Gene Page: MSX1

Summary
GeneID  4487
Symbol  MSX1
Synonyms  HOX7|HYD1
Description  msh homeobox 1
See related  HGNC:7391|MIM:142983|Ensembl:ENSG00000163132|HPRD:00866|
Locus tag  -
Gene type  protein-coding
Map location  4p16.3-p16.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIEA-
GO:0005515protein bindingIEA-
GO:0016564transcription repressor activityIEA-
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0030901midbrain developmentIEABrain (GO term level: 8)-
GO:0030900forebrain developmentIEABrain (GO term level: 8)-
GO:0000122negative regulation of transcription from RNA polymerase II promoterIEA-
GO:0001501skeletal system developmentTAS8696335 
GO:0001701in utero embryonic developmentIEA-
GO:0003007heart morphogenesisIEA-
GO:0008285negative regulation of cell proliferationIEA-
GO:0007517muscle developmentIEA-
GO:0007275multicellular organismal developmentIEA-
GO:0043066negative regulation of apoptosisIEA-
GO:0030509BMP signaling pathwayIEA-
GO:0030326embryonic limb morphogenesisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CREBBPCBP | KAT3A | RSTSCREB binding protein-HPRD,BioGRID10215616 |11115394 
DLX2TES-1 | TES1distal-less homeobox 2Reconstituted Complex
Two-hybrid		BioGRID9111364 
DLX5-distal-less homeobox 5Reconstituted ComplexBioGRID9111364 
HOXC8HOX3 | HOX3Ahomeobox C8Reconstituted ComplexBioGRID9111364 
LHX2LH2 | MGC138390 | hLhx2LIM homeobox 2-HPRD,BioGRID9697309 
MSX1HOX7 | HYD1msh homeobox 1Reconstituted Complex
Two-hybrid		BioGRID9111364 
MSX2CRS2 | FPP | HOX8 | MSH | PFM | PFM1msh homeobox 2-HPRD,BioGRID9111364 
PAX3CDHS | HUP2 | MGC120381 | MGC120382 | MGC120383 | MGC120384 | MGC134778 | WS1paired box 3Reconstituted ComplexBioGRID10529415 
RGS7-regulator of G-protein signaling 7-HPRD10862767 
SP1-Sp1 transcription factor-HPRD,BioGRID10215616 
TAF1BA2R | CCG1 | CCGS | DYT3 | KAT4 | N-TAF1 | NSCL2 | OF | P250 | TAF2A | TAFII250TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa-HPRD,BioGRID8700832 
TBPGTF2D | GTF2D1 | MGC117320 | MGC126054 | MGC126055 | SCA17 | TFIIDTATA box binding proteinAffinity Capture-Western
in vivo
Phenotypic Suppression
Reconstituted Complex		BioGRID8700832 |9111364 
|10215616 
-HPRD8700832 |10215616 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53MSX1 interacts with TP53 (p53). This interaction was modeled on a demonstrated interaction between MSX1 from an unspecified species, and human p53.BIND15705871 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
HOLLMANN_APOPTOSIS_VIA_CD40_DN 267178All SZGR genes in this pathway
ROY_WOUND_BLOOD_VESSEL_UP 5030All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_6HR_UP 8554All SZGR genes in this pathway
UDAYAKUMAR_MED1_TARGETS_DN 240171All SZGR genes in this pathway
LEE_NEURAL_CREST_STEM_CELL_UP 14699All SZGR genes in this pathway
SABATES_COLORECTAL_ADENOMA_UP 14175All SZGR genes in this pathway
KIM_WT1_TARGETS_12HR_UP 162116All SZGR genes in this pathway
VANHARANTA_UTERINE_FIBROID_DN 6745All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
LIEN_BREAST_CARCINOMA_METAPLASTIC 3525All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
TESAR_ALK_TARGETS_HUMAN_ES_5D_UP 55All SZGR genes in this pathway
ROZANOV_MMP14_TARGETS_UP 266171All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
BECKER_TAMOXIFEN_RESISTANCE_DN 5237All SZGR genes in this pathway
SASAKI_ADULT_T_CELL_LEUKEMIA 176122All SZGR genes in this pathway
SANSOM_APC_TARGETS_UP 12684All SZGR genes in this pathway
ZHANG_TARGETS_OF_EWSR1_FLI1_FUSION 8868All SZGR genes in this pathway
HADDAD_B_LYMPHOCYTE_PROGENITOR 293193All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_DN 4127All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP 240152All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
ZHU_CMV_ALL_UP 12089All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_10HR_UP 10169All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_6HR_UP 7148All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
ZHU_CMV_8_HR_UP 4739All SZGR genes in this pathway
LEIN_CHOROID_PLEXUS_MARKERS 10361All SZGR genes in this pathway
SANSOM_WNT_PATHWAY_REQUIRE_MYC 5843All SZGR genes in this pathway
RIGGINS_TAMOXIFEN_RESISTANCE_DN 220147All SZGR genes in this pathway
TESAR_ALK_TARGETS_EPISC_3D_UP 77All SZGR genes in this pathway
TESAR_ALK_TARGETS_EPISC_4D_UP 76All SZGR genes in this pathway
TESAR_ALK_AND_JAK_TARGETS_MOUSE_ES_D4_UP 55All SZGR genes in this pathway
HELLER_HDAC_TARGETS_UP 317208All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP 461298All SZGR genes in this pathway
AMUNDSON_GAMMA_RADIATION_RESPONSE 4025All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
HANN_RESISTANCE_TO_BCL2_INHIBITOR_DN 4831All SZGR genes in this pathway
PODAR_RESPONSE_TO_ADAPHOSTIN_UP 14798All SZGR genes in this pathway
TOOKER_GEMCITABINE_RESISTANCE_DN 12284All SZGR genes in this pathway
ZAIDI_OSTEOBLAST_TRANSCRIPTION_FACTORS 1412All SZGR genes in this pathway
HOFMANN_MYELODYSPLASTIC_SYNDROM_LOW_RISK_UP 2215All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1017177231Ahsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-1447167231A,m8hsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-217817871Ahsa-miR-21brainUAGCUUAUCAGACUGAUGUUGA
hsa-miR-590GAGCUUAUUCAUAAAAGUGCAG
miR-3297007061Ahsa-miR-329brainAACACACCUGGUUAACCUCUUU
miR-369-3p7487541Ahsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-374748754m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-4957617671Ahsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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