Summary ?
GeneID5025
SymbolP2RX4
SynonymsP2X4|P2X4R
Descriptionpurinergic receptor P2X 4
ReferenceMIM:600846|HGNC:HGNC:8535|Ensembl:ENSG00000135124|HPRD:09017|Vega:OTTHUMG00000169155
Gene typeprotein-coding
Map location12q24.32
Pascal p-value0.033
Sherlock p-value0.666
eGeneMeta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingISSNeurotransmitter (GO term level: 4)17785580 
GO:0001614purinergic nucleotide receptor activityIDA9016352 
GO:0001614purinergic nucleotide receptor activityIMP11606481 
GO:0004872receptor activityIEA-
GO:0004931ATP-gated cation channel activityIDA9016352 
GO:0004931ATP-gated cation channel activityIEA-
GO:0005507copper ion bindingISS12819199 
GO:0005524ATP bindingIEA-
GO:0005216ion channel activityIEA-
GO:0008270zinc ion bindingISS12819199 
GO:0042803protein homodimerization activityNAS17895406 
GO:0045296cadherin bindingIPI12088286 
GO:0046982protein heterodimerization activityISS17785580 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0060079regulation of excitatory postsynaptic membrane potentialIEAneuron, Synap (GO term level: 10)-
GO:0002028regulation of sodium ion transportISS17785580 
GO:0001894tissue homeostasisNAS17264311 
GO:0008217regulation of blood pressureIMP11606481 |15130891 
GO:0010524positive regulation of calcium ion transport into cytosolIDA10969036 
GO:0010524positive regulation of calcium ion transport into cytosolIMP10899068 
GO:0007165signal transductionIDA9016352 
GO:0010614negative regulation of cardiac muscle hypertrophyIMP15130891 
GO:0006816calcium ion transportIEA-
GO:0006811ion transportIEA-
GO:0006809nitric oxide biosynthetic processIEA-
GO:0042981regulation of apoptosisIDA17264311 
GO:0042311vasodilationIEA-
GO:0033198response to ATPIDA9016352 
GO:0042118endothelial cell activationTAS12088286 
GO:0032308positive regulation of prostaglandin secretionNAS10899068 
GO:0019233sensory perception of painISS14978347 
GO:0034405response to fluid shear stressIDA10969036 
GO:0050850positive regulation of calcium-mediated signalingIDA10969036 
GO:0050850positive regulation of calcium-mediated signalingIMP10899068 
GO:0045429positive regulation of nitric oxide biosynthetic processNAS10899068 
GO:0055117regulation of cardiac muscle contractionIMP11606481 |15130891 
GO:0055119relaxation of cardiac muscleIMP11606481 |15130891 
GO:0051899membrane depolarizationIDA9016352 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneISS17785580 
GO:0005887integral to plasma membraneTAS9016352 
GO:0048471perinuclear region of cytoplasmIDA12088286 
GO:0030054cell junctionIDA12088286 
GO:0045177apical part of cellIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CALCIUM SIGNALING PATHWAY 178134All SZGR 2.0 genes in this pathway
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS DN 309191All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579346All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC UP 185126All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP 157104All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINDED IN ERYTHROCYTE UP 4430All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770415All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN 394258All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747453All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584395All SZGR 2.0 genes in this pathway
LE EGR2 TARGETS UP 10875All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL LONG TERM 302191All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830547All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS UP 268157All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS DN 14192All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953554All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783442All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION A 6752All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR UP 221150All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2 356214All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN 457302All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE UP 181106All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721492All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP 242159All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP 397206All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS UP 217131All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS GROUP1 13676All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549316All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP 259159All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745475All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682433All SZGR 2.0 genes in this pathway
VANLOO SP3 TARGETS DN 8947All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN 418245All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL DN 428246All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-17-5p/20/93.mr/106/519.d3813881A,m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU