Gene Page: NFKBIB
Summary ?
| GeneID | 4793 |
| Symbol | NFKBIB |
| Synonyms | IKBB|TRIP9 |
| Description | NFKB inhibitor beta |
| Reference | MIM:604495|HGNC:HGNC:7798|Ensembl:ENSG00000104825|HPRD:07260|Vega:OTTHUMG00000177631 |
| Gene type | protein-coding |
| Map location | 19q13.1 |
| Pascal p-value | 0.003 |
| Sherlock p-value | 0.623 |
| eGene | Cortex |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0888 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| STAC2 | 0.68 | 0.48 |
| APOL2 | 0.67 | 0.62 |
| VAMP1 | 0.67 | 0.50 |
| SCN1B | 0.66 | 0.55 |
| SYT2 | 0.66 | 0.42 |
| LGI3 | 0.65 | 0.57 |
| CTSZ | 0.63 | 0.57 |
| KCNS1 | 0.63 | 0.38 |
| TNK2 | 0.63 | 0.55 |
| ZBTB7A | 0.63 | 0.57 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ALKBH2 | -0.38 | -0.41 |
| RBMX2 | -0.38 | -0.46 |
| EXOSC8 | -0.38 | -0.43 |
| NR2C2AP | -0.38 | -0.40 |
| TCTEX1D2 | -0.38 | -0.44 |
| C9orf46 | -0.38 | -0.45 |
| YBX1 | -0.38 | -0.43 |
| DYNLT1 | -0.38 | -0.49 |
| RARS2 | -0.37 | -0.37 |
| NKIRAS2 | -0.37 | -0.30 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004872 | receptor activity | IEA | - | |
| GO:0004871 | signal transducer activity | TAS | 7776974 | |
| GO:0003713 | transcription coactivator activity | TAS | 7776974 | |
| GO:0005515 | protein binding | IPI | 10498867 |14743216 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006350 | transcription | TAS | 7776974 | |
| GO:0007165 | signal transduction | TAS | 7776974 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005829 | cytosol | EXP | 10723127 | |
| GO:0005634 | nucleus | IEA | - | |
| GO:0005737 | cytoplasm | IEA | - |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| BTRC | BETA-TRCP | FBW1A | FBXW1 | FBXW1A | FWD1 | MGC4643 | bTrCP | bTrCP1 | betaTrCP | beta-transducin repeat containing | - | HPRD,BioGRID | 10514424 |
| CHUK | IKBKA | IKK-alpha | IKK1 | IKKA | NFKBIKA | TCF16 | conserved helix-loop-helix ubiquitous kinase | - | HPRD | 9252186 |
| DSP | DPI | DPII | desmoplakin | - | HPRD | 14743216 |
| EXOC4 | MGC27170 | REC8 | SEC8 | SEC8L1 | Sec8p | exocyst complex component 4 | - | HPRD | 14743216 |
| HSPA8 | HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71 | heat shock 70kDa protein 8 | - | HPRD | 14743216 |
| IKBKB | FLJ40509 | IKK-beta | IKK2 | IKKB | MGC131801 | NFKBIKB | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | IKK-beta phosphorylates I-kappa-B-beta. | BIND | 9346485 |
| KIF18A | DKFZp434G2226 | MS-KIF18A | kinesin family member 18A | - | HPRD | 14743216 |
| MCC | DKFZp762O1615 | FLJ38893 | FLJ46755 | MCC1 | mutated in colorectal cancers | MCC1 interacts with NFKBIB (I-kappa-B-beta). | BIND | 14743216 |
| NKIRAS1 | KBRAS1 | kappaB-Ras1 | NFKB inhibitor interacting Ras-like 1 | Affinity Capture-Western | BioGRID | 12672800 |
| POLR1A | DKFZp586M0122 | FLJ21915 | MGC87965 | RPA1 | RPO1-4 | polymerase (RNA) I polypeptide A, 194kDa | - | HPRD | 14743216 |
| POLR1D | FLJ20616 | MGC9850 | POLR1C | RPA16 | RPA9 | RPAC2 | RPO1-3 | polymerase (RNA) I polypeptide D, 16kDa | - | HPRD | 14743216 |
| POLR1E | FLJ13390 | FLJ13970 | PAF53 | PRAF1 | RP11-405L18.3 | polymerase (RNA) I polypeptide E, 53kDa | - | HPRD | 14743216 |
| POLR2E | RPABC1 | RPB5 | XAP4 | hRPB25 | hsRPB5 | polymerase (RNA) II (DNA directed) polypeptide E, 25kDa | - | HPRD | 14743216 |
| RASAL2 | MGC129919 | nGAP | RAS protein activator like 2 | - | HPRD | 14743216 |
| REL | C-Rel | v-rel reticuloendotheliosis viral oncogene homolog (avian) | Affinity Capture-Western | BioGRID | 10706725 |
| RELA | MGC131774 | NFKB3 | p65 | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | - | HPRD,BioGRID | 8816457 |12672800 |
| RELA | MGC131774 | NFKB3 | p65 | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | RelA, the p65 subunit of the NF-kappaB complex, interacts with I-kappaB-beta | BIND | 14685242 |
| RELA | MGC131774 | NFKB3 | p65 | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | I-kappa-B-beta interacts with p65. This interaction was modeled on a demonstrated interaction between mouse I-kappa-B-beta and mouse p65. | BIND | 8816457 |
| RXRA | FLJ00280 | FLJ00318 | FLJ16020 | FLJ16733 | MGC102720 | NR2B1 | retinoid X receptor, alpha | - | HPRD,BioGRID | 7776974 |9452433 |
| SRPRB | APMCF1 | signal recognition particle receptor, B subunit | - | HPRD | 14743216 |
| TIMM50 | MGC102733 | TIM50 | TIM50L | translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) | - | HPRD | 14743216 |
| TUBA3C | TUBA2 | bA408E5.3 | tubulin, alpha 3c | - | HPRD | 14743216 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG CHEMOKINE SIGNALING PATHWAY | 190 | 128 | All SZGR 2.0 genes in this pathway |
| KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY | 62 | 47 | All SZGR 2.0 genes in this pathway |
| KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY | 71 | 51 | All SZGR 2.0 genes in this pathway |
| KEGG CYTOSOLIC DNA SENSING PATHWAY | 56 | 44 | All SZGR 2.0 genes in this pathway |
| KEGG T CELL RECEPTOR SIGNALING PATHWAY | 108 | 89 | All SZGR 2.0 genes in this pathway |
| KEGG B CELL RECEPTOR SIGNALING PATHWAY | 75 | 56 | All SZGR 2.0 genes in this pathway |
| KEGG NEUROTROPHIN SIGNALING PATHWAY | 126 | 103 | All SZGR 2.0 genes in this pathway |
| KEGG ADIPOCYTOKINE SIGNALING PATHWAY | 67 | 57 | All SZGR 2.0 genes in this pathway |
| KEGG LEISHMANIA INFECTION | 72 | 56 | All SZGR 2.0 genes in this pathway |
| BIOCARTA P53HYPOXIA PATHWAY | 23 | 21 | All SZGR 2.0 genes in this pathway |
| ST TUMOR NECROSIS FACTOR PATHWAY | 29 | 20 | All SZGR 2.0 genes in this pathway |
| SIG CD40PATHWAYMAP | 34 | 28 | All SZGR 2.0 genes in this pathway |
| ST GAQ PATHWAY | 28 | 22 | All SZGR 2.0 genes in this pathway |
| ST GA13 PATHWAY | 37 | 32 | All SZGR 2.0 genes in this pathway |
| ST T CELL SIGNAL TRANSDUCTION | 45 | 33 | All SZGR 2.0 genes in this pathway |
| ST B CELL ANTIGEN RECEPTOR | 40 | 32 | All SZGR 2.0 genes in this pathway |
| ST FAS SIGNALING PATHWAY | 65 | 54 | All SZGR 2.0 genes in this pathway |
| PID BCR 5PATHWAY | 65 | 50 | All SZGR 2.0 genes in this pathway |
| REACTOME TRIF MEDIATED TLR3 SIGNALING | 74 | 54 | All SZGR 2.0 genes in this pathway |
| REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | 18 | 15 | All SZGR 2.0 genes in this pathway |
| REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR | 97 | 66 | All SZGR 2.0 genes in this pathway |
| REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | 64 | 43 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY THE B CELL RECEPTOR BCR | 126 | 90 | All SZGR 2.0 genes in this pathway |
| REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX | 23 | 17 | All SZGR 2.0 genes in this pathway |
| REACTOME TRAF6 MEDIATED NFKB ACTIVATION | 21 | 17 | All SZGR 2.0 genes in this pathway |
| REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION | 77 | 57 | All SZGR 2.0 genes in this pathway |
| REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE | 72 | 53 | All SZGR 2.0 genes in this pathway |
| REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS | 73 | 57 | All SZGR 2.0 genes in this pathway |
| REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE | 83 | 63 | All SZGR 2.0 genes in this pathway |
| REACTOME INNATE IMMUNE SYSTEM | 279 | 178 | All SZGR 2.0 genes in this pathway |
| REACTOME ACTIVATED TLR4 SIGNALLING | 93 | 69 | All SZGR 2.0 genes in this pathway |
| REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
| REACTOME TOLL RECEPTOR CASCADES | 118 | 84 | All SZGR 2.0 genes in this pathway |
| REACTOME ADAPTIVE IMMUNE SYSTEM | 539 | 350 | All SZGR 2.0 genes in this pathway |
| GILMORE CORE NFKB PATHWAY | 14 | 10 | All SZGR 2.0 genes in this pathway |
| SCHEIDEREIT IKK TARGETS | 18 | 15 | All SZGR 2.0 genes in this pathway |
| RASHI RESPONSE TO IONIZING RADIATION 2 | 127 | 92 | All SZGR 2.0 genes in this pathway |
| RASHI NFKB1 TARGETS | 19 | 18 | All SZGR 2.0 genes in this pathway |
| WEI MYCN TARGETS WITH E BOX | 795 | 478 | All SZGR 2.0 genes in this pathway |
| LIAO METASTASIS | 539 | 324 | All SZGR 2.0 genes in this pathway |
| BENPORATH MYC MAX TARGETS | 775 | 494 | All SZGR 2.0 genes in this pathway |
| SHIN B CELL LYMPHOMA CLUSTER 8 | 36 | 28 | All SZGR 2.0 genes in this pathway |
| RADMACHER AML PROGNOSIS | 78 | 52 | All SZGR 2.0 genes in this pathway |
| TOYOTA TARGETS OF MIR34B AND MIR34C | 463 | 262 | All SZGR 2.0 genes in this pathway |
| MUELLER PLURINET | 299 | 189 | All SZGR 2.0 genes in this pathway |
| MARSHALL VIRAL INFECTION RESPONSE DN | 29 | 21 | All SZGR 2.0 genes in this pathway |
| AGUIRRE PANCREATIC CANCER COPY NUMBER UP | 298 | 174 | All SZGR 2.0 genes in this pathway |
| DANG BOUND BY MYC | 1103 | 714 | All SZGR 2.0 genes in this pathway |
| GOBERT OLIGODENDROCYTE DIFFERENTIATION DN | 1080 | 713 | All SZGR 2.0 genes in this pathway |