Summary ?
GeneID4644
SymbolMYO5A
SynonymsGS1|MYH12|MYO5|MYR12
Descriptionmyosin VA
ReferenceMIM:160777|HGNC:HGNC:7602|Ensembl:ENSG00000197535|HPRD:01179|Vega:OTTHUMG00000137383
Gene typeprotein-coding
Map location15q21
Pascal p-value0.001
Sherlock p-value0.661
Fetal beta-1.267
eGeneCaudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Frontal Cortex BA9
Myers' cis & trans
Meta
SupportINTRACELLULAR TRAFFICKING
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.humanNRC
CompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17712061chr518173266MYO5A46440.15trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SSRP10.960.95
ING10.960.95
U2AF20.950.96
HNRNPA00.950.95
HNRNPUL10.940.95
DDX230.940.95
RPIA0.940.94
ZCCHC30.940.93
SMARCB10.940.90
ZNF2120.940.94
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.74-0.89
C5orf53-0.73-0.76
AF347015.27-0.73-0.89
MT-CO2-0.72-0.88
AF347015.33-0.71-0.87
HLA-F-0.71-0.76
FXYD1-0.71-0.84
S100B-0.70-0.80
IFI27-0.69-0.82
MT-CYB-0.69-0.85

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000146microfilament motor activityNAS10448864 
GO:0000166nucleotide bindingIEA-
GO:0003774motor activityIEA-
GO:0003674molecular_functionND-
GO:0005516calmodulin bindingIEA-
GO:0005524ATP bindingIEA-
GO:0051015actin filament bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008150biological_processND-
GO:0030048actin filament-based movementNAS10448864 
GO:0006810transportNAS11980908 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043005neuron projectionNASneuron, axon, neurite, dendrite (GO term level: 5)10391919 
GO:0030426growth coneNASaxon, dendrite (GO term level: 5)10391919 
GO:0001726ruffleIDA9852149 
GO:0005813centrosomeIDA18029348 
GO:0005737cytoplasmIDA9852149 
GO:0005925focal adhesionIDA18029348 
GO:0016459myosin complexIEA-
GO:0016459myosin complexNAS9826529 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME DIABETES PATHWAYS 13391All SZGR 2.0 genes in this pathway
REACTOME INSULIN SYNTHESIS AND PROCESSING 2115All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579346All SZGR 2.0 genes in this pathway
WIKMAN ASBESTOS LUNG CANCER DN 2813All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781465All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485334All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2A DN 14184All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS A UP 191128All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584356All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B 392251All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584395All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795478All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN 382224All SZGR 2.0 genes in this pathway
MORI SMALL PRE BII LYMPHOCYTE UP 8657All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL CIS 12877All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398262All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN 309206All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475313All SZGR 2.0 genes in this pathway
LIAN LIPA TARGETS 6M 7447All SZGR 2.0 genes in this pathway
LIAN LIPA TARGETS 3M 5936All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953554All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783442All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528324All SZGR 2.0 genes in this pathway
LEIN NEURON MARKERS 6945All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN DN 353226All SZGR 2.0 genes in this pathway
ENGELMANN CANCER PROGENITORS UP 4831All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940425All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB UP 245159All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518299All SZGR 2.0 genes in this pathway
SYED ESTRADIOL RESPONSE 1915All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP 397206All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918550All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898516All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 AND SATB1 DN 180116All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.1486648721Ahsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/506489849041Ahsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-1451291361A,m8hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-1904484551A,m8hsa-miR-190UGAUAUGUUUGAUAUAUUAGGU
miR-25/32/92/363/367177117781A,m8hsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-30-5p7027091A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-539496549711Ahsa-miR-539GGAGAAAUUAUCCUUGGUGUGU