Gene Page: ASGR1

Summary ?
GeneID432
SymbolASGR1
SynonymsASGPR|ASGPR1|CLEC4H1|HL-1
Descriptionasialoglycoprotein receptor 1
ReferenceMIM:108360|HGNC:HGNC:742|Ensembl:ENSG00000141505|HPRD:00151|Vega:OTTHUMG00000102159
Gene typeprotein-coding
Map location17p13.2
Pascal p-value6.873E-4
Sherlock p-value0.74
eGeneMyers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs6048101chr2022429986ASGR14320.07trans
rs4632416chr2022437090ASGR14320.06trans
rs4459793chr2022439811ASGR14320.08trans
rs6048112chr2022442814ASGR14320.18trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
POP40.790.75
PYCRL0.780.76
TRUB20.780.74
PHKG20.780.75
SNX170.780.79
MED290.780.79
DRG20.780.77
FLOT10.770.75
UQCRC10.770.76
FOXRED10.770.73
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.18-0.49-0.33
AF347015.2-0.46-0.25
MT-ATP8-0.45-0.31
AC010300.1-0.45-0.42
AF347015.8-0.44-0.29
MT-CYB-0.44-0.29
AF347015.26-0.44-0.27
AF347015.15-0.44-0.28
AF347015.21-0.41-0.27
MT-CO2-0.40-0.26

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
DELYS THYROID CANCER DN 232154All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER UP 181108All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024594All SZGR 2.0 genes in this pathway
HSIAO LIVER SPECIFIC GENES 244154All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC UP 202115All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP 210124All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540340All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL UP 185112All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
FONTAINE FOLLICULAR THYROID ADENOMA UP 7543All SZGR 2.0 genes in this pathway
FONTAINE PAPILLARY THYROID CARCINOMA DN 8053All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S3 266180All SZGR 2.0 genes in this pathway
OHGUCHI LIVER HNF4A TARGETS DN 14985All SZGR 2.0 genes in this pathway
WARTERS RESPONSE TO IR SKIN 8344All SZGR 2.0 genes in this pathway