Gene Page: NPM1

Summary ?
GeneID4869
SymbolNPM1
SynonymsB23|NPM
Descriptionnucleophosmin (nucleolar phosphoprotein B23, numatrin)
ReferenceMIM:164040|HGNC:HGNC:7910|Ensembl:ENSG00000181163|HPRD:01246|Vega:OTTHUMG00000130465
Gene typeprotein-coding
Map location5q35.1
Pascal p-value0.045
Sherlock p-value0.318
SupportG2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.0276 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0597 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ITPKA0.900.92
GRASP0.850.91
CAMK2N10.840.77
MYPOP0.830.75
NECAB30.800.65
ASPHD10.800.88
TMEM38A0.800.88
CACNA1F0.800.85
DDN0.800.93
FAM131A0.800.77
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FADS2-0.55-0.64
KIAA1949-0.53-0.61
TUBB2B-0.53-0.68
GPR125-0.52-0.57
TIGD1-0.51-0.61
SH3BP2-0.51-0.66
IDH1-0.50-0.63
SEMA4B-0.50-0.60
ZNF193-0.50-0.60
AF186192.1-0.50-0.67

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003676nucleic acid bindingIEA-
GO:0003713transcription coactivator activityIDA15087454 
GO:0003723RNA bindingTAS9121481 
GO:0051082unfolded protein bindingIDA10211837 
GO:0051082unfolded protein bindingISS-
GO:0051059NF-kappaB bindingIDA15087454 
GO:0051059NF-kappaB bindingISS-
GO:0030957Tat protein bindingIDA9094689 
GO:0042803protein homodimerization activityIDA9121481 
GO:0046982protein heterodimerization activityIMP12080348 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006950response to stressIMP12080348 
GO:0007165signal transductionTAS16130169 
GO:0007098centrosome cycleIMP11051553 
GO:0007098centrosome cycleISS-
GO:0008285negative regulation of cell proliferationIMP12080348 
GO:0008285negative regulation of cell proliferationISS-
GO:0007569cell agingIMP12080348 
GO:0007569cell agingISS-
GO:0006916anti-apoptosisTAS16130169 
GO:0006913nucleocytoplasmic transportTAS12080348 
GO:0006886intracellular protein transportTAS12080348 
GO:0042255ribosome assemblyTAS12080348 
GO:0051092positive regulation of NF-kappaB transcription factor activityIMP15087454 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005813centrosomeIDA11051553 
GO:0005813centrosomeISS-
GO:0005634nucleusIDA12080348 
GO:0005634nucleusISS-
GO:0005634nucleusTAS16130169 
GO:0005730nucleolusIDA12080348 |17475909 
GO:0005737cytoplasmIDA9121481 
GO:0005737cytoplasmISS-
GO:0005737cytoplasmTAS16130169 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ALKCD246 | Ki-1 | TFG/ALKanaplastic lymphoma receptor tyrosine kinase-HPRD11888936 
ARF1-ADP-ribosylation factor 1-HPRD14636574 |15684379 
BARD1-BRCA1 associated RING domain 1Affinity Capture-MS
Affinity Capture-Western
Reconstituted Complex		BioGRID15184379 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onsetAffinity Capture-MS
Affinity Capture-Western
Reconstituted Complex		BioGRID15184379 
EIF2AK2EIF2AK1 | MGC126524 | PKR | PRKReukaryotic translation initiation factor 2-alpha kinase 2-HPRD12882984 
GADD45ADDIT1 | GADD45growth arrest and DNA-damage-inducible, alpha-HPRD15644315 
HAND2DHAND2 | FLJ16260 | Hed | MGC125303 | MGC125304 | Thing2 | bHLHa26 | dHandheart and neural crest derivatives expressed 2-HPRD,BioGRID11812799 
HIST3H3H3.4 | H3/g | H3FT | H3t | MGC126886 | MGC126888histone cluster 3, H3-HPRD,BioGRID11602260 
LYARFLJ20425 | ZLYARLy1 antibody reactive homolog (mouse)Affinity Capture-MSBioGRID17353931 
MAP3K14FTDCR1B | HS | HSNIK | NIKmitogen-activated protein kinase kinase kinase 14-HPRD14743216 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)Myc interacts with NPM1 (B23)BIND15944709 
NCLC23 | FLJ45706nucleolin-HPRD,BioGRID8620867 |10503877 
NOP2MGC117384 | MGC149287 | MGC149288 | NOL1 | NOP120 | NSUN1 | p120NOP2 nucleolar protein homolog (yeast)-HPRD8089149 
PLK1PLK | STPK13polo-like kinase 1 (Drosophila)-HPRD15190079 
RELAMGC131774 | NFKB3 | p65v-rel reticuloendotheliosis viral oncogene homolog A (avian)-HPRD14743216 
SFRS12DKFZp564B176 | MGC133045 | SRrp508 | SRrp86splicing factor, arginine/serine-rich 12-HPRD14559993 
SWAP70FLJ39540 | HSPC321 | KIAA0640 | SWAP-70SWAP-70 protein-HPRD,BioGRID9642267 
TCERG1CA150 | MGC133200 | TAF2Stranscription elongation regulator 1-HPRD,BioGRID15456888 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53-HPRD12080348 
USF2FIP | bHLHb12upstream transcription factor 2, c-fos interactingAffinity Capture-MSBioGRID17353931 
XPO1CRM1 | DKFZp686B1823exportin 1 (CRM1 homolog, yeast)An unspecified isoform of NPM1 (NPM) interacts with XPO1 (CRM1).BIND16041368 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID AURORA B PATHWAY 3924All SZGR 2.0 genes in this pathway
PID MYC ACTIV PATHWAY 7962All SZGR 2.0 genes in this pathway
PID HIF1 TFPATHWAY 6652All SZGR 2.0 genes in this pathway
PID BARD1 PATHWAY 2919All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421253All SZGR 2.0 genes in this pathway
REACTOME CHROMOSOME MAINTENANCE 12280All SZGR 2.0 genes in this pathway
REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 6443All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION 207122All SZGR 2.0 genes in this pathway
REACTOME HOST INTERACTIONS OF HIV FACTORS 13281All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526357All SZGR 2.0 genes in this pathway
CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 UP 14686All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663425All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP 430232All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN 362238All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 DN 242165All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 DN 281186All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE UP 204140All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633376All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722443All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 DN 229142All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
CAIRO PML TARGETS BOUND BY MYC UP 2317All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584356All SZGR 2.0 genes in this pathway
SEIDEN ONCOGENESIS BY MET 8853All SZGR 2.0 genes in this pathway
MYLLYKANGAS AMPLIFICATION HOT SPOT 27 158All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747453All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE 217143All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479299All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK 10173All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779480All SZGR 2.0 genes in this pathway
GARCIA TARGETS OF FLI1 AND DAX1 DN 176104All SZGR 2.0 genes in this pathway
DEN INTERACT WITH LCA5 2621All SZGR 2.0 genes in this pathway
BENPORATH ES 1 379235All SZGR 2.0 genes in this pathway
PARK HSC VS MULTIPOTENT PROGENITORS DN 1812All SZGR 2.0 genes in this pathway
MENSSEN MYC TARGETS 5335All SZGR 2.0 genes in this pathway
BHATTACHARYA EMBRYONIC STEM CELL 8960All SZGR 2.0 genes in this pathway
BROWN MYELOID CELL DEVELOPMENT DN 12986All SZGR 2.0 genes in this pathway
HU GENOTOXIN ACTION DIRECT VS INDIRECT 24HR 5538All SZGR 2.0 genes in this pathway
JIANG VHL TARGETS 13891All SZGR 2.0 genes in this pathway
ZHU CMV ALL UP 12089All SZGR 2.0 genes in this pathway
ZHU CMV 24 HR UP 9365All SZGR 2.0 genes in this pathway
BILD MYC ONCOGENIC SIGNATURE 206117All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND FIBROBLAST 13293All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS DN 12081All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP 285167All SZGR 2.0 genes in this pathway
CHNG MULTIPLE MYELOMA HYPERPLOID UP 5225All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299189All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374247All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323240All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL DN 175103All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389245All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518299All SZGR 2.0 genes in this pathway
IRITANI MAD1 TARGETS DN 4730All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE DN 18197All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605377All SZGR 2.0 genes in this pathway
DANG MYC TARGETS UP 143100All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
WU APOPTOSIS BY CDKN1A VIA TP53 5531All SZGR 2.0 genes in this pathway
BAE BRCA1 TARGETS DN 3227All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE DN 10367All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517302All SZGR 2.0 genes in this pathway