Summary ?
GeneID4294
SymbolMAP3K10
SynonymsMEKK10|MLK2|MST
Descriptionmitogen-activated protein kinase kinase kinase 10
ReferenceMIM:600137|HGNC:HGNC:6849|Ensembl:ENSG00000130758|HPRD:02533|Vega:OTTHUMG00000182591
Gene typeprotein-coding
Map location19q13.2
Pascal p-value0.484
Sherlock p-value0.659
Fetal beta-0.627
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg200056241940697059MAP3K101.36E-9-0.0151.37E-6DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AP000349.10.990.90
GPC20.890.84
SBK10.890.82
ACTG10.880.79
C6orf1340.880.84
MYD880.870.82
SRC0.870.80
TMEM440.870.80
LRRC610.870.83
IGLON50.870.81
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C5orf53-0.63-0.74
HLA-F-0.62-0.71
ALDOC-0.61-0.68
CLU-0.61-0.68
AIFM3-0.61-0.68
FBXO2-0.61-0.65
PTH1R-0.60-0.64
LDHD-0.60-0.65
RGN-0.59-0.68
AP003117.1-0.59-0.66

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CDC42CDC42Hs | G25Kcell division cycle 42 (GTP binding protein, 25kDa)-HPRD,BioGRID9427749 
CLTCCHC | CHC17 | CLH-17 | CLTCL2 | Hc | KIAA0034clathrin, heavy chain (Hc)-HPRD,BioGRID12105200 
CNKSR1CNK | CNK1 | KSRconnector enhancer of kinase suppressor of Ras 1CNKSR1 (hCNK1) interacts with MAP3K10 (MLK2). This interaction was modelled on a demonstrated interaction between human CNKSR1 and MAP3K10 from an unspecified species.BIND15753034 
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)-HPRD,BioGRID11152698 
DNM1DNMdynamin 1Reconstituted ComplexBioGRID9742220 
DNM1LDLP1 | DRP1 | DVLP | DYMPLE | DYNIV-11 | FLJ41912 | HDYNIV | VPS1dynamin 1-like-HPRD9742220 
HPCABDR2hippocalcinAffinity Capture-WesternBioGRID9427749 
HTTHD | IT15huntingtinMLK2 SH3 domain interacts with HuntingtinBIND10801775 
HTTHD | IT15huntingtin-HPRD,BioGRID10801775 
KIF17KIAA1405 | KIF17B | KIF3Xkinesin family member 17Two-hybridBioGRID9427749 
KIF3A-kinesin family member 3A-HPRD,BioGRID9427749 
KIF3BHH0048 | KIAA0359kinesin family member 3B-HPRD9427749 
KIFAP3FLJ22818 | KAP3 | SMAP | Smg-GDS | dJ190I16.1kinesin-associated protein 3-HPRD,BioGRID9427749 
KRTAP3P1KAP3Akeratin associated protein 3 pseudogene 1Affinity Capture-WesternBioGRID9427749 
MAP2K4JNKK | JNKK1 | MAPKK4 | MEK4 | MKK4 | PRKMK4 | SEK1 | SERK1mitogen-activated protein kinase kinase 4-HPRD,BioGRID9182538 
MAPK8IP1IB1 | JIP-1 | JIP1 | PRKM8IPmitogen-activated protein kinase 8 interacting protein 1Affinity Capture-Western
Reconstituted Complex
BioGRID10490659 
MAPK8IP2IB2 | JIP2 | PRKM8IPLmitogen-activated protein kinase 8 interacting protein 2Affinity Capture-Western
Reconstituted Complex
BioGRID10490659 
NEUROD1BETA2 | BHF-1 | NEUROD | bHLHa3neurogenic differentiation 1Affinity Capture-Western
Biochemical Activity
Two-hybrid
BioGRID12881483 
PHBPHB1prohibitin-HPRD9629920 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)Reconstituted ComplexBioGRID9427749 
RACGAP1HsCYK-4 | ID-GAP | MgcRacGAPRac GTPase activating protein 1-HPRD9427749 
SH3RF1FLJ21602 | KIAA1494 | POSH | RNF142 | SH3MD2SH3 domain containing ring finger 1-HPRD14504284 
TUBB2ATUBB | TUBB2 | dJ40E16.7tubulin, beta 2A-HPRD9629920 
YWHAE14-3-3E | FLJ45465 | KCIP-1 | MDCR | MDStyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide-HPRD,BioGRID9427749 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BIOCARTA MAPK PATHWAY 8768All SZGR 2.0 genes in this pathway
ST P38 MAPK PATHWAY 3728All SZGR 2.0 genes in this pathway
ST JNK MAPK PATHWAY 4030All SZGR 2.0 genes in this pathway
PID P38 MKK3 6PATHWAY 2621All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
DER IFN ALPHA RESPONSE UP 7448All SZGR 2.0 genes in this pathway
DER IFN BETA RESPONSE UP 10267All SZGR 2.0 genes in this pathway
DER IFN GAMMA RESPONSE UP 7145All SZGR 2.0 genes in this pathway
KUUSELO PANCREATIC CANCER 19Q13 AMPLIFICATION 3522All SZGR 2.0 genes in this pathway
LIU IL13 MEMORY MODEL UP 1712All SZGR 2.0 genes in this pathway