Gene Page: MAP3K5

Summary
GeneID  4217
Symbol  MAP3K5
Synonyms  ASK1|MAPKKK5|MEKK5
Description  mitogen-activated protein kinase kinase kinase 5
See related  HGNC:6857|MIM:602448|Ensembl:ENSG00000197442|HPRD:03904|
Locus tag  RP3-325F22.4
Gene type  protein-coding
Map location  6q22.33
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.139 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
GLI20.890.51
KIFC10.870.49
FOXM10.870.51
IQGAP30.870.42
NOTCH10.870.53
CDT10.860.52
PLK10.860.45
CDC200.860.56
KIF18B0.850.51
MYBL20.850.48
Top 10 negatively co-expressed genes
C5orf53-0.27-0.36
CCNI2-0.27-0.34
RAPGEF4-0.26-0.35
SERPINI1-0.26-0.33
CKMT1A-0.25-0.33
NPM2-0.25-0.31
CKMT1B-0.25-0.27
OSBPL1A-0.25-0.33
AF347015.27-0.25-0.33
CHN1-0.24-0.30
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIDA17210579 
GO:0005524ATP bindingIDA17210579 
GO:0004674protein serine/threonine kinase activityIEA-
GO:0004709MAP kinase kinase kinase activityIDA17210579 
GO:0008656caspase activator activityIDA14761963 
GO:0016740transferase activityIEA-
GO:0042803protein homodimerization activityIDA11920685 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000165MAPKKK cascadeIDA17210579 
GO:0006468protein amino acid phosphorylationIEA-
GO:0007257activation of JNK activityTAS8974401 
GO:0006915apoptosisIEA-
GO:0008624induction of apoptosis by extracellular signalsTAS8974401 
GO:0044419interspecies interaction between organismsIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARRB2ARB2 | ARR2 | BARR2 | DKFZp686L0365arrestin, beta 2Affinity Capture-WesternBioGRID11090355 
-HPRD11356842 
CDC25ACDC25A2cell division cycle 25 homolog A (S. pombe)-HPRD,BioGRID11416155 
CDKN1ACAP20 | CDKN1 | CIP1 | MDA-6 | P21 | SDI1 | WAF1 | p21CIP1cyclin-dependent kinase inhibitor 1A (p21, Cip1)Affinity Capture-WesternBioGRID12820963 
DAB2IPAF9Q34 | AIP1 | DIP1/2 | FLJ39072 | KIAA1743DAB2 interacting protein-HPRD12813029 
DAXXBING2 | DAP6 | EAP1 | MGC126245 | MGC126246death-domain associated protein-HPRD,BioGRID9743501 
DUSP19DUSP17 | LMWDSP3 | MGC138210 | SKRP1 | TS-DSP1dual specificity phosphatase 19-HPRD,BioGRID11959862 
EIF2AK2EIF2AK1 | MGC126524 | PKR | PRKReukaryotic translation initiation factor 2-alpha kinase 2-HPRD,BioGRID12473108 
ERN1FLJ30999 | IRE1 | IRE1P | MGC163277 | MGC163279endoplasmic reticulum to nucleus signaling 1-HPRD,BioGRID12050113 
GADD45BDKFZp566B133 | GADD45BETA | MYD118growth arrest and DNA-damage-inducible, betaAffinity Capture-Western
Reconstituted Complex		BioGRID14743220 
GLRXGRX | GRX1 | MGC117407glutaredoxin (thioltransferase)GLRX (GRX) interacts with MAP3K5 (ASK1).BIND12244106 
-HPRD,BioGRID12244106 
GSTM1GST1 | GSTM1-1 | GSTM1a-1a | GSTM1b-1b | GTH4 | GTM1 | H-B | MGC26563 | MU | MU-1glutathione S-transferase mu 1-HPRD,BioGRID11278289 |12077134 
HSPA1AFLJ54303 | FLJ54370 | FLJ54392 | FLJ54408 | FLJ75127 | HSP70-1 | HSP70-1A | HSP70I | HSP72 | HSPA1 | HSPA1Bheat shock 70kDa protein 1A-HPRD,BioGRID12391142 
MAP2K6MAPKK6 | MEK6 | MKK6 | PRKMK6 | SAPKK3mitogen-activated protein kinase kinase 6Biochemical Activity
Reconstituted Complex		BioGRID11689443 |12820963 
MKK6 interacts with ASK1. This interaction was modeled on a demonstrated interaction between human MKK6 and ASK1 from an unspecified species.BIND15866172 
MAP2K7Jnkk2 | MAPKK7 | MKK7 | PRKMK7mitogen-activated protein kinase kinase 7Affinity Capture-WesternBioGRID11959862 
MAP3K2MEKK2 | MEKK2Bmitogen-activated protein kinase kinase kinase 2-HPRD12912994 
MAP3K5ASK1 | MAPKKK5 | MEKK5mitogen-activated protein kinase kinase kinase 5-HPRD,BioGRID11920685 
MAP3K6ASK2 | MAPKKK6 | MGC125653 | MGC20114mitogen-activated protein kinase kinase kinase 6-HPRD,BioGRID9875215 
MAP3K7TAK1 | TGF1amitogen-activated protein kinase kinase kinase 7-HPRD,BioGRID10921914 
MAPK8IP3DKFZp762N1113 | FLJ00027 | JIP3 | JSAP1 | KIAA1066 | SYD2mitogen-activated protein kinase 8 interacting protein 3-HPRD,BioGRID12189133 
MLLALL-1 | CXXC7 | FLJ11783 | HRX | HTRX1 | KMT2A | MLL/GAS7 | MLL1A | TET1-MLL | TRX1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)Affinity Capture-WesternBioGRID14607843 
PDCD6ALG-2 | FLJ46208 | MGC111017 | MGC119050 | MGC9123 | PEF1Bprogrammed cell death 6-HPRD,BioGRID12372597 
PPP5CFLJ36922 | PP5 | PPP5protein phosphatase 5, catalytic subunit-HPRD,BioGRID11689443 
QARSGLNRS | PRO2195glutaminyl-tRNA synthetase-HPRD,BioGRID11096076 
RAF1CRAF | NS5 | Raf-1 | c-Rafv-raf-1 murine leukemia viral oncogene homolog 1-HPRD,BioGRID11427728 
RB1CC1CC1 | DRAGOU14 | FIP200RB1-inducible coiled-coil 1Affinity Capture-WesternBioGRID17015619 
TRAF1EBI6 | MGC:10353TNF receptor-associated factor 1Affinity Capture-WesternBioGRID9774977 
TRAF2MGC:45012 | TRAP | TRAP3TNF receptor-associated factor 2-HPRD,BioGRID9774977 |10523862 
TRAF3CAP-1 | CD40bp | CRAF1 | LAP1TNF receptor-associated factor 3Affinity Capture-WesternBioGRID9774977 
TRAF5MGC:39780 | RNF84TNF receptor-associated factor 5-HPRD,BioGRID10523862 
TRAF6MGC:3310 | RNF85TNF receptor-associated factor 6-HPRD,BioGRID10523862 
TXNDKFZp686B1993 | MGC61975 | TRX | TRX1thioredoxinAffinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID9564042 |11689443 
|12089063 
TXN (TRX) interacts with MAP3K5 (ASK1). This interaction was modeled on a demonstrated interaction between human TXN and MAP3K5 from an unspecified species.BIND12244106 
-HPRD9564042 |12089063 
YWHAZKCIP-1 | MGC111427 | MGC126532 | MGC138156tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide-HPRD,BioGRID10411906|11336675 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 126103All SZGR genes in this pathway
KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 5343All SZGR genes in this pathway
BIOCARTA_HIVNEF_PATHWAY 5843All SZGR genes in this pathway
BIOCARTA_KERATINOCYTE_PATHWAY 4638All SZGR genes in this pathway
BIOCARTA_MAPK_PATHWAY 8768All SZGR genes in this pathway
BIOCARTA_P38MAPK_PATHWAY 4031All SZGR genes in this pathway
BIOCARTA_41BB_PATHWAY 1715All SZGR genes in this pathway
ST_P38_MAPK_PATHWAY 3728All SZGR genes in this pathway
ST_GA13_PATHWAY 3732All SZGR genes in this pathway
ST_JNK_MAPK_PATHWAY 4030All SZGR genes in this pathway
ST_FAS_SIGNALING_PATHWAY 6554All SZGR genes in this pathway
PID_P38_MKK3_6PATHWAY 2621All SZGR genes in this pathway
PID_TNF_PATHWAY 4633All SZGR genes in this pathway
PID_HIV_NEF_PATHWAY 3526All SZGR genes in this pathway
PID_PI3KCI_AKT_PATHWAY 3530All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP 255177All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN 320184All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_UP 276165All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_UP 341197All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
VANHARANTA_UTERINE_FIBROID_DN 6745All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL 326213All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_DN 10364All SZGR genes in this pathway
STANELLE_E2F1_TARGETS 2920All SZGR genes in this pathway
LU_IL4_SIGNALING 9456All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN 225163All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_DN 10170All SZGR genes in this pathway
LU_AGING_BRAIN_UP 262186All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_DN 261183All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_DN 318220All SZGR genes in this pathway
DAZARD_UV_RESPONSE_CLUSTER_G6 153112All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_12HR_DN 10164All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3 491310All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
ZHENG_FOXP3_TARGETS_IN_THYMUS_UP 196137All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_DN 154101All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_DN 270181All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
IZADPANAH_STEM_CELL_ADIPOSE_VS_BONE_UP 12692All SZGR genes in this pathway
ROSS_LEUKEMIA_WITH_MLL_FUSIONS 7849All SZGR genes in this pathway
AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_DN 238145All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_DN 170105All SZGR genes in this pathway
YAMASHITA_LIVER_CANCER_STEM_CELL_UP 4738All SZGR genes in this pathway
YAMASHITA_LIVER_CANCER_STEM_CELL_DN 7651All SZGR genes in this pathway
SETLUR_PROSTATE_CANCER_TMPRSS2_ERG_FUSION_UP 6748All SZGR genes in this pathway
SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_UP 8363All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_DN 267160All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_DN 210141All SZGR genes in this pathway
GUTIERREZ_CHRONIC_LYMPHOCYTIC_LEUKEMIA_DN 5639All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
SASSON_RESPONSE_TO_GONADOTROPHINS_UP 9159All SZGR genes in this pathway
SASSON_RESPONSE_TO_FORSKOLIN_UP 9058All SZGR genes in this pathway
HIRSCH_CELLULAR_TRANSFORMATION_SIGNATURE_UP 242159All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN 8861All SZGR genes in this pathway
DELPUECH_FOXO3_TARGETS_UP 6849All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_1 4633All SZGR genes in this pathway
WANG_MLL_TARGETS 289188All SZGR genes in this pathway
ZHANG_ADIPOGENESIS_BY_BMP7 1412All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1453683741Ahsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-17-5p/20/93.mr/106/519.d981051A,m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-1993673731Ahsa-miR-199aCCCAGUGUUCAGACUACCUGUUC
hsa-miR-199bCCCAGUGUUUAGACUAUCUGUUC
miR-23384390m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-30-5p117123m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-3233843901Ahsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-3753723781Ahsa-miR-375UUUGUUCGUUCGGCUCGCGUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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