Gene Page: MXRA7
Summary ?
| GeneID | 439921 |
| Symbol | MXRA7 |
| Synonyms | PS1TP1|TMAP1 |
| Description | matrix-remodelling associated 7 |
| Reference | HGNC:HGNC:7541|Ensembl:ENSG00000182534|HPRD:18199|Vega:OTTHUMG00000180370 |
| Gene type | protein-coding |
| Map location | 17q25.1 |
| Pascal p-value | 0.151 |
| Sherlock p-value | 0.538 |
| Fetal beta | -2.052 |
| DMG | 1 (# studies) |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg13387113 | 17 | 74696737 | MXRA7 | 2.698E-4 | 0.667 | 0.038 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs12449557 | 17 | 74664614 | MXRA7 | ENSG00000182534.9 | 7.559E-7 | 0.01 | 42484 | gtex_brain_ba24 |
| rs7221855 | 17 | 74664854 | MXRA7 | ENSG00000182534.9 | 7.533E-7 | 0.01 | 42244 | gtex_brain_ba24 |
| rs7226267 | 17 | 74665054 | MXRA7 | ENSG00000182534.9 | 7.529E-7 | 0.01 | 42044 | gtex_brain_ba24 |
| rs11870540 | 17 | 74665855 | MXRA7 | ENSG00000182534.9 | 6.593E-8 | 0.01 | 41243 | gtex_brain_ba24 |
| rs9910052 | 17 | 74668801 | MXRA7 | ENSG00000182534.9 | 1.281E-7 | 0.01 | 38297 | gtex_brain_ba24 |
| rs9897324 | 17 | 74671008 | MXRA7 | ENSG00000182534.9 | 3.245E-9 | 0.01 | 36090 | gtex_brain_ba24 |
| rs2159358 | 17 | 74671208 | MXRA7 | ENSG00000182534.9 | 3.222E-9 | 0.01 | 35890 | gtex_brain_ba24 |
| rs10473 | 17 | 74672407 | MXRA7 | ENSG00000182534.9 | 1.173E-7 | 0.01 | 34691 | gtex_brain_ba24 |
| rs6501918 | 17 | 74672830 | MXRA7 | ENSG00000182534.9 | 1.139E-7 | 0.01 | 34268 | gtex_brain_ba24 |
| rs11869629 | 17 | 74677156 | MXRA7 | ENSG00000182534.9 | 5.809E-9 | 0.01 | 29942 | gtex_brain_ba24 |
| rs11077854 | 17 | 74679357 | MXRA7 | ENSG00000182534.9 | 3.641E-8 | 0.01 | 27741 | gtex_brain_ba24 |
| rs9892163 | 17 | 74679597 | MXRA7 | ENSG00000182534.9 | 3.222E-9 | 0.01 | 27501 | gtex_brain_ba24 |
| rs2286593 | 17 | 74681435 | MXRA7 | ENSG00000182534.9 | 2.276E-8 | 0.01 | 25663 | gtex_brain_ba24 |
| rs2286591 | 17 | 74681613 | MXRA7 | ENSG00000182534.9 | 9.154E-9 | 0.01 | 25485 | gtex_brain_ba24 |
| rs7223751 | 17 | 74682885 | MXRA7 | ENSG00000182534.9 | 8.235E-9 | 0.01 | 24213 | gtex_brain_ba24 |
| rs4788942 | 17 | 74684598 | MXRA7 | ENSG00000182534.9 | 1.282E-8 | 0.01 | 22500 | gtex_brain_ba24 |
| rs12943636 | 17 | 74685384 | MXRA7 | ENSG00000182534.9 | 1.061E-8 | 0.01 | 21714 | gtex_brain_ba24 |
| rs200502850 | 17 | 74688299 | MXRA7 | ENSG00000182534.9 | 5.758E-8 | 0.01 | 18799 | gtex_brain_ba24 |
| rs11077857 | 17 | 74691636 | MXRA7 | ENSG00000182534.9 | 1.352E-8 | 0.01 | 15462 | gtex_brain_ba24 |
| rs10459894 | 17 | 74696030 | MXRA7 | ENSG00000182534.9 | 4.153E-9 | 0.01 | 11068 | gtex_brain_ba24 |
| rs62085152 | 17 | 74702510 | MXRA7 | ENSG00000182534.9 | 3.335E-7 | 0.01 | 4588 | gtex_brain_ba24 |
| rs62085110 | 17 | 74662956 | MXRA7 | ENSG00000182534.9 | 2.706E-7 | 0 | 44142 | gtex_brain_putamen_basal |
| rs60065367 | 17 | 74663080 | MXRA7 | ENSG00000182534.9 | 4.937E-7 | 0 | 44018 | gtex_brain_putamen_basal |
| rs12449557 | 17 | 74664614 | MXRA7 | ENSG00000182534.9 | 9.292E-7 | 0 | 42484 | gtex_brain_putamen_basal |
| rs7221855 | 17 | 74664854 | MXRA7 | ENSG00000182534.9 | 9.29E-7 | 0 | 42244 | gtex_brain_putamen_basal |
| rs7226267 | 17 | 74665054 | MXRA7 | ENSG00000182534.9 | 3.131E-8 | 0 | 42044 | gtex_brain_putamen_basal |
| rs11870540 | 17 | 74665855 | MXRA7 | ENSG00000182534.9 | 7.831E-9 | 0 | 41243 | gtex_brain_putamen_basal |
| rs9910053 | 17 | 74667807 | MXRA7 | ENSG00000182534.9 | 9.264E-7 | 0 | 39291 | gtex_brain_putamen_basal |
| rs9910052 | 17 | 74668801 | MXRA7 | ENSG00000182534.9 | 4.565E-8 | 0 | 38297 | gtex_brain_putamen_basal |
| rs9897324 | 17 | 74671008 | MXRA7 | ENSG00000182534.9 | 1.08E-9 | 0 | 36090 | gtex_brain_putamen_basal |
| rs2159358 | 17 | 74671208 | MXRA7 | ENSG00000182534.9 | 1.087E-9 | 0 | 35890 | gtex_brain_putamen_basal |
| rs10473 | 17 | 74672407 | MXRA7 | ENSG00000182534.9 | 3.22E-9 | 0 | 34691 | gtex_brain_putamen_basal |
| rs6501918 | 17 | 74672830 | MXRA7 | ENSG00000182534.9 | 3.112E-9 | 0 | 34268 | gtex_brain_putamen_basal |
| rs11869629 | 17 | 74677156 | MXRA7 | ENSG00000182534.9 | 8.352E-15 | 0 | 29942 | gtex_brain_putamen_basal |
| rs11077854 | 17 | 74679357 | MXRA7 | ENSG00000182534.9 | 5.302E-11 | 0 | 27741 | gtex_brain_putamen_basal |
| rs9892163 | 17 | 74679597 | MXRA7 | ENSG00000182534.9 | 8.59E-10 | 0 | 27501 | gtex_brain_putamen_basal |
| rs2286593 | 17 | 74681435 | MXRA7 | ENSG00000182534.9 | 8.289E-9 | 0 | 25663 | gtex_brain_putamen_basal |
| rs2286591 | 17 | 74681613 | MXRA7 | ENSG00000182534.9 | 1.413E-11 | 0 | 25485 | gtex_brain_putamen_basal |
| rs7223751 | 17 | 74682885 | MXRA7 | ENSG00000182534.9 | 2.034E-10 | 0 | 24213 | gtex_brain_putamen_basal |
| rs4788942 | 17 | 74684598 | MXRA7 | ENSG00000182534.9 | 2.018E-10 | 0 | 22500 | gtex_brain_putamen_basal |
| rs12943636 | 17 | 74685384 | MXRA7 | ENSG00000182534.9 | 2.258E-10 | 0 | 21714 | gtex_brain_putamen_basal |
| rs200502850 | 17 | 74688299 | MXRA7 | ENSG00000182534.9 | 7.251E-11 | 0 | 18799 | gtex_brain_putamen_basal |
| rs11077857 | 17 | 74691636 | MXRA7 | ENSG00000182534.9 | 2.018E-10 | 0 | 15462 | gtex_brain_putamen_basal |
| rs10459894 | 17 | 74696030 | MXRA7 | ENSG00000182534.9 | 7.2E-7 | 0 | 11068 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| LIU PROSTATE CANCER DN | 481 | 290 | All SZGR 2.0 genes in this pathway |
| ONKEN UVEAL MELANOMA UP | 783 | 507 | All SZGR 2.0 genes in this pathway |
| BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER DN | 169 | 118 | All SZGR 2.0 genes in this pathway |
| SCHUETZ BREAST CANCER DUCTAL INVASIVE UP | 351 | 230 | All SZGR 2.0 genes in this pathway |
| DAVICIONI MOLECULAR ARMS VS ERMS UP | 332 | 228 | All SZGR 2.0 genes in this pathway |
| CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA UP | 177 | 110 | All SZGR 2.0 genes in this pathway |
| CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN | 460 | 312 | All SZGR 2.0 genes in this pathway |
| OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN | 275 | 168 | All SZGR 2.0 genes in this pathway |
| PAPASPYRIDONOS UNSTABLE ATEROSCLEROTIC PLAQUE DN | 43 | 29 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC3 TARGETS UP | 501 | 327 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN | 805 | 505 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA ANAPLASTIC DN | 537 | 339 | All SZGR 2.0 genes in this pathway |
| CHEBOTAEV GR TARGETS DN | 120 | 73 | All SZGR 2.0 genes in this pathway |
| GAUSSMANN MLL AF4 FUSION TARGETS C UP | 170 | 114 | All SZGR 2.0 genes in this pathway |
| LUI THYROID CANCER CLUSTER 1 | 51 | 33 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| NUYTTEN EZH2 TARGETS UP | 1037 | 673 | All SZGR 2.0 genes in this pathway |
| SCHAEFFER PROSTATE DEVELOPMENT 12HR DN | 57 | 45 | All SZGR 2.0 genes in this pathway |
| BENPORATH ES WITH H3K27ME3 | 1118 | 744 | All SZGR 2.0 genes in this pathway |
| ROSS AML WITH PML RARA FUSION | 77 | 62 | All SZGR 2.0 genes in this pathway |
| PENG RAPAMYCIN RESPONSE UP | 203 | 130 | All SZGR 2.0 genes in this pathway |
| VERHAAK AML WITH NPM1 MUTATED DN | 246 | 180 | All SZGR 2.0 genes in this pathway |
| REN ALVEOLAR RHABDOMYOSARCOMA DN | 408 | 274 | All SZGR 2.0 genes in this pathway |
| BAELDE DIABETIC NEPHROPATHY DN | 434 | 302 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 | 720 | 440 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 5 | 482 | 296 | All SZGR 2.0 genes in this pathway |
| HELLER HDAC TARGETS UP | 317 | 208 | All SZGR 2.0 genes in this pathway |
| WALLACE PROSTATE CANCER RACE UP | 299 | 167 | All SZGR 2.0 genes in this pathway |
| VICENT METASTASIS UP | 14 | 11 | All SZGR 2.0 genes in this pathway |
| FLOTHO PEDIATRIC ALL THERAPY RESPONSE UP | 53 | 33 | All SZGR 2.0 genes in this pathway |
| VALK AML CLUSTER 12 | 30 | 20 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC HCP WITH H3K4ME2 | 491 | 319 | All SZGR 2.0 genes in this pathway |
| KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP | 682 | 440 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |
| KOINUMA TARGETS OF SMAD2 OR SMAD3 | 824 | 528 | All SZGR 2.0 genes in this pathway |
| KRIEG HYPOXIA NOT VIA KDM3A | 770 | 480 | All SZGR 2.0 genes in this pathway |
| RATTENBACHER BOUND BY CELF1 | 467 | 251 | All SZGR 2.0 genes in this pathway |
| LIM MAMMARY STEM CELL UP | 489 | 314 | All SZGR 2.0 genes in this pathway |
| ZWANG EGF INTERVAL DN | 214 | 124 | All SZGR 2.0 genes in this pathway |