Gene Page: MFGE8
Summary ?
| GeneID | 4240 |
| Symbol | MFGE8 |
| Synonyms | BA46|EDIL1|HMFG|HsT19888|MFG-E8|MFGM|OAcGD3S|SED1|SPAG10|hP47 |
| Description | milk fat globule-EGF factor 8 protein |
| Reference | MIM:602281|HGNC:HGNC:7036|Ensembl:ENSG00000140545|HPRD:03789|Vega:OTTHUMG00000148682 |
| Gene type | protein-coding |
| Map location | 15q25 |
| Pascal p-value | 0.002 |
| Sherlock p-value | 0.185 |
| eGene | Putamen basal ganglia |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs35043347 | 15 | 89459603 | MFGE8 | ENSG00000140545.10 | 6.641E-7 | 0.01 | -2961 | gtex_brain_putamen_basal |
| rs375529947 | 15 | 89462604 | MFGE8 | ENSG00000140545.10 | 5.084E-7 | 0.01 | -5962 | gtex_brain_putamen_basal |
| rs7172810 | 15 | 89464652 | MFGE8 | ENSG00000140545.10 | 2.64E-6 | 0.01 | -8010 | gtex_brain_putamen_basal |
| rs34717912 | 15 | 89465534 | MFGE8 | ENSG00000140545.10 | 5.716E-7 | 0.01 | -8892 | gtex_brain_putamen_basal |
| rs12903721 | 15 | 89466511 | MFGE8 | ENSG00000140545.10 | 8.004E-7 | 0.01 | -9869 | gtex_brain_putamen_basal |
| rs34924463 | 15 | 89468556 | MFGE8 | ENSG00000140545.10 | 8.691E-7 | 0.01 | -11914 | gtex_brain_putamen_basal |
| rs34452911 | 15 | 89468661 | MFGE8 | ENSG00000140545.10 | 8.212E-7 | 0.01 | -12019 | gtex_brain_putamen_basal |
| rs12901796 | 15 | 89470098 | MFGE8 | ENSG00000140545.10 | 1.153E-6 | 0.01 | -13456 | gtex_brain_putamen_basal |
| rs12903118 | 15 | 89471101 | MFGE8 | ENSG00000140545.10 | 1.121E-6 | 0.01 | -14459 | gtex_brain_putamen_basal |
| rs34779849 | 15 | 89472597 | MFGE8 | ENSG00000140545.10 | 1.379E-6 | 0.01 | -15955 | gtex_brain_putamen_basal |
| rs12912569 | 15 | 89473153 | MFGE8 | ENSG00000140545.10 | 1.496E-6 | 0.01 | -16511 | gtex_brain_putamen_basal |
| rs35861497 | 15 | 89474338 | MFGE8 | ENSG00000140545.10 | 1.786E-6 | 0.01 | -17696 | gtex_brain_putamen_basal |
| rs12913878 | 15 | 89475081 | MFGE8 | ENSG00000140545.10 | 1.794E-6 | 0.01 | -18439 | gtex_brain_putamen_basal |
| rs17792423 | 15 | 89477088 | MFGE8 | ENSG00000140545.10 | 1.786E-6 | 0.01 | -20446 | gtex_brain_putamen_basal |
| rs10520679 | 15 | 89477225 | MFGE8 | ENSG00000140545.10 | 1.786E-6 | 0.01 | -20583 | gtex_brain_putamen_basal |
| rs55953398 | 15 | 89477902 | MFGE8 | ENSG00000140545.10 | 1.786E-6 | 0.01 | -21260 | gtex_brain_putamen_basal |
| rs10520680 | 15 | 89478638 | MFGE8 | ENSG00000140545.10 | 1.786E-6 | 0.01 | -21996 | gtex_brain_putamen_basal |
| rs12898558 | 15 | 89479043 | MFGE8 | ENSG00000140545.10 | 1.786E-6 | 0.01 | -22401 | gtex_brain_putamen_basal |
| rs35760425 | 15 | 89480162 | MFGE8 | ENSG00000140545.10 | 1.786E-6 | 0.01 | -23520 | gtex_brain_putamen_basal |
| rs12907042 | 15 | 89480621 | MFGE8 | ENSG00000140545.10 | 1.799E-6 | 0.01 | -23979 | gtex_brain_putamen_basal |
| rs12908884 | 15 | 89481022 | MFGE8 | ENSG00000140545.10 | 1.81E-6 | 0.01 | -24380 | gtex_brain_putamen_basal |
| rs200065909 | 15 | 89481688 | MFGE8 | ENSG00000140545.10 | 2.513E-6 | 0.01 | -25046 | gtex_brain_putamen_basal |
| rs12900886 | 15 | 89483298 | MFGE8 | ENSG00000140545.10 | 1.902E-6 | 0.01 | -26656 | gtex_brain_putamen_basal |
| rs12324224 | 15 | 89483568 | MFGE8 | ENSG00000140545.10 | 1.899E-6 | 0.01 | -26926 | gtex_brain_putamen_basal |
| rs71149248 | 15 | 89487788 | MFGE8 | ENSG00000140545.10 | 2.41E-6 | 0.01 | -31146 | gtex_brain_putamen_basal |
| rs35207204 | 15 | 89496711 | MFGE8 | ENSG00000140545.10 | 1.25E-6 | 0.01 | -40069 | gtex_brain_putamen_basal |
| rs62023554 | 15 | 89496780 | MFGE8 | ENSG00000140545.10 | 6.492E-7 | 0.01 | -40138 | gtex_brain_putamen_basal |
| rs34528037 | 15 | 89497031 | MFGE8 | ENSG00000140545.10 | 6.589E-7 | 0.01 | -40389 | gtex_brain_putamen_basal |
| rs12050555 | 15 | 89497822 | MFGE8 | ENSG00000140545.10 | 6.619E-7 | 0.01 | -41180 | gtex_brain_putamen_basal |
| rs35607289 | 15 | 89508742 | MFGE8 | ENSG00000140545.10 | 1.568E-6 | 0.01 | -52100 | gtex_brain_putamen_basal |
| rs4360903 | 15 | 89510110 | MFGE8 | ENSG00000140545.10 | 1.4E-6 | 0.01 | -53468 | gtex_brain_putamen_basal |
| rs11854739 | 15 | 89511746 | MFGE8 | ENSG00000140545.10 | 6.921E-7 | 0.01 | -55104 | gtex_brain_putamen_basal |
| rs34549079 | 15 | 89511981 | MFGE8 | ENSG00000140545.10 | 1.576E-6 | 0.01 | -55339 | gtex_brain_putamen_basal |
| rs71408899 | 15 | 89515617 | MFGE8 | ENSG00000140545.10 | 1.567E-6 | 0.01 | -58975 | gtex_brain_putamen_basal |
| rs35864015 | 15 | 89516606 | MFGE8 | ENSG00000140545.10 | 1.624E-6 | 0.01 | -59964 | gtex_brain_putamen_basal |
| rs34631560 | 15 | 89516923 | MFGE8 | ENSG00000140545.10 | 1.592E-6 | 0.01 | -60281 | gtex_brain_putamen_basal |
| rs56782657 | 15 | 89517421 | MFGE8 | ENSG00000140545.10 | 1.702E-6 | 0.01 | -60779 | gtex_brain_putamen_basal |
| rs71462477 | 15 | 89518236 | MFGE8 | ENSG00000140545.10 | 1.83E-6 | 0.01 | -61594 | gtex_brain_putamen_basal |
| rs201599081 | 15 | 89518258 | MFGE8 | ENSG00000140545.10 | 2.204E-6 | 0.01 | -61616 | gtex_brain_putamen_basal |
| rs71403963 | 15 | 89518262 | MFGE8 | ENSG00000140545.10 | 8.851E-7 | 0.01 | -61620 | gtex_brain_putamen_basal |
| rs62024770 | 15 | 89519346 | MFGE8 | ENSG00000140545.10 | 1.595E-6 | 0.01 | -62704 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PID AVB3 INTEGRIN PATHWAY | 75 | 53 | All SZGR 2.0 genes in this pathway |
| PID TAP63 PATHWAY | 54 | 40 | All SZGR 2.0 genes in this pathway |
| REACTOME AMYLOIDS | 83 | 63 | All SZGR 2.0 genes in this pathway |
| THUM SYSTOLIC HEART FAILURE UP | 423 | 283 | All SZGR 2.0 genes in this pathway |
| CHARAFE BREAST CANCER LUMINAL VS BASAL DN | 455 | 304 | All SZGR 2.0 genes in this pathway |
| CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN | 460 | 312 | All SZGR 2.0 genes in this pathway |
| DELYS THYROID CANCER UP | 443 | 294 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN UP | 1142 | 669 | All SZGR 2.0 genes in this pathway |
| MISSIAGLIA REGULATED BY METHYLATION UP | 126 | 78 | All SZGR 2.0 genes in this pathway |
| MCBRYAN PUBERTAL BREAST 3 4WK UP | 214 | 144 | All SZGR 2.0 genes in this pathway |
| MCBRYAN PUBERTAL BREAST 4 5WK UP | 271 | 175 | All SZGR 2.0 genes in this pathway |
| MCBRYAN PUBERTAL TGFB1 TARGETS UP | 169 | 127 | All SZGR 2.0 genes in this pathway |
| AMUNDSON GENOTOXIC SIGNATURE | 105 | 68 | All SZGR 2.0 genes in this pathway |
| SHETH LIVER CANCER VS TXNIP LOSS PAM1 | 229 | 137 | All SZGR 2.0 genes in this pathway |
| COWLING MYCN TARGETS | 43 | 27 | All SZGR 2.0 genes in this pathway |
| BENPORATH ES 1 | 379 | 235 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER MYC TGFA UP | 61 | 40 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER ACOX1 UP | 64 | 40 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER CIPROFIBRATE UP | 60 | 42 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER DENA UP | 60 | 40 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER E2F1 UP | 62 | 35 | All SZGR 2.0 genes in this pathway |
| NADLER OBESITY UP | 61 | 34 | All SZGR 2.0 genes in this pathway |
| CROMER METASTASIS UP | 79 | 46 | All SZGR 2.0 genes in this pathway |
| REN ALVEOLAR RHABDOMYOSARCOMA DN | 408 | 274 | All SZGR 2.0 genes in this pathway |
| HENDRICKS SMARCA4 TARGETS UP | 56 | 35 | All SZGR 2.0 genes in this pathway |
| YAMAZAKI TCEB3 TARGETS UP | 175 | 116 | All SZGR 2.0 genes in this pathway |
| RODWELL AGING KIDNEY NO BLOOD UP | 222 | 139 | All SZGR 2.0 genes in this pathway |
| RODWELL AGING KIDNEY UP | 487 | 303 | All SZGR 2.0 genes in this pathway |
| WELCSH BRCA1 TARGETS UP | 198 | 132 | All SZGR 2.0 genes in this pathway |
| JIANG HYPOXIA NORMAL | 311 | 205 | All SZGR 2.0 genes in this pathway |
| MONNIER POSTRADIATION TUMOR ESCAPE DN | 373 | 196 | All SZGR 2.0 genes in this pathway |
| LEIN ASTROCYTE MARKERS | 42 | 35 | All SZGR 2.0 genes in this pathway |
| COATES MACROPHAGE M1 VS M2 DN | 78 | 44 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER RELAPSE IN BONE DN | 315 | 197 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER LUMINAL B DN | 564 | 326 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER BASAL UP | 648 | 398 | All SZGR 2.0 genes in this pathway |
| ZHENG GLIOBLASTOMA PLASTICITY UP | 250 | 168 | All SZGR 2.0 genes in this pathway |
| MATZUK SPERMATOZOA | 114 | 77 | All SZGR 2.0 genes in this pathway |
| GRADE COLON CANCER UP | 871 | 505 | All SZGR 2.0 genes in this pathway |
| BRUECKNER TARGETS OF MIRLET7A3 DN | 78 | 49 | All SZGR 2.0 genes in this pathway |
| HUNSBERGER EXERCISE REGULATED GENES | 31 | 26 | All SZGR 2.0 genes in this pathway |
| CHANG CORE SERUM RESPONSE DN | 209 | 137 | All SZGR 2.0 genes in this pathway |
| CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | All SZGR 2.0 genes in this pathway |
| MILI PSEUDOPODIA HAPTOTAXIS DN | 668 | 419 | All SZGR 2.0 genes in this pathway |
| WONG ADULT TISSUE STEM MODULE | 721 | 492 | All SZGR 2.0 genes in this pathway |
| CHICAS RB1 TARGETS CONFLUENT | 567 | 365 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP B | 549 | 316 | All SZGR 2.0 genes in this pathway |
| KASLER HDAC7 TARGETS 1 UP | 194 | 133 | All SZGR 2.0 genes in this pathway |
| LEE BMP2 TARGETS UP | 745 | 475 | All SZGR 2.0 genes in this pathway |
| ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL UP | 289 | 184 | All SZGR 2.0 genes in this pathway |
| NABA ECM GLYCOPROTEINS | 196 | 99 | All SZGR 2.0 genes in this pathway |
| NABA CORE MATRISOME | 275 | 148 | All SZGR 2.0 genes in this pathway |
| NABA MATRISOME | 1028 | 559 | All SZGR 2.0 genes in this pathway |