Gene Page: OAS3

Summary ?
GeneID4940
SymbolOAS3
Synonymsp100|p100OAS
Description2'-5'-oligoadenylate synthetase 3
ReferenceMIM:603351|HGNC:HGNC:8088|Ensembl:ENSG00000111331|HPRD:04519|Vega:OTTHUMG00000169795
Gene typeprotein-coding
Map location12q24.2
Pascal p-value0.21
Fetal beta-0.277
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg1645850712113376293OAS37.91E-5-0.320.025DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17092900chr173003409OAS349400trans
rs12091025chr1149989802OAS349400.08trans
rs11205098chr1152717431OAS349400.02trans
rs4595321chr1232382509OAS349400.07trans
rs4311833chr1232382629OAS349400.15trans
snp_a-21429220OAS349400.13trans
rs12328584chr260069938OAS349400.03trans
rs9653546chr260098315OAS349400.11trans
rs1900263chr280376061OAS349404.503E-4trans
rs10496239chr280376968OAS349404.503E-4trans
rs11679783chr280377391OAS349404.503E-4trans
rs17018721chr280385148OAS349400trans
rs2862022chr280388509OAS349404.503E-4trans
rs17043176chr2114025371OAS349400.11trans
rs7612673chr3154499328OAS349400trans
rs17071241chr4182295874OAS349400.18trans
rs159171chr521186325OAS349400.02trans
rs1678893chr531763244OAS349406.959E-4trans
snp_a-22745050OAS349400trans
rs6895909chr5119669742OAS349400.13trans
rs13176869chr5179203478OAS349400trans
rs13362722chr66171044OAS349400.11trans
rs9396602chr615766500OAS349400.04trans
rs16883826chr691671158OAS349400.04trans
rs9397692chr6154487314OAS349400trans
rs10485060chr6154516100OAS349400.04trans
rs9384190chr6154524473OAS349400.01trans
rs17292544chr6154544809OAS349408.001E-5trans
rs17160749chr777689922OAS349400.04trans
rs3779321chr777691378OAS349400.04trans
rs11974883chr778068523OAS349400.04trans
rs6943724chr786977647OAS349400.16trans
rs6586742chr818208340OAS349400.17trans
rs6994367chr858489813OAS349400.02trans
rs16922399chr858514611OAS349400.02trans
rs6994006chr858584893OAS349400.02trans
rs10283729chr92981636OAS349400.06trans
rs12349278chr923523816OAS349400.02trans
rs10833144chr1119656451OAS349400.02trans
rs12296937chr1281494251OAS349400.1trans
rs11067420chr12115559121OAS349400.19trans
rs17061055chr1340835399OAS349402.554E-4trans
rs17066364chr1345515988OAS349405.331E-4trans
rs3783149chr1345582764OAS349400.09trans
rs7332969chr1345612902OAS349405.331E-4trans
rs16955413chr1529677652OAS349405.018E-5trans
rs16955238chr1681415690OAS349400.1trans
rs16955255chr1681420130OAS349400trans
rs16955259chr1681420188OAS349400.1trans
rs17701187chr1715256066OAS349400.18trans
rs7214294chr1755329212OAS349400.08trans
rs16979927chr2055019249OAS349402.37E-7trans
rs17347454chrX23347700OAS349407.353E-6trans
rs5952435chrX47321870OAS349400.17trans
rs64183660OAS349400.08trans
snp_a-19988820OAS349400.05trans
rs16982879chrX92924110OAS349400.07trans
rs689365chrX97074769OAS349400.05trans
rs108561330OAS349400.11trans
rs16995164chrX148536507OAS349400.01trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME INTERFERON GAMMA SIGNALING 6348All SZGR 2.0 genes in this pathway
REACTOME INTERFERON ALPHA BETA SIGNALING 6450All SZGR 2.0 genes in this pathway
REACTOME INTERFERON SIGNALING 159116All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270204All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463290All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP 182110All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D UP 15791All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP 194122All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D UP 175108All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431237All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552347All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
SHIRAISHI PLZF TARGETS UP 105All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER CLUSTER 1 4423All SZGR 2.0 genes in this pathway
XU HGF TARGETS INDUCED BY AKT1 6HR 198All SZGR 2.0 genes in this pathway
XU AKT1 TARGETS 6HR 2718All SZGR 2.0 genes in this pathway
DAUER STAT3 TARGETS DN 5034All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584395All SZGR 2.0 genes in this pathway
GROSS ELK3 TARGETS DN 3217All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464276All SZGR 2.0 genes in this pathway
SANA TNF SIGNALING UP 8356All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN 371218All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS DN 314188All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE UP 15692All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270181All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO RADIATION THERAPY 3220All SZGR 2.0 genes in this pathway
ZHANG INTERFERON RESPONSE 2314All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN 442275All SZGR 2.0 genes in this pathway
MIKKELSEN IPS LCP WITH H3K4ME3 174100All SZGR 2.0 genes in this pathway
TSAI DNAJB4 TARGETS UP 138All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA MS DN 4624All SZGR 2.0 genes in this pathway
STAMBOLSKY TARGETS OF MUTATED TP53 DN 5024All SZGR 2.0 genes in this pathway
BOSCO INTERFERON INDUCED ANTIVIRAL MODULE 7848All SZGR 2.0 genes in this pathway
ALTEMEIER RESPONSE TO LPS WITH MECHANICAL VENTILATION 12881All SZGR 2.0 genes in this pathway
HECKER IFNB1 TARGETS 9554All SZGR 2.0 genes in this pathway