SZGR2

Summary ?

GeneID	498
Symbol	ATP5A1
Synonyms	ATP5A\|ATP5AL2\|ATPM\|COXPD22\|HEL-S-123m\|MC5DN4\|MOM2\|OMR\|ORM\|hATP1
Description	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
Reference	MIM:164360\|HGNC:HGNC:823\|Ensembl:ENSG00000152234\|HPRD:01258\|Vega:OTTHUMG00000132637
Gene type	protein-coding
Map location	18q21
Pascal p-value	0.275
Sherlock p-value	0.407
Fetal beta	0.711
eGene	Meta
Support	G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.human_clathrin G2Cdb.human_mitochondria G2Cdb.human_Synaptosome G2Cdb.human_TAP-PSD-95-CORE G2Cdb.humanNRC G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet Darnell FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
DOCK1	0.83	0.78
MYO6	0.81	0.78
ACSS3	0.80	0.78
PPAP2B	0.80	0.82
PPARA	0.80	0.76
BMPR1B	0.80	0.72
ALDH6A1	0.79	0.76
ATP13A4	0.79	0.67
MYO10	0.79	0.74
MSI2	0.78	0.79

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
SLC26A4	-0.44	-0.46
AC011491.1	-0.38	-0.36
FAM19A1	-0.37	-0.33
AC093307.1	-0.36	-0.30
RTN4RL1	-0.35	-0.28
TTC9B	-0.35	-0.37
GNRHR	-0.34	-0.34
NANOS3	-0.34	-0.35
ARHGAP20	-0.34	-0.27
RTN2	-0.33	-0.31

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0005515	protein binding	IPI		11410595
GO:0005524	ATP binding	IEA		-
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	IEA		-
GO:0005215	transporter activity	NAS		1830491
GO:0016887	ATPase activity	IDA		12110673
GO:0042288	MHC class I protein binding	IDA		17643490
GO:0043499	eukaryotic cell surface binding	IDA		10077593
GO:0046933	hydrogen ion transporting ATP synthase activity, rotational mechanism	IEA		-
GO:0046872	metal ion binding	IEA		-
GO:0046961	hydrogen ion transporting ATPase activity, rotational mechanism	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0001937	negative regulation of endothelial cell proliferation	IMP		10077593
GO:0006811	ion transport	IEA		-
GO:0015992	proton transport	IEA		-
GO:0015986	ATP synthesis coupled proton transport	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005739	mitochondrion	TAS		1830491
GO:0005753	mitochondrial proton-transporting ATP synthase complex	IDA		12110673
GO:0005759	mitochondrial matrix	EXP		4517936
GO:0005886	plasma membrane	IDA		10077593
GO:0016469	proton-transporting two-sector ATPase complex	IEA		-
GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG OXIDATIVE PHOSPHORYLATION	135	73	All SZGR 2.0 genes in this pathway
KEGG ALZHEIMERS DISEASE	169	110	All SZGR 2.0 genes in this pathway
KEGG PARKINSONS DISEASE	133	78	All SZGR 2.0 genes in this pathway
KEGG HUNTINGTONS DISEASE	185	109	All SZGR 2.0 genes in this pathway
BIOCARTA ETC PATHWAY	12	7	All SZGR 2.0 genes in this pathway
REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT	141	85	All SZGR 2.0 genes in this pathway
REACTOME MITOCHONDRIAL PROTEIN IMPORT	58	24	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS	518	242	All SZGR 2.0 genes in this pathway
REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	98	56	All SZGR 2.0 genes in this pathway
REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	16	9	All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP	305	185	All SZGR 2.0 genes in this pathway
DITTMER PTHLH TARGETS UP	112	68	All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS UP	456	228	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP	530	342	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 5 6WK DN	137	97	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 6 7WK UP	197	135	All SZGR 2.0 genes in this pathway
LUI THYROID CANCER PAX8 PPARG DN	45	29	All SZGR 2.0 genes in this pathway
CHOI ATL STAGE PREDICTOR	44	24	All SZGR 2.0 genes in this pathway
LUI THYROID CANCER CLUSTER 3	28	16	All SZGR 2.0 genes in this pathway
LUI TARGETS OF PAX8 PPARG FUSION	34	23	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP	236	139	All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE DN	121	79	All SZGR 2.0 genes in this pathway
SANA TNF SIGNALING DN	90	57	All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT OK VS DONOR UP	151	100	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN	546	351	All SZGR 2.0 genes in this pathway
SASAKI ADULT T CELL LEUKEMIA	176	122	All SZGR 2.0 genes in this pathway
CROMER METASTASIS DN	81	58	All SZGR 2.0 genes in this pathway
LU AGING BRAIN DN	153	120	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY NO BLOOD DN	150	93	All SZGR 2.0 genes in this pathway
JI RESPONSE TO FSH DN	58	43	All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE DN	123	76	All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY DN	145	88	All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE DN	261	183	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC UP	123	75	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN	540	340	All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP	374	247	All SZGR 2.0 genes in this pathway
MOOTHA PGC	420	269	All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER DN	238	145	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
PHESSE TARGETS OF APC AND MBD2 UP	20	14	All SZGR 2.0 genes in this pathway
BILANGES RAPAMYCIN SENSITIVE VIA TSC1 AND TSC2	73	37	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP	682	433	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-493-5p	93	99	m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: ATP5A1