Summary ?
GeneID5021
SymbolOXTR
SynonymsOT-R
Descriptionoxytocin receptor
ReferenceMIM:167055|HGNC:HGNC:8529|Ensembl:ENSG00000180914|HPRD:01328|Vega:OTTHUMG00000090537
Gene typeprotein-coding
Map location3p25
Pascal p-value0.622
Sherlock p-value0.074
Fetal beta-0.156
eGeneCaudate basal ganglia
Cerebellar Hemisphere
Hypothalamus
Nucleus accumbens basal ganglia
Putamen basal ganglia
Myers' cis & trans
Meta
SupportPotential synaptic genes

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
ExpressionMeta-analysis of gene expressionP value: 1.48 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs591585chr443424979OXTR50210.09trans
rs9405470chr61363889OXTR50210.18trans
rs9392285chr61365265OXTR50210.1trans
rs16873760chr645729388OXTR50210.07trans
rs16873861chr645752854OXTR50210.06trans
rs17109578chr1090351347OXTR50210.11trans
rs6598553chr1599339208OXTR50210.17trans
rs17342483chrX102250155OXTR50210.05trans
rs5957194chrX118769609OXTR50210.05trans
rs23789738808285OXTRENSG00000180914.61.337E-60.033029gtex_brain_putamen_basal
rs380667538811646OXTRENSG00000180914.67.558E-70.03-332gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
CHN10.840.87
SYTL20.840.86
RGS40.830.86
CASQ10.830.76
GCNT40.810.81
KCNK10.800.82
HLF0.800.84
NRSN10.790.72
KIAA07480.790.84
GALNTL50.790.80
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PKN1-0.54-0.63
PDE9A-0.54-0.68
FADS2-0.53-0.57
SH3BP2-0.53-0.69
BCL7C-0.52-0.69
KIAA1949-0.52-0.59
TUBB2B-0.52-0.66
SH2B2-0.51-0.67
TRAF4-0.51-0.66
KCTD11-0.51-0.62

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0004990oxytocin receptor activityTAS10858434 
GO:0005000vasopressin receptor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007186G-protein coupled receptor protein signaling pathwayIEA-
GO:0007595lactationTAS1313946 
GO:0007565female pregnancyTAS1313946 
GO:0006936muscle contractionTAS1313946 
GO:0045777positive regulation of blood pressureIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005886plasma membraneTAS10858434 |10910058 
GO:0005887integral to plasma membraneTAS10858434 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CALCIUM SIGNALING PATHWAY 178134All SZGR 2.0 genes in this pathway
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205136All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 188108All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305177All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Q SIGNALLING EVENTS 184116All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408246All SZGR 2.0 genes in this pathway
ZHONG RESPONSE TO AZACITIDINE AND TSA UP 183119All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL DN 198110All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS DUCTAL NORMAL DN 9153All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS LOBULAR NORMAL UP 9459All SZGR 2.0 genes in this pathway
WILCOX RESPONSE TO PROGESTERONE DN 6644All SZGR 2.0 genes in this pathway
LIU TARGETS OF VMYB VS CMYB DN 4330All SZGR 2.0 genes in this pathway
MOROSETTI FACIOSCAPULOHUMERAL MUSCULAR DISTROPHY DN 126All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
PEREZ TP63 TARGETS 355243All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
BALDWIN PRKCI TARGETS UP 3526All SZGR 2.0 genes in this pathway
WESTON VEGFA TARGETS 6HR 5938All SZGR 2.0 genes in this pathway
WESTON VEGFA TARGETS 12HR 3523All SZGR 2.0 genes in this pathway
WESTON VEGFA TARGETS 10871All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS UP 280183All SZGR 2.0 genes in this pathway
ENGELMANN CANCER PROGENITORS DN 7044All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476285All SZGR 2.0 genes in this pathway
ZHENG IL22 SIGNALING UP 5636All SZGR 2.0 genes in this pathway
MATZUK POST-IMPLANTATION AND POST-PARTUM 1413All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425298All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536296All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER DN 13483All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435318All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS GROWING 243155All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT 567365All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745475All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38 337236All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP 489314All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516308All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-294264331A,m8hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU