Gene Page: NFKBIB

Summary
GeneID  4793
Symbol  NFKBIB
Synonyms  IKBB|TRIP9
Description  nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
See related  HGNC:7798|MIM:604495|Ensembl:ENSG00000104825|HPRD:07260|
Locus tag  -
Gene type  protein-coding
Map location  19q13.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0888 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
STAC20.680.48
APOL20.670.62
VAMP10.670.50
SCN1B0.660.55
SYT20.660.42
LGI30.650.57
CTSZ0.630.57
KCNS10.630.38
TNK20.630.55
ZBTB7A0.630.57
Top 10 negatively co-expressed genes
ALKBH2-0.38-0.41
RBMX2-0.38-0.46
EXOSC8-0.38-0.43
NR2C2AP-0.38-0.40
TCTEX1D2-0.38-0.44
C9orf46-0.38-0.45
YBX1-0.38-0.43
DYNLT1-0.38-0.49
RARS2-0.37-0.37
NKIRAS2-0.37-0.30
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0004871signal transducer activityTAS7776974 
GO:0003713transcription coactivator activityTAS7776974 
GO:0005515protein bindingIPI10498867 |14743216 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006350transcriptionTAS7776974 
GO:0007165signal transductionTAS7776974 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP10723127 
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BTRCBETA-TRCP | FBW1A | FBXW1 | FBXW1A | FWD1 | MGC4643 | bTrCP | bTrCP1 | betaTrCPbeta-transducin repeat containing-HPRD,BioGRID10514424 
CHUKIKBKA | IKK-alpha | IKK1 | IKKA | NFKBIKA | TCF16conserved helix-loop-helix ubiquitous kinase-HPRD9252186 
DSPDPI | DPIIdesmoplakin-HPRD14743216 
EXOC4MGC27170 | REC8 | SEC8 | SEC8L1 | Sec8pexocyst complex component 4-HPRD14743216 
HSPA8HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71heat shock 70kDa protein 8-HPRD14743216 
IKBKBFLJ40509 | IKK-beta | IKK2 | IKKB | MGC131801 | NFKBIKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase betaIKK-beta phosphorylates I-kappa-B-beta.BIND9346485 
KIF18ADKFZp434G2226 | MS-KIF18Akinesin family member 18A-HPRD14743216 
MCCDKFZp762O1615 | FLJ38893 | FLJ46755 | MCC1mutated in colorectal cancersMCC1 interacts with NFKBIB (I-kappa-B-beta).BIND14743216 
NKIRAS1KBRAS1 | kappaB-Ras1NFKB inhibitor interacting Ras-like 1Affinity Capture-WesternBioGRID12672800 
POLR1ADKFZp586M0122 | FLJ21915 | MGC87965 | RPA1 | RPO1-4polymerase (RNA) I polypeptide A, 194kDa-HPRD14743216 
POLR1DFLJ20616 | MGC9850 | POLR1C | RPA16 | RPA9 | RPAC2 | RPO1-3polymerase (RNA) I polypeptide D, 16kDa-HPRD14743216 
POLR1EFLJ13390 | FLJ13970 | PAF53 | PRAF1 | RP11-405L18.3polymerase (RNA) I polypeptide E, 53kDa-HPRD14743216 
POLR2ERPABC1 | RPB5 | XAP4 | hRPB25 | hsRPB5polymerase (RNA) II (DNA directed) polypeptide E, 25kDa-HPRD14743216 
RASAL2MGC129919 | nGAPRAS protein activator like 2-HPRD14743216 
RELC-Relv-rel reticuloendotheliosis viral oncogene homolog (avian)Affinity Capture-WesternBioGRID10706725 
RELAMGC131774 | NFKB3 | p65v-rel reticuloendotheliosis viral oncogene homolog A (avian)-HPRD,BioGRID8816457 |12672800 
RelA, the p65 subunit of the NF-kappaB complex, interacts with I-kappaB-betaBIND14685242 
I-kappa-B-beta interacts with p65. This interaction was modeled on a demonstrated interaction between mouse I-kappa-B-beta and mouse p65.BIND8816457 
RXRAFLJ00280 | FLJ00318 | FLJ16020 | FLJ16733 | MGC102720 | NR2B1retinoid X receptor, alpha-HPRD,BioGRID7776974 |9452433 
SRPRBAPMCF1signal recognition particle receptor, B subunit-HPRD14743216 
TIMM50MGC102733 | TIM50 | TIM50Ltranslocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)-HPRD14743216 
TUBA3CTUBA2 | bA408E5.3tubulin, alpha 3c-HPRD14743216 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CHEMOKINE_SIGNALING_PATHWAY 190128All SZGR genes in this pathway
KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 6247All SZGR genes in this pathway
KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY 7151All SZGR genes in this pathway
KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY 5644All SZGR genes in this pathway
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 10889All SZGR genes in this pathway
KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY 7556All SZGR genes in this pathway
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 126103All SZGR genes in this pathway
KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY 6757All SZGR genes in this pathway
KEGG_LEISHMANIA_INFECTION 7256All SZGR genes in this pathway
BIOCARTA_P53HYPOXIA_PATHWAY 2321All SZGR genes in this pathway
ST_TUMOR_NECROSIS_FACTOR_PATHWAY 2920All SZGR genes in this pathway
SIG_CD40PATHWAYMAP 3428All SZGR genes in this pathway
ST_GAQ_PATHWAY 2822All SZGR genes in this pathway
ST_GA13_PATHWAY 3732All SZGR genes in this pathway
ST_T_CELL_SIGNAL_TRANSDUCTION 4533All SZGR genes in this pathway
ST_B_CELL_ANTIGEN_RECEPTOR 4032All SZGR genes in this pathway
ST_FAS_SIGNALING_PATHWAY 6554All SZGR genes in this pathway
PID_BCR_5PATHWAY 6550All SZGR genes in this pathway
REACTOME_TRIF_MEDIATED_TLR3_SIGNALING 7454All SZGR genes in this pathway
REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI 1815All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR 9766All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS 6443All SZGR genes in this pathway
REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 12690All SZGR genes in this pathway
REACTOME_TAK1_ACTIVATES_NFKB_BY_PHOSPHORYLATION_AND_ACTIVATION_OF_IKKS_COMPLEX 2317All SZGR genes in this pathway
REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION 2117All SZGR genes in this pathway
REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION 7757All SZGR genes in this pathway
REACTOME_NFKB_AND_MAP_KINASES_ACTIVATION_MEDIATED_BY_TLR4_SIGNALING_REPERTOIRE 7253All SZGR genes in this pathway
REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS 7357All SZGR genes in this pathway
REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE 8363All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_ACTIVATED_TLR4_SIGNALLING 9369All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_TOLL_RECEPTOR_CASCADES 11884All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
GILMORE_CORE_NFKB_PATHWAY 1410All SZGR genes in this pathway
SCHEIDEREIT_IKK_TARGETS 1815All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_2 12792All SZGR genes in this pathway
RASHI_NFKB1_TARGETS 1918All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
LIAO_METASTASIS 539324All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
SHIN_B_CELL_LYMPHOMA_CLUSTER_8 3628All SZGR genes in this pathway
RADMACHER_AML_PROGNOSIS 7852All SZGR genes in this pathway
TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C 463262All SZGR genes in this pathway
MUELLER_PLURINET 299189All SZGR genes in this pathway
MARSHALL_VIRAL_INFECTION_RESPONSE_DN 2921All SZGR genes in this pathway
AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_UP 298174All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway


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