Gene Page: MSX2

Summary
GeneID  4488
Symbol  MSX2
Synonyms  CRS2|FPP|HOX8|MSH|PFM|PFM1
Description  msh homeobox 2
See related  HGNC:7392|MIM:123101|Ensembl:ENSG00000120149|HPRD:00421|
Locus tag  -
Gene type  protein-coding
Map location  5q34-q35
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.0276 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIEA-
GO:0005515protein bindingIPI12145306 
GO:0043565sequence-specific DNA bindingIDA9073066 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001501skeletal system developmentTAS8968743 
GO:0003007heart morphogenesisIEA-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0008285negative regulation of cell proliferationIEA-
GO:0007275multicellular organismal developmentIEA-
GO:0043066negative regulation of apoptosisIEA-
GO:0030509BMP signaling pathwayIEA-
GO:0030326embryonic limb morphogenesisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005737cytoplasmIDA18029348 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CEBPAC/EBP-alpha | CEBPCCAAT/enhancer binding protein (C/EBP), alpha-HPRD,BioGRID12925529 
DLX2TES-1 | TES1distal-less homeobox 2-HPRD,BioGRID9111364 
DLX5-distal-less homeobox 5-HPRD,BioGRID9111364 
GTF2F1BTF4 | RAP74 | TF2F1 | TFIIFgeneral transcription factor IIF, polypeptide 1, 74kDa-HPRD,BioGRID9265625 
GTF2F2BTF4 | RAP30 | TF2F2 | TFIIFgeneral transcription factor IIF, polypeptide 2, 30kDa-HPRD,BioGRID9265625 
MAGED1DLXIN-1 | NRAGEmelanoma antigen family D, 1-HPRD,BioGRID11084035 |11959851 
MSX1HOX7 | HYD1msh homeobox 1-HPRD,BioGRID9111364 
MSX2CRS2 | FPP | HOX8 | MSH | PFM | PFM1msh homeobox 2-HPRD,BioGRID9111364 
PITX2ARP1 | Brx1 | IDG2 | IGDS | IGDS2 | IHG2 | IRID2 | MGC111022 | MGC20144 | Otlx2 | PTX2 | RGS | RIEG | RIEG1 | RSpaired-like homeodomain 2Phenotypic SuppressionBioGRID11763998 
RUNX2AML3 | CBFA1 | CCD | CCD1 | MGC120022 | MGC120023 | OSF2 | PEA2aA | PEBP2A1 | PEBP2A2 | PEBP2aA | PEBP2aA1runt-related transcription factor 2-HPRD,BioGRID11683913 
SPENKIAA0929 | MINT | RP1-134O19.1 | SHARPspen homolog, transcriptional regulator (Drosophila)-HPRD10451362 
ZBTB17MIZ-1 | ZNF151 | ZNF60 | pHZ-67zinc finger and BTB domain containing 17-HPRD9256341 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP 255177All SZGR genes in this pathway
PUIFFE_INVASION_INHIBITED_BY_ASCITES_DN 14591All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP 450256All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_UP 430232All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_6HR_DN 167100All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP 557331All SZGR genes in this pathway
SABATES_COLORECTAL_ADENOMA_UP 14175All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP 239157All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
RODRIGUES_NTN1_AND_DCC_TARGETS 3525All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL 326213All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_BASAL 330217All SZGR genes in this pathway
FARMER_BREAST_CANCER_CLUSTER_7 2011All SZGR genes in this pathway
YANG_BREAST_CANCER_ESR1_LASER_UP 3425All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
WILLERT_WNT_SIGNALING 2413All SZGR genes in this pathway
OKUMURA_INFLAMMATORY_RESPONSE_LPS 183115All SZGR genes in this pathway
BECKER_TAMOXIFEN_RESISTANCE_DN 5237All SZGR genes in this pathway
KANG_IMMORTALIZED_BY_TERT_DN 10267All SZGR genes in this pathway
VIETOR_IFRD1_TARGETS 2313All SZGR genes in this pathway
RAMASWAMY_METASTASIS_UP 6643All SZGR genes in this pathway
KRASNOSELSKAYA_ILF3_TARGETS_DN 4638All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_6HR_DN 160101All SZGR genes in this pathway
SU_PLACENTA 3018All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_GAMMA_AND_UV_RADIATION 8865All SZGR genes in this pathway
KYNG_DNA_DAMAGE_UP 226164All SZGR genes in this pathway
KONDO_EZH2_TARGETS 245148All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_DN 543317All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
ZAIDI_OSTEOBLAST_TRANSCRIPTION_FACTORS 1412All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
SCHRAETS_MLL_TARGETS_UP 3521All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A12 317177All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_DN 13483All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3 349234All SZGR genes in this pathway
NAKAYAMA_SOFT_TISSUE_TUMORS_PCA2_UP 8750All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 210148All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B 549316All SZGR genes in this pathway
SCHMIDT_POR_TARGETS_IN_LIMB_BUD_DN 87All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-13510961102m8hsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
miR-217128712931Ahsa-miR-217UACUGCAUCAGGAACUGAUUGGAU
miR-329102110271Ahsa-miR-329brainAACACACCUGGUUAACCUCUUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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