Gene Page: METTL1
Summary ?
GeneID | 4234 |
Symbol | METTL1 |
Synonyms | C12orf1|TRM8|TRMT8|YDL201w |
Description | methyltransferase like 1 |
Reference | MIM:604466|HGNC:HGNC:7030|Ensembl:ENSG00000037897|HPRD:06834|Vega:OTTHUMG00000150143 |
Gene type | protein-coding |
Map location | 12q13 |
Pascal p-value | 0.769 |
Sherlock p-value | 0.045 |
Fetal beta | -0.352 |
eGene | Hippocampus |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0161 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
ATP5G3 | 0.91 | 0.86 |
UROD | 0.90 | 0.87 |
UQCRFSL1 | 0.89 | 0.84 |
ATP5G1 | 0.89 | 0.82 |
UQCRQ | 0.88 | 0.84 |
NDUFB9 | 0.88 | 0.77 |
COX5B | 0.88 | 0.82 |
MRPS15 | 0.88 | 0.85 |
COX5A | 0.88 | 0.81 |
ZFAND2A | 0.88 | 0.81 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
ZC3H13 | -0.47 | -0.46 |
MAP4K4 | -0.47 | -0.53 |
BAT2D1 | -0.47 | -0.42 |
MYH9 | -0.47 | -0.38 |
RBM25 | -0.47 | -0.53 |
MACF1 | -0.45 | -0.46 |
SFRS12 | -0.45 | -0.48 |
ZNF326 | -0.44 | -0.46 |
TNKS1BP1 | -0.43 | -0.39 |
GIGYF2 | -0.43 | -0.38 |
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0016740 | transferase activity | IEA | - | |
GO:0008176 | tRNA (guanine-N7-)-methyltransferase activity | IDA | 12403464 | |
GO:0008176 | tRNA (guanine-N7-)-methyltransferase activity | IEA | - | |
GO:0008168 | methyltransferase activity | IEA | - | |
GO:0008168 | methyltransferase activity | TAS | 10329009 | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0006400 | tRNA modification | IDA | 12403464 | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0005575 | cellular_component | ND | - |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP | 368 | 234 | All SZGR 2.0 genes in this pathway |
DODD NASOPHARYNGEAL CARCINOMA DN | 1375 | 806 | All SZGR 2.0 genes in this pathway |
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN | 770 | 415 | All SZGR 2.0 genes in this pathway |
LOCKWOOD AMPLIFIED IN LUNG CANCER | 214 | 139 | All SZGR 2.0 genes in this pathway |
BENPORATH MYC MAX TARGETS | 775 | 494 | All SZGR 2.0 genes in this pathway |
NIKOLSKY BREAST CANCER 12Q13 Q21 AMPLICON | 46 | 21 | All SZGR 2.0 genes in this pathway |
TCGA GLIOBLASTOMA COPY NUMBER UP | 75 | 36 | All SZGR 2.0 genes in this pathway |
PENG GLUTAMINE DEPRIVATION DN | 337 | 230 | All SZGR 2.0 genes in this pathway |
IVANOVA HEMATOPOIESIS EARLY PROGENITOR | 532 | 309 | All SZGR 2.0 genes in this pathway |
CUI TCF21 TARGETS 2 UP | 428 | 266 | All SZGR 2.0 genes in this pathway |
BILD MYC ONCOGENIC SIGNATURE | 206 | 117 | All SZGR 2.0 genes in this pathway |
MONNIER POSTRADIATION TUMOR ESCAPE UP | 393 | 244 | All SZGR 2.0 genes in this pathway |
SANSOM APC MYC TARGETS | 217 | 138 | All SZGR 2.0 genes in this pathway |
SANSOM APC TARGETS REQUIRE MYC | 210 | 123 | All SZGR 2.0 genes in this pathway |
YAUCH HEDGEHOG SIGNALING PARACRINE DN | 264 | 159 | All SZGR 2.0 genes in this pathway |
RUTELLA RESPONSE TO CSF2RB AND IL4 UP | 338 | 225 | All SZGR 2.0 genes in this pathway |
RUTELLA RESPONSE TO HGF UP | 418 | 282 | All SZGR 2.0 genes in this pathway |
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP | 408 | 276 | All SZGR 2.0 genes in this pathway |
KYNG WERNER SYNDROM AND NORMAL AGING DN | 225 | 124 | All SZGR 2.0 genes in this pathway |
DANG MYC TARGETS UP | 143 | 100 | All SZGR 2.0 genes in this pathway |
DANG BOUND BY MYC | 1103 | 714 | All SZGR 2.0 genes in this pathway |
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 11 | 103 | 68 | All SZGR 2.0 genes in this pathway |
MARTENS TRETINOIN RESPONSE DN | 841 | 431 | All SZGR 2.0 genes in this pathway |
BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |
TERAO AOX4 TARGETS SKIN UP | 38 | 27 | All SZGR 2.0 genes in this pathway |
KRIEG KDM3A TARGETS NOT HYPOXIA | 208 | 107 | All SZGR 2.0 genes in this pathway |