Gene Page: MMP17

Summary ?
GeneID4326
SymbolMMP17
SynonymsMMP-17|MT4-MMP|MT4MMP|MTMMP4
Descriptionmatrix metallopeptidase 17
ReferenceMIM:602285|HGNC:HGNC:7163|Ensembl:ENSG00000198598|HPRD:03793|Vega:OTTHUMG00000168050
Gene typeprotein-coding
Map location12q24.3
Pascal p-value0.415
Sherlock p-value0.942
Fetal beta-0.447
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg1063250712132317390MMP171.951E-40.4340.035DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs6588375chr150594945MMP1743260.11trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
LTK0.850.76
KIAA07480.770.75
FHL20.770.60
AC103681.10.750.69
HTR3B0.750.70
SLC22A90.750.70
ITPKA0.740.71
GALNTL50.740.68
SLC25A450.740.73
EXTL10.740.72
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PKN1-0.44-0.49
PDE9A-0.43-0.52
TUBB2B-0.42-0.53
YBX1-0.42-0.53
FAM36A-0.42-0.48
KIAA1949-0.41-0.45
IDH1-0.41-0.48
NKIRAS2-0.40-0.34
GPR125-0.40-0.38
ARMCX6-0.40-0.44

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX 2911All SZGR 2.0 genes in this pathway
REACTOME EXTRACELLULAR MATRIX ORGANIZATION 8742All SZGR 2.0 genes in this pathway
SCIAN INVERSED TARGETS OF TP53 AND TP73 UP 119All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 12Q24 AMPLICON 157All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL TRANS 185114All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
VERRECCHIA DELAYED RESPONSE TO TGFB1 3926All SZGR 2.0 genes in this pathway
VERRECCHIA RESPONSE TO TGFB1 C4 1310All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP 210124All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701446All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351238All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721492All SZGR 2.0 genes in this pathway
MURAKAMI UV RESPONSE 1HR UP 1710All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN 448282All SZGR 2.0 genes in this pathway
ALFANO MYC TARGETS 239156All SZGR 2.0 genes in this pathway
NABA ECM REGULATORS 238125All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway