Gene Page: P2RX4
Summary ?
GeneID | 5025 |
Symbol | P2RX4 |
Synonyms | P2X4|P2X4R |
Description | purinergic receptor P2X 4 |
Reference | MIM:600846|HGNC:HGNC:8535|Ensembl:ENSG00000135124|HPRD:09017|Vega:OTTHUMG00000169155 |
Gene type | protein-coding |
Map location | 12q24.32 |
Pascal p-value | 0.033 |
Sherlock p-value | 0.666 |
eGene | Meta |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 2 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0005102 | receptor binding | ISS | Neurotransmitter (GO term level: 4) | 17785580 |
GO:0001614 | purinergic nucleotide receptor activity | IDA | 9016352 | |
GO:0001614 | purinergic nucleotide receptor activity | IMP | 11606481 | |
GO:0004872 | receptor activity | IEA | - | |
GO:0004931 | ATP-gated cation channel activity | IDA | 9016352 | |
GO:0004931 | ATP-gated cation channel activity | IEA | - | |
GO:0005507 | copper ion binding | ISS | 12819199 | |
GO:0005524 | ATP binding | IEA | - | |
GO:0005216 | ion channel activity | IEA | - | |
GO:0008270 | zinc ion binding | ISS | 12819199 | |
GO:0042803 | protein homodimerization activity | NAS | 17895406 | |
GO:0045296 | cadherin binding | IPI | 12088286 | |
GO:0046982 | protein heterodimerization activity | ISS | 17785580 | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0060079 | regulation of excitatory postsynaptic membrane potential | IEA | neuron, Synap (GO term level: 10) | - |
GO:0002028 | regulation of sodium ion transport | ISS | 17785580 | |
GO:0001894 | tissue homeostasis | NAS | 17264311 | |
GO:0008217 | regulation of blood pressure | IMP | 11606481 |15130891 | |
GO:0010524 | positive regulation of calcium ion transport into cytosol | IDA | 10969036 | |
GO:0010524 | positive regulation of calcium ion transport into cytosol | IMP | 10899068 | |
GO:0007165 | signal transduction | IDA | 9016352 | |
GO:0010614 | negative regulation of cardiac muscle hypertrophy | IMP | 15130891 | |
GO:0006816 | calcium ion transport | IEA | - | |
GO:0006811 | ion transport | IEA | - | |
GO:0006809 | nitric oxide biosynthetic process | IEA | - | |
GO:0042981 | regulation of apoptosis | IDA | 17264311 | |
GO:0042311 | vasodilation | IEA | - | |
GO:0033198 | response to ATP | IDA | 9016352 | |
GO:0042118 | endothelial cell activation | TAS | 12088286 | |
GO:0032308 | positive regulation of prostaglandin secretion | NAS | 10899068 | |
GO:0019233 | sensory perception of pain | ISS | 14978347 | |
GO:0034405 | response to fluid shear stress | IDA | 10969036 | |
GO:0050850 | positive regulation of calcium-mediated signaling | IDA | 10969036 | |
GO:0050850 | positive regulation of calcium-mediated signaling | IMP | 10899068 | |
GO:0045429 | positive regulation of nitric oxide biosynthetic process | NAS | 10899068 | |
GO:0055117 | regulation of cardiac muscle contraction | IMP | 11606481 |15130891 | |
GO:0055119 | relaxation of cardiac muscle | IMP | 11606481 |15130891 | |
GO:0051899 | membrane depolarization | IDA | 9016352 | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0016020 | membrane | IEA | - | |
GO:0016021 | integral to membrane | IEA | - | |
GO:0005886 | plasma membrane | ISS | 17785580 | |
GO:0005887 | integral to plasma membrane | TAS | 9016352 | |
GO:0048471 | perinuclear region of cytoplasm | IDA | 12088286 | |
GO:0030054 | cell junction | IDA | 12088286 | |
GO:0045177 | apical part of cell | IEA | - |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
KEGG CALCIUM SIGNALING PATHWAY | 178 | 134 | All SZGR 2.0 genes in this pathway |
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION | 272 | 195 | All SZGR 2.0 genes in this pathway |
LIU SOX4 TARGETS DN | 309 | 191 | All SZGR 2.0 genes in this pathway |
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP | 579 | 346 | All SZGR 2.0 genes in this pathway |
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC UP | 185 | 126 | All SZGR 2.0 genes in this pathway |
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP | 157 | 104 | All SZGR 2.0 genes in this pathway |
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINDED IN ERYTHROCYTE UP | 44 | 30 | All SZGR 2.0 genes in this pathway |
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN | 770 | 415 | All SZGR 2.0 genes in this pathway |
BERENJENO TRANSFORMED BY RHOA DN | 394 | 258 | All SZGR 2.0 genes in this pathway |
PATIL LIVER CANCER | 747 | 453 | All SZGR 2.0 genes in this pathway |
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN | 584 | 395 | All SZGR 2.0 genes in this pathway |
LE EGR2 TARGETS UP | 108 | 75 | All SZGR 2.0 genes in this pathway |
IVANOVA HEMATOPOIESIS STEM CELL LONG TERM | 302 | 191 | All SZGR 2.0 genes in this pathway |
CUI TCF21 TARGETS 2 DN | 830 | 547 | All SZGR 2.0 genes in this pathway |
XU GH1 AUTOCRINE TARGETS UP | 268 | 157 | All SZGR 2.0 genes in this pathway |
WELCSH BRCA1 TARGETS DN | 141 | 92 | All SZGR 2.0 genes in this pathway |
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP | 953 | 554 | All SZGR 2.0 genes in this pathway |
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP | 783 | 442 | All SZGR 2.0 genes in this pathway |
MARSON BOUND BY FOXP3 STIMULATED | 1022 | 619 | All SZGR 2.0 genes in this pathway |
LINDSTEDT DENDRITIC CELL MATURATION A | 67 | 52 | All SZGR 2.0 genes in this pathway |
ZHANG TLX TARGETS 36HR UP | 221 | 150 | All SZGR 2.0 genes in this pathway |
COLINA TARGETS OF 4EBP1 AND 4EBP2 | 356 | 214 | All SZGR 2.0 genes in this pathway |
CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | All SZGR 2.0 genes in this pathway |
MILI PSEUDOPODIA CHEMOTAXIS DN | 457 | 302 | All SZGR 2.0 genes in this pathway |
JISON SICKLE CELL DISEASE UP | 181 | 106 | All SZGR 2.0 genes in this pathway |
WONG ADULT TISSUE STEM MODULE | 721 | 492 | All SZGR 2.0 genes in this pathway |
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP | 242 | 159 | All SZGR 2.0 genes in this pathway |
WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP | 397 | 206 | All SZGR 2.0 genes in this pathway |
WIERENGA STAT5A TARGETS UP | 217 | 131 | All SZGR 2.0 genes in this pathway |
WIERENGA STAT5A TARGETS GROUP1 | 136 | 76 | All SZGR 2.0 genes in this pathway |
BRUINS UVC RESPONSE VIA TP53 GROUP B | 549 | 316 | All SZGR 2.0 genes in this pathway |
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP | 259 | 159 | All SZGR 2.0 genes in this pathway |
LEE BMP2 TARGETS UP | 745 | 475 | All SZGR 2.0 genes in this pathway |
FEVR CTNNB1 TARGETS UP | 682 | 433 | All SZGR 2.0 genes in this pathway |
VANLOO SP3 TARGETS DN | 89 | 47 | All SZGR 2.0 genes in this pathway |
PEDRIOLI MIR31 TARGETS DN | 418 | 245 | All SZGR 2.0 genes in this pathway |
LIM MAMMARY STEM CELL DN | 428 | 246 | All SZGR 2.0 genes in this pathway |
Section VI. microRNA annotation
miRNA family | Target position | miRNA ID | miRNA seq | ||
---|---|---|---|---|---|
UTR start | UTR end | Match method | |||
miR-17-5p/20/93.mr/106/519.d | 381 | 388 | 1A,m8 | hsa-miR-17-5p | CAAAGUGCUUACAGUGCAGGUAGU |
hsa-miR-20abrain | UAAAGUGCUUAUAGUGCAGGUAG | ||||
hsa-miR-106a | AAAAGUGCUUACAGUGCAGGUAGC | ||||
hsa-miR-106bSZ | UAAAGUGCUGACAGUGCAGAU | ||||
hsa-miR-20bSZ | CAAAGUGCUCAUAGUGCAGGUAG | ||||
hsa-miR-519d | CAAAGUGCCUCCCUUUAGAGUGU |
- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.