SZGR2

Summary ?

GeneID	4217
Symbol	MAP3K5
Synonyms	ASK1\|MAPKKK5\|MEKK5
Description	mitogen-activated protein kinase kinase kinase 5
Reference	MIM:602448\|HGNC:HGNC:6857\|Ensembl:ENSG00000197442\|HPRD:03904\|Vega:OTTHUMG00000015647
Gene type	protein-coding
Map location	6q22.33
Pascal p-value	0.383
Sherlock p-value	0.444
Fetal beta	-2.716
DMG	1 (# studies)
eGene	Myers' cis & trans
Support	Ascano FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	1
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.139

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg07868909	6	137114217	MAP3K5	2.02E-9	-0.038	1.64E-6	DMG:Jaffe_2016

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs17034560	chr1	10229157	MAP3K5	4217		0.08		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
GLI2	0.89	0.51
KIFC1	0.87	0.49
FOXM1	0.87	0.51
IQGAP3	0.87	0.42
NOTCH1	0.87	0.53
CDT1	0.86	0.52
PLK1	0.86	0.45
CDC20	0.86	0.56
KIF18B	0.85	0.51
MYBL2	0.85	0.48

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
C5orf53	-0.27	-0.36
CCNI2	-0.27	-0.34
RAPGEF4	-0.26	-0.35
SERPINI1	-0.26	-0.33
CKMT1A	-0.25	-0.33
NPM2	-0.25	-0.31
CKMT1B	-0.25	-0.27
OSBPL1A	-0.25	-0.33
AF347015.27	-0.25	-0.33
CHN1	-0.24	-0.30

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0000287	magnesium ion binding	IDA		17210579
GO:0005524	ATP binding	IDA		17210579
GO:0004674	protein serine/threonine kinase activity	IEA		-
GO:0004709	MAP kinase kinase kinase activity	IDA		17210579
GO:0008656	caspase activator activity	IDA		14761963
GO:0016740	transferase activity	IEA		-
GO:0042803	protein homodimerization activity	IDA		11920685
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000165	MAPKKK cascade	IDA		17210579
GO:0006468	protein amino acid phosphorylation	IEA		-
GO:0007257	activation of JNK activity	TAS		8974401
GO:0006915	apoptosis	IEA		-
GO:0008624	induction of apoptosis by extracellular signals	TAS		8974401
GO:0044419	interspecies interaction between organisms	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ARRB2	ARB2 \| ARR2 \| BARR2 \| DKFZp686L0365	arrestin, beta 2	Affinity Capture-Western	BioGRID	11090355
ARRB2	ARB2 \| ARR2 \| BARR2 \| DKFZp686L0365	arrestin, beta 2	-	HPRD	11356842
CDC25A	CDC25A2	cell division cycle 25 homolog A (S. pombe)	-	HPRD,BioGRID	11416155
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	Affinity Capture-Western	BioGRID	12820963
DAB2IP	AF9Q34 \| AIP1 \| DIP1/2 \| FLJ39072 \| KIAA1743	DAB2 interacting protein	-	HPRD	12813029
DAXX	BING2 \| DAP6 \| EAP1 \| MGC126245 \| MGC126246	death-domain associated protein	-	HPRD,BioGRID	9743501
DUSP19	DUSP17 \| LMWDSP3 \| MGC138210 \| SKRP1 \| TS-DSP1	dual specificity phosphatase 19	-	HPRD,BioGRID	11959862
EIF2AK2	EIF2AK1 \| MGC126524 \| PKR \| PRKR	eukaryotic translation initiation factor 2-alpha kinase 2	-	HPRD,BioGRID	12473108
ERN1	FLJ30999 \| IRE1 \| IRE1P \| MGC163277 \| MGC163279	endoplasmic reticulum to nucleus signaling 1	-	HPRD,BioGRID	12050113
GADD45B	DKFZp566B133 \| GADD45BETA \| MYD118	growth arrest and DNA-damage-inducible, beta	Affinity Capture-Western Reconstituted Complex	BioGRID	14743220
GLRX	GRX \| GRX1 \| MGC117407	glutaredoxin (thioltransferase)	GLRX (GRX) interacts with MAP3K5 (ASK1).	BIND	12244106
GLRX	GRX \| GRX1 \| MGC117407	glutaredoxin (thioltransferase)	-	HPRD,BioGRID	12244106
GSTM1	GST1 \| GSTM1-1 \| GSTM1a-1a \| GSTM1b-1b \| GTH4 \| GTM1 \| H-B \| MGC26563 \| MU \| MU-1	glutathione S-transferase mu 1	-	HPRD,BioGRID	11278289 \|12077134
HSPA1A	FLJ54303 \| FLJ54370 \| FLJ54392 \| FLJ54408 \| FLJ75127 \| HSP70-1 \| HSP70-1A \| HSP70I \| HSP72 \| HSPA1 \| HSPA1B	heat shock 70kDa protein 1A	-	HPRD,BioGRID	12391142
MAP2K6	MAPKK6 \| MEK6 \| MKK6 \| PRKMK6 \| SAPKK3	mitogen-activated protein kinase kinase 6	Biochemical Activity Reconstituted Complex	BioGRID	11689443 \|12820963
MAP2K6	MAPKK6 \| MEK6 \| MKK6 \| PRKMK6 \| SAPKK3	mitogen-activated protein kinase kinase 6	MKK6 interacts with ASK1. This interaction was modeled on a demonstrated interaction between human MKK6 and ASK1 from an unspecified species.	BIND	15866172
MAP2K7	Jnkk2 \| MAPKK7 \| MKK7 \| PRKMK7	mitogen-activated protein kinase kinase 7	Affinity Capture-Western	BioGRID	11959862
MAP3K2	MEKK2 \| MEKK2B	mitogen-activated protein kinase kinase kinase 2	-	HPRD	12912994
MAP3K5	ASK1 \| MAPKKK5 \| MEKK5	mitogen-activated protein kinase kinase kinase 5	-	HPRD,BioGRID	11920685
MAP3K6	ASK2 \| MAPKKK6 \| MGC125653 \| MGC20114	mitogen-activated protein kinase kinase kinase 6	-	HPRD,BioGRID	9875215
MAP3K7	TAK1 \| TGF1a	mitogen-activated protein kinase kinase kinase 7	-	HPRD,BioGRID	10921914
MAPK8IP3	DKFZp762N1113 \| FLJ00027 \| JIP3 \| JSAP1 \| KIAA1066 \| SYD2	mitogen-activated protein kinase 8 interacting protein 3	-	HPRD,BioGRID	12189133
MLL	ALL-1 \| CXXC7 \| FLJ11783 \| HRX \| HTRX1 \| KMT2A \| MLL/GAS7 \| MLL1A \| TET1-MLL \| TRX1	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	Affinity Capture-Western	BioGRID	14607843
PDCD6	ALG-2 \| FLJ46208 \| MGC111017 \| MGC119050 \| MGC9123 \| PEF1B	programmed cell death 6	-	HPRD,BioGRID	12372597
PPP5C	FLJ36922 \| PP5 \| PPP5	protein phosphatase 5, catalytic subunit	-	HPRD,BioGRID	11689443
QARS	GLNRS \| PRO2195	glutaminyl-tRNA synthetase	-	HPRD,BioGRID	11096076
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	-	HPRD,BioGRID	11427728
RB1CC1	CC1 \| DRAGOU14 \| FIP200	RB1-inducible coiled-coil 1	Affinity Capture-Western	BioGRID	17015619
TRAF1	EBI6 \| MGC:10353	TNF receptor-associated factor 1	Affinity Capture-Western	BioGRID	9774977
TRAF2	MGC:45012 \| TRAP \| TRAP3	TNF receptor-associated factor 2	-	HPRD,BioGRID	9774977 \|10523862
TRAF3	CAP-1 \| CD40bp \| CRAF1 \| LAP1	TNF receptor-associated factor 3	Affinity Capture-Western	BioGRID	9774977
TRAF5	MGC:39780 \| RNF84	TNF receptor-associated factor 5	-	HPRD,BioGRID	10523862
TRAF6	MGC:3310 \| RNF85	TNF receptor-associated factor 6	-	HPRD,BioGRID	10523862
TXN	DKFZp686B1993 \| MGC61975 \| TRX \| TRX1	thioredoxin	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	9564042 \|11689443 \|12089063
TXN	DKFZp686B1993 \| MGC61975 \| TRX \| TRX1	thioredoxin	TXN (TRX) interacts with MAP3K5 (ASK1). This interaction was modeled on a demonstrated interaction between human TXN and MAP3K5 from an unspecified species.	BIND	12244106
TXN	DKFZp686B1993 \| MGC61975 \| TRX \| TRX1	thioredoxin	-	HPRD	9564042 \|12089063
YWHAZ	KCIP-1 \| MGC111427 \| MGC126532 \| MGC138156	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	-	HPRD,BioGRID	10411906\|11336675

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG MAPK SIGNALING PATHWAY	267	205	All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY	126	103	All SZGR 2.0 genes in this pathway
KEGG AMYOTROPHIC LATERAL SCLEROSIS ALS	53	43	All SZGR 2.0 genes in this pathway
BIOCARTA HIVNEF PATHWAY	58	43	All SZGR 2.0 genes in this pathway
BIOCARTA KERATINOCYTE PATHWAY	46	38	All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY	87	68	All SZGR 2.0 genes in this pathway
BIOCARTA P38MAPK PATHWAY	40	31	All SZGR 2.0 genes in this pathway
BIOCARTA 41BB PATHWAY	17	15	All SZGR 2.0 genes in this pathway
ST P38 MAPK PATHWAY	37	28	All SZGR 2.0 genes in this pathway
ST GA13 PATHWAY	37	32	All SZGR 2.0 genes in this pathway
ST JNK MAPK PATHWAY	40	30	All SZGR 2.0 genes in this pathway
ST FAS SIGNALING PATHWAY	65	54	All SZGR 2.0 genes in this pathway
PID P38 MKK3 6PATHWAY	26	21	All SZGR 2.0 genes in this pathway
PID TNF PATHWAY	46	33	All SZGR 2.0 genes in this pathway
PID HIV NEF PATHWAY	35	26	All SZGR 2.0 genes in this pathway
PID PI3KCI AKT PATHWAY	35	30	All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP	567	375	All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP	255	177	All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP	579	346	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN	320	184	All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 UP	276	165	All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 UP	341	197	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN	805	505	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN	485	334	All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP	443	294	All SZGR 2.0 genes in this pathway
VANHARANTA UTERINE FIBROID DN	67	45	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL	326	213	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN	712	443	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN	637	377	All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS	1062	725	All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS	775	494	All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF DN	103	64	All SZGR 2.0 genes in this pathway
STANELLE E2F1 TARGETS	29	20	All SZGR 2.0 genes in this pathway
LU IL4 SIGNALING	94	56	All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN	225	163	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR DN	101	70	All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP	262	186	All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE DN	261	183	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN	318	220	All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G6	153	112	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 12HR DN	101	64	All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3	491	310	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED	1022	619	All SZGR 2.0 genes in this pathway
ZHENG FOXP3 TARGETS IN THYMUS UP	196	137	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP	673	430	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN	593	372	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN	591	366	All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION DN	154	101	All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN	270	181	All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP	430	288	All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING	510	309	All SZGR 2.0 genes in this pathway
IZADPANAH STEM CELL ADIPOSE VS BONE UP	126	92	All SZGR 2.0 genes in this pathway
ROSS LEUKEMIA WITH MLL FUSIONS	78	49	All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER DN	238	145	All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS CTNNB1 DN	170	105	All SZGR 2.0 genes in this pathway
YAMASHITA LIVER CANCER STEM CELL UP	47	38	All SZGR 2.0 genes in this pathway
YAMASHITA LIVER CANCER STEM CELL DN	76	51	All SZGR 2.0 genes in this pathway
SETLUR PROSTATE CANCER TMPRSS2 ERG FUSION UP	67	48	All SZGR 2.0 genes in this pathway
SAKAI CHRONIC HEPATITIS VS LIVER CANCER UP	83	63	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA DN	267	160	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES DN	210	141	All SZGR 2.0 genes in this pathway
GUTIERREZ CHRONIC LYMPHOCYTIC LEUKEMIA DN	56	39	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO GONADOTROPHINS UP	91	59	All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN UP	90	58	All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP	242	159	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN	505	328	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 DN	88	61	All SZGR 2.0 genes in this pathway
DELPUECH FOXO3 TARGETS UP	68	49	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN	1080	713	All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 1	46	33	All SZGR 2.0 genes in this pathway
WANG MLL TARGETS	289	188	All SZGR 2.0 genes in this pathway
ZHANG ADIPOGENESIS BY BMP7	14	12	All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B	517	302	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-145	368	374	1A	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-17-5p/20/93.mr/106/519.d	98	105	1A,m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-199	367	373	1A	hsa-miR-199a	CCCAGUGUUCAGACUACCUGUUC
miR-199	367	373	1A	hsa-miR-199b	CCCAGUGUUUAGACUAUCUGUUC
miR-23	384	390	m8	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	384	390	m8	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-30-5p	117	123	m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-323	384	390	1A	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-375	372	378	1A	hsa-miR-375	UUUGUUCGUUCGGCUCGCGUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: MAP3K5