Gene Page: NEK1

Summary ?
GeneID4750
SymbolNEK1
SynonymsNY-REN-55|SRPS2|SRPS2A|SRTD6
DescriptionNIMA related kinase 1
ReferenceMIM:604588|HGNC:HGNC:7744|Ensembl:ENSG00000137601|HPRD:06847|Vega:OTTHUMG00000160963
Gene typeprotein-coding
Map location4q33
Pascal p-value2.514E-5
Sherlock p-value0.909
Fetal beta0.414
eGeneCerebellar Hemisphere
Putamen basal ganglia
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs68495584170301682NEK1ENSG00000137601.112.65321E-60.05232098gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PHF190.850.68
SMO0.840.75
NOTCH10.840.69
SIX50.840.80
TGIF20.830.60
FBXL70.830.72
ASAP30.820.73
CRB20.820.74
JUB0.820.67
FLNA0.810.71
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FGF12-0.34-0.41
FBXW7-0.34-0.40
RALYL-0.34-0.44
FABP3-0.33-0.35
BEX5-0.33-0.37
SERPINI1-0.33-0.38
BEND6-0.32-0.32
PPEF1-0.32-0.42
CALM2-0.32-0.41
LNX1-0.32-0.40

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CSN2CASBcasein beta-HPRD1382974 
CTNNAL1CLLP | FLJ08121 | alpha-CATUcatenin (cadherin-associated protein), alpha-like 1NEK1 interacts with alpha-catulin.BIND14690447 
EXOSC4FLJ20591 | RRP41 | RRP41A | Rrp41p | SKI6 | Ski6p | hRrp41p | p12Aexosome component 4-HPRD15231747 
FEZ1-fasciculation and elongation protein zeta 1 (zygin I)NEK1 interacts with FEZ-1.BIND14690447 
FEZ2HUM3CL | MGC117372fasciculation and elongation protein zeta 2 (zygin II)NEK1 interacts with FEZ-2.BIND14690447 
KIF3A-kinesin family member 3ANEK1 interacts with KIF3A.BIND14690447 
MRE11AATLD | HNGS1 | MRE11 | MRE11BMRE11 meiotic recombination 11 homolog A (S. cerevisiae)NEK1 interacts with MRE11BIND14690447 
PPP2R5DB56D | MGC2134 | MGC8949protein phosphatase 2, regulatory subunit B', delta isoformNEK1 interacts with PP2A.BIND14690447 
TP53BP153BP1 | FLJ41424 | MGC138366 | p202tumor protein p53 binding protein 1NEK1 interacts with 53BP1.BIND14690447 
TSC2FLJ43106 | LAM | TSC4tuberous sclerosis 2NEK1 interacts with Tuberin.BIND14690447 
YWHAHYWHA1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptideNEK1 interacts with 14-3-3.BIND14690447 
ZNF350ZBRK1 | ZFQRzinc finger protein 350NEK1 interacts with ZBRK1BIND14690447 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
SA G2 AND M PHASES 87All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE DN 244147All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D DN 205127All SZGR 2.0 genes in this pathway
XU HGF TARGETS REPRESSED BY AKT1 DN 9558All SZGR 2.0 genes in this pathway
SILIGAN BOUND BY EWS FLT1 FUSION 4734All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855609All SZGR 2.0 genes in this pathway
GEORGES CELL CYCLE MIR192 TARGETS 6246All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893528All SZGR 2.0 genes in this pathway
SAKAI TUMOR INFILTRATING MONOCYTES DN 8151All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL TRANS 185114All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830547All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN 298200All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504323All SZGR 2.0 genes in this pathway
BILD CTNNB1 ONCOGENIC SIGNATURE 8252All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953554All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783442All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270181All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP 439257All SZGR 2.0 genes in this pathway
IZADPANAH STEM CELL ADIPOSE VS BONE DN 10868All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP 425253All SZGR 2.0 genes in this pathway
EHLERS ANEUPLOIDY UP 4129All SZGR 2.0 genes in this pathway
PODAR RESPONSE TO ADAPHOSTIN UP 14798All SZGR 2.0 genes in this pathway
CHEN HOXA5 TARGETS 9HR UP 223132All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491316All SZGR 2.0 genes in this pathway
QI HYPOXIA 14096All SZGR 2.0 genes in this pathway
GABRIELY MIR21 TARGETS 289187All SZGR 2.0 genes in this pathway