SZGR2

Summary ?

GeneID	4644
Symbol	MYO5A
Synonyms	GS1\|MYH12\|MYO5\|MYR12
Description	myosin VA
Reference	MIM:160777\|HGNC:HGNC:7602\|Ensembl:ENSG00000197535\|HPRD:01179\|Vega:OTTHUMG00000137383
Gene type	protein-coding
Map location	15q21
Pascal p-value	0.001
Sherlock p-value	0.661
Fetal beta	-1.267
eGene	Caudate basal ganglia Cerebellar Hemisphere Cerebellum Frontal Cortex BA9 Myers' cis & trans Meta
Support	INTRACELLULAR TRAFFICKING G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.humanNRC CompositeSet Darnell FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 2

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs17712061	chr5	18173266	MYO5A	4644		0.15		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
SSRP1	0.96	0.95
ING1	0.96	0.95
U2AF2	0.95	0.96
HNRNPA0	0.95	0.95
HNRNPUL1	0.94	0.95
DDX23	0.94	0.95
RPIA	0.94	0.94
ZCCHC3	0.94	0.93
SMARCB1	0.94	0.90
ZNF212	0.94	0.94

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.31	-0.74	-0.89
C5orf53	-0.73	-0.76
AF347015.27	-0.73	-0.89
MT-CO2	-0.72	-0.88
AF347015.33	-0.71	-0.87
HLA-F	-0.71	-0.76
FXYD1	-0.71	-0.84
S100B	-0.70	-0.80
IFI27	-0.69	-0.82
MT-CYB	-0.69	-0.85

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000146	microfilament motor activity	NAS		10448864
GO:0000166	nucleotide binding	IEA		-
GO:0003774	motor activity	IEA		-
GO:0003674	molecular_function	ND		-
GO:0005516	calmodulin binding	IEA		-
GO:0005524	ATP binding	IEA		-
GO:0051015	actin filament binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0008150	biological_process	ND		-
GO:0030048	actin filament-based movement	NAS		10448864
GO:0006810	transport	NAS		11980908
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0043005	neuron projection	NAS	neuron, axon, neurite, dendrite (GO term level: 5)	10391919
GO:0030426	growth cone	NAS	axon, dendrite (GO term level: 5)	10391919
GO:0001726	ruffle	IDA		9852149
GO:0005813	centrosome	IDA		18029348
GO:0005737	cytoplasm	IDA		9852149
GO:0005925	focal adhesion	IDA		18029348
GO:0016459	myosin complex	IEA		-
GO:0016459	myosin complex	NAS		9826529

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
REACTOME DIABETES PATHWAYS	133	91	All SZGR 2.0 genes in this pathway
REACTOME INSULIN SYNTHESIS AND PROCESSING	21	15	All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP	579	346	All SZGR 2.0 genes in this pathway
WIKMAN ASBESTOS LUNG CANCER DN	28	13	All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN	781	465	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN	485	334	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2A DN	141	84	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP	1142	669	All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS A UP	191	128	All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP	584	356	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B	392	251	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN	584	395	All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX	795	478	All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN	382	224	All SZGR 2.0 genes in this pathway
MORI SMALL PRE BII LYMPHOCYTE UP	86	57	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL CIS	128	77	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP	398	262	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN	309	206	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION	475	313	All SZGR 2.0 genes in this pathway
LIAN LIPA TARGETS 6M	74	47	All SZGR 2.0 genes in this pathway
LIAN LIPA TARGETS 3M	59	36	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP	953	554	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP	783	442	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1	528	324	All SZGR 2.0 genes in this pathway
LEIN NEURON MARKERS	69	45	All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN DN	353	226	All SZGR 2.0 genes in this pathway
ENGELMANN CANCER PROGENITORS UP	48	31	All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN	940	425	All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB UP	245	159	All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK	1210	725	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP	518	299	All SZGR 2.0 genes in this pathway
SYED ESTRADIOL RESPONSE	19	15	All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP	397	206	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN	918	550	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A	898	516	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE	1137	655	All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 AND SATB1 DN	180	116	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	4866	4872	1A	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124.1	4866	4872	1A	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	4898	4904	1A	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	4898	4904	1A	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-145	129	136	1A,m8	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-190	448	455	1A,m8	hsa-miR-190	UGAUAUGUUUGAUAUAUUAGGU
miR-25/32/92/363/367	1771	1778	1A,m8	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-30-5p	702	709	1A,m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-539	4965	4971	1A	hsa-miR-539	GGAGAAAUUAUCCUUGGUGUGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: MYO5A