Gene Page: ATP5A1

Summary
GeneID  498
Symbol  ATP5A1
Synonyms  ATP5A|ATP5AL2|ATPM|MOM2|OMR|ORM|hATP1
Description  ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
See related  HGNC:823|MIM:164360|Ensembl:ENSG00000152234|HPRD:01258|
Locus tag  -
Gene type  protein-coding
Map location  18q12-q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
DOCK10.830.78
MYO60.810.78
ACSS30.800.78
PPAP2B0.800.82
PPARA0.800.76
BMPR1B0.800.72
ALDH6A10.790.76
ATP13A40.790.67
MYO100.790.74
MSI20.780.79
Top 10 negatively co-expressed genes
SLC26A4-0.44-0.46
AC011491.1-0.38-0.36
FAM19A1-0.37-0.33
AC093307.1-0.36-0.30
RTN4RL1-0.35-0.28
TTC9B-0.35-0.37
GNRHR-0.34-0.34
NANOS3-0.34-0.35
ARHGAP20-0.34-0.27
RTN2-0.33-0.31
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIPI11410595 
GO:0005524ATP bindingIEA-
GO:0016820hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substancesIEA-
GO:0005215transporter activityNAS1830491 
GO:0016887ATPase activityIDA12110673 
GO:0042288MHC class I protein bindingIDA17643490 
GO:0043499eukaryotic cell surface bindingIDA10077593 
GO:0046933hydrogen ion transporting ATP synthase activity, rotational mechanismIEA-
GO:0046872metal ion bindingIEA-
GO:0046961hydrogen ion transporting ATPase activity, rotational mechanismIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001937negative regulation of endothelial cell proliferationIMP10077593 
GO:0006811ion transportIEA-
GO:0015992proton transportIEA-
GO:0015986ATP synthesis coupled proton transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005739mitochondrionTAS1830491 
GO:0005753mitochondrial proton-transporting ATP synthase complexIDA12110673 
GO:0005759mitochondrial matrixEXP4517936 
GO:0005886plasma membraneIDA10077593 
GO:0016469proton-transporting two-sector ATPase complexIEA-
GO:0045261proton-transporting ATP synthase complex, catalytic core F(1)IEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATPAF2ATP12 | ATP12p | LP3663 | MGC29736ATP synthase mitochondrial F1 complex assembly factor 2-HPRD,BioGRID11410595 
MAP3K14FTDCR1B | HS | HSNIK | NIKmitogen-activated protein kinase kinase kinase 14-HPRD14743216 
MAP3K3MAPKKK3 | MEKK3mitogen-activated protein kinase kinase kinase 3-HPRD14743216 
RELAMGC131774 | NFKB3 | p65v-rel reticuloendotheliosis viral oncogene homolog A (avian)-HPRD14743216 
TBK1FLJ11330 | NAK | T2KTANK-binding kinase 1-HPRD14743216 
TNFRSF1ACD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60tumor necrosis factor receptor superfamily, member 1A-HPRD14743216 
TNFRSF1BCD120b | TBPII | TNF-R-II | TNF-R75 | TNFBR | TNFR1B | TNFR2 | TNFR80 | p75 | p75TNFRtumor necrosis factor receptor superfamily, member 1B-HPRD14743216 
YWHAG14-3-3GAMMAtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide-HPRD15324660 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_OXIDATIVE_PHOSPHORYLATION 13573All SZGR genes in this pathway
KEGG_ALZHEIMERS_DISEASE 169110All SZGR genes in this pathway
KEGG_PARKINSONS_DISEASE 13378All SZGR genes in this pathway
KEGG_HUNTINGTONS_DISEASE 185109All SZGR genes in this pathway
BIOCARTA_ETC_PATHWAY 127All SZGR genes in this pathway
REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT 14185All SZGR genes in this pathway
REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT 5824All SZGR genes in this pathway
REACTOME_METABOLISM_OF_PROTEINS 518242All SZGR genes in this pathway
REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ 9856All SZGR genes in this pathway
REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING 169All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP 305185All SZGR genes in this pathway
DITTMER_PTHLH_TARGETS_UP 11268All SZGR genes in this pathway
ODONNELL_TFRC_TARGETS_UP 456228All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_5_6WK_DN 13797All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_6_7WK_UP 197135All SZGR genes in this pathway
LUI_THYROID_CANCER_PAX8_PPARG_DN 4529All SZGR genes in this pathway
CHOI_ATL_STAGE_PREDICTOR 4424All SZGR genes in this pathway
LUI_THYROID_CANCER_CLUSTER_3 2816All SZGR genes in this pathway
LUI_TARGETS_OF_PAX8_PPARG_FUSION 3423All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_UP 236139All SZGR genes in this pathway
NING_CHRONIC_OBSTRUCTIVE_PULMONARY_DISEASE_DN 12179All SZGR genes in this pathway
SANA_TNF_SIGNALING_DN 9057All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 151100All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
SASAKI_ADULT_T_CELL_LEUKEMIA 176122All SZGR genes in this pathway
CROMER_METASTASIS_DN 8158All SZGR genes in this pathway
LU_AGING_BRAIN_DN 153120All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_NO_BLOOD_DN 15093All SZGR genes in this pathway
JI_RESPONSE_TO_FSH_DN 5843All SZGR genes in this pathway
KAYO_AGING_MUSCLE_DN 12376All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_DN 14588All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_DN 261183All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_SCC_UP 12375All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_UP 374247All SZGR genes in this pathway
MOOTHA_PGC 420269All SZGR genes in this pathway
AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_DN 238145All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
PHESSE_TARGETS_OF_APC_AND_MBD2_UP 2014All SZGR genes in this pathway
BILANGES_RAPAMYCIN_SENSITIVE_VIA_TSC1_AND_TSC2 7337All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-493-5p9399m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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