cPLA2	K(lysine) acetyltransferase 5	-	HPRD,BioGRID	11927554
MAPKAPK2	MK2	mitogen-activated protein kinase-activated protein kinase 2	MDM2 (HDM2) interacts with MAPKAPK2 isoform 1 (MK2). This interaction was modeled on a demonstrated interaction between MDM2 from an unspecified species, and human MAPKAPK2.	BIND	15688025
MAPKAPK2	MK2	mitogen-activated protein kinase-activated protein kinase 2	MDM2 (HDM2) interacts with MAPKAPK2 (MK2) isoform 2. This interaction was modeled on a demonstrated interaction between MDM2 from an unspecified species, and human MAPKAPK2.	BIND	15688025
MDC1	DKFZp781A0122 \| KIAA0170 \| MGC166888 \| NFBD1	mediator of DNA damage checkpoint 1	Protein-peptide	BioGRID	14578343
MDM2	HDMX \| MGC71221 \| hdm2	Mdm2 p53 binding protein homolog (mouse)	Mdm2 auto-ubiquitinates. This interaction was modeled on a demonstrated interaction between Mdm2 from an unspecified species.	BIND	16023600
MDM2	HDMX \| MGC71221 \| hdm2	Mdm2 p53 binding protein homolog (mouse)	Biochemical Activity	BioGRID	10722742
MDM2	HDMX \| MGC71221 \| hdm2	Mdm2 p53 binding protein homolog (mouse)	Mdm2 ubiquitinates itself.	BIND	10822382
MDM2	HDMX \| MGC71221 \| hdm2	Mdm2 p53 binding protein homolog (mouse)	An unspecified isoform of MDM2 interacts and ubiquitinates itself intermolecularly. This interaction was modeled on a demonstrated interaction between MDM2 from an unspecified species.	BIND	15933712
MDM2	HDMX \| MGC71221 \| hdm2	Mdm2 p53 binding protein homolog (mouse)	Hdm2 interacts with Hdm2.	BIND	15916963
MDM4	DKFZp781B1423 \| HDMX \| MDMX \| MGC132766 \| MRP1	Mdm4 p53 binding protein homolog (mouse)	MDM2 interacts with MDM4 (MDMX).	BIND	10608892
MDM4	DKFZp781B1423 \| HDMX \| MDMX \| MGC132766 \| MRP1	Mdm4 p53 binding protein homolog (mouse)	-	HPRD,BioGRID	10218570 \|12393902 \|12483531
MDM4	DKFZp781B1423 \| HDMX \| MDMX \| MGC132766 \| MRP1	Mdm4 p53 binding protein homolog (mouse)	Mdm2 interacts with Hdmx.	BIND	15916963
MTBP	MDM2BP	Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa	-	HPRD,BioGRID	10906133
NUMB	S171	numb homolog (Drosophila)	-	HPRD,BioGRID	12646252
PIAS1	DDXBP1 \| GBP \| GU/RH-II \| MGC141878 \| MGC141879 \| ZMIZ3	protein inhibitor of activated STAT, 1	-	HPRD	12393906
PJA1	RNF70	praja 1	-	HPRD	10722742
PML	MYL \| PP8675 \| RNF71 \| TRIM19	promyelocytic leukemia	PML interacts with Mdm2.	BIND	15195100
PML	MYL \| PP8675 \| RNF71 \| TRIM19	promyelocytic leukemia	-	HPRD,BioGRID	12759344 \|12915590 \|14507915 \|15195100
PSMD10	dJ889N15.2 \| p28	proteasome (prosome, macropain) 26S subunit, non-ATPase, 10	An unspecified isoform of gankyrin interacts with Mdm2.	BIND	16023600
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	-	HPRD,BioGRID	7791904\|10078201 \|10721693
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	Rb interacts with Mdm2.	BIND	15577944
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	Rb interacts with MDM2.	BIND	15485814
RBL2	FLJ26459 \| P130 \| Rb2	retinoblastoma-like 2 (p130)	p130 interacts with Mdm2.	BIND	15577944
RPL11	GIG34	ribosomal protein L11	Affinity Capture-MS Affinity Capture-Western	BioGRID	14612427
RPL11	GIG34	ribosomal protein L11	L11 interacts with Hdm2.	BIND	12842086
RPL5	MGC117339 \| MSTP030	ribosomal protein L5	-	HPRD,BioGRID	7935455 \|14612427
SP1	-	Sp1 transcription factor	SP1 interacts with the MDM2 intronic promoter.	BIND	15550242
SUMO1	DAP-1 \| GMP1 \| OFC10 \| PIC1 \| SENP2 \| SMT3 \| SMT3C \| SMT3H3 \| SUMO-1 \| UBL1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	-	HPRD	10892746
TAF1	BA2R \| CCG1 \| CCGS \| DYT3 \| KAT4 \| N-TAF1 \| NSCL2 \| OF \| P250 \| TAF2A \| TAFII250	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	-	HPRD,BioGRID	9388200
TBP	GTF2D \| GTF2D1 \| MGC117320 \| MGC126054 \| MGC126055 \| SCA17 \| TFIID	TATA box binding protein	Reconstituted Complex	BioGRID	9271120 \|9388200
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	TP53 (p53) interacts with the MDM2-promoter.	BIND	15735750
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	An unspecified isoform of HDM2 interacts with p53. This interaction was modelled on a demonstrated interaction between human HDM2 and p53 from an unspecified species.	BIND	15950904
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	Affinity Capture-Western Biochemical Activity Co-fractionation Reconstituted Complex	BioGRID	7686617 \|9271120 \|9529249 \|9809062 \|10722742 \|10766163 \|10892746 \|11709713 \|12208736 \|12426395 \|12620407 \|12915590 \|14612427 \|14671306
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	p53 interacts with Mdm2.	BIND	15577944
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	HDM-2 interacts with p53	BIND	15558054
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	p53 interacts with mdm2 promoter.	BIND	16009130
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	MDM2 (HDM2) interacts with TP53 (p53). This interaction was modeled on a demonstrated interaction between MDM2 from an unspecified species, and human TP53.	BIND	15688025
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	Mdm2 ubiquitinates p53.	BIND	10822382
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	Mdm2 interacts with p53.	BIND	11046142
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	hdm2 interacts with p53. This interaction was modeled on a demonstrated interaction between hdm2 and p53 both from an unspecified species.	BIND	9223638
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	Mdm2 interacts with p53.	BIND	16023600
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	An unspecified isoform of MDM2 interacts with and ubiquitinates p53. This interaction was modeled on a demonstrated interaction between MDM2 from an unspecified species and human p53.	BIND	15933712
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	Mdm2 interacts with and ubiquitinates p53.	BIND	15280377
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	p53 interacts with Mdm2.	BIND	11597128
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	Mdm2 interacts with and ubiquitinates p53	BIND	14671306
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	p53 interacts with unspecified isoform of Mdm2.	BIND	15824742
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	p53 interacts with and is ubiquitinated by Mdm2.	BIND	15577914
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	-	HPRD	7686617 \|8058315 \|10721693 \|11709713 \|12372616
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	Hdm2 interacts with p53.	BIND	15210108
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	An unspecifed isoform of Mdm2 interacts with p53.	BIND	15867431
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	Mdm2 ubiquitinates p53. This interaction was modeled on a demonstrated interaction between mouse Mdm2 and human p53.	BIND	15242646
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	Mdm2 interacts with p53.	BIND	10562557
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	p53 interacts with mdm2. This interaction was modelled on a demonstrated interaction between human p53 and mdm2 from an unspecified species.	BIND	10781812
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	p53 interacts with the hdm2 promoter.	BIND	15525514
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	An unspecified isoform of Mdm2 ubiquitinates p53. This interaction was modeled on a demonstrated interaction between Mdm2 and p53 both from an unspecified species.	BIND	15963787
TP73	P73	tumor protein p73	-	HPRD,BioGRID	10207051
TSG101	TSG10 \| VPS23	tumor susceptibility gene 101	-	HPRD,BioGRID	11172000
UBE2A	HHR6A \| RAD6A \| UBC2	ubiquitin-conjugating enzyme E2A (RAD6 homolog)	Affinity Capture-Western	BioGRID	12640129
USP7	HAUSP \| TEF1	ubiquitin specific peptidase 7 (herpes virus-associated)	Mdm2 interacts with HAUSP. This interaction was modeled on a demonstrated interaction between Mdm2 from an unspecified species and human HAUSP.	BIND	15916963
YY1	DELTA \| INO80S \| NF-E1 \| UCRBP \| YIN-YANG-1	YY1 transcription factor	YY1 interacts with Hdm2.	BIND	15210108

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CELL CYCLE	128	84	All SZGR 2.0 genes in this pathway
KEGG P53 SIGNALING PATHWAY	69	45	All SZGR 2.0 genes in this pathway
KEGG UBIQUITIN MEDIATED PROTEOLYSIS	138	98	All SZGR 2.0 genes in this pathway
KEGG ENDOCYTOSIS	183	132	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG GLIOMA	65	56	All SZGR 2.0 genes in this pathway
KEGG PROSTATE CANCER	89	75	All SZGR 2.0 genes in this pathway
KEGG MELANOMA	71	57	All SZGR 2.0 genes in this pathway
KEGG BLADDER CANCER	42	33	All SZGR 2.0 genes in this pathway
KEGG CHRONIC MYELOID LEUKEMIA	73	59	All SZGR 2.0 genes in this pathway
BIOCARTA ATM PATHWAY	20	16	All SZGR 2.0 genes in this pathway
BIOCARTA G2 PATHWAY	24	20	All SZGR 2.0 genes in this pathway
BIOCARTA CTCF PATHWAY	23	18	All SZGR 2.0 genes in this pathway
BIOCARTA HIVNEF PATHWAY	58	43	All SZGR 2.0 genes in this pathway
BIOCARTA P53HYPOXIA PATHWAY	23	21	All SZGR 2.0 genes in this pathway
BIOCARTA P53 PATHWAY	16	13	All SZGR 2.0 genes in this pathway
BIOCARTA ARF PATHWAY	17	13	All SZGR 2.0 genes in this pathway
SA G1 AND S PHASES	15	10	All SZGR 2.0 genes in this pathway
PID ERBB4 PATHWAY	38	32	All SZGR 2.0 genes in this pathway
PID P73PATHWAY	79	59	All SZGR 2.0 genes in this pathway
PID ATR PATHWAY	39	25	All SZGR 2.0 genes in this pathway
PID ATM PATHWAY	34	25	All SZGR 2.0 genes in this pathway
PID REG GR PATHWAY	82	60	All SZGR 2.0 genes in this pathway
PID RANBP2 PATHWAY	11	11	All SZGR 2.0 genes in this pathway
PID P53 DOWNSTREAM PATHWAY	137	94	All SZGR 2.0 genes in this pathway
PID AR TF PATHWAY	53	38	All SZGR 2.0 genes in this pathway
PID DELTA NP63 PATHWAY	47	34	All SZGR 2.0 genes in this pathway
PID AURORA A PATHWAY	31	20	All SZGR 2.0 genes in this pathway
PID TAP63 PATHWAY	54	40	All SZGR 2.0 genes in this pathway
PID P53 REGULATION PATHWAY	59	50	All SZGR 2.0 genes in this pathway
PID RB 1PATHWAY	65	46	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY SCF KIT	78	59	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE	421	253	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB4	90	67	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2	101	78	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER	109	80	All SZGR 2.0 genes in this pathway
REACTOME PI3K EVENTS IN ERBB4 SIGNALING	38	28	All SZGR 2.0 genes in this pathway
REACTOME PI3K EVENTS IN ERBB2 SIGNALING	44	34	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	97	66	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR	126	90	All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	137	105	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE	127	88	All SZGR 2.0 genes in this pathway
REACTOME PI3K AKT ACTIVATION	38	29	All SZGR 2.0 genes in this pathway
REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	12	10	All SZGR 2.0 genes in this pathway
REACTOME GAB1 SIGNALOSOME	38	29	All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	186	155	All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM	279	221	All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL	137	110	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE CHECKPOINTS	124	70	All SZGR 2.0 genes in this pathway
REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE	57	35	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF	122	93	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	95	76	All SZGR 2.0 genes in this pathway
REACTOME TRAFFICKING OF AMPA RECEPTORS	28	23	All SZGR 2.0 genes in this pathway
REACTOME PI 3K CASCADE	56	39	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR	100	74	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
REACTOME PIP3 ACTIVATES AKT SIGNALING	29	20	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR	112	80	All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP	408	247	All SZGR 2.0 genes in this pathway
NOJIMA SFRP2 TARGETS DN	25	18	All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS DN	240	171	All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN	228	137	All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP	239	157	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP	1142	669	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP	612	367	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP	536	340	All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS	1174	695	All SZGR 2.0 genes in this pathway
DUTTA APOPTOSIS VIA NFKB	33	25	All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 2	127	92	All SZGR 2.0 genes in this pathway
RASHI NFKB1 TARGETS	19	18	All SZGR 2.0 genes in this pathway
LI LUNG CANCER	41	30	All SZGR 2.0 genes in this pathway
SCHAVOLT TARGETS OF TP53 AND TP63	16	12	All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL	326	213	All SZGR 2.0 genes in this pathway
HEIDENBLAD AMPLIFIED IN SOFT TISSUE CANCER	13	7	All SZGR 2.0 genes in this pathway
KOMMAGANI TP63 GAMMA TARGETS	9	7	All SZGR 2.0 genes in this pathway
HONRADO BREAST CANCER BRCA1 VS BRCA2	18	12	All SZGR 2.0 genes in this pathway
SHI SPARC TARGETS UP	24	17	All SZGR 2.0 genes in this pathway
AMUNDSON DNA DAMAGE RESPONSE TP53	16	9	All SZGR 2.0 genes in this pathway
SNIJDERS AMPLIFIED IN HEAD AND NECK TUMORS	37	27	All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER UP	227	137	All SZGR 2.0 genes in this pathway
MANN RESPONSE TO AMIFOSTINE UP	20	12	All SZGR 2.0 genes in this pathway
CEBALLOS TARGETS OF TP53 AND MYC DN	38	31	All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK	101	73	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK	423	265	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
NAKAYAMA FRA2 TARGETS	43	27	All SZGR 2.0 genes in this pathway
ROPERO HDAC2 TARGETS	114	71	All SZGR 2.0 genes in this pathway
SCHWAB TARGETS OF BMYB POLYMORPHIC VARIANTS UP	13	9	All SZGR 2.0 genes in this pathway
FRIDMAN SENESCENCE UP	77	60	All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX	230	156	All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES	648	385	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 12Q13 Q21 AMPLICON	46	21	All SZGR 2.0 genes in this pathway
TCGA GLIOBLASTOMA COPY NUMBER UP	75	36	All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 UP	140	85	All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT UP	197	110	All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO UP	205	126	All SZGR 2.0 genes in this pathway
FERNANDEZ BOUND BY MYC	182	116	All SZGR 2.0 genes in this pathway
HOFMANN CELL LYMPHOMA UP	50	35	All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS UP	214	133	All SZGR 2.0 genes in this pathway
MA MYELOID DIFFERENTIATION UP	39	29	All SZGR 2.0 genes in this pathway
BRACHAT RESPONSE TO CISPLATIN	22	11	All SZGR 2.0 genes in this pathway
ONGUSAHA TP53 TARGETS	38	23	All SZGR 2.0 genes in this pathway
SIMBULAN PARP1 TARGETS UP	31	23	All SZGR 2.0 genes in this pathway
INGA TP53 TARGETS	17	13	All SZGR 2.0 genes in this pathway
BRACHAT RESPONSE TO METHOTREXATE UP	26	16	All SZGR 2.0 genes in this pathway
ZHANG PROLIFERATING VS QUIESCENT	51	41	All SZGR 2.0 genes in this pathway
CHIBA RESPONSE TO TSA DN	23	14	All SZGR 2.0 genes in this pathway
YIH RESPONSE TO ARSENITE C3	36	24	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 6HR DN	160	101	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 2	473	224	All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3	491	310	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED	1022	619	All SZGR 2.0 genes in this pathway
MCGOWAN RSP6 TARGETS UP	18	12	All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN	940	425	All SZGR 2.0 genes in this pathway
KUMAMOTO RESPONSE TO NUTLIN 3A UP	9	5	All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP	198	128	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP	293	203	All SZGR 2.0 genes in this pathway
TAVAZOIE METASTASIS	108	68	All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN	253	192	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP	504	321	All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 AND SATB1 DN	180	116	All SZGR 2.0 genes in this pathway
LIU TOPBP1 TARGETS	16	8	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 36HR	29	23	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D	882	506	All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES	462	273	All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 2HR UP	53	33	All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 6HR UP	166	97	All SZGR 2.0 genes in this pathway
GHANDHI DIRECT IRRADIATION UP	110	68	All SZGR 2.0 genes in this pathway
WARTERS RESPONSE TO IR SKIN	83	44	All SZGR 2.0 genes in this pathway
WARTERS IR RESPONSE 5GY	47	23	All SZGR 2.0 genes in this pathway

Gene Page: MDM2